{"id":"https://openalex.org/W2990794595","doi":"https://doi.org/10.1021/acs.molpharmaceut.9b00937","title":"In Situ Crystal Growth Rate Distributions of Active Pharmaceutical Ingredients","display_name":"In Situ Crystal Growth Rate Distributions of Active Pharmaceutical Ingredients","publication_year":2019,"publication_date":"2019-11-26","ids":{"openalex":"https://openalex.org/W2990794595","doi":"https://doi.org/10.1021/acs.molpharmaceut.9b00937","mag":"2990794595","pmid":"https://pubmed.ncbi.nlm.nih.gov/31769985"},"language":"en","primary_location":{"id":"doi:10.1021/acs.molpharmaceut.9b00937","doi":"https://doi.org/10.1021/acs.molpharmaceut.9b00937","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.9b00937","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053373796","display_name":"Sreya Sarkar","orcid":"https://orcid.org/0000-0002-1614-3730","observed_orcids":["https://orcid.org/0000-0002-1614-3730"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sreya Sarkar","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States"],"raw_orcid":"https://orcid.org/0000-0002-1614-3730","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088053056","display_name":"Zhengtian Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengtian Song","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064925804","display_name":"Scott R. Griffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott R. Griffin","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081120599","display_name":"Nita Takanti","orcid":"https://orcid.org/0000-0001-6818-2443","observed_orcids":["https://orcid.org/0000-0001-6818-2443"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nita Takanti","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025972574","display_name":"Andrew D. Vogt","orcid":"https://orcid.org/0000-0003-2490-3637","observed_orcids":["https://orcid.org/0000-0003-2490-3637"]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Vogt","raw_affiliation_strings":["AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035947285","display_name":"Alexander Ruggles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Ruggles","raw_affiliation_strings":["AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037971332","display_name":"Gerald D. Danzer","orcid":"https://orcid.org/0000-0003-4761-7991","observed_orcids":["https://orcid.org/0000-0003-4761-7991"]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald D. Danzer","raw_affiliation_strings":["AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Inc., 1 N Waukegan Road, North Chicago, Illinois 60064, United States","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061854559","display_name":"Garth J. Simpson","orcid":"https://orcid.org/0000-0002-3932-848X","observed_orcids":["https://orcid.org/0000-0002-3932-848X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Garth J. Simpson","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States"],"raw_orcid":"https://orcid.org/0000-0002-3932-848X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061854559"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.4511,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.5526674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"3","first_page":"769","last_page":"776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12358","display_name":"Thermal and Kinetic Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11278","display_name":"Calcium Carbonate Crystallization and Inhibition","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crystal-growth-rate","display_name":"crystal growth rate","score":0.7789999842643738},{"id":"https://openalex.org/keywords/single-particle-tracking","display_name":"single-particle tracking","score":0.7760000228881836},{"id":"https://openalex.org/keywords/active-pharmaceutical-ingredients","display_name":"active pharmaceutical ingredients","score":0.7990000247955322},{"id":"https://openalex.org/keywords/second-harmonic-generation","display_name":"second harmonic generation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/nonlinear-optical-microscopy","display_name":"nonlinear optical microscopy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/crystal-nucleation","display_name":"crystal nucleation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/shot-noise","display_name":"shot noise","score":0.734000027179718},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.8799999952316284},{"id":"https://openalex.org/keywords/accelerated-stability-testing","display_name":"accelerated stability testing","score":0.9020000100135803},{"id":"https://openalex.org/keywords/noncentrosymmetric-crystals","display_name":"noncentrosymmetric crystals","score":0.8460000157356262},{"id":"https://openalex.org/keywords/pharmaceutical-formulation-design","display_name":"drug formulation design","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.8521355390548706},{"id":"https://openalex.org/C26456737","wikidata":"https://www.wikidata.org/wiki/Q185154","display_name":"Crystal growth","level":2,"score":0.6175711750984192},{"id":"https://openalex.org/C2781285689","wikidata":"https://www.wikidata.org/wiki/Q21921428","display_name":"Crystal (programming language)","level":2,"score":0.6050543189048767},{"id":"https://openalex.org/C137637335","wikidata":"https://www.wikidata.org/wiki/Q899604","display_name":"Crystallite","level":2,"score":0.5451698303222656},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.49672776460647583},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.4801161289215088},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4453073740005493},{"id":"https://openalex.org/C2778312390","wikidata":"https://www.wikidata.org/wiki/Q4139973","display_name":"Growth rate","level":2,"score":0.4368322491645813},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.4356367886066437},{"id":"https://openalex.org/C30713254","wikidata":"https://www.wikidata.org/wiki/Q1455635","display_name":"Second-harmonic