{"id":"https://openalex.org/W2990935518","doi":"https://doi.org/10.2174/1389200220666191127110857","title":"Potential Therapeutic Applications of C-Phycocyanin","display_name":"Potential Therapeutic Applications of C-Phycocyanin","publication_year":2019,"publication_date":"2019-11-28","ids":{"openalex":"https://openalex.org/W2990935518","doi":"https://doi.org/10.2174/1389200220666191127110857","mag":"2990935518","pmid":"https://pubmed.ncbi.nlm.nih.gov/31775595"},"language":"en","primary_location":{"id":"doi:10.2174/1389200220666191127110857","doi":"https://doi.org/10.2174/1389200220666191127110857","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389200220666191127110857","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081248210","display_name":"Saira M. Bannu","orcid":"https://orcid.org/0000-0001-8134-5884","observed_orcids":["https://orcid.org/0000-0001-8134-5884"]},"institutions":[{"id":"https://openalex.org/I83073037","display_name":"Yogi Vemana University","ror":"https://ror.org/0137gef36","country_code":"IN","type":"education","lineage":["https://openalex.org/I83073037"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saira M. Bannu","raw_affiliation_strings":["Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India"],"raw_orcid":"https://orcid.org/0000-0001-8134-5884","affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India","institution_ids":["https://openalex.org/I83073037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060716656","display_name":"Dakshayani Lomada","orcid":"https://orcid.org/0000-0002-6448-5102","observed_orcids":["https://orcid.org/0000-0002-6448-5102"]},"institutions":[{"id":"https://openalex.org/I83073037","display_name":"Yogi Vemana University","ror":"https://ror.org/0137gef36","country_code":"IN","type":"education","lineage":["https://openalex.org/I83073037"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dakshayani Lomada","raw_affiliation_strings":["Department of Genetics and Genomics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India"],"raw_orcid":"https://orcid.org/0000-0002-6448-5102","affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India","institution_ids":["https://openalex.org/I83073037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088006315","display_name":"Surendra Gulla","orcid":"https://orcid.org/0000-0003-1555-2046","observed_orcids":["https://orcid.org/0000-0003-1555-2046"]},"institutions":[{"id":"https://openalex.org/I83073037","display_name":"Yogi Vemana University","ror":"https://ror.org/0137gef36","country_code":"IN","type":"education","lineage":["https://openalex.org/I83073037"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Surendra Gulla","raw_affiliation_strings":["Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India"],"raw_orcid":"https://orcid.org/0000-0003-1555-2046","affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India","institution_ids":["https://openalex.org/I83073037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034257237","display_name":"Thummala Chandrasekhar","orcid":"https://orcid.org/0000-0001-9186-1452","observed_orcids":["https://orcid.org/0000-0001-9186-1452"]},"institutions":[{"id":"https://openalex.org/I83073037","display_name":"Yogi Vemana University","ror":"https://ror.org/0137gef36","country_code":"IN","type":"education","lineage":["https://openalex.org/I83073037"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Thummala Chandrasekhar","raw_affiliation_strings":["Department of Environmental Science, Yogi Vemana University, Kadapa, Andhra Pradesh 516005, India"],"raw_orcid":"https://orcid.org/0000-0001-9186-1452","affiliations":[{"raw_affiliation_string":"Department of Environmental Science, Yogi Vemana University, Kadapa, Andhra Pradesh 516005, India","institution_ids":["https://openalex.org/I83073037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102931708","display_name":"Pallu Reddanna","orcid":"https://orcid.org/0000-0003-4823-7544","observed_orcids":["https://orcid.org/0000-0003-4823-7544"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pallu Reddanna","raw_affiliation_strings":["Department of Animal Sciences, University of Hyderabad, Hyderabad, Telangana 500 046, India"],"raw_orcid":"https://orcid.org/0000-0003-4823-7544","affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, University of Hyderabad, Hyderabad, Telangana 500 046, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048951475","display_name":"Madhava C. Reddy","orcid":"https://orcid.org/0000-0003-4885-0437","observed_orcids":["https://orcid.org/0000-0003-4885-0437"]},"institutions":[{"id":"https://openalex.org/I83073037","display_name":"Yogi Vemana University","ror":"https://ror.org/0137gef36","country_code":"IN","type":"education","lineage":["https://openalex.org/I83073037"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Madhava