{"id":"https://openalex.org/W2990823666","doi":"https://doi.org/10.1289/isee.2011.01780","title":"INTERACTIONS BETWEEN DISINFECTION BY PRODUCTS IN DRINKING WATER AND GENETIC SUSCEPTIBILITY VARIANTS IN RELATION TO ADVERSE REPRODUCTIVE OUTCOMES (THE HIWATE STUDY)","display_name":"INTERACTIONS BETWEEN DISINFECTION BY PRODUCTS IN DRINKING WATER AND GENETIC SUSCEPTIBILITY VARIANTS IN RELATION TO ADVERSE REPRODUCTIVE OUTCOMES (THE HIWATE STUDY)","publication_year":2011,"publication_date":"2011-09-13","ids":{"openalex":"https://openalex.org/W2990823666","doi":"https://doi.org/10.1289/isee.2011.01780","mag":"2990823666"},"language":"en","primary_location":{"id":"doi:10.1289/isee.2011.01780","doi":"https://doi.org/10.1289/isee.2011.01780","is_oa":false,"landing_page_url":"https://doi.org/10.1289/isee.2011.01780","pdf_url":null,"source":{"id":"https://openalex.org/S4210195765","display_name":"ISEE Conference Abstracts","issn_l":"1078-0475","issn":["1078-0475","2169-2181"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISEE Conference Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052680269","display_name":"Mariona Bustamante","orcid":"https://orcid.org/0000-0003-0127-2860","observed_orcids":["https://orcid.org/0000-0003-0127-2860"]},"institutions":[{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mariona Bustamante","raw_affiliation_strings":["Center for Research in Environmental Epidemiology, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Environmental Epidemiology, Spain","institution_ids":["https://openalex.org/I4210092159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066366865","display_name":"Ana Espinosa","orcid":"https://orcid.org/0000-0001-7399-3267","observed_orcids":["https://orcid.org/0000-0001-7399-3267"]},"institutions":[{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Espinosa","raw_affiliation_strings":["Center for Research in Environmental Epidemiology, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Environmental Epidemiology, Spain","institution_ids":["https://openalex.org/I4210092159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690068","display_name":"Juan R. Gonz\u00e1lez","orcid":"https://orcid.org/0000-0003-3267-2146","observed_orcids":["https://orcid.org/0000-0003-3267-2146","https://orcid.org/0000-0003-0284-5114"]},"institutions":[{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan R Gonzalez","raw_affiliation_strings":["Center for Research in Environmental Epidemiology, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Environmental Epidemiology, Spain","institution_ids":["https://openalex.org/I4210092159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052722977","display_name":"Asta Danilevi\u010di\u016bt\u0117","orcid":"https://orcid.org/0000-0001-8304-6570","observed_orcids":["https://orcid.org/0000-0001-8304-6570"]},"institutions":[{"id":"https://openalex.org/I188730046","display_name":"Vytautas Magnus University","ror":"https://ror.org/04y7eh037","country_code":"LT","type":"education","lineage":["https://openalex.org/I188730046"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Asta Danilevi\u010di\u016bt\u0117","raw_affiliation_strings":["Vytautas Magnus University, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vytautas Magnus University, Lithuania","institution_ids":["https://openalex.org/I188730046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015709540","display_name":"C\u00e9cile Chevrier","orcid":"https://orcid.org/0000-0003-3101-8222","observed_orcids":["https://orcid.org/0000-0003-3101-8222"]},"institutions":[{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cecile Chevrier","raw_affiliation_strings":["Universit\u00e9 Rennes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Rennes, France","institution_ids":["https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022922658","display_name":"Regina Gra\u017eulevi\u010dien\u0117","orcid":"https://orcid.org/0000-0002-0210-8053","observed_orcids":["https://orcid.org/0000-0002-0210-8053"]},"institutions":[{"id":"https://openalex.org/I188730046","display_name":"Vytautas Magnus University","ror":"https://ror.org/04y7eh037","country_code":"LT","type":"education","lineage":["https://openalex.org/I188730046"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Regina Grazuleviciene","raw_affiliation_strings":["Vytautas