{"id":"https://openalex.org/W2991004281","doi":"https://doi.org/10.3389/fnmol.2019.00294","title":"The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain","display_name":"The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain","publication_year":2019,"publication_date":"2019-11-29","ids":{"openalex":"https://openalex.org/W2991004281","doi":"https://doi.org/10.3389/fnmol.2019.00294","mag":"2991004281","pmid":"https://pubmed.ncbi.nlm.nih.gov/31849607","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6895903"},"language":"en","primary_location":{"id":"doi:10.3389/fnmol.2019.00294","doi":"https://doi.org/10.3389/fnmol.2019.00294","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2019.00294","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnmol.2019.00294/pdf","source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnmol.2019.00294/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024283686","display_name":"Wei Lei","orcid":"https://orcid.org/0000-0002-0374-8642","observed_orcids":["https://orcid.org/0000-0002-0374-8642"]},"institutions":[{"id":"https://openalex.org/I137582240","display_name":"Presbyterian College","ror":"https://ror.org/01s9sxm36","country_code":"US","type":"education","lineage":["https://openalex.org/I137582240"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Lei","raw_affiliation_strings":["Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, Presbyterian College, Clinton, SC, United States","Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, Presbyterian College, Clinton, SC, United States","institution_ids":["https://openalex.org/I137582240"]},{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065274606","display_name":"David I. Duron","orcid":"https://orcid.org/0000-0003-4601-3803","observed_orcids":["https://orcid.org/0000-0003-4601-3803"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David I. Duron","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000862400","display_name":"Carrie Stine","orcid":"https://orcid.org/0000-0001-8171-3464","observed_orcids":["https://orcid.org/0000-0001-8171-3464"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie Stine","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101512522","display_name":"Sanket J. Mishra","orcid":"https://orcid.org/0000-0002-6010-7374","observed_orcids":["https://orcid.org/0000-0002-6010-7374"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanket Mishra","raw_affiliation_strings":["Department of Chemistry & Biochemistry, College of Science, University of Notre Dame, Notre Dame, IN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, College of Science, University of Notre Dame, Notre Dame, IN, United States","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062921807","display_name":"Brian S. J. Blagg","orcid":"https://orcid.org/0000-0002-6200-3480","observed_orcids":["https://orcid.org/0000-0002-6200-3480"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian S. J. Blagg","raw_affiliation_strings":["Department of Chemistry & Biochemistry, College of Science, University of Notre Dame, Notre Dame, IN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, College of Science, University of Notre Dame, Notre Dame, IN, United States","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041595412","display_name":"John M. Streicher","orcid":"https://orcid.org/0000-0002-4173-7362","observed_orcids":["https://orcid.org/0000-0002-4173-7362"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John M. Streicher","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041595412"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.8197,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.69381727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":null,"first_page":"294","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.11680000275373459,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90alpha","display_name":"HSP90\u03b1","score":0.777999997138977},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8199999928474426},{"id":"https://openalex.org/keywords/p23","display_name":"p23","score":0.824999988079071},{"id":"https://openalex.org/keywords/cdc37","display_name":"Cdc37","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aha1","display_name":"Aha1","score":0.7730000019073486},{"id":"https://openalex.org/keywords/grp94","display_name":"GRP94","score":0.8090000152587891},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.8349999785423279},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.859000027179718},{"id":"https://openalex.org/keywords/opioid-side-effects","display_name":"opioid side effects","score":0.4390000104904175},{"id":"https://openalex.org/keywords/biased-agonism","display_name":"biased agonism","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mrna-translation","display_name":"mRNA translation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/crispr-cas9-genome-editing","display_name":"CRISPR/Cas9 genome editing","score":0.8050000071525574},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.7404906153678894},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6575397253036499},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.602717399597168},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5858232975006104},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5383871793746948},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5332130193710327},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.48561373353004456},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42101797461509705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3534805178642273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3514469265937805},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3325180411338806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1825236976146698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16107714176177979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.154137521982193},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09399530291557312},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fnmol.2019.00294","doi":"https://doi.org/10.3389/fnmol.2019.00294","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2019.00294","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnmol.2019.00294/pdf","source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5869287","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6895903","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6895903","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6895903","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Mol