{"id":"https://openalex.org/W2990769031","doi":null,"title":"[Diagnosis and treatment of rheumatoid arthritis:toward the best practice. Anti-bone resorbing treatment for rheumatoid arthritis.]","display_name":"[Diagnosis and treatment of rheumatoid arthritis:toward the best practice. Anti-bone resorbing treatment for rheumatoid arthritis.]","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2990769031","mag":"2990769031","pmid":"https://pubmed.ncbi.nlm.nih.gov/29731457"},"language":"ja","primary_location":{"id":"pmid:29731457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29731457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015953107","display_name":"Yoshiya Tanaka","orcid":"https://orcid.org/0000-0002-0807-7139","observed_orcids":["https://orcid.org/0000-0002-0807-7139"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiya Tanaka","raw_affiliation_strings":["The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan","institution_ids":["https://openalex.org/I188700360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015953107"],"corresponding_institution_ids":["https://openalex.org/I188700360"],"apc_list":null,"apc_paid":null,"fwci":0.1863,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.48937681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"28","issue":"5","first_page":"630","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anti-rankl-therapy","display_name":"anti-RANKL therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8130000233650208},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/bone-erosion","display_name":"bone erosion","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.734000027179718},{"id":"https://openalex.org/keywords/il-6-inhibitors","display_name":"IL-6 inhibitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/biological-dmards","display_name":"biologic DMARDs","score":0.9490000009536743},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9729999899864197},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.7049999833106995},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/joint-damage","display_name":"joint destruction","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8792487382888794},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.8542643189430237},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.8402820229530334},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7476240396499634},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6968922019004822},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6752060055732727},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6457977294921875},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6180314421653748},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5343678593635559},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4773837924003601},{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.45730239152908325},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3495091199874878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3443054258823395},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12644189596176147},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.060084372758865356}],"mesh":[{"descriptor_ui":"D000093242","descriptor_name":"Interleukin-6 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:29731457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29731457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},{"id":"mag:2990769031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29731457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W1988041575","https://openalex.org/W2801668030","https://openalex.org/W2331840422","https://openalex.org/W2553588510","https://openalex.org/W2941181135","https://openalex.org/W3025270435","https://openalex.org/W2982611184","https://openalex.org/W4322011609","https://openalex.org/W2396539229","https://openalex.org/W2752018562"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis(RA)is":[1],"a":[2],"systemic":[3],"inflammatory":[4],"disease":[5],"characterized":[6],"by":[7,90],"chronic":[8,21],"synovitis":[9],"and":[10,18,41,61,74,96,131,143],"bone":[11,47,88,115,129,142],"damage.":[12],"The":[13],"imbalance":[14,45],"in":[15,24,46,72,99,117,128],"immune":[16],"system":[17],"its":[19],"mediated":[20],"inflammation":[22],"result":[23],"pathological":[25],"processes":[26],"such":[27,38],"as":[28,31,33,39,101,103],"joint":[29],"destruction":[30,130],"well":[32,102],"secondary":[34],"osteoporosis.":[35],"Proinflammatory":[36],"cytokines":[37],"TNF":[40,60],"IL-6":[42,62],"cause":[43],"an":[44],"metabolism":[48],"via":[49],"direct":[50],"and/or":[51],"indirect":[52],"effects":[53],"on":[54],"osteoclasts.":[55],"However,":[56],"biologic":[57],"DMARDs":[58],"targeting":[59],"have":[63],"revolutionized":[64],"the":[65,92,107,112,139],"treatment":[66],"of":[67,94,114,125,141],"RA,":[68],"producing":[69],"significant":[70],"improvements":[71],"clinical":[73],"structural":[75],"outcomes":[76],"that":[77],"were":[78],"not":[79],"previously":[80],"observed.":[81],"An":[82],"anti-RANKL":[83],"antibody":[84],"denosumab":[85,110],"inhibits":[86],"osteoclast-induced":[87],"resorption":[89],"preventing":[91],"binding":[93],"RANKL":[95],"improves":[97],"osteoporosis":[98,132],"cortical":[100],"trabecula":[104],"bone.":[105],"In":[106],"DRIVE":[108],"study":[109,136],"inhibited":[111],"progression":[113],"erosion":[116],"Japanese":[118],"patients":[119],"with":[120],"RA.":[121],"Thus,":[122],"differential":[123],"efficacy":[124],"different":[126],"therapies":[127],"would":[133],"warrant":[134],"further":[135],"to":[137],"clarify":[138],"mechanisms":[140],"joints":[144],"diseases.":[145]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-12-05T00:00:00"}