{"id":"https://openalex.org/W2990869740","doi":"https://doi.org/10.1007/s11357-019-00126-7","title":"Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice","display_name":"Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice","publication_year":2019,"publication_date":"2019-11-27","ids":{"openalex":"https://openalex.org/W2990869740","doi":"https://doi.org/10.1007/s11357-019-00126-7","mag":"2990869740","pmid":"https://pubmed.ncbi.nlm.nih.gov/31776883"},"language":"en","primary_location":{"id":"doi:10.1007/s11357-019-00126-7","doi":"https://doi.org/10.1007/s11357-019-00126-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-019-00126-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-019-00126-7.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11357-019-00126-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079236406","display_name":"Jessie Axsom","orcid":"https://orcid.org/0000-0002-8013-9576","observed_orcids":["https://orcid.org/0000-0002-8013-9576"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessie E. Axsom","raw_affiliation_strings":["Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA","School of Nursing, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8013-9576","affiliations":[{"raw_affiliation_string":"Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"School of Nursing, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028774868","display_name":"Alay P. Nanavati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I275799156","display_name":"University of New England","ror":"https://ror.org/02n2ava60","country_code":"US","type":"education","lineage":["https://openalex.org/I275799156"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alay P. Nanavati","raw_affiliation_strings":["College of Osteopathic Medicine, University of New England, Biddeford, ME, USA","Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Osteopathic Medicine, University of New England, Biddeford, ME, USA","institution_ids":["https://openalex.org/I275799156"]},{"raw_affiliation_string":"Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078098309","display_name":"Carolyn Rutishauser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn A. Rutishauser","raw_affiliation_strings":["Department of Anatomy, Case Western Reserve University, Cleveland, OH, USA","Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002940471","display_name":"Janet Elise Bonin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet E. Bonin","raw_affiliation_strings":["Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA","School of Medicine, University of Maryland, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"School of Medicine, University of Maryland, Baltimore, MD, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084235848","display_name":"Jack M. Moen","orcid":"https://orcid.org/0000-0003-3112-667X","observed_orcids":["https://orcid.org/0000-0003-3112-667X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack M. Moen","raw_affiliation_strings":["Cellular and Molecular Physiology, Yale University, New Haven, CT, USA","Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Physiology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060742163","display_name":"Edward G. Lakatta","orcid":"https://orcid.org/0000-0002-4772-0035","observed_orcids":["https://orcid.org/0000-0002-4772-0035","https://orcid.org/0000-0002-6663-1556"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward G. Lakatta","raw_affiliation_strings":["Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA. lakattae@mail.nih.gov","Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA. lakattae@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5060742163"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":{"value":3760,"currency":"USD","value_usd":3760},"fwci":1.7991,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.872837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"42","issue":"1","first_page":"217","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermoneutral-housing","display_name":"thermoneutral housing","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cold-stress","display_name":"cold stress","score":0.625},{"id":"https://openalex.org/keywords/cardiovascular-aging","display_name":"cardiovascular aging","score":0.7850000262260437},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.8050000071525574},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":1.0},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.8090000152587891},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9290000200271606},{"id":"https://openalex.org/keywords/autonomic-regulation","display_name":"autonomic regulation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/telemetry","display_name":"telemetry","score":0.33500000834465027},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8659999966621399},{"id":"https://openalex.org/keywords/housing-temperature","display_name":"housing temperature","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.8577711582183838},{"id":"https://openalex.org/C119406331","wikidata":"https://www.wikidata.org/wiki/Q419763","display_name":"Acclimatization","level":2,"score":0.7898691296577454},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.7489858865737915},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.6350055932998657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5614193081855774},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5612793564796448},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4774076044559479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4665859341621399},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.45979544520378113},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4128165543079376},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.38380908966064453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34023064374923706},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.20060935616493225},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000064","descriptor_name":"Acclimatization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000064","descriptor_name":"Acclimatization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000064","descriptor_name":"Acclimatization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11357-019-00126-7","doi":"https://doi.org/10.1007/s11357-019-00126-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-019-00126-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-019-00126-7.