Magnus University, Lithuania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vytautas Magnus University, Lithuania","institution_ids":["https://openalex.org/I188730046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038295731","display_name":"Evridiki Patelarou","orcid":"https://orcid.org/0000-0002-0892-3200","observed_orcids":["https://orcid.org/0000-0002-0892-3200"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evridiki Patelarou","raw_affiliation_strings":["University of Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023068489","display_name":"Cristina M. Villanueva","orcid":"https://orcid.org/0000-0002-0783-1259","observed_orcids":["https://orcid.org/0000-0002-0783-1259"]},"institutions":[{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina M Villanueva","raw_affiliation_strings":["Center for Research in Environmental Epidemiology, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Environmental Epidemiology, Spain","institution_ids":["https://openalex.org/I4210092159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023963030","display_name":"Mark J Nieuwenhuijsen","orcid":"https://orcid.org/0000-0001-9461-7981","observed_orcids":["https://orcid.org/0000-0001-9461-7981"]},"institutions":[{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mark Nieuwenhuijsen","raw_affiliation_strings":["Center for Research in Environmental Epidemiology, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Environmental Epidemiology, Spain","institution_ids":["https://openalex.org/I4210092159"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025023257","display_name":"Manolis Kogevinas","orcid":"https://orcid.org/0000-0002-9605-0461","observed_orcids":["https://orcid.org/0000-0002-9605-0461"]},"institutions":[{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manolis Kogevinas","raw_affiliation_strings":["Center for Research in Environmental Epidemiology, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Environmental Epidemiology, Spain","institution_ids":["https://openalex.org/I4210092159"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2011","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disinfection-by-products","display_name":"disinfection by-products","score":0.9919999837875366},{"id":"https://openalex.org/keywords/drinking-water","display_name":"drinking water","score":0.9129999876022339},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.6480000019073486},{"id":"https://openalex.org/keywords/trihalomethanes","display_name":"trihalomethanes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.878000020980835},{"id":"https://openalex.org/keywords/small-for-gestational-age","display_name":"small for gestational age","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6079999804496765},{"id":"https://openalex.org/keywords/gstz1","display_name":"GSTZ1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/gstt1","display_name":"GSTT1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9049999713897705},{"id":"https://openalex.org/keywords/detoxification-genes","display_name":"detoxification genes","score":0.718999981880188},{"id":"https://openalex.org/keywords/reproductive-outcomes","display_name":"reproductive outcomes","score":0.656000018119812},{"id":"https://openalex.org/keywords/birth-cohort","display_name":"birth cohort","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5363667607307434},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.45437145233154297},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.44346484541893005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43069469928741455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39570188522338867},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.36291828751564026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35620322823524475},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3444860577583313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18422314524650574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14070942997932434}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1289/isee.2011.01780","doi":"https://doi.org/10.1289/isee.2011.01780","is_oa":false,"landing_page_url":"https://doi.org/10.1289/isee.2011.01780","pdf_url":null,"source":{"id":"https://openalex.org/S4210195765","display_name":"ISEE