{"id":"https://openalex.org/W2990955574","doi":"https://doi.org/10.1371/journal.pone.0225095","title":"DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy","display_name":"DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy","publication_year":2019,"publication_date":"2019-11-19","ids":{"openalex":"https://openalex.org/W2990955574","doi":"https://doi.org/10.1371/journal.pone.0225095","mag":"2990955574","pmid":"https://pubmed.ncbi.nlm.nih.gov/31743348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6863550"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0225095","doi":"https://doi.org/10.1371/journal.pone.0225095","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0225095","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0225095&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0225095&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004778417","display_name":"Eunseo Jang","orcid":"https://orcid.org/0000-0002-6152-441X","observed_orcids":["https://orcid.org/0000-0002-6152-441X"]},"institutions":[{"id":"https://openalex.org/I4210162961","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210162961"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunseo Jang","raw_affiliation_strings":["Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea","institution_ids":["https://openalex.org/I4210162961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107999930","display_name":"Min\u2010Hee Son","orcid":"https://orcid.org/0000-0001-5874-5556","observed_orcids":["https://orcid.org/0000-0001-5874-5556"]},"institutions":[{"id":"https://openalex.org/I4210157252","display_name":"Dae Hwa Pharm (South Korea)","ror":"https://ror.org/05h9jst55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210157252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minhee Son","raw_affiliation_strings":["Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea","institution_ids":["https://openalex.org/I4210157252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045387950","display_name":"Junhee Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157252","display_name":"Dae Hwa Pharm (South Korea)","ror":"https://ror.org/05h9jst55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210157252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Junhee Jang","raw_affiliation_strings":["Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea","institution_ids":["https://openalex.org/I4210157252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038146704","display_name":"In\u2010Hyun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157252","display_name":"Dae Hwa Pharm (South Korea)","ror":"https://ror.org/05h9jst55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210157252"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In-Hyun Lee","raw_affiliation_strings":["Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea","institution_ids":["https://openalex.org/I4210157252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698372","display_name":"Sol Kim","orcid":"https://orcid.org/0009-0003-9411-3232","observed_orcids":["https://orcid.org/0009-0003-9411-3232","https://orcid.org/0009-0008-0722-3457"]},"institutions":[{"id":"https://openalex.org/I4210157252","display_name":"Dae Hwa Pharm (South Korea)","ror":"https://ror.org/05h9jst55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210157252"]},{"id":"https://openalex.org/I4210162961","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210162961"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sol Kim","raw_affiliation_strings":["Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea","Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea","institution_ids":["https://openalex.org/I4210157252"]},{"raw_affiliation_string":"Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea","institution_ids":["https://openalex.org/I4210162961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103405018","display_name":"Tae-Jun Kwon","orcid":"https://orcid.org/0000-0003-1630-6947","observed_orcids":["https://orcid.org/0000-0003-1630-6947"]},"institutions":[{"id":"https://openalex.org/I4210162961","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210162961"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taejun Kwon","raw_affiliation_strings":["Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea","institution_ids":["https://openalex.org/I4210162961"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong-hyun Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162961","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210162961"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-hyun Jeon","raw_affiliation_strings":["Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea","institution_ids":["https://openalex.org/I4210162961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009594899","display_name":"Woo-Suk Koh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162961","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210162961"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo-Suk Koh","raw_affiliation_strings":["Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea","institution_ids":["https://openalex.org/I4210162961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050286398","display_name":"Kil\u2010Soo