{"id":"https://openalex.org/W2990592352","doi":"https://doi.org/10.1002/biof.1587","title":"The role of Interleukin 1 receptor antagonist in mesenchymal stem cell\u2010based tissue repair and regeneration","display_name":"The role of Interleukin 1 receptor antagonist in mesenchymal stem cell\u2010based tissue repair and regeneration","publication_year":2019,"publication_date":"2019-11-22","ids":{"openalex":"https://openalex.org/W2990592352","doi":"https://doi.org/10.1002/biof.1587","mag":"2990592352","pmid":"https://pubmed.ncbi.nlm.nih.gov/31755595"},"language":"en","primary_location":{"id":"doi:10.1002/biof.1587","doi":"https://doi.org/10.1002/biof.1587","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biof.1587","pdf_url":null,"source":{"id":"https://openalex.org/S75531928","display_name":"BioFactors","issn_l":"0951-6433","issn":["0951-6433","1872-8081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030705885","display_name":"Carl Randall Harrell","orcid":"https://orcid.org/0000-0002-5906-9198","observed_orcids":["https://orcid.org/0000-0002-5906-9198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Randall Harrell","raw_affiliation_strings":["Regenerative Processing Plant, LLC, Palm Harbor, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Processing Plant, LLC, Palm Harbor, Florida","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016290215","display_name":"Bojana Simovi\u0107 Markovi\u0107","orcid":"https://orcid.org/0000-0001-8408-4624","observed_orcids":["https://orcid.org/0000-0001-8408-4624"]},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Bojana Simovic Markovic","raw_affiliation_strings":["Faculty of Medical Sciences, Department for Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Department for Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026875028","display_name":"Crissy Fellabaum","orcid":"https://orcid.org/0000-0001-6652-1042","observed_orcids":["https://orcid.org/0000-0001-6652-1042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Crissy Fellabaum","raw_affiliation_strings":["Regenerative Processing Plant, LLC, Palm Harbor, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Processing Plant, LLC, Palm Harbor, Florida","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005031112","display_name":"Neboj\u0161a Arsenijevi\u0107","orcid":"https://orcid.org/0000-0002-2107-3490","observed_orcids":["https://orcid.org/0000-0002-2107-3490"]},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Nebojsa Arsenijevic","raw_affiliation_strings":["Faculty of Medical Sciences, Department for Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Department for Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062544738","display_name":"Valentin Djonov","orcid":"https://orcid.org/0000-0002-5062-1169","observed_orcids":["https://orcid.org/0000-0002-5062-1169"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Valentin Djonov","raw_affiliation_strings":["Institute of Anatomy, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":null,"display_name":"Vladislav Volarevic","orcid":"https://orcid.org/0000-0002-9057-9460","observed_orcids":["https://orcid.org/0000-0002-9057-9460"]},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Vladislav Volarevic","raw_affiliation_strings":["Faculty of Medical Sciences, Department for Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia"],"raw_orcid":"https://orcid.org/0000-0002-9057-9460","affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Department for Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia","institution_ids":["https://openalex.org/I14245010"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I14245010"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.0742,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.73086934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"46","issue":"2","first_page":"263","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/il-1beta-signaling","display_name":"IL-1\u03b2 signaling","score":0.7710000276565552},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8730000257492065},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.734000027179718},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.7960000038146973},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.9869999885559082},{"id":"https://openalex.org/keywords/corneal-injury","display_name":"corneal