{"id":"https://openalex.org/W2990657115","doi":"https://doi.org/10.3390/antiox8120603","title":"Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung Cancer","display_name":"Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung Cancer","publication_year":2019,"publication_date":"2019-11-29","ids":{"openalex":"https://openalex.org/W2990657115","doi":"https://doi.org/10.3390/antiox8120603","mag":"2990657115","pmid":"https://pubmed.ncbi.nlm.nih.gov/31795465","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6943435"},"language":"en","primary_location":{"id":"doi:10.3390/antiox8120603","doi":"https://doi.org/10.3390/antiox8120603","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antiox8120603","pdf_url":"https://www.mdpi.com/2076-3921/8/12/603/pdf?version=1575035556","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3921/8/12/603/pdf?version=1575035556","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074448604","display_name":"Cindy Mendes","orcid":"https://orcid.org/0000-0002-8808-5082","observed_orcids":["https://orcid.org/0000-0002-8808-5082"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cindy Mendes","raw_affiliation_strings":["CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 130, 1169-056 Lisboa, Portugal","Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto, 1099-023 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 130, 1169-056 Lisboa, Portugal","institution_ids":["https://openalex.org/I83558840"]},{"raw_affiliation_string":"Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto, 1099-023 Lisboa, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047987801","display_name":"Jacinta Serpa","orcid":"https://orcid.org/0000-0002-1548-5907","observed_orcids":["https://orcid.org/0000-0002-1548-5907"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Jacinta Serpa","raw_affiliation_strings":["CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 130, 1169-056 Lisboa, Portugal","Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto, 1099-023 Lisboa, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-1548-5907","affiliations":[{"raw_affiliation_string":"CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, Campo dos M\u00e1rtires da P\u00e1tria, 130, 1169-056 Lisboa, Portugal","institution_ids":["https://openalex.org/I83558840"]},{"raw_affiliation_string":"Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil (IPOLFG), Rua Prof Lima Basto, 1099-023 Lisboa, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047987801"],"corresponding_institution_ids":["https://openalex.org/I4210103180","https://openalex.org/I83558840"],"apc_list":{"value":1200,"currency":"CHF","value_usd":1216},"apc_paid":{"value":1200,"currency":"CHF","value_usd":1216},"fwci":0.1857,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.21340687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"12","first_page":"603","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.968999981880188},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7929999828338623},{"id":"https://openalex.org/keywords/metabolic-changes","display_name":"metabolic changes","score":0.42399999499320984},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.671999990940094},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.546999990940094},{"id":"https://openalex.org/keywords/resistance-mechanisms","display_name":"resistance mechanisms","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7693179249763489},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.652894139289856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.599165678024292},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.5397208333015442},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5156334638595581},{"id":"https://openalex.org/C2778807442","wikidata":"https://www.wikidata.org/wiki/Q6152005","display_name":"Treatment of lung