generation","level":3,"score":0.4245245158672333},{"id":"https://openalex.org/C73922627","wikidata":"https://www.wikidata.org/wiki/Q754943","display_name":"Single crystal","level":2,"score":0.4201808571815491},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.4145648181438446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4012056887149811},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36772871017456055},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3334025740623474},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2109605371952057},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.14978954195976257},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14100223779678345},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.13880854845046997},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12905800342559814},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10786321759223938},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10754930973052979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000073798","descriptor_name":"Second Harmonic Generation Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003102","descriptor_name":"Colloids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006601","descriptor_name":"Hexoses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006813","descriptor_name":"Humidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014753","descriptor_name":"Vinyl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.molpharmaceut.9b00937","doi":"https://doi.org/10.1021/acs.molpharmaceut.9b00937","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.9b00937","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:31769985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31769985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G275102145","display_name":null,"funder_award_id":"1643745","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3148318513","display_name":null,"funder_award_id":"1710475","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G7467300578","display_name":null,"funder_award_id":"P200A150136","funder_id":"https://openalex.org/F4320306106","funder_display_name":"U.S. Department of Education"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306106","display_name":"U.S. Department of Education","ror":"https://ror.org/021adze67"},{"id":"https://openalex.org/F4320333023","display_name":"AbbVie Biotherapeutics","ror":"https://ror.org/03a0g6939"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W123401843","https://openalex.org/W130874531","https://openalex.org/W230017261","https://openalex.org/W633570903","https://openalex.org/W1964097253","https://openalex.org/W1965028792","https://openalex.org/W1967935934","https://openalex.org/W1968290693","https://openalex.org/W1969768793","https://openalex.org/W1992456610","https://openalex.org/W1995383798","https://openalex.org/W2029687056","https://openalex.org/W2034056979","https://openalex.org/W2034277254","https://openalex.org/W2036531306","https://openalex.org/W2052081265","https://openalex.org/W2056434768","https://openalex.org/W2065527895","https://openalex.org/W2073776376","https://openalex.org/W2115969927","https://openalex.org/W2131595369","https://openalex.org/W2283615177","https://openalex.org/W2289216359","https://openalex.org/W2313117920","https://openalex.org/W2316437357","https://openalex.org/W2336919468","https://openalex.org/W2339271230","https://openalex.org/W2604793721","https://openalex.org/W2612714942","https://openalex.org/W2791394532","https://openalex.org/W2808227203","https://openalex.org/W2896940868","https://openalex.org/W2898462957","https://openalex.org/W4250571491"],"related_works":["https://openalex.org/W2013737531","https://openalex.org/W2322907937","https://openalex.org/W2594325684","https://openalex.org/W2335696116","https://openalex.org/W2921201935","https://openalex.org/W2322592977","https://openalex.org/W2018213274","https://openalex.org/W4387064992","https://openalex.org/W118310357","https://openalex.org/W6983428908"],"abstract_inverted_index":{"Single-particle":[0,92],"tracking":[1,93],"of":[2,58,77,84,96,100,108,131,140],"crystal":[3,18,97,123],"growth":[4,21,98,124],"performed":[5],"in":[6,11,68,80,117,134],"situ":[7],"enables":[8,94,104],"substantial":[9],"improvements":[10,116],"the":[12,62,69,74,118],"signal-to-noise":[13,119],"ratio":[14],"(SNR)":[15],"for":[16,120,138],"recovered":[17],"nucleation":[19,109,121],"and":[20,53,103,122],"rates":[22,99],"by":[23,40],"nonlinear":[24],"optical":[25],"microscopy.":[26],"Second":[27],"harmonic":[28],"generation":[29],"(SHG)":[30],"is":[31],"exquisitely":[32],"sensitive":[33],"to":[34,127],"noncentrosymmetric":[35],"crystals,":[36],"including":[37],"those":[38],"produced":[39],"many":[41],"homochiral":[42],"active":[43],"pharmaceutical":[44,59],"ingredients":[45],"(APIs).":[46],"Accelerated":[47],"stability":[48,90],"testing":[49],"at":[50],"elevated":[51],"temperatures":[52],"relative":[54],"humidity":[55],"informs":[56],"design":[57],"formulations.":[60],"In":[61],"present":[63,79],"work,":[64],"we":[65],"demonstrate":[66],"reduction":[67,133],"Poisson":[70],"noise":[71],"associated":[72],"with":[73],"finite":[75],"number":[76],"particles":[78],"a":[81],"given":[82],"field":[83],"view":[85],"through":[86],"continuous":[87],"monitoring":[88],"during":[89],"testing.":[91],"recovery":[95,139],"individual":[101],"crystallites":[102],"unambiguous":[105],"direct":[106],"detection":[107],"events.":[110],"Collectively,":[111],"these":[112],"capabilities":[113],"provide":[114],"significant":[115],"measurements,":[125],"corresponding":[126],"approximately":[128],"an":[129],"order":[130],"magnitude":[132],"anticipated":[135],"measurement":[136],"time":[137],"kinetics":[141],"parameters.":[142]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-05T00:00:00"}