Kim","orcid":"https://orcid.org/0000-0001-7370-2685","observed_orcids":["https://orcid.org/0000-0001-7370-2685","https://orcid.org/0000-0003-1960-4464"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]},{"id":"https://openalex.org/I4210162961","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210162961"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kil-Soo Kim","raw_affiliation_strings":["College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea","Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea","institution_ids":["https://openalex.org/I4210162961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072689710","display_name":"Sang Kyoon Kim","orcid":"https://orcid.org/0000-0001-9848-301X","observed_orcids":["https://orcid.org/0000-0001-9848-301X"]},"institutions":[{"id":"https://openalex.org/I4210157252","display_name":"Dae Hwa Pharm (South Korea)","ror":"https://ror.org/05h9jst55","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210157252"]},{"id":"https://openalex.org/I4210162961","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210162961"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Kyoon Kim","raw_affiliation_strings":["Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea","Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea"],"raw_orcid":"https://orcid.org/0000-0001-9848-301X","affiliations":[{"raw_affiliation_string":"Dae Hwa Pharmaceutical Co. Ltd., Pangyo Research Laboratory, Sungnam City, South Korea","institution_ids":["https://openalex.org/I4210157252"]},{"raw_affiliation_string":"Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea","institution_ids":["https://openalex.org/I4210162961"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072689710"],"corresponding_institution_ids":["https://openalex.org/I4210157252","https://openalex.org/I4210162961"],"apc_list":{"value":1595,"currency":"USD","value_usd":1595},"apc_paid":{"value":1595,"currency":"USD","value_usd":1595},"fwci":0.2238,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53672418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"14","issue":"11","first_page":"e0225095","last_page":"e0225095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.38769999146461487,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.38769999146461487,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.27639999985694885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.2304999977350235,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8999999761581421},{"id":"https://openalex.org/keywords/oral-chemotherapy","display_name":"oral chemotherapy","score":0.6700000166893005},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9769999980926514},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8320000171661377},{"id":"https://openalex.org/keywords/taxol-comparison","display_name":"taxol comparison","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.9041163325309753},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.845937192440033},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7499846816062927},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7033314108848572},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6806539297103882},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.6516865491867065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6492142677307129},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5498448014259338},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41730859875679016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40225109457969666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24765479564666748},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0225095","doi":"https://doi.org/10.1371/journal.pone.0225095","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0225095","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0225095&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:31743348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31743348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6863550","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6863550/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:31204c84ebcb43e286ee5428fb1055c8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/31204c84ebcb43e286ee5428fb1055c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 14, Iss 11, p e0225095 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/10368248","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/DHP23002_as_a_next_generation_oral_paclitaxel_formulation_for_pancreatic_cancer_therapy/10368248","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0225095","doi":"https://doi.org/10.1371/journal.pone.0225095","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0225095","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0225095&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4277724595","display_name":null,"funder_award_id":"HI15C0001","funder_id":"https://openalex.org/F4320322034","funder_display_name":"Ministry of Health and Welfare"},{"id":"https://openalex.org/G5071035352","display_name":null,"funder_award_id":"HT13C0002","funder_id":"https://openalex.org/F4320322034","funder_display_name":"Ministry of Health and