injury","score":0.9649999737739563},{"id":"https://openalex.org/keywords/fulminant-hepatitis","display_name":"fulminant hepatitis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/infection-risk","display_name":"infection risk","score":0.6119999885559082},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7915711402893066},{"id":"https://openalex.org/C149892131","wikidata":"https://www.wikidata.org/wiki/Q14914156","display_name":"Interleukin 1 receptor antagonist","level":5,"score":0.572780191898346},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4909715950489044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48346051573753357},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4571499824523926},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.42389628291130066},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.3938741981983185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2530662715435028},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.248782217502594},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24243080615997314},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16898185014724731},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.15324676036834717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1126546859741211}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/biof.1587","doi":"https://doi.org/10.1002/biof.1587","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biof.1587","pdf_url":null,"source":{"id":"https://openalex.org/S75531928","display_name":"BioFactors","issn_l":"0951-6433","issn":["0951-6433","1872-8081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors","raw_type":"journal-article"},{"id":"pmid:31755595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31755595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:doi:10.7892/boris.149210","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/45204","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:149210","doi":null,"is_oa":false,"landing_page_url":"https://boris.unibe.ch/149210/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401747","display_name":"BORIS (University Library Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210103840","host_organization_name":"Nakuru County Council","host_organization_lineage":["https://openalex.org/I4210103840"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Harrell, Carl Randall; Markovic, Bojana Simovic; Fellabaum, Crissy; Arsenijevic, Nebojsa; Djonov, Valentin; Volarevic, Vladislav (2020). The role of Interleukin 1 receptor antagonist in mesenchymal stem cell-based tissue repair and regeneration. BioFactors, 46(2), pp. 263-275. Wiley 10.1002/biof.1587 &lt;http://dx.doi.org/10.1002/biof.1587&gt;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W315593768","https://openalex.org/W1537718629","https://openalex.org/W1586272693","https://openalex.org/W1798012002","https://openalex.org/W1965676394","https://openalex.org/W1975503903","https://openalex.org/W1978462186","https://openalex.org/W1980926727","https://openalex.org/W1984002529","https://openalex.org/W1984705347","https://openalex.org/W1986312649","https://openalex.org/W1986843662","https://openalex.org/W1987352783","https://openalex.org/W1999644843","https://openalex.org/W2004803235","https://openalex.org/W2017348165","https://openalex.org/W2019317799","https://openalex.org/W2022855248","https://openalex.org/W2023771664","https://openalex.org/W2036932644","https://openalex.org/W2060542991","https://openalex.org/W2082097191","https://openalex.org/W2087769239","https://openalex.org/W2087835557","https://openalex.org/W2091076719","https://openalex.org/W2094250218","https://openalex.org/W2101467349","https://openalex.org/W2115754452","https://openalex.org/W2124807755","https://openalex.org/W2127014397","https://openalex.org/W2128418292","https://openalex.org/W2133375451","https://openalex.org/W2134429782","https://openalex.org/W2144675149","https://openalex.org/W2148913003","https://openalex.org/W2150266966","https://openalex.org/W2154547515","https://openalex.org/W2158738222","https://openalex.org/W2161601812","https://openalex.org/W2170126288","https://openalex.org/W2209427166","https://openalex.org/W2279938184","https://openalex.org/W2317488575","https://openalex.org/W2461747480","https://openalex.org/W2473212441","https://openalex.org/W2516386455","https://openalex.org/W2546226096","https://openalex.org/W2560577160","https://openalex.org/W2597472