Conference Abstracts","issn_l":"1078-0475","issn":["1078-0475","2169-2181"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISEE Conference Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749},{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.6618000268936157}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2313715411","https://openalex.org/W2361601855","https://openalex.org/W2989580625","https://openalex.org/W2890076769","https://openalex.org/W2025869885","https://openalex.org/W2503829108","https://openalex.org/W2973367241","https://openalex.org/W2141594189","https://openalex.org/W2740673095","https://openalex.org/W2085567513"],"abstract_inverted_index":{"Background":[0],"and":[1,30,75,86,93,114,121,156,186,199,267,295],"Aims:":[2],"The":[3],"Hiwate":[4,62],"project":[5],"(Heath":[6],"Impacts":[7],"of":[8,37,42,227,248,273],"Long-Term":[9],"Exposure":[10],"to":[11,23,125,131,216,232,237,243,276],"Disinfection":[12],"By-Products":[13],"in":[14,27,50,99,143,167,193,202,214,262],"Drinking":[15],"Water)":[16],"studied":[17],"the":[18,126,135,168,228,249,263,271,284],"relation":[19,215],"between":[20],"prenatal":[21,241,274],"exposure":[22,130,242,275],"DBPs":[24],"(Disinfection":[25],"by-products)":[26],"drinking":[28],"water":[29],"adverse":[31],"reproductive":[32,279],"outcomes,":[33],"without":[34],"finding":[35],"evidence":[36],"any":[38],"effect.":[39],"This":[40],"lack":[41],"association":[43],"could":[44],"be":[45,238,287],"partially":[46],"caused":[47],"by":[48],"differences":[49],"genetic":[51,146,154],"background.":[52],"Thus,":[53],"a":[54,159],"gene*environment":[55],"(G*E)":[56],"interaction":[57,211],"study":[58,69],"was":[59,70,140],"undertaken":[60],"within":[61],"project.":[63],"Methods:":[64],"A":[65,191],"nested":[66],"case":[67],"control":[68],"designed":[71],"using":[72,119],"samples":[73],"(maternal":[74],"child":[76,197,207],"DNA)":[77,208],"from":[78],"four":[79],"European":[80],"birth":[81],"cohorts":[82],"(INMA,":[83],"KAUNAS,":[84],"PELAGIE":[85],"RHEA).":[87],"Forty-nine":[88],"Single":[89],"Nucleotide":[90],"Polymorphims":[91],"(SNPs)":[92],"4":[94],"Copy":[95],"Number":[96],"Variants":[97],"(CNVs)":[98],"DBP":[100,138],"detoxification":[101],"genes":[102],"(CYP1A":[103],"cluster,":[104,108,111,265],"CYP2A6,":[105],"CYP2E1,":[106],"CYP3A":[107],"GSTP1,":[109],"GSTT1":[110,229,268],"GSTZ1,":[112],"GSTM1":[113],"GSTM4)":[115],"were":[116,148,165,189,251,293],"successfully":[117],"genotyped":[118],"Illumina":[120],"MLPA,":[122],"respectively,":[123],"blindly":[124],"case-control":[127],"status.":[128],"Prenatal":[129],"total":[132],"trihalomethanes":[133],"(tTHMs),":[134],"most":[136],"abundant":[137],"group,":[139],"considered":[141],"continuous":[142],"models.":[144],"Main":[145],"effects":[147,292],"initially":[149],"explored":[150],"under":[151],"an":[152,210],"additive":[153],"model,":[155],"those":[157],"with":[158,212,224,289],"p-val<0.2":[160],"(in":[161,196,204],"mothers":[162,223],"or":[163],"children)":[164],"included":[166],"G*E":[169],"analysis.":[170],"Results:":[171],"In":[172],"total,":[173],"270/228":[174],"(mother/child":[175],"DNAs)":[176],"preterm":[177,217],"cases,":[178,185],"368/377":[179],"small":[180,294],"for":[181,256],"gestational":[182],"age":[183],"(SGA)":[184],"416/429":[187],"controls":[188],"analyzed.":[190],"SNP":[192],"CYP1A":[194,264],"cluster":[195],"DNA),":[198],"two":[200],"SNPs":[201],"GSTZ1":[203,266],"maternal":[205],"and/or":[206],"showed":[209],"tTHMs":[213,244],"(p":[218,245],"int":[219],"\u22640.052).":[220],"Regarding":[221],"SGA,":[222],"0":[225],"copies":[226],"CNV":[230],"tended":[231],"have":[233],"children":[234],"more":[235],"susceptible":[236],"SGA":[239],"after":[240,254],"int=0.050).":[246],"None":[247],"interactions":[250],"statistically":[252],"significant":[253],"correction":[255],"multiple":[257],"testing.":[258],"Conclusions:":[259],"Genetic":[260],"variants":[261],"may":[269],"modulate":[270],"effect":[272],"DPBs":[277],"on":[278],"outcomes.":[280],"Although":[281],"biologically":[282],"plausible,":[283],"findings":[285],"should":[286],"interpreted":[288],"caution":[290],"because":[291],"only":[296],"marginally":[297],"significant.":[298]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-12-05T00:00:00"}