Welfare"},{"id":"https://openalex.org/G5375263557","display_name":null,"funder_award_id":"27306C0002","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6264369153","display_name":null,"funder_award_id":"HT13C0002","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G6988248355","display_name":null,"funder_award_id":"27304C0002","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7257029295","display_name":null,"funder_award_id":"HT13C0002","funder_id":"https://openalex.org/F4320328011","funder_display_name":"Daegu-Gyeongbuk Medical Innovation Foundation"},{"id":"https://openalex.org/G7614435906","display_name":null,"funder_award_id":"HI15C0001","funder_id":"https://openalex.org/F4320328011","funder_display_name":"Daegu-Gyeongbuk Medical Innovation Foundation"},{"id":"https://openalex.org/G8667789225","display_name":null,"funder_award_id":"HI15C0001","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"}],"funders":[{"id":"https://openalex.org/F4320322034","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/00vxgjw72"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320328011","display_name":"Daegu-Gyeongbuk Medical Innovation Foundation","ror":"https://ror.org/05cc1v231"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990955574.pdf","grobid_xml":"https://content.openalex.org/works/W2990955574.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1587064582","https://openalex.org/W1757407923","https://openalex.org/W1801994275","https://openalex.org/W1931508686","https://openalex.org/W1965697619","https://openalex.org/W2001683026","https://openalex.org/W2009102978","https://openalex.org/W2044884111","https://openalex.org/W2102903528","https://openalex.org/W2137597770","https://openalex.org/W2142969660","https://openalex.org/W2154985964","https://openalex.org/W2401475323","https://openalex.org/W2554987853","https://openalex.org/W2588739288","https://openalex.org/W2724614897","https://openalex.org/W2757092391","https://openalex.org/W2915480655"],"related_works":["https://openalex.org/W2999365191","https://openalex.org/W2891057236","https://openalex.org/W1587064582","https://openalex.org/W1964666360","https://openalex.org/W1965697619","https://openalex.org/W4393989013","https://openalex.org/W2035433078","https://openalex.org/W2061333709","https://openalex.org/W1972810098","https://openalex.org/W4240450862"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1,273],"study":[2,44],"aimed":[3],"to":[4,13,56,71,117,130,262,291],"develop":[5],"a":[6,21,34,42,163,169,177,183,194,209,220,263,268,283],"new":[7],"oral":[8,30,160,292],"paclitaxel":[9,40,132,142,276],"formulation":[10],"(DHP23002)":[11,133],"and":[12,17,52,81,217,247,280],"evaluate":[14,57],"its":[15],"absorption":[16,31,171,258],"antitumor":[18,59,265],"effects":[19],"in":[20,49,63,114,135,143,219,230,236,259,267],"pancreatic":[22,64,269],"tumor":[23,112,137,211,288],"mouse":[24,157,222,271],"model.":[25,272],"METHODS:":[26],"To":[27],"investigate":[28],"the":[29,58,67,87,90,95,136,139,156,287],"of":[32,45,61,89,97,110,141,179,185,196,214,244],"DHP23002,":[33,46],"newly":[35],"developed":[36],"lipid-based":[37],"orally":[38,239],"active":[39],"formulation,":[41],"pharmacokinetic":[43,158],"was":[47,69,92,120,145],"conducted":[48],"mice":[50,75,115],"(62.5":[51],"125":[53,82,200,248],"mg/kg).":[54],"Moreover,":[55,129],"effect":[60,213],"DHP23002":[62,167,191,255,293],"cancer":[65,270],"treatment,":[66],"drug":[68],"administered":[70,240],"female":[72],"athymic":[73],"nude":[74],"at":[76,101,182,193,242,286],"0":[77],"(vehicle),":[78],"25,":[79,197,245],"62.5,":[80,198,246],"mg/kg":[83,103,201,249],"on":[84,174,202],"alternate":[85,203],"days;":[86],"efficacy":[88,96],"agent":[91],"compared":[93],"with":[94,150,176,254],"intravenous":[98],"Taxol\u00ae":[99,161],"injections":[100],"10":[102],"once":[104,241],"per":[105],"week.":[106],"After":[107],"3":[108,206],"weeks":[109,125,207],"administration,":[111],"growth":[113],"belonging":[116],"each":[118],"group":[119],"further":[121],"monitored":[122],"for":[123,205,233,282],"4":[124],"after":[126,225],"discontinuing":[127],"medication.":[128],"examine":[131],"accumulation":[134,229],"tissue,":[138],"amount":[140],"tumor/blood":[144],"quantified":[146],"using":[147],"liquid":[148],"chromatography":[149],"quadruple-TOF":[151],"mass":[152],"spectrometry.":[153],"RESULTS:":[154],"In":[155,188],"study,":[159],"showed":[162,168,208,256],"negligible":[164],"absorption,":[165],"whereas":[166],"high":[170],"rate":[172],"dependent":[173],"dosage,":[175],"bioavailability":[178],"approximately":[180],"40%":[181],"dose":[184,195],"62.5":[186],"mg/kg.":[187],"efficacy-related":[189],"studies,":[190],"administration":[192],"or":[199],"days":[204],"superior":[210],"inhibitory":[212],"80%,":[215],"92%,":[216],"97%":[218],"xenograft":[221],"model,":[223],"respectively,":[224],"7":[226],"weeks.":[227],"Paclitaxel":[228],"tumors":[231],"persisted":[232],">24":[234],"h":[235],"mice,":[237],"when":[238],"doses":[243],"DHP23002.":[250],"CONCLUSION:":[251],"Oral":[252],"chemotherapy":[253],"excellent":[257],"animals":[260],"owing":[261,290],"strong":[264],"activity":[266],"demonstrates":[274],"that":[275],"is":[277],"largely":[278],"distributed":[279],"persists":[281],"prolonged":[284],"period":[285],"site":[289],"administration.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}