{"id":"https://openalex.org/W2990632174","doi":"https://doi.org/10.3390/cancers11121849","title":"The Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling","display_name":"The Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling","publication_year":2019,"publication_date":"2019-11-22","ids":{"openalex":"https://openalex.org/W2990632174","doi":"https://doi.org/10.3390/cancers11121849","mag":"2990632174","pmid":"https://pubmed.ncbi.nlm.nih.gov/31771104","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6966592"},"language":"en","primary_location":{"id":"doi:10.3390/cancers11121849","doi":"https://doi.org/10.3390/cancers11121849","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11121849","pdf_url":"https://www.mdpi.com/2072-6694/11/12/1849/pdf?version=1576398472","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/11/12/1849/pdf?version=1576398472","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007507062","display_name":"Suji Han","orcid":"https://orcid.org/0000-0002-5460-7786","observed_orcids":["https://orcid.org/0000-0002-5460-7786"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suji Han","raw_affiliation_strings":["Department of Health Sciences & Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea","Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea"],"raw_orcid":"https://orcid.org/0000-0002-5460-7786","affiliations":[{"raw_affiliation_string":"Department of Health Sciences & Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101399037","display_name":"Hyemi Shin","orcid":"https://orcid.org/0000-0002-8168-4429","observed_orcids":["https://orcid.org/0000-0002-8168-4429","https://orcid.org/0009-0006-5619-2920"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyemi Shin","raw_affiliation_strings":["Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea"],"raw_orcid":"https://orcid.org/0000-0002-8168-4429","affiliations":[{"raw_affiliation_string":"Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070906604","display_name":"Jeong-Woo Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong-Woo Oh","raw_affiliation_strings":["Department of Health Sciences & Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea","Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences & Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yun Jeong Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun Jeong Oh","raw_affiliation_strings":["Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071501594","display_name":"Nam-Gu Her","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Nam-Gu Her","raw_affiliation_strings":["Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea","institution_ids":["https://openalex.org/I2802194831"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090117550","display_name":"Do\u2010Hyun Nam","orcid":"https://orcid.org/0000-0002-8477-6791","observed_orcids":["https://orcid.org/0000-0002-8477-6791"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Do-Hyun Nam","raw_affiliation_strings":["Department of Health Sciences & Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea","Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University, Seoul 06351, Korea","Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences & Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University, Seoul 06351, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Institute for Refractory Cancer Research, Samsung Medical Center, Seoul 06351, Korea","institution_ids":["https://openalex.org/I2802194831"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071501594","https://openalex.org/A5090117550"],"corresponding_institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":1.7973,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.86882069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"12","first_page":"1849","last_page":"1849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mln4924","display_name":"MLN4924","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neddylation-inhibition","display_name":"neddylation inhibition","score":0.8240000009536743},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nedd8-activating-enzyme","display_name":"NEDD8-activating enzyme","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nae1","display_name":"NAE1","score":0.7739999890327454},{"id":"https://openalex.org/keywords/uba3","display_name":"UBA3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C45005369","wikidata":"https://www.wikidata.org/wiki/Q21115705","display_name":"Neddylation","level":5,"score":0.9125003218650818},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.8098469972610474},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6653952598571777},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6532411575317383},{"id":"https://openalex.org/C2779231659","wikidata":"https://www.wikidata.org/wiki/Q6953444","display_name":"NEDD8","level":5,"score":0.6080275774002075},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5648519992828369},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48876500129699707},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47805291414260864},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.42798542976379395},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.41856276988983154},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4123702347278595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.372020959854126},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32539263367652893},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1048491895198822},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.050711482763290405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04884976148605347},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.04421725869178772},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers11121849","doi":"https://doi.org/10.3390/cancers11121849","