{"id":"https://openalex.org/W2990946906","doi":"https://doi.org/10.3324/haematol.2019.225961","title":"circASXL1-1 regulates BAP1 deubiquitinase activity in leukemia","display_name":"circASXL1-1 regulates BAP1 deubiquitinase activity in leukemia","publication_year":2019,"publication_date":"2019-11-28","ids":{"openalex":"https://openalex.org/W2990946906","doi":"https://doi.org/10.3324/haematol.2019.225961","mag":"2990946906","pmid":"https://pubmed.ncbi.nlm.nih.gov/31780633","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7327662"},"language":"en","primary_location":{"id":"doi:10.3324/haematol.2019.225961","doi":"https://doi.org/10.3324/haematol.2019.225961","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2019.225961","pdf_url":"https://haematologica.org/article/download/9956/71942","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://haematologica.org/article/download/9956/71942","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091669621","display_name":"Shweta Pradip Jadhav","orcid":"https://orcid.org/0009-0001-8923-449X","observed_orcids":["https://orcid.org/0009-0001-8923-449X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shweta Pradip Jadhav","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101743033","display_name":"Nishi Kumari","orcid":"https://orcid.org/0000-0003-4311-7578","observed_orcids":["https://orcid.org/0000-0003-4311-7578"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nishi Kumari","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore","Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108989827","display_name":"Larry Ng","orcid":"https://orcid.org/0009-0005-8808-2083","observed_orcids":["https://orcid.org/0009-0005-8808-2083"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Larry Ng","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore","Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079645451","display_name":"Pei Fang Tan","orcid":"https://orcid.org/0000-0003-1475-8886","observed_orcids":["https://orcid.org/0000-0003-1475-8886"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Pei Fang Tan","raw_affiliation_strings":["Singapore Institute for Clinical Sciences, A*STAR, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Institute for Clinical Sciences, A*STAR, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046067297","display_name":"Nicole Shu Ling Yeo-Teh","orcid":"https://orcid.org/0000-0002-9153-9663","observed_orcids":["https://orcid.org/0000-0002-9153-9663"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nicole Shu Ling Yeo-Teh","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore","National University of Singapore Graduate School for Integrative Sciences and Engineering, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"National University of Singapore Graduate School for Integrative Sciences and Engineering, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008593628","display_name":"Yufen Goh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yufen Goh","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020559422","display_name":"Wee Nih Fam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wee Nih Fam","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048249682","display_name":"Jia Qi Tng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jia Qi Tng","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072366649","display_name":"Johann Shane Tian","orcid":"https://orcid.org/0000-0002-5794-6089","observed_orcids":["https://orcid.org/0000-0002-5794-6089"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Johann Shane Tian","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore","Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070123551","display_name":"Bryan T. H. Koh","orcid":"https://orcid.org/0000-0002-1768-5144","observed_orcids":["https://orcid.org/0000-0002-1768-5144"]},"institutions":[{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bryan T. H. Koh","raw_affiliation_strings":["Department of Orthopedic Surgery, National University Health Systems, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, National University Health Systems, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chan Ming Chun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chan Ming Chun","raw_affiliation_strings":["Department of Orthopedic Surgery, National University Health Systems, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, National University Health Systems, Singapore","institution_ids":["https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001648352","display_name":"Wilson Wang","orcid":"https://orcid.org/0000-0002-1098-0247","observed_orcids":["https://orcid.org/0000-0002-1098-0247","https://orcid.org/0000-0003-3803-9392"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wilson Wang","raw_affiliation_strings":["Department of Orthopedic Surgery, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066282840","display_name":"Wee Joo Chng","orcid":"https://orcid.org/0000-0003-2578-8335","observed_orcids":["https://orcid.org/0000-0003-2578-8335"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210103786","display_name":"National