{"id":"https://openalex.org/W2990597010","doi":"https://doi.org/10.1038/s41598-019-54368-8","title":"Genetic and epigenetic alterations induced by bisphenol A exposure during different periods of spermatogenesis: from spermatozoa to the progeny","display_name":"Genetic and epigenetic alterations induced by bisphenol A exposure during different periods of spermatogenesis: from spermatozoa to the progeny","publication_year":2019,"publication_date":"2019-12-02","ids":{"openalex":"https://openalex.org/W2990597010","doi":"https://doi.org/10.1038/s41598-019-54368-8","mag":"2990597010","pmid":"https://pubmed.ncbi.nlm.nih.gov/31792261","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6889327"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-54368-8","doi":"https://doi.org/10.1038/s41598-019-54368-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-54368-8","pdf_url":"https://www.nature.com/articles/s41598-019-54368-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-54368-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033545944","display_name":"Marta Lomb\u00f3","orcid":"https://orcid.org/0000-0002-2042-798X","observed_orcids":["https://orcid.org/0000-0002-2042-798X"]},"institutions":[{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Lomb\u00f3","raw_affiliation_strings":["Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, 24071, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, 24071, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108119408","display_name":"Cristina Fern\u00e1ndez-D\u00edez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166295","display_name":"Instituto de Ganader\u00eda de Monta\u00f1a","ror":"https://ror.org/05hy3q009","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210166295","https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Fern\u00e1ndez-D\u00edez","raw_affiliation_strings":["Instituto Ganadero de Mota\u00f1a (IGM), Finca Marzanas-Grulleros Vega de Infanzones, Le\u00f3n, 24346, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Ganadero de Mota\u00f1a (IGM), Finca Marzanas-Grulleros Vega de Infanzones, Le\u00f3n, 24346, Spain","institution_ids":["https://openalex.org/I4210166295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090218515","display_name":"Silvia Gonz\u00e1lez-Rojo","orcid":"https://orcid.org/0000-0002-9630-4468","observed_orcids":["https://orcid.org/0000-0002-9630-4468"]},"institutions":[{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia Gonz\u00e1lez-Rojo","raw_affiliation_strings":["Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, 24071, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, 24071, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055086538","display_name":"M.P. Herr\u00e1ez","orcid":"https://orcid.org/0000-0002-0028-3616","observed_orcids":["https://orcid.org/0000-0002-0028-3616"]},"institutions":[{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Mar\u00eda Paz Herr\u00e1ez","raw_affiliation_strings":["Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, 24071, Spain. paz.herraez@unileon.es","Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, 24071, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, 24071, Spain. paz.herraez@unileon.es","institution_ids":["https://openalex.org/I8833935"]},{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Biology and Environmental Sciences, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, 24071, Spain","institution_ids":["https://openalex.org/I8833935"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055086538"],"corresponding_institution_ids":["https://openalex.org/I8833935"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":4.8887,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.97263504,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"18029","last_page":"18029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.17870000004768372,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":1.0},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sperm-dna-damage","display_name":"sperm DNA damage","score":0.800000011920929},{"id":"https://openalex.org/keywords/paternal-epigenetic-inheritance","display_name":"paternal epigenetic inheritance","score":0.628000020980835},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/h3k9ac","display_name":"H3K9ac","score":0.7450000047683716},{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.9990000128746033},{"id":"https://openalex.org/keywords/early-embryonic-development","display_name":"early embryonic