{"id":"https://openalex.org/W2990959639","doi":null,"title":"Molecular alterations induced by fructose and its impact on metabolic diseases","display_name":"Molecular alterations induced by fructose and its impact on metabolic diseases","publication_year":2019,"publication_date":"2019-01-28","ids":{"openalex":"https://openalex.org/W2990959639","mag":"2990959639","pmid":"https://pubmed.ncbi.nlm.nih.gov/30777418"},"language":"es","primary_location":{"id":"pmid:30777418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30777418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista medica del Instituto Mexicano del Seguro Social","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002920902","display_name":"Stephanie Sarai Loza-Medrano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie Sarai Loza-Medrano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075767841","display_name":"Lu\u00eds Arturo Baiza-Gutman","orcid":"https://orcid.org/0000-0002-3669-4185","observed_orcids":["https://orcid.org/0000-0002-3669-4185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis Arturo Baiza-Gutman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089737584","display_name":"Miguel \u00c1ngel Ib\u00e1\u00f1ez-Hern\u00e1ndez","orcid":"https://orcid.org/0000-0003-4013-6888","observed_orcids":["https://orcid.org/0000-0003-4013-6888","https://orcid.org/0000-0003-4337-1349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel \u00c1ngel Ib\u00e1\u00f1ez-Hern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064103007","display_name":"Miguel Cruz","orcid":"https://orcid.org/0000-0001-9985-6172","observed_orcids":["https://orcid.org/0000-0001-9985-6172","https://orcid.org/0000-0003-4280-4501","https://orcid.org/0000-0001-6909-2941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Cruz-L\u00f3pez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071954858","display_name":"Margarita D\u00edaz-Flores","orcid":"https://orcid.org/0000-0001-9764-2701","observed_orcids":["https://orcid.org/0000-0001-9764-2701"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Margarita D\u00edaz-Flores","raw_affiliation_strings":["Instituto Mexicano del Seguro Social, Hospital de Especialidades \u201cDr. Bernardo Sep\u00falveda Guti\u00e9rrez\u201d, Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica. Ciudad de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Mexicano del Seguro Social, Hospital de Especialidades \u201cDr. Bernardo Sep\u00falveda Guti\u00e9rrez\u201d, Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica. Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I164915025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3945,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.66386156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"56","issue":"5","first_page":"491","last_page":"504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fructose","display_name":"fructose","score":0.968999981880188},{"id":"https://openalex.org/keywords/high-fructose-corn-syrup","display_name":"high fructose corn syrup","score":0.9950000047683716},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.7300000190734863},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8709999918937683},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6859999895095825},{"id":"https://openalex.org/keywords/triose-phosphate","display_name":"triose phosphate","score":0.6819999814033508},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.6309999823570251},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.7609999775886536},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.925000011920929},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.574999988079071},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.6326346397399902},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5977601408958435},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5106809735298157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4897768497467041},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.44367432594299316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38325396180152893},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3594379425048828},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3031041622161865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3024166226387024},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2444974184036255}],"mesh":[{"descriptor_ui":"D000073417","descriptor_name":"Dietary Sugars","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000073417","descriptor_name":"Dietary