University Cancer Institute, Singapore","ror":"https://ror.org/025yypj46","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210103786","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wee Joo Chng","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore","Department of Hematology-Oncology, National University Cancer Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Department of Hematology-Oncology, National University Cancer Institute, Singapore","institution_ids":["https://openalex.org/I4210103786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087492673","display_name":"Melissa J. Fullwood","orcid":"https://orcid.org/0000-0003-0321-7865","observed_orcids":["https://orcid.org/0000-0003-0321-7865","https://orcid.org/0000-0003-2355-7277"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Melissa Jane Fullwood","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore","Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore","School of Biological Sciences, Nanyang Technological Institute, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological Institute, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072332593","display_name":"Ernesto Guccione","orcid":"https://orcid.org/0000-0001-7764-5307","observed_orcids":["https://orcid.org/0000-0001-7764-5307"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Ernesto Guccione","raw_affiliation_strings":["Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore","Tisch Cancer Institute, Department of Oncological Sciences and Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Tisch Cancer Institute, Department of Oncological Sciences and Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080697479","display_name":"Neerja Karnani","orcid":"https://orcid.org/0000-0002-5301-409X","observed_orcids":["https://orcid.org/0000-0002-5301-409X"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Neerja Karnani","raw_affiliation_strings":["Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","Singapore Institute for Clinical Sciences, A*STAR, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Institute for Clinical Sciences, A*STAR, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056687452","display_name":"Daniel Geoffrey Tenen","orcid":"https://orcid.org/0000-0002-6423-3888","observed_orcids":["https://orcid.org/0000-0002-6423-3888"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Daniel G. Tenen","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore","Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009877131","display_name":"Sudhakar Jha","orcid":"https://orcid.org/0000-0002-5093-4843","observed_orcids":["https://orcid.org/0000-0002-5093-4843"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Sudhakar Jha","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore","Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"EUR","value_usd":2157},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2157},"fwci":1.264,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78937875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"105","issue":"7","first_page":"e343","last_page":"e348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.859000027179718},{"id":"https://openalex.org/keywords/asxl1","display_name":"ASXL1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/bap1","display_name":"BAP1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/deubiquitinase-activity","display_name":"deubiquitinase activity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5329999923706055},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/chronic-myelomonocytic-leukemia","display_name":"chronic myelomonocytic leukemia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.8629999756813049},{"id":"https://openalex.org/keywords/epigenetic-modifiers","display_name":"epigenetic regulators","score":0.5989999771118164},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C102658986","wikidata":"https://www.wikidata.org/wiki/Q5266092","display_name":"Deubiquitinating enzyme","level":4,"score":0.9028452634811401},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45492616295814514},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4501306414604187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37049493193626404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2685757875442505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21298092603683472},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18667063117027283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12016803026199341},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.0863390862941742}],"mesh":[{"descriptor_ui":"D000072017","descriptor_name":"Deubiquitinating Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074084","descriptor_name":"THP-1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3324/haematol.2019.225961","doi":"https://doi.org/10.3324/haematol.2019.225961","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2019.225961","pdf_url":"https://haematologica.org/article/download/9956/71942","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7327662","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7327662","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Text"},{"id":"pmid:31780633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31780633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Letter"},{"id":"pmh:oai:doaj.org/article:c6d689f208794cfdb06ff5e2260d5be8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c6d689f208794cfdb06ff5e2260d5be8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 