{"id":"https://openalex.org/W2990657361","doi":"https://doi.org/10.1002/da.22978","title":"A meta\u2010analysis of dropout rates from exposure with response prevention and pharmacological treatment for youth with obsessive compulsive disorder","display_name":"A meta\u2010analysis of dropout rates from exposure with response prevention and pharmacological treatment for youth with obsessive compulsive disorder","publication_year":2019,"publication_date":"2019-11-28","ids":{"openalex":"https://openalex.org/W2990657361","doi":"https://doi.org/10.1002/da.22978","mag":"2990657361","pmid":"https://pubmed.ncbi.nlm.nih.gov/31778595"},"language":"en","primary_location":{"id":"doi:10.1002/da.22978","doi":"https://doi.org/10.1002/da.22978","is_oa":true,"landing_page_url":"https://doi.org/10.1002/da.22978","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/da.22978","source":{"id":"https://openalex.org/S192592622","display_name":"Depression and Anxiety","issn_l":"1091-4269","issn":["1091-4269","1520-6394"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Depression and Anxiety","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/da.22978","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043972700","display_name":"Carly J. Johnco","orcid":"https://orcid.org/0000-0002-2212-507X","observed_orcids":["https://orcid.org/0000-0002-2212-507X"]},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Carly Johnco","raw_affiliation_strings":["Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0002-2212-507X","affiliations":[{"raw_affiliation_string":"Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, Australia","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024284243","display_name":"Joseph F. Mcguire","orcid":"https://orcid.org/0000-0002-6128-8138","observed_orcids":["https://orcid.org/0000-0002-6128-8138"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph F. McGuire","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":"https://orcid.org/0000-0002-6128-8138","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004530314","display_name":"Tegan Roper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tegan Roper","raw_affiliation_strings":["Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, Australia","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089897759","display_name":"Eric A. Storch","orcid":"https://orcid.org/0000-0002-7631-3703","observed_orcids":["https://orcid.org/0000-0002-7631-3703"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric A. Storch","raw_affiliation_strings":["Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-7631-3703","affiliations":[{"raw_affiliation_string":"Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043972700"],"corresponding_institution_ids":["https://openalex.org/I99043593"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.7373,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.6056338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"37","issue":"5","first_page":"407","last_page":"417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10214","display_name":"Psychotherapy Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.8970000147819519},{"id":"https://openalex.org/keywords/youth","display_name":"youth","score":0.7739999890327454},{"id":"https://openalex.org/keywords/exposure-and-response-prevention","display_name":"exposure and response prevention","score":0.8460000157356262},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dropout-rates","display_name":"dropout rates","score":0.8080000281333923},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/serotonin-reuptake-inhibitors","display_name":"serotonin reuptake inhibitors","score":0.9559999704360962},{"id":"https://openalex.org/keywords/clomipramine","display_name":"clomipramine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/wait-list-control","display_name":"waitlist control","score":0.6729999780654907},{"id":"https://openalex.org/keywords/metacognitive-therapy","display_name":"metacognitive therapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/relaxation-training","display_name":"relaxation training","score":0.6389999985694885},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.8386424779891968},{"id":"https://openalex.org/C2780553607","wikidata":"https://www.wikidata.org/wiki/Q684868","display_name":"Attrition","level":2,"score":0.5651046633720398},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5206753015518188},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5147769451141357},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.481302410364151},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.437644898891449},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.43240344524383545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4205614924430847},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.36887580156326294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3177069425582886},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067489","descriptor_name":"Metacognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007171","descriptor_name":"Implosive Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010352","descriptor_name":"Patient Dropouts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015928","descriptor_name":"Cognitive Behavioral Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/da.22978","doi":"https://doi.org/10.1002/da.22978","is_oa":true,"landing_page_url":"https://doi.org/10.1002/da.22978","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/da.22978","source":{"id":"https://openalex.org/S192592622","display_name":"Depression and Anxiety","issn_l":"1091-4269","issn":["1091-4269","1520-6394"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Depression and