C. Reddy","raw_affiliation_strings":["Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India"],"raw_orcid":"https://orcid.org/0000-0003-4885-0437","affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India","institution_ids":["https://openalex.org/I83073037"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048951475"],"corresponding_institution_ids":["https://openalex.org/I83073037"],"apc_list":null,"apc_paid":null,"fwci":0.526,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.43609023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"20","issue":"12","first_page":"967","last_page":"976"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.4284999966621399,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.4284999966621399,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.28049999475479126,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.06469999998807907,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-phycocyanin","display_name":"C-phycocyanin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cyanobacterial-pigments","display_name":"cyanobacterial pigments","score":0.871999979019165},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9760000109672546},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.578000009059906},{"id":"https://openalex.org/keywords/liver-and-kidney-protection","display_name":"liver and kidney protection","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2778093064","wikidata":"https://www.wikidata.org/wiki/Q414177","display_name":"Phycocyanin","level":4,"score":0.6917562484741211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23859870433807373},{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.03448250889778137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010798","descriptor_name":"Phycocyanin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010798","descriptor_name":"Phycocyanin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010798","descriptor_name":"Phycocyanin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045524","descriptor_name":"Phycobilisomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1389200220666191127110857","doi":"https://doi.org/10.2174/1389200220666191127110857","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389200220666191127110857","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},{"id":"pmid:31775595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31775595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4865669319","display_name":null,"funder_award_id":"EMR/2016/007208","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W59427252","https://openalex.org/W202102868","https://openalex.org/W263582355","https://openalex.org/W640892390","https://openalex.org/W1481016231","https://openalex.org/W1518039627","https://openalex.org/W1585774086","https://openalex.org/W1764000830","https://openalex.org/W1821716958","https://openalex.org/W1844649980","https://openalex.org/W1864955501","https://openalex.org/W1964014751","https://openalex.org/W1965710900","https://openalex.org/W1966058779","https://openalex.org/W1969068304","https://openalex.org/W1969089943","https://openalex.org/W1969240146","https://openalex.org/W1969583152","https://openalex.org/W1969587909","https://openalex.org/W1975566197","https://openalex.org/W1978211370","https://openalex.org/W1980013512","https://openalex.org/W1980733261","https://openalex.org/W1983029593","https://openalex.org/W1990304018","https://openalex.org/W1990856625","https://openalex.org/W1991801420","https://openalex.org/W1992128203","https://openalex.org/W1993501991","https://openalex.org/W1996971959","https://openalex.org/W1998318428","https://openalex.org/W2000708416","https://openalex.org/W2001682948","https://openalex.org/W2002165948","https://openalex.org/W2009299131","https://openalex.org/W2011438992","https://openalex.org/W2012921958","https://openalex.org/W2014633444","https://openalex.org/W2016155849","https://openalex.org/W2016427462","https://openalex.org/W2016867252","https://openalex.org/W2017148655","https://openalex.org/W2022343152","https://openalex.org/W2030848330","https://openalex.org/W2031798364","https://openalex.org/W2031895959","https://openalex.org/W2033631648","https://openalex.org/W2040089320","https://openalex.org/W2043829516","https://openalex.org/W2043999200","https://openalex.org/W2044599346","https://openalex.org/W2046179899","https://openalex.org/W2048400927","https://openalex.org/W2050877147","https://openalex.org/W2052001991","https://openalex.org/W2052874941","https://openalex.org/W2056161205","https://openalex.org/W2061944588","https://openalex.org/W2063573498","https://openalex.org/W2069485647","https://openalex.org/W2070321855","https://openalex.org/W2072820135","https://openalex.org/W2075501972","https://openalex.org/W2076985028","https://openalex.org/W2077560514","https://openalex.org/W2080822311","https://openalex.org/W2083165115","https://openalex.org/W2083575719","https://openalex.org/W2085603264","https://