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11121849","pdf_url":"https://www.mdpi.com/2072-6694/11/12/1849/pdf?version=1576398472","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5942994","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6966592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31771104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31771104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6966592","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6966592/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/cancers11121849","doi":"https://doi.org/10.3390/cancers11121849","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11121849","pdf_url":"https://www.mdpi.com/2072-6694/11/12/1849/pdf?version=1576398472","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G458137265","display_name":null,"funder_award_id":"NRF-2015M3A9A7029740","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G4837183821","display_name":null,"funder_award_id":"2015M3A9A7029740","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G5486286354","display_name":null,"funder_award_id":"NRF-2015M3A9A7029740","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G7283856674","display_name":null,"funder_award_id":"HI14C3418","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990632174.pdf","grobid_xml":"https://content.openalex.org/works/W2990632174.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1504206591","https://openalex.org/W1560814177","https://openalex.org/W1598608016","https://openalex.org/W1851733051","https://openalex.org/W1872239493","https://openalex.org/W1893588436","https://openalex.org/W1973642840","https://openalex.org/W1979721942","https://openalex.org/W1984250533","https://openalex.org/W1994939674","https://openalex.org/W1999463649","https://openalex.org/W2011728195","https://openalex.org/W2014114945","https://openalex.org/W2014841048","https://openalex.org/W2018671779","https://openalex.org/W2021846401","https://openalex.org/W2027241628","https://openalex.org/W2032039673","https://openalex.org/W2062980622","https://openalex.org/W2063038041","https://openalex.org/W2071853918","https://openalex.org/W2076194625","https://openalex.org/W2081524299","https://openalex.org/W2085006244","https://openalex.org/W2088369745","https://openalex.org/W2091718191","https://openalex.org/W2093904762","https://openalex.org/W2096287682","https://openalex.org/W2096441981","https://openalex.org/W2099692341","https://openalex.org/W2102619694","https://openalex.org/W2107132417","https://openalex.org/W2119034410","https://openalex.org/W2122128696","https://openalex.org/W2122405410","https://openalex.org/W2123077018","https://openalex.org/W2128546338","https://openalex.org/W2130410032","https://openalex.org/W2132485651","https://openalex.org/W2133540186","https://openalex.org/W2140510391","https://openalex.org/W2147045066","https://openalex.org/W2148532207","https://openalex.org/W2148533572","https://openalex.org/W2158645948","https://openalex.org/W2161289668","https://openalex.org/W2163859522","https://openalex.org/W2167882141","https://openalex.org/W2168979257","https://openalex.org/W2252610880","https://openalex.org/W2515715601"],"related_works":["https://openalex.org/W2983081724","https://openalex.org/W2099692341","https://openalex.org/W2740115523","https://openalex.org/W2887066494","https://openalex.org/W4231446599","https://openalex.org/W2588892316","https://openalex.org/W4367182272","https://openalex.org/W3083566368","https://openalex.org/W7096082159","https://openalex.org/W4399849229"],"abstract_inverted_index":{"Glioblastoma":[0,116],"is":[1,19],"a":[2],"highly":[3,124,206],"aggressive":[4],"and":[5,23,69,73,106,119,164,180,200,205],"lethal":[6],"brain":[7],"tumor,":[8],"with":[9,85],"limited":[10],"treatment":[11],"options.":[12],"Abnormal":[13],"activation":[14,202],"of":[15,97,158,198],"the":[16,24,196],"neddylation":[17,209],"pathway":[18,62],"observed":[20],"in":[21,36,48,66,77,101,140,183,195],"glioblastoma,":[22],"NEDD8-activating":[25],"enzyme":[26],"(NAE)":[27],"inhibitor,":[28],"MLN4924,":[29,127],"was":[30],"previously":[31],"shown":[32],"to":[33,58,126],"be":[34],"effective":[35],"glioblastoma":[37,50,67,78,103,109,143,192],"cell":[38,104,117],"line":[39],"models.":[40],"However,":[41],"its":[42],"effect":[43],"has":[44],"not":[45],"been":[46],"tested":[47],"patient-derived":[49,108,120,142,191],"stem":[51,110,121,144,193],"cells.":[52,186],"We":[53,174],"first":[54],"analyzed":[55],"public":[56],"data":[57],"determine":[59],"whether":[60],"NEDD8":[61,81],"proteins":[63],"are":[64,203],"important":[65],"development":[68],"patient":[70],"survival.":[71],"NAE1":[72],"UBA3":[74],"levels":[75,82],"increased":[76],"patients;":[79],"high":[80,113],"were":[83,99,123,132,137],"associated":[84],"poor":[86],"clinical":[87],"outcomes.":[88],"Immunohistochemistry":[89],"results":[90],"also":[91,169],"supported":[92],"this":[93],"result.":[94],"The":[95],"effects":[96],"MLN4924":[98,147,153,177,184],"evaluated":[100],"4":[102],"lines":[105,118],"15":[107,141],"cells":[111,122,145,155,194],"using":[112],"content":[114],"analysis.":[115],"susceptible":[125],"while":[128],"normal":[129],"human":[130],"astrocytes":[131],"resistant.":[133],"In":[134],"addition,":[135],"there":[136],"various":[138],"responses":[139],"upon":[146],"treatment.":[148],"Genomic":[149],"analyses":[150],"indicated":[151],"that":[152,176,190],"sensitive":[154,185,204],"exhibited":[156],"enrichment":[157],"Extracellular":[159],"Signal":[160],"Regulated":[161],"Kinase":[162],"(ERK)":[163],"Protein":[165],"kinase":[166],"B":[167],"(AKT,":[168],"known":[170],"as":[171],"PKB)":[172],"signaling.":[173],"verified":[175],"inhibits":[178],"ERK":[179,199],"AKT":[181,201],"phosphorylation":[182],"Our":[187],"findings":[188],"suggest":[189],"context":[197],"regulated":[207],"by":[208],"inhibition.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}