Anxiety","raw_type":"journal-article"},{"id":"pmid:31778595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31778595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Depression and anxiety","raw_type":"Journal Article"},{"id":"mag:3167600218","doi":null,"is_oa":false,"landing_page_url":"https://eurekamag.com/research/069/563/069563086.php","pdf_url":null,"source":{"id":"https://openalex.org/S4306525565","display_name":"References","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"References","raw_type":null}],"best_oa_location":{"id":"doi:10.1002/da.22978","doi":"https://doi.org/10.1002/da.22978","is_oa":true,"landing_page_url":"https://doi.org/10.1002/da.22978","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/da.22978","source":{"id":"https://openalex.org/S192592622","display_name":"Depression and Anxiety","issn_l":"1091-4269","issn":["1091-4269","1520-6394"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Depression and Anxiety","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320591","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990657361.pdf","grobid_xml":"https://content.openalex.org/works/W2990657361.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W608931859","https://openalex.org/W814739761","https://openalex.org/W1541501625","https://openalex.org/W1918307986","https://openalex.org/W1976304862","https://openalex.org/W1979475756","https://openalex.org/W1986710838","https://openalex.org/W2008551461","https://openalex.org/W2008863502","https://openalex.org/W2016291757","https://openalex.org/W2028678936","https://openalex.org/W2030246057","https://openalex.org/W2031129187","https://openalex.org/W2034718004","https://openalex.org/W2039432189","https://openalex.org/W2047842365","https://openalex.org/W2049700186","https://openalex.org/W2052746469","https://openalex.org/W2052861911","https://openalex.org/W2055015127","https://openalex.org/W2059049783","https://openalex.org/W2074260396","https://openalex.org/W2077347008","https://openalex.org/W2078600098","https://openalex.org/W2081271683","https://openalex.org/W2081387417","https://openalex.org/W2082188531","https://openalex.org/W2086747636","https://openalex.org/W2086891655","https://openalex.org/W2087034164","https://openalex.org/W2090335173","https://openalex.org/W2091074718","https://openalex.org/W2106992945","https://openalex.org/W2121070134","https://openalex.org/W2122350405","https://openalex.org/W2146068512","https://openalex.org/W2160214171","https://openalex.org/W2165130631","https://openalex.org/W2168767441","https://openalex.org/W2300438987","https://openalex.org/W2326727100","https://openalex.org/W2587651746","https://openalex.org/W2806993355","https://openalex.org/W2992743278","https://openalex.org/W3022903699","https://openalex.org/W3197972117"],"related_works":["https://openalex.org/W2300438987","https://openalex.org/W2214878341","https://openalex.org/W2900343521","https://openalex.org/W2025221944","https://openalex.org/W2516009509","https://openalex.org/W2113404249","https://openalex.org/W4295807321","https://openalex.org/W7166017859","https://openalex.org/W2052746469","https://openalex.org/W2015917653"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Beliefs":[1],"that":[2],"exposure":[3],"with":[4,37,43,79,181,247],"response":[5],"prevention":[6],"(ERP)":[7],"is":[8,215,218,231],"excessively":[9],"distressing":[10],"and":[11,71,100,121,148,186,217,227],"will":[12],"result":[13],"in":[14],"client":[15],"dropout":[16],"from":[17,146,163,192,209,213],"treatment":[18,31,45,167,244],"are":[19],"commonly-cited":[20],"reasons":[21],"for":[22,33,35,77,86,196,204,234,245],"clinicians":[23,236],"not":[24,123,169,237],"providing":[25],"evidence-based":[26],"treatment.":[27],"This":[28],"meta-analysis":[29],"examined":[30],"attrition":[32,109,145,162,226],"ERP":[34,59,74,87,104,147,193,214,240],"youth":[36,78,246],"obsessive":[38],"compulsive":[39],"disorder":[40],"(OCD)":[41],"compared":[42,89,110,172,199],"other":[44],"modalities.":[46],"METHOD:":[47],"A":[48],"systematic":[49],"literature":[50],"search":[51],"identified":[52],"11":[53],"randomized":[54],"controlled":[55],"trials":[56],"(RCTs)":[57],"comparing":[58,67,73],"to":[60,69,75,90,111,126,173,200,238],"active":[61,93,112],"or":[62],"waitlist":[63,127],"control":[64,94,113],"conditions,":[65],"9":[66],"pharmacotherapy":[68,76,91,149,158],"control,":[70],"3":[72],"OCD.":[80,248],"RESULTS:":[81],"Attrition":[82,191,212],"rates":[83],"were":[84],"low":[85],"(10.24%)":[88],"(17.29%),":[92],"(e.g.,":[95],"relaxation,":[96],"metacognitive":[97],"therapy;":[98],"20.63%),":[99],"pill":[101],"placebo":[102,174],"(23.49%).":[103],"had":[105],"lower":[106,220],"risk":[107,143,160],"of":[108,144,161,202],"conditions":[114],"(RR":[115,128,150,175],"=":[116,119,129,132,151,154,176,179,189],"0.60;":[117],"p":[118,131,153,178],".02),":[120],"was":[122,138,168,194],"significantly":[124,170],"different":[125,171],"0.80;":[130],".59).":[133],"In":[134],"head-to-head":[135],"trials,":[136,159],"there":[137,230],"no":[139,182],"difference":[140,183],"between":[141,184],"the":[142,157],"1.26;":[152],".74).":[155],"Of":[156],"serotonin":[164],"reuptake":[165],"inhibitors":[166],"0.94;":[177],".76),":[180],"antidepressants":[185],"clomipramine":[187],"(p":[188],".19).":[190],"primarily":[195],"logistical":[197],"reasons,":[198],"lack":[201],"efficacy":[203,228],"relaxation":[205],"and/or":[206],"adverse":[207],"reactions":[208],"pharmacotherapy.":[210],"CONCLUSIONS:":[211],"low,":[216],"generally":[219],"than":[221],"non-ERP":[222],"interventions.":[223],"Given":[224],"favorable":[225],"data,":[229],"little":[232],"justification":[233],"appropriately-trained":[235],"offer":[239],"as":[241],"a":[242],"first-line":[243]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-05T00:00:00"}