cancer","level":3,"score":0.45958155393600464},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.44018301367759705},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4182499349117279},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3983477056026459},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.285500168800354},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.19900119304656982},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1856307089328766},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1574338972568512}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/antiox8120603","doi":"https://doi.org/10.3390/antiox8120603","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antiox8120603","pdf_url":"https://www.mdpi.com/2076-3921/8/12/603/pdf?version=1575035556","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6943435","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6943435","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmid:31795465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31795465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:run.unl.pt:10362/89813","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/89813","pdf_url":"http://hdl.handle.net/10362/89813","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review"}],"best_oa_location":{"id":"doi:10.3390/antiox8120603","doi":"https://doi.org/10.3390/antiox8120603","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antiox8120603","pdf_url":"https://www.mdpi.com/2076-3921/8/12/603/pdf?version=1575035556","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2673245850","display_name":null,"funder_award_id":"PT2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2734793695","display_name":null,"funder_award_id":"PT2020","funder_id":"https://openalex.org/F4320323642","funder_display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior"},{"id":"https://openalex.org/G7763239512","display_name":null,"funder_award_id":"PT2020","funder_id":"https://openalex.org/F4320323809","funder_display_name":"Minist\u00e9rio da Educa\u00e7\u00e3o"},{"id":"https://openalex.org/G7858748947","display_name":null,"funder_award_id":"iNOVA4Health","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G929281750","display_name":null,"funder_award_id":"PT 2020","funder_id":"https://openalex.org/F4320321868","funder_display_name":"Minist\u00e9rio da Educa\u00e7\u00e3o e Ci\u00eancia"}],"funders":[{"id":"https://openalex.org/F4320321868","display_name":"Minist\u00e9rio da Educa\u00e7\u00e3o e Ci\u00eancia","ror":"https://ror.org/02xv42m49"},{"id":"https://openalex.org/F4320323642","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","ror":"https://ror.org/045b9pr88"},{"id":"https://openalex.org/F4320323809","display_name":"Minist\u00e9rio da Educa\u00e7\u00e3o","ror":"https://ror.org/04d0xx942"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990657115.pdf","grobid_xml":"https://content.openalex.org/works/W2990657115.grobid-xml"},"referenced_works_count":233,"referenced_works":["https://openalex.org/W934857437","https://openalex.org/W1458147944","https://openalex.org/W1498909884","https://openalex.org/W1514403557","https://openalex.org/W1546552389","https://openalex.org/W1571252195","https://openalex.org/W1581731557","https://openalex.org/W1598971691","https://openalex.org/W1759734542","https://openalex.org/W1908940658","https://openalex.org/W1918156452","https://openalex.org/W1938186703","https://openalex.org/W1964122947","https://openalex.org/W1965186484","https://openalex.org/W1967980682","https://openalex.org/W1968963363","https://openalex.org/W1971886895","https://openalex.org/W1972562299","https://openalex.org/W1974107986","https://openalex.org/W1974903221","https://openalex.org/W1978230043","https://openalex.org/W1980058210","https://openalex.org/W1980497534","https://openalex.org/W1984418041","https://openalex.org/W1985264867","https://openalex.org/W1986889886","https://openalex.org/W1988024355","https://openalex.org/W1988605167","https://openalex.org/W1989800846","https://openalex.org/W1990609536","https://openalex.org/W1990626198","https://openalex.org/W1991429659","https://openalex.org/W1992018638","https://openalex.org/W1993534135","https://openalex.org/W1995047266","https://openalex.org/W1997476230","https://openalex.org/W1997909566","https://openalex.org/W1998166655","https://openalex.org/W1998971866","https://openalex.org/W1998976350","https://openalex.org/W2000227671","https://openalex.org/W2002575472","https://openalex.org/W2006953772","https://openalex.org/W2008693067","https://openalex.org/W2010711320","https://openalex.org/W2014988241","https://openalex.org/W2021568546","https://openalex.org/W2022916868","https://openalex.org/W2024728867","https://openalex.org/W2026198465","https://openalex.org/W2026327431","https://openalex.org/W2027705428","https