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},{"id":"pmid:31776883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31776883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7031176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7031176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"GeroScience","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s11357-019-00126-7","doi":"https://doi.org/10.1007/s11357-019-00126-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-019-00126-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-019-00126-7.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/12","score":0.4399999976158142,"display_name":"Responsible consumption and production"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990869740.pdf","grobid_xml":"https://content.openalex.org/works/W2990869740.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1562120209","https://openalex.org/W1959222363","https://openalex.org/W1967900132","https://openalex.org/W1982723196","https://openalex.org/W1985867301","https://openalex.org/W1987801468","https://openalex.org/W1989205597","https://openalex.org/W1989262348","https://openalex.org/W1993272783","https://openalex.org/W2002442019","https://openalex.org/W2002634573","https://openalex.org/W2005449474","https://openalex.org/W2005576024","https://openalex.org/W2016305334","https://openalex.org/W2023989509","https://openalex.org/W2051794578","https://openalex.org/W2056310801","https://openalex.org/W2057053976","https://openalex.org/W2076386730","https://openalex.org/W2086106297","https://openalex.org/W2090296913","https://openalex.org/W2091796573","https://openalex.org/W2093912976","https://openalex.org/W2095233676","https://openalex.org/W2095562808","https://openalex.org/W2097972359","https://openalex.org/W2098501353","https://openalex.org/W2111772099","https://openalex.org/W2112458144","https://openalex.org/W2114821999","https://openalex.org/W2115175546","https://openalex.org/W2122464624","https://openalex.org/W2130111393","https://openalex.org/W2132656350","https://openalex.org/W2133589238","https://openalex.org/W2136429434","https://openalex.org/W2139433132","https://openalex.org/W2139768411","https://openalex.org/W2145912168","https://openalex.org/W2146614096","https://openalex.org/W2157846167","https://openalex.org/W2165636960","https://openalex.org/W2168638573","https://openalex.org/W2285072859","https://openalex.org/W2383759838","https://openalex.org/W2431856244","https://openalex.org/W2765945674","https://openalex.org/W2774486220","https://openalex.org/W2895333514","https://openalex.org/W2950126964","https://openalex.org/W3150483392","https://openalex.org/W4298441315"],"related_works":["https://openalex.org/W1548647706","https://openalex.org/W4378746560","https://openalex.org/W2501692008","https://openalex.org/W4386224683","https://openalex.org/W2338113542","https://openalex.org/W4214500667","https://openalex.org/W4360974335","https://openalex.org/W3120791867","https://openalex.org/W1847525600","https://openalex.org/W4385546015"],"abstract_inverted_index":{"Mice":[0],"are":[1,263],"among":[2],"the":[3],"most":[4],"widely":[5],"used":[6],"translational":[7],"models":[8],"of":[9,47,58,74,99,118,123,143,181,242,249,252,257],"cardiovascular":[10,253],"aging":[11],"and":[12,127,137,140,156,178,184,206],"offer":[13],"a":[14,22,33,54,70,84,144,266],"method":[15],"to":[16,52,69,88,103,112,194,216],"quickly":[17],"assess":[18],"lifespan":[19],"changes":[20,119],"in":[21,42,77,120,152,203,225,255,265],"controlled":[23],"environment.":[24,269],"The":[25,97],"standard":[26],"laboratory":[27],"temperature":[28,57,165,241],"(20-22":[29],"\u00b0C),":[30],"however,":[31],"imposes":[32],"cold":[34,85],"stress":[35],"on":[36],"mice":[37,78,90,163,186,234,256],"that":[38,132,261],"causes":[39],"an":[40,246],"increase":[41],"sympathetic":[43,107],"nervous":[44],"system-mediated":[45],"activation":[46],"brown":[48],"adipose":[49],"tissue":[50],"(BAT)":[51],"maintain":[53],"core":[55],"body":[56],"36-37":[59],"\u00b0C.":[60,175,196,244],"Thus,":[61,245],"while":[62],"physiologic":[63],"data":[64],"obtained":[65],"recapitulate":[66],"human":[67],"physiology":[68],"certain":[71],"degree,":[72],"interpretations":[73],"previous":[75],"research":[76],"may":[79],"have":[80],"been":[81],"contaminated":[82],"by":[83,110],"stress,":[86],"due":[87],"housing":[89],"below":[91],"their":[92,238],"thermoneutral":[93,239],"zone":[94],"(30":[95,158],"\u00b0C).":[96],"purpose":[98],"this":[100],"investigation":[101],"was":[102],"examine":[104],"how":[105],"chronic":[106],"stimulation":[108],"evoked":[109],"acclimation":[111,166],"20":[113,174,195,217,229],"\u00b0C":[114,172,192,214,218,230],"might":[115],"obscure":[116],"interpretation":[117],"autonomic":[121,250],"modulation":[122,251],"heart":[124,128],"rate":[125,129],"(HR)":[126],"variability":[130,211],"(HRV)":[131],"accompany":[133],"advancing":[134],"age.":[135],"HR":[136,180],"HRV":[138,201,226],"before":[139],"after":[141],"administration":[142],"dual-autonomic":[145],"blockade":[146],"were":[147,231,235],"measured":[148],"via":[149],"in-vivo":[150],"ECG":[151],"young":[153,183],"(3":[154],"months)":[155,159],"aged":[157,185],"male":[160],"C57BL/6":[161],"telemetry-implanted":[162],"following":[164],"for":[167],"3":[168],"days":[169],"at":[170,190,212,228,237],"30":[171,191,213,243],"or":[173],"Mean":[176],"basal":[177,220],"intrinsic":[179],"both":[182,198],"became":[187],"markedly":[188],"reduced":[189],"compared":[193,215],"In":[197],"age":[199,259],"groups,":[200],"parameters":[202],"time,":[204],"frequency,":[205],"non-linear":[207],"domains":[208],"displayed":[209],"increased":[210],"under":[219],"conditions.":[221],"Importantly,":[222],"age-associated":[223],"declines":[224],"observed":[227],"ameliorated":[232],"when":[233],"studied":[236],"ambient":[240],"accurate":[247],"understanding":[248],"functions":[254],"advanced":[258],"requires":[260],"they":[262],"housed":[264],"metabolically":[267],"neutral":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