openalex.org/W2089623865","https://openalex.org/W2094782454","https://openalex.org/W2095837827","https://openalex.org/W2100286089","https://openalex.org/W2102558459","https://openalex.org/W2107872107","https://openalex.org/W2113473184","https://openalex.org/W2121023856","https://openalex.org/W2122696588","https://openalex.org/W2124411039","https://openalex.org/W2128257738","https://openalex.org/W2133220600","https://openalex.org/W2142762026","https://openalex.org/W2146798875","https://openalex.org/W2152639174","https://openalex.org/W2155165616","https://openalex.org/W2161080732","https://openalex.org/W2161908938","https://openalex.org/W2229964270","https://openalex.org/W2273448686","https://openalex.org/W2286008940","https://openalex.org/W2287747421","https://openalex.org/W2312295151","https://openalex.org/W2318967109","https://openalex.org/W2370360129","https://openalex.org/W2509320573","https://openalex.org/W2529094237","https://openalex.org/W2548549036","https://openalex.org/W2586246594","https://openalex.org/W2587210947","https://openalex.org/W2587309196","https://openalex.org/W2600524610","https://openalex.org/W2605364250","https://openalex.org/W2751361579","https://openalex.org/W2751788082","https://openalex.org/W2769858669","https://openalex.org/W2770929983","https://openalex.org/W2780036929","https://openalex.org/W2781393748","https://openalex.org/W2783176256","https://openalex.org/W2789995443","https://openalex.org/W2795048334","https://openalex.org/W2803680797","https://openalex.org/W2893635842","https://openalex.org/W2905246928","https://openalex.org/W2913115889","https://openalex.org/W2931952323","https://openalex.org/W2941375619","https://openalex.org/W2951143198","https://openalex.org/W2955125133","https://openalex.org/W2963681574","https://openalex.org/W4211075163"],"related_works":["https://openalex.org/W2756555938","https://openalex.org/W2811364489","https://openalex.org/W7037581885","https://openalex.org/W599524710","https://openalex.org/W4281741338","https://openalex.org/W7203588308","https://openalex.org/W7118721929","https://openalex.org/W1984197345","https://openalex.org/W2955125133","https://openalex.org/W2052001991"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cancer":[1],"and":[2,10,69,72,83,108,129,154,175,200,213,222,237],"other":[3,57],"disorders":[4],"such":[5,168],"as":[6,141,169],"inflammation,":[7],"autoimmune":[8,180],"diseases":[9,33,151],"diabetes":[11],"are":[12],"the":[13,20,29,52,65,100,133,137,163,192,215],"major":[14],"health":[15],"problems":[16],"observed":[17],"all":[18],"over":[19],"world.":[21],"Therefore,":[22],"identifying":[23],"a":[24,142],"therapeutic":[25,121,164,233],"target":[26],"molecule":[27],"for":[28,94,187],"treatment":[30],"of":[31,67,90,92,102,123,127,139,166,178,183,185,194,208,218,235],"these":[32],"is":[34,43,191,210],"urgently":[35],"needed":[36],"to":[37,211,242],"benefit":[38],"public":[39,244],"health.":[40,245],"C-Phycocyanin":[41],"(C-PC)":[42],"an":[44,118],"important":[45],"light":[46,228],"yielding":[47],"pigment":[48],"intermittently":[49],"systematized":[50],"in":[51,64,110,136,202],"cyanobacterial":[53],"species":[54],"along":[55],"with":[56],"algal":[58],"species.":[59],"It":[60],"has":[61],"numerous":[62],"applications":[63,122,165,234],"field":[66,138],"biotechnology":[68],"drug":[70,143],"industry":[71],"also":[73],"possesses":[74],"antioxidant,":[75],"anticancer,":[76],"antiinflammatory,":[77],"enhanced":[78],"immune":[79],"function,":[80],"including":[81,152],"liver":[82],"kidney":[84],"protection":[85],"properties.":[86],"The":[87,114,157,205],"molecular":[88,216],"mechanism":[89,126,217],"action":[91,128,184],"C-PC":[93,140,167,186,209,236],"its":[95,125,188,219],"anticancer":[96,189],"activity":[97,174,190],"could":[98],"be":[99],"blockage":[101,193],"cell":[103,195],"cycle":[104,196],"progression,":[105,197],"inducing":[106,198],"apoptosis":[107,199],"autophagy":[109,201],"cancer":[111,153,203],"cells.":[112,204],"OBJECTIVES:":[113],"current":[115],"review":[116],"summarizes":[117],"update":[119],"on":[120,132,229,232],"C-PC,":[124],"mainly":[130],"focuses":[131],"recent":[134],"development":[135],"that":[144],"exhibits":[145],"beneficial":[146],"effects":[147],"against":[148],"various":[149,160],"human":[150],"inflammation.":[155],"CONCLUSION:":[156],"data":[158],"from":[159],"studies":[161],"suggest":[162],"anti-cancer":[170],"activity,":[171],"anti-inflammation,":[172],"anti-angiogenic":[173],"healing":[176],"capacity":[177],"certain":[179],"disorders.":[181],"Mechanism":[182],"future":[206],"perspective":[207],"identify":[212],"define":[214],"anti-cancer,":[220],"anti-inflammatory":[221],"antioxidant":[223],"activities,":[224],"which":[225],"would":[226],"shed":[227],"our":[230],"knowledge":[231],"may":[238],"contribute":[239],"significant":[240],"benefits":[241],"global":[243]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-12-05T00:00:00"}