Neurosci","raw_type":"Text"},{"id":"pmid:31849607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31849607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in molecular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:repository.arizona.edu:10150/636746","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/636746","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Frontiers in molecular neuroscience","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:9fc67b842b574c10b83d599bf299a5bc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9fc67b842b574c10b83d599bf299a5bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Molecular Neuroscience, Vol 12 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnmol.2019.00294","doi":"https://doi.org/10.3389/fnmol.2019.00294","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2019.00294","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnmol.2019.00294/pdf","source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2041840133","display_name":null,"funder_award_id":"ADHS18-198875","funder_id":"https://openalex.org/F4320332140","funder_display_name":"Arizona Biomedical Research Commission"},{"id":"https://openalex.org/G3874440852","display_name":"New paradigms for Hsp90 inhibition","funder_award_id":"R01CA213566","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332140","display_name":"Arizona Biomedical Research Commission","ror":"https://ror.org/01smpj292"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2991004281.pdf","grobid_xml":"https://content.openalex.org/works/W2991004281.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1966238197","https://openalex.org/W1986579014","https://openalex.org/W2003199957","https://openalex.org/W2004551214","https://openalex.org/W2015087988","https://openalex.org/W2025623674","https://openalex.org/W2030858953","https://openalex.org/W2032255930","https://openalex.org/W2044996865","https://openalex.org/W2053040310","https://openalex.org/W2079334276","https://openalex.org/W2085879736","https://openalex.org/W2087684358","https://openalex.org/W2100881236","https://openalex.org/W2106835772","https://openalex.org/W2109083102","https://openalex.org/W2112370465","https://openalex.org/W2112374700","https://openalex.org/W2119064835","https://openalex.org/W2126158484","https://openalex.org/W2135385360","https://openalex.org/W2136979317","https://openalex.org/W2152165944","https://openalex.org/W2165671231","https://openalex.org/W2172201406","https://openalex.org/W2189515633","https://openalex.org/W2238888716","https://openalex.org/W2439195794","https://openalex.org/W2488050956","https://openalex.org/W2512819857","https://openalex.org/W2563237420","https://openalex.org/W2608001712","https://openalex.org/W2612796016","https://openalex.org/W2746419333","https://openalex.org/W2751190598","https://openalex.org/W2770319189","https://openalex.org/W2789738555","https://openalex.org/W2907450274","https://openalex.org/W2914579864","https://openalex.org/W2957907886","https://openalex.org/W3119696430","https://openalex.org/W4245469960"],"related_works":["https://openalex.org/W3174428061","https://openalex.org/W3016909129","https://openalex.org/W2608001712","https://openalex.org/W2790270040","https://openalex.org/W3176530855","https://openalex.org/W4389018459","https://openalex.org/W4389007631","https://openalex.org/W2597439263","https://openalex.org/W3021210502","https://openalex.org/W7164010218"],"abstract_inverted_index":{"Opioid":[0],"activation":[1],"of":[2,26,45,76,138,157,168,186,197,233,241,268],"the":[3,42,46,80,94,131,136,158,183,190,198,222,250],"mu":[4],"opioid":[5,39,77,187,214,234,242,257,282],"receptor":[6],"(MOR)":[7],"promotes":[8,256],"signaling":[9,43],"cascades":[10,44],"that":[11,155,195,207,226],"evoke":[12],"both":[13,262],"analgesic":[14],"responses":[15],"to":[16,37,92,135,142,224,280],"pain":[17],"and":[18,23,73,97,148,176,201,272],"side":[19],"effects":[20],"like":[21],"addiction":[22],"dependence.":[24],"Manipulation":[25],"these":[27,208,245],"cascades,":[28],"such":[29],"as":[30,70,122,124,182],"by":[31,82,99,130,253],"biased":[32],"agonism,":[33],"has":[34],"great":[35],"promise":[36],"improve":[38,263,281],"therapy.":[40,283],"However,":[41],"MOR":[47,269],"are":[48],"in":[49,79,165,189,212,221],"general":[50],"poorly":[51],"understood,":[52],"providing":[53],"few":[54],"targets":[55,110,276],"for":[56,111,238,277],"drug":[57],"development.":[58],"In":[59,87],"our":[60,264],"earlier":[61],"work":[62],"we":[63,90,217],"identified":[64],"Heat":[65],"shock":[66],"protein":[67,228],"90":[68],"(Hsp90)":[69],"a":[71,166],"novel":[72,117],"crucial":[74],"regulator":[75,185],"anti-nociception":[78,164],"brain":[81,223],"promoting":[83,213],"ERK":[84,175],"MAPK":[85,178],"activation.":[86],"this":[88,104],"study":[89],"sought":[91],"identify":[93],"molecular":[95,251],"isoforms":[96,145],"co-chaperones":[98,149,199,209],"which":[100,106,254],"Hsp90":[101,144,239,255],"carried":[102],"out":[103],"role,":[105],"could":[107,273],"provide":[108,247,274],"specific":[109],"future":[112,275],"clinical":[113,278],"intervention.":[114],"We":[115,153,192],"used":[116,218],"selective":[118],"small":[119],"molecule":[120],"inhibitors":[121],"well":[123],"CRISPR/Cas9":[125],"gene":[126],"editing":[127],"constructs":[128],"delivered":[129],"intracerebroventricular":[132],"(icv)":[133],"route":[134],"brains":[137],"adult":[139],"CD-1":[140],"mice":[141],"target":[143],"(Hsp90\u03b1/\u03b2,":[146],"Grp94)":[147],"(p23,":[150],"Cdc37,":[151],"Aha1).":[152],"found":[154,194],"inhibition":[156,196],"isoform":[159],"Hsp90\u03b1":[160,181,211],"fully":[161],"blocked":[162,203],"morphine":[163,204],"model":[167],"post-surgical":[169],"paw":[170],"incision":[171],"pain,":[172],"while":[173],"blocking":[174],"JNK":[177],"activation,":[179],"suggesting":[180,206],"main":[184],"response":[188],"brain.":[191],"further":[193],"p23":[200],"Cdc37":[202],"anti-nociception,":[205],"assist":[210],"anti-nociception.":[215,258],"Lastly":[216],"cycloheximide":[219],"treatment":[220,235],"demonstrate":[225],"rapid":[227],"translation":[229],"within":[230],"30":[231],"minutes":[232],"is":[236],"required":[237],"regulation":[240],"response.":[243],"Together":[244],"studies":[246],"insight":[248],"into":[249],"mechanisms":[252],"These":[259],"findings":[260],"thus":[261],"basic":[265],"science":[266],"knowledge":[267],"signal":[270],"transduction":[271],"intervention":[279]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}