435","https://openalex.org/W2612651702","https://openalex.org/W2620482670","https://openalex.org/W2730829347","https://openalex.org/W2737929320","https://openalex.org/W2748188097","https://openalex.org/W2754267893","https://openalex.org/W2770118279","https://openalex.org/W2774136216","https://openalex.org/W2778610355","https://openalex.org/W2789558225","https://openalex.org/W2790037113","https://openalex.org/W2790965559","https://openalex.org/W2792580051","https://openalex.org/W2793138562","https://openalex.org/W2796457881","https://openalex.org/W2800341151","https://openalex.org/W2801129414","https://openalex.org/W2804996343","https://openalex.org/W2892642834","https://openalex.org/W2900226360","https://openalex.org/W2903246763","https://openalex.org/W2906440626","https://openalex.org/W2921566503","https://openalex.org/W2943233832","https://openalex.org/W2944999663","https://openalex.org/W2945162057","https://openalex.org/W2948352832","https://openalex.org/W2949060698","https://openalex.org/W2949267588","https://openalex.org/W2952643930","https://openalex.org/W2952988705","https://openalex.org/W2953076136","https://openalex.org/W2954447202","https://openalex.org/W3020992950","https://openalex.org/W6677308222","https://openalex.org/W6683349621","https://openalex.org/W6764405705"],"related_works":["https://openalex.org/W2277734620","https://openalex.org/W2793138562","https://openalex.org/W2133375451","https://openalex.org/W58266109","https://openalex.org/W2116961229","https://openalex.org/W2379066033","https://openalex.org/W2319610976","https://openalex.org/W7170041867","https://openalex.org/W4380840960","https://openalex.org/W3028740533"],"abstract_inverted_index":{"Interleukin":[0],"(IL)-1":[1],"receptor":[2],"antagonist":[3,8],"(IL-1Ra),":[4],"a":[5,210],"naturally":[6],"occurring":[7],"of":[9,20,31,46,53,66,72,77,87,92,105,110,120,130,146,163,176,182,187,200,218],"IL-1\u03b1/IL-1\u03b2":[10],"signaling":[11],"pathways,":[12],"has":[13],"been":[14],"attributed":[15],"to":[16,112],"the":[17,59,67,103,113,216],"immunosuppressive":[18,54],"effects":[19,86,199],"mesenchymal":[21],"stem":[22],"cells":[23,48,57,125],"(MSCs).":[24],"MSCs,":[25,136],"in":[26,33,39,58,63,79,90,128,137,150,167],"IL-1Ra-dependent":[27,138,180],"manner,":[28,139],"suppressed":[29,75],"production":[30,76,104,145],"IL-1\u03b2":[32,78],"dermal":[34],"macrophages,":[35],"induced":[36],"their":[37],"polarization":[38],"anti-inflammatory":[40],"M2":[41],"phenotype,":[42],"attenuated":[43,118],"antigen-presenting":[44],"properties":[45],"dendritic":[47],"(DCs),":[49],"and":[50,74,99,117,123,133,165,173,192,220],"promoted":[51],"expansion":[52],"T":[55],"regulatory":[56],"skin,":[60],"which":[61],"resulted":[62,127],"enhanced":[64,161],"repair":[65],"nonhealing":[68],"wounds.":[69],"Reduced":[70],"activation":[71],"inflammasome":[73],"macrophages":[80],"were":[81],"mainly":[82],"responsible":[83,159],"for":[84,160,215],"beneficial":[85,178],"MSC-derived":[88,201],"IL-1Ra":[89,154,202],"alleviation":[91,129],"acute":[93,219],"lung":[94],"injury,":[95],"dry":[96],"eye":[97],"syndrome,":[98],"corneal":[100],"injury.":[101],"Through":[102],"IL-1Ra,":[106],"MSCs":[107,205],"reduced":[108,140],"migration":[109],"DCs":[111],"draining":[114],"lymph":[115],"nodes":[116],"generation":[119],"inflammatory":[121,222],"Th1":[122],"Th17":[124],"that":[126],"fulminant":[131],"hepatitis":[132],"rheumatoid":[134],"arthritis.":[135],"liver":[141],"fibrosis":[142],"by":[143],"suppressing":[144],"Type":[147],"I":[148],"collagen":[149],"hepatic":[151],"stellate":[152],"cells.":[153],"was,":[155],"at":[156],"least":[157],"partially,":[158],"proliferation":[162],"hepatocytes":[164],"chondrocytes":[166],"MSC-treated":[168],"animals":[169],"with":[170],"partial":[171],"hepatectomy":[172],"osteoarthritis.":[174],"Despite":[175],"these":[177],"effects,":[179],"inhibition":[181],"IL-1\u03b1/IL-1\u03b2-signaling":[183],"significantly":[184],"increased":[185],"risk":[186],"infections.":[188],"Therefore,":[189],"future":[190],"experimental":[191],"clinical":[193],"studies":[194],"should":[195],"delineate":[196],"potential":[197],"side":[198],"before":[203],"IL-1Ra-overexpressing":[204],"could":[206],"be":[207],"used":[208],"as":[209],"potentially":[211],"new":[212],"therapeutic":[213],"agent":[214],"treatment":[217],"chronic":[221],"diseases.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-05T00:00:00"}
