{"id":"https://openalex.org/W2990523447","doi":null,"title":"What are the risks associated with the use of NSAIDs as an adjunct to SSRIs for treatment of depression? An evaluation of current evidence.","display_name":"What are the risks associated with the use of NSAIDs as an adjunct to SSRIs for treatment of depression? An evaluation of current evidence.","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W2990523447","mag":"2990523447","pmid":"https://pubmed.ncbi.nlm.nih.gov/28953795"},"language":"en","primary_location":{"id":"pmid:28953795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28953795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria Danubina","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043989071","display_name":"Amie Varney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amie Varney","raw_affiliation_strings":["Lucy Cavendish College, University of Cambridge, Lady Margaret Road, University of Cambridge, Cambridge, CB3 0BU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lucy Cavendish College, University of Cambridge, Lady Margaret Road, University of Cambridge, Cambridge, CB3 0BU, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079544734","display_name":"Kate Womersley","orcid":"https://orcid.org/0000-0002-2272-9842","observed_orcids":["https://orcid.org/0000-0002-2272-9842"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kate Womersley","raw_affiliation_strings":["Lucy Cavendish College, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lucy Cavendish College, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101428835","display_name":"Mark A Agius","orcid":"https://orcid.org/0000-0002-5929-8580","observed_orcids":["https://orcid.org/0000-0002-5929-8580"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Agius","raw_affiliation_strings":["Clare College University of Cambridge Cambridge UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clare College University of Cambridge Cambridge UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":0.1761,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48101266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"29","issue":"Suppl 3","first_page":"375","last_page":"382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8199999928474426},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9110000133514404},{"id":"https://openalex.org/keywords/adjunctive-antidepressant-therapy","display_name":"adjunctive antidepressant therapy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.8230000138282776},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.6439999938011169},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.8130000233650208},{"id":"https://openalex.org/keywords/co-prescription","display_name":"co-prescription","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.7848837375640869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7781031131744385},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6338229179382324},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6214318871498108},{"id":"https://openalex.org/C2777056012","wikidata":"https://www.wikidata.org/wiki/Q1975444","display_name":"Adjunct","level":2,"score":0.6208696961402893},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.475736141204834},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4593413770198822},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.4553471505641937},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4276294410228729},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33739325404167175},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.11943468451499939},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:28953795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28953795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria Danubina","raw_type":"Journal Article"},{"id":"mag:2990523447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28953795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W10976030","https://openalex.org/W1557314957","https://openalex.org/W1966523374","https://openalex.org/W1971273396","https://openalex.org/W1976582031","https://openalex.org/W1976594978","https://openalex.org/W1981348240","https://openalex.org/W1985438873","https://openalex.org/W2000349797","https://openalex.org/W2010899039","https://openalex.org/W2012762343","https://openalex.org/W2029123366","https://openalex.org/W2033053214","https://openalex.org/W2039009675","https://openalex.org/W2043177024","https://openalex.org/W2045599452","https://openalex.org/W2048876068","https://openalex.org/W2049808835","https://openalex.org/W2053818485","https://openalex.org/W2054139588","https://openalex.org/W2062903848","https://openalex.org/W2069643552","https://openalex.org/W2069758270","https://openalex.org/W2075103004","https://openalex.org/W2088277656","https://openalex.org/W2092902579","https://openalex.org/W2097740790","https://openalex.org/W2102204071","https://openalex.org/W2108569388","https://openalex.org/W2109668208","https://openalex.org/W2114058973","https://openalex.org/W2134144722","https://openalex.org/W2156150528","https://openalex.org/W2194924010","https://openalex.org/W2214895385","https://openalex.org/W2412677285","https://openalex.org/W4327671605"],"related_works":["https://openalex.org/W4412786007","https://openalex.org/W1486348189","https://openalex.org/W4294189454","https://openalex.org/W2487645772","https://openalex.org/W2887318475","https://openalex.org/W2908723162","https://openalex.org/W206464396","https://openalex.org/W4311692285","https://openalex.org/W3005877643","https://openalex.org/W2255329104"],"abstract_inverted_index":{"BACKGROUND:":[0],"Over":[1],"the":[2,10,17,27,43,65,84,98,101,116,134,150,164,170,188,197],"past":[3],"twenty":[4],"years,":[5],"psychiatric":[6],"researchers":[7],"have":[8],"recognised":[9],"important":[11],"role":[12],"played":[13],"by":[14],"inflammation":[15],"in":[16,26,59],"pathogenesis":[18],"of":[19,29,45,67,91,103,137,152,163,190,194,201],"depression.":[20],"There":[21],"has":[22],"been":[23],"increasing":[24],"interest":[25],"use":[28,102],"anti-inflammatory":[30,35,135],"drugs,":[31],"such":[32,119],"as":[33,38,105,142,144],"non-steroidal":[34],"drugs":[36,58,111],"(NSAIDs),":[37],"a":[39,75,120,160],"way":[40],"to":[41,96,108,131,182],"enhance":[42],"efficacy":[44],"antidepressant":[46,110],"treatments.":[47],"It":[48],"is":[49,74,129,168,172,180],"essential":[50],"that":[51,127,147],"psychiatrists":[52],"and":[53,83,87,112,166,192],"GPs":[54],"who":[55],"prescribe":[56],"these":[57],"conjunction,":[60],"understand":[61],"possible":[62],"interactions,":[63],"particularly":[64],"risk":[66,151,198],"bleeding.":[68],"SUBJECTS":[69],"AND":[70],"METHODS:":[71],"This":[72],"paper":[73],"literature":[76],"review":[77,94,171],"regarding":[78],"NSAID":[79,191],"co-prescription":[80],"with":[81,156],"SSRIs":[82],"potential":[85],"risks":[86,165],"benefits.":[88],"The":[89],"objectives":[90],"this":[92,114],"systematic":[93],"are":[95],"assess":[97],"evidence":[99,117,130,145],"for":[100,139,176],"NSAIDs":[104,138,148],"an":[106],"adjunct":[107],"standard":[109],"evaluate":[113],"against":[115],"contraindicating":[118],"treatment":[121,195],"combination.":[122],"RESULTS:":[123],"Our":[124],"research":[125,179],"suggests":[126],"there":[128],"support":[132],"both":[133],"benefits":[136,167],"treating":[140],"depression,":[141],"well":[143],"suggesting":[146],"increases":[149],"bleeding":[153],"when":[154],"co-prescribed":[155],"SSRIs.":[157],"CONCLUSIONS:":[158],"When":[159],"broad":[161],"consideration":[162],"done,":[169],"inconclusive":[173],"about":[174,186],"guidelines":[175],"co-prescription.":[177,202],"More":[178],"required":[181],"make":[183],"strong":[184],"claims":[185],"whether":[187],"type":[189],"duration":[193],"influences":[196],"(or":[199],"benefit)":[200]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}