development","score":0.7070000171661377},{"id":"https://openalex.org/keywords/embryo-apoptosis","display_name":"embryo apoptosis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7960000038146973},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8009999990463257},{"id":"https://openalex.org/keywords/male-reproductive-toxicity","display_name":"male reproductive toxicity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5350000262260437},{"id":"https://openalex.org/keywords/timing-of-exposure","display_name":"exposure timing","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.7999914884567261},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7483571171760559},{"id":"https://openalex.org/C2779684741","wikidata":"https://www.wikidata.org/wiki/Q271980","display_name":"Bisphenol A","level":3,"score":0.5734570622444153},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.558578610420227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5266128778457642},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4329245686531067},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35927677154541016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2583009600639343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23495084047317505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2065415382385254},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C166595027","wikidata":"https://www.wikidata.org/wiki/Q143983","display_name":"Epoxy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000098826","descriptor_name":"Bisphenol A Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D052244","descriptor_name":"Endocrine Disruptors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-019-54368-8","doi":"https://doi.org/10.1038/s41598-019-54368-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-54368-8","pdf_url":"https://www.nature.com/articles/s41598-019-54368-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:31792261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31792261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6889327","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6889327/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:buleria.unileon.es:10612/18184","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10612/18184","pdf_url":null,"source":{"id":"https://openalex.org/S4306401642","display_name":"Buleria (Universidad de Le\u00f3n)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169046204","host_organization_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","host_organization_lineage":["https://openalex.org/I169046204"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:396398485a1246238b0781c39159ada5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/396398485a1246238b0781c39159ada5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-54368-8","doi":"https://doi.org/10.1038/s41598-019-54368-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-54368-8","pdf_url":"https://www.nature.com/articles/s41598-019-54368-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1014161495","display_name":null,"funder_award_id":"BES-2015-071885","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G268517103","display_name":null,"funder_award_id":"AGL2014-53167-C3-3-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G2772317834","display_name":null,"funder_award_id":"AGL2014","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G4523457881","display_name":null,"funder_award_id":"AGL2014-53167","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990597010.pdf","grobid_xml":"https://content.openalex.org/works/W2990597010.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W133399819","https://openalex.org/W396736222","https://openalex.org/W1562023594","https://openalex.org/W1594472165","https://openalex.org/W1895000577","https://openalex.org/W1910049290","https://openalex.org/W1915620309","https://openalex.org/W1976182007","https://openalex.org/W1979705230","https://openalex.org/W1983570177","https://openalex.org/W1984236721","https://openalex.org/W1988448112","https://openalex.org/W1989187489","https://openalex.org/W1997128871","https://openalex.org/W2007555020","https://openalex.org/W2009901032","https://openalex.org/W2019723274","https://openalex.org/W2024630063","https://openalex.org/W2031853363","https://openalex.org/W2039027073","https://openalex.org/W2048637593","https://openalex.org/W2050176560","https://openalex.org/W2053992892","https://openalex.org/W2054280836","https://openalex.org/W2058958453","https://openalex.org/W2068189517","https://openalex.org/W2080671154","