105, Iss 7 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3324/haematol.2019.225961","doi":"https://doi.org/10.3324/haematol.2019.225961","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2019.225961","pdf_url":"https://haematologica.org/article/download/9956/71942","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1154542692","display_name":null,"funder_award_id":"MOE2014-T3-1-006","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G4019076671","display_name":null,"funder_award_id":"MOE2014- T3-1-006","funder_id":"https://openalex.org/F4320320698","funder_display_name":"National University of Singapore"},{"id":"https://openalex.org/G4965126306","display_name":null,"funder_award_id":"R-713-006-014-271","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G7016736585","display_name":null,"funder_award_id":"MOE2014-T3-1-006","funder_id":"https://openalex.org/F4320336974","funder_display_name":"Cancer Science Institute of Singapore, National University of Singapore"},{"id":"https://openalex.org/G7844527391","display_name":null,"funder_award_id":"MOE2014-T3-1-006","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G869157032","display_name":"Mechanisms of regulation by RNA in acute myeloid leukemia","funder_award_id":"R35CA197697","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000876163","display_name":"Functional consequences of stem and progenitor cell heterogeneity","funder_award_id":"P01HL131477","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320320701","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320326827","display_name":"National University Cancer Institute, Singapore","ror":"https://ror.org/025yypj46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320332616","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"},{"id":"https://openalex.org/F4320335265","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94"},{"id":"https://openalex.org/F4320336974","display_name":"Cancer Science Institute of Singapore, National University of Singapore","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990946906.pdf","grobid_xml":"https://content.openalex.org/works/W2990946906.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1986302429","https://openalex.org/W1992320498","https://openalex.org/W2034305079","https://openalex.org/W2051615060","https://openalex.org/W2135835093","https://openalex.org/W2258553021","https://openalex.org/W2318224129","https://openalex.org/W2531078297","https://openalex.org/W2600059165","https://openalex.org/W2764294957","https://openalex.org/W2794939602","https://openalex.org/W2797367925","https://openalex.org/W2798204307","https://openalex.org/W2820089296","https://openalex.org/W2883062882"],"related_works":["https://openalex.org/W3165091557","https://openalex.org/W2258553021","https://openalex.org/W3042933286","https://openalex.org/W3174455059","https://openalex.org/W3026261489","https://openalex.org/W2820089296","https://openalex.org/W2090150670","https://openalex.org/W2551323805","https://openalex.org/W3195795499","https://openalex.org/W2591832628"],"abstract_inverted_index":{"circASXL1-1":[0],"regulates":[1],"BAP1":[2,104],"deubiquitinase":[3,92,99],"activity":[4,105],"in":[5,7,20,41,74,126],"leukemiaMutations":[6],"epigenetics":[8],"remodelers":[9],"such":[10],"as":[11],"ASXL1":[12,38,71,115],"(additional":[13],"sex":[14],"combs":[15],"1)":[16],"have":[17,47],"been":[18,48],"identified":[19],"acute":[21],"myeloid":[22,53],"leukemia,":[23],"chronic":[24],"myelomonocytic":[25],"leukemia":[26],"and":[27,30,84],"myelodysplastic":[28],"syndrome":[29],"are":[31],"associated":[32,87],"with":[33],"poor":[34],"overall":[35],"survival.":[36],"1Some":[37],"mutations":[39,72],"resulting":[40],"a":[42,78,91,122],"loss":[43,56],"of":[44,57,77,121],"protein":[45,88],"expression":[46,59,76],"shown":[49],"to":[50,52,94,108],"contribute":[51],"transformation":[54],"through":[55],"H3K27me3":[58],"at":[60],"the":[61,67,75,96,110,119],"HOX":[62],"gene":[63],"loci.":[64],"2":[65],"On":[66],"other":[68],"hand,":[69],"some":[70],"result":[73],"truncated":[79,114],"protein,":[80,116],"which":[81],"can":[82],"bind":[83],"activate":[85],"BRCA-1":[86],"1":[89],"(BAP1),":[90],"enzyme,":[93],"form":[95],"polycomb":[97],"repressive":[98],"complex":[100],"(PR-DUB).4][5]":[101],"Conversely,":[102],"reduced":[103],"is":[106],"sufficient":[107],"halt":[109],"leukemogenesis":[111],"driven":[112],"by":[113],"6":[117],"highlighting":[118],"importance":[120],"balanced":[123],"ASXL1-BAP1":[124],"axis":[125],"normal":[127],"hematopoiesis.":[128]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":16}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-05T00:00:00"}