Sugars","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D033461","descriptor_name":"Hyperuricemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:30777418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30777418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista medica del Instituto Mexicano del Seguro Social","raw_type":"Journal Article"},{"id":"pmh:oai:redalyc.org:457758201010","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=457758201010","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instname:Universidad Nacional Aut\u00f3noma de M\u00e9xico","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2990959639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30777418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W32965766","https://openalex.org/W1850330438","https://openalex.org/W1931350247","https://openalex.org/W1948104620","https://openalex.org/W1957051282","https://openalex.org/W1967008598","https://openalex.org/W1973054372","https://openalex.org/W2001574810","https://openalex.org/W2004920315","https://openalex.org/W2018127398","https://openalex.org/W2026454238","https://openalex.org/W2027831465","https://openalex.org/W2036047239","https://openalex.org/W2040035201","https://openalex.org/W2041176515","https://openalex.org/W2044842369","https://openalex.org/W2049193460","https://openalex.org/W2059617884","https://openalex.org/W2065133613","https://openalex.org/W2065402200","https://openalex.org/W2065486513","https://openalex.org/W2067174853","https://openalex.org/W2080304351","https://openalex.org/W2098555833","https://openalex.org/W2100980533","https://openalex.org/W2102767551","https://openalex.org/W2105544198","https://openalex.org/W2110792757","https://openalex.org/W2111732109","https://openalex.org/W2112710584","https://openalex.org/W2114597116","https://openalex.org/W2114918553","https://openalex.org/W2119065763","https://openalex.org/W2122347435","https://openalex.org/W2123981205","https://openalex.org/W2130578257","https://openalex.org/W2133811076","https://openalex.org/W2136877174","https://openalex.org/W2141501627","https://openalex.org/W2148551969","https://openalex.org/W2151834039","https://openalex.org/W2153117421","https://openalex.org/W2153416462","https://openalex.org/W2162627097","https://openalex.org/W2167196393","https://openalex.org/W2277093054","https://openalex.org/W2286797029","https://openalex.org/W2472823754","https://openalex.org/W2563466404","https://openalex.org/W2565680418","https://openalex.org/W2572954835"],"related_works":["https://openalex.org/W7120847268","https://openalex.org/W6998552619","https://openalex.org/W4293276412","https://openalex.org/W3202109875","https://openalex.org/W4293440287","https://openalex.org/W6887533666","https://openalex.org/W7027935884","https://openalex.org/W2588083033","https://openalex.org/W2901447021","https://openalex.org/W4391700922"],"abstract_inverted_index":{"Scientific":[0],"evidence":[1],"has":[2],"identified":[3],"that":[4,76,87],"the":[5,28,45,50,71,78,98,116,124,132],"excessive":[6],"consumption":[7,125],"of":[8,31,41,73,82,100,113,126,134,147],"products":[9],"made":[10],"from":[11],"high-fructose":[12],"corn":[13],"syrup":[14],"is":[15,37,57,63,128],"a":[16,33],"trigger":[17],"for":[18],"obesity,":[19],"whose":[20],"prevalence":[21],"increased":[22],"in":[23],"recent":[24],"years.":[25],"Due":[26],"to":[27,49,97,130,140,144],"metabolic":[29,135],"characteristics":[30],"fructose,":[32],"rapid":[34],"gastric":[35],"emptying":[36],"produced,":[38],"altering":[39],"signals":[40],"hunger-satiety":[42],"and":[43,59,80,85,94,110,119],"decreasing":[44],"appetite.":[46],"In":[47],"addition":[48],"hepatic":[51],"level":[52],"during":[53],"catabolism,":[54],"triose":[55],"phosphate":[56,69],"generated":[58],"adenosine":[60],"triphosphate":[61],"(ATP)":[62],"reduced,":[64],"producing":[65],"uric":[66],"acid.":[67],"Triose":[68],"triggers":[70],"synthesis":[72],"fatty":[74,107],"acids":[75],"increase":[77],"production":[79],"accumulation":[81],"triglycerides,":[83],"diacylglycerols":[84],"ceramides":[86],"induce":[88],"insulin":[89,92],"resistance.":[90],"Hyperlipidemia,":[91],"resistance":[93],"hyperuricemia":[95],"contribute":[96],"development":[99,133],"hypertension,":[101],"cardiovascular":[102],"disease,":[103],"kidney":[104],"failure,":[105],"non-alcoholic":[106],"liver":[108],"disease":[109],"some":[111],"kinds":[112],"cancer.":[114],"Understanding":[115],"molecular":[117],"mechanisms":[118],"signaling":[120],"pathways":[121],"altered":[122],"by":[123],"fructose":[127],"relevant":[129],"understand":[131],"diseases,":[136],"as":[137,139],"well":[138],"seek":[141],"therapeutic":[142],"strategies":[143],"improve":[145],"quality":[146],"life.":[148]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}