https://openalex.org/W2089491135","https://openalex.org/W2093351415","https://openalex.org/W2098813936","https://openalex.org/W2103260955","https://openalex.org/W2111144101","https://openalex.org/W2112381039","https://openalex.org/W2114854528","https://openalex.org/W2116039169","https://openalex.org/W2125349610","https://openalex.org/W2128799803","https://openalex.org/W2130282432","https://openalex.org/W2137399444","https://openalex.org/W2139455764","https://openalex.org/W2146917475","https://openalex.org/W2148278506","https://openalex.org/W2152558985","https://openalex.org/W2158861165","https://openalex.org/W2160704247","https://openalex.org/W2162224252","https://openalex.org/W2167858141","https://openalex.org/W2216778680","https://openalex.org/W2282954994","https://openalex.org/W2288264962","https://openalex.org/W2292927854","https://openalex.org/W2334719722","https://openalex.org/W2344332687","https://openalex.org/W2466598046","https://openalex.org/W2469289905","https://openalex.org/W2500874296","https://openalex.org/W2501050123","https://openalex.org/W2550185754","https://openalex.org/W2570167758","https://openalex.org/W2580767461","https://openalex.org/W2606412267","https://openalex.org/W2725629422","https://openalex.org/W2763927309","https://openalex.org/W2769561691","https://openalex.org/W2800816467","https://openalex.org/W2801005106","https://openalex.org/W2873538059","https://openalex.org/W2888581300","https://openalex.org/W2891507167","https://openalex.org/W2908508002","https://openalex.org/W2913502276","https://openalex.org/W2914450436","https://openalex.org/W2948038978","https://openalex.org/W2948525041","https://openalex.org/W2954055671","https://openalex.org/W3015443984","https://openalex.org/W3023781752"],"related_works":["https://openalex.org/W2914450436","https://openalex.org/W4253383644","https://openalex.org/W7138303855","https://openalex.org/W4307162590","https://openalex.org/W3041897046","https://openalex.org/W3006846959","https://openalex.org/W2077350687","https://openalex.org/W3143214853","https://openalex.org/W3045198699","https://openalex.org/W2912363754"],"abstract_inverted_index":{"Exposure":[0,102],"to":[1,8,63,103,157,171],"bisphenol":[2],"A":[3],"(BPA)":[4],"has":[5],"been":[6],"related":[7],"male":[9,163],"reproductive":[10],"disorders.":[11],"Since":[12],"this":[13,42],"endocrine":[14],"disruptor":[15],"also":[16],"displays":[17],"genotoxic":[18],"and":[19,33,56,65,72,78,85,97,136,145,152,168,179,194],"epigenotoxic":[20,79],"effects,":[21],"it":[22],"likely":[23],"alters":[24],"the":[25,53,74,159,172,189,192,195],"spermatogenesis,":[26],"a":[27,175,181],"process":[28],"in":[29,118,133,150],"which":[30],"both":[31,185],"hormones":[32],"chromatin":[34,112],"remodeling":[35],"play":[36],"crucial":[37],"roles.":[38],"The":[39,120],"hypothesis":[40],"of":[41,122,127,174,180,191,198],"work":[43],"is":[44],"that":[45],"BPA":[46,68,106,162],"impairs":[47],"early":[48,70,134],"embryo":[49,135],"development":[50,91,169],"by":[51],"modifying":[52],"spermatic":[54],"genetic":[55],"epigenetic":[57,98],"information.":[58],"Zebrafish":[59],"males":[60,155],"were":[61,100],"exposed":[62,156],"100":[64,104],"2000":[66],"\u03bcg/L":[67],"during":[69,73,107],"spermatogenesis":[71],"whole":[75],"process.":[76],"Genotoxic":[77],"effects":[80],"on":[81,188],"spermatozoa":[82,151],"(comet":[83],"assay":[84],"immunocytochemistry)":[86],"as":[87,89],"well":[88],"progeny":[90],"(mortality,":[92],"DNA":[93,115,129],"repairing":[94,116],"activity,":[95],"apoptosis":[96,132],"profile)":[99],"evaluated.":[101],"\u00b5g/L":[105],"mitosis":[108],"slightly":[109],"increased":[110],"sperm":[111,128],"fragmentation,":[113],"enhancing":[114],"activity":[117],"embryos.":[119],"rest":[121],"treatments":[123],"promoted":[124],"high":[125],"levels":[126],"damage,":[130],"triggering":[131],"severely":[137],"impairing":[138],"survival.":[139],"Regarding":[140],"epigenetics,":[141],"histone":[142,183],"acetylation":[143],"(H3K9Ac":[144],"H3K27Ac)":[146],"was":[147],"similarly":[148],"enhanced":[149],"embryos":[153],"from":[154],"all":[158],"treatments.":[160],"Therefore,":[161],"exposure":[164],"jeopardizes":[165],"embryonic":[166],"survival":[167],"due":[170],"transmission":[173],"paternal":[176],"damaged":[177],"genome":[178],"hyper-acetylated":[182],"profile,":[184],"alterations":[186],"depending":[187],"dose":[190],"toxicant":[193],"temporal":[196],"window":[197],"exposure.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":11},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}