://openalex.org/W2027817200","https://openalex.org/W2028216531","https://openalex.org/W2035779563","https://openalex.org/W2041729369","https://openalex.org/W2043696829","https://openalex.org/W2044594989","https://openalex.org/W2048251803","https://openalex.org/W2049264404","https://openalex.org/W2049537372","https://openalex.org/W2050126271","https://openalex.org/W2050249255","https://openalex.org/W2050605886","https://openalex.org/W2054333460","https://openalex.org/W2055242813","https://openalex.org/W2055402151","https://openalex.org/W2057140993","https://openalex.org/W2058433906","https://openalex.org/W2058493425","https://openalex.org/W2058689793","https://openalex.org/W2060699679","https://openalex.org/W2061112270","https://openalex.org/W2062340497","https://openalex.org/W2062681436","https://openalex.org/W2063264144","https://openalex.org/W2064710674","https://openalex.org/W2066715779","https://openalex.org/W2069269337","https://openalex.org/W2070150128","https://openalex.org/W2070202276","https://openalex.org/W2072618321","https://openalex.org/W2076704022","https://openalex.org/W2081269875","https://openalex.org/W2082346247","https://openalex.org/W2085650758","https://openalex.org/W2088700096","https://openalex.org/W2088888762","https://openalex.org/W2091528050","https://openalex.org/W2095374177","https://openalex.org/W2095618958","https://openalex.org/W2096156234","https://openalex.org/W2096731080","https://openalex.org/W2097259163","https://openalex.org/W2098142549","https://openalex.org/W2098455835","https://openalex.org/W2098742726","https://openalex.org/W2101441514","https://openalex.org/W2103359811","https://openalex.org/W2104347254","https://openalex.org/W2104830962","https://openalex.org/W2105665764","https://openalex.org/W2106926141","https://openalex.org/W2107735218","https://openalex.org/W2108535907","https://openalex.org/W2109762957","https://openalex.org/W2110716203","https://openalex.org/W2112601576","https://openalex.org/W2116720928","https://openalex.org/W2117692326","https://openalex.org/W2118263932","https://openalex.org/W2118793608","https://openalex.org/W2119472087","https://openalex.org/W2121389354","https://openalex.org/W2123585286","https://openalex.org/W2124813314","https://openalex.org/W2126863322","https://openalex.org/W2127286396","https://openalex.org/W2129992678","https://openalex.org/W2130784515","https://openalex.org/W2131348261","https://openalex.org/W2131487381","https://openalex.org/W2132870547","https://openalex.org/W2133488997","https://openalex.org/W2133525371","https://openalex.org/W2136765222","https://openalex.org/W2137386173","https://openalex.org/W2137463275","https://openalex.org/W2138017475","https://openalex.org/W2138260154","https://openalex.org/W2140525205","https://openalex.org/W2143036691","https://openalex.org/W2143481229","https://openalex.org/W2143913849","https://openalex.org/W2145835533","https://openalex.org/W2147595835","https://openalex.org/W2148057257","https://openalex.org/W2148587874","https://openalex.org/W2148755064","https://openalex.org/W2151334606","https://openalex.org/W2153568365","https://openalex.org/W2154149901","https://openalex.org/W2155450096","https://openalex.org/W2156353875","https://openalex.org/W2156647409","https://openalex.org/W2157199218","https://openalex.org/W2158157639","https://openalex.org/W2158794894","https://openalex.org/W2159588477","https://openalex.org/W2160586729","https://openalex.org/W2162420845","https://openalex.org/W2166084034","https://openalex.org/W2168168277","https://openalex.org/W2168889003","https://openalex.org/W2171222510","https://openalex.org/W2171228244","https://openalex.org/W2172010139","https://openalex.org/W2232613537","https://openalex.org/W2234115940","https://openalex.org/W2258066491","https://openalex.org/W2264411128","https://openalex.org/W2276797565","https://openalex.org/W2280957887","https://openalex.org/W2284388501","https://openalex.org/W2289922904","https://openalex.org/W2321338941","https://openalex.org/W2322116467","https://openalex.org/W2323751645","https://openalex.org/W2395626624","https://openalex.org/W2405048763","https://openalex.org/W2418589037","https://openalex.org/W2435167068","https://openalex.org/W2439107762","https://openalex.org/W2469120040","https://openalex.org/W2475037643","https://openalex.org/W2482427906","https://openalex.org/W2496616613","https://openalex.org/W2503851771","https://openalex.org/W2508069933","https://openalex.org/W2517682664","https://openalex.org/W2522175988","https://openalex.org/W2522462738","https://openalex.org/W2531335099","https://openalex.org/W2533210290","https://openalex.org/W2560535385","https://openalex.org/W2560704457","https://openalex.org/W2569357796","https://openalex.org/W2572174216","https://openalex.org/W2575507470","https://openalex.org/W2587048937","https://openalex.org/W2587420003","https://openalex.org/W2592243930","https://openalex.org/W2600567604","https://openalex.org/W2606686841","https://openalex.org/W2611436342","https://openalex.org/W2611704203","https://openalex.org/W2620892894","https://openalex.org/W2624860396","https://openalex.org/W2677344660","https://openalex.org/W2737125479","https://openalex.org/W2737952479","https://openalex.org/W2751122093","https://openalex.org/W2763979809","https://openalex.org/W2767072667","https://openalex.org/W2773012806","https://openalex.org/W2775125633","https://openalex.org/W2778659609","https://openalex.org/W2782381855","https://openalex.org/W2784371446","https://openalex.org/W2789011876","https://openalex.org/W2791106616","https://openalex.org/W2793096195","https://openalex.org/W2804040141","https://openalex.org/W2808734808","https://openalex.org/W2809388839","https://openalex.org/W2810951976","https://openalex.org/W2889488326","https://openalex.org/W2899130161","https://openalex.org/W2919690794","https://openalex.org/W2920775348","https://openalex.org/W2922415295","https://openalex.org/W2945234874","https://openalex.org/W2945995202","https://openalex.org/W2957166771","https://openalex.org/W2976596814","https://openalex.org/W3174363935","https://openalex.org/W4242070201","https://openalex.org/W4244605837","https://openalex.org/W4247211370","https://openalex.org/W6630798844","https://openalex.org/W6635796083","https://openalex.org/W6650204128","https://openalex.org/W6717301734"],"related_works":["https://openalex.org/W3009965031","https://openalex.org/W4396666347","https://openalex.org/W7222894955","https://openalex.org/W7212256401","https://openalex.org/W3129532875","https://openalex.org/W4405915226","https://openalex.org/W3211309537","https://openalex.org/W4396681472","https://openalex.org/W2569376773","https://openalex.org/W2767952553"],"abstract_inverted_index":{"Metabolic":[0],"remodelling":[1],"is":[2,18,27,123],"a":[3,19,28,165],"hallmark":[4],"of":[5,31,48,80,112,132,153],"cancer,":[6,34],"however":[7],"little":[8],"has":[9],"been":[10,99],"unravelled":[11],"in":[12,15,101,125],"its":[13],"role":[14],"chemoresistance,":[16],"which":[17],"major":[20],"hurdle":[21],"to":[22,37,45,50,62,71,145],"cancer":[23,26,92,103,133,162],"control.":[24],"Lung":[25],"leading":[29],"cause":[30],"death":[32],"by":[33,90],"mainly":[35],"due":[36],"the":[38,46,110,151],"diagnosis":[39],"at":[40],"an":[41],"advanced":[42],"stage":[43],"and":[44,104,109,115,117,136,155],"development":[47],"resistance":[49,67,84,140],"therapy.":[51],"Targeted":[52],"therapeutic":[53,82,107,148,170],"agents":[54],"combined":[55],"with":[56],"comprehensive":[57],"drugs":[58,114],"are":[59,69,87],"commonly":[60],"used":[61],"treat":[63],"lung":[64,91,102],"cancer.":[65],"However,":[66],"mechanisms":[68,85,141],"difficult":[70],"avoid.":[72],"In":[73],"this":[74,126],"review,":[75],"we":[76],"will":[77,142],"address":[78],"some":[79],"those":[81],"regimens,":[83],"that":[86,96],"eventually":[88],"developed":[89],"cells,":[93],"metabolic":[94,159,167],"alterations":[95],"have":[97],"already":[98],"described":[100],"putative":[105],"new":[106,147],"strategies,":[108,149],"integration":[111],"conventional":[113],"genetic":[116],"metabolic-targeted":[118],"therapies.":[119],"The":[120],"oxidative":[121],"stress":[122],"pivotal":[124],"whole":[127],"network.":[128],"A":[129],"better":[130],"understanding":[131],"cell":[134],"metabolism":[135],"molecular":[137],"adaptations":[138],"underlying":[139],"provide":[143],"clues":[144],"design":[146],"including":[150],"combination":[152],"chemotherapeutic":[154],"targeted":[156],"agents,":[157],"considering":[158],"intervenients.":[160],"As":[161],"cells":[163],"undergo":[164],"constant":[166],"adaptive":[168],"drift,":[169],"regimens":[171],"must":[172],"constantly":[173],"adapt.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}