{"id":"https://openalex.org/W2990501161","doi":"https://doi.org/10.1183/13993003.congress-2019.pa550","title":"The Pleural and blood gene expression level of GBP5 and STAT1 were associated with pleural tuberculosis: TB pleura diagnostic biomarkers","display_name":"The Pleural and blood gene expression level of GBP5 and STAT1 were associated with pleural tuberculosis: TB pleura diagnostic biomarkers","publication_year":2019,"publication_date":"2019-09-28","ids":{"openalex":"https://openalex.org/W2990501161","doi":"https://doi.org/10.1183/13993003.congress-2019.pa550","mag":"2990501161"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2019.pa550","doi":"https://doi.org/10.1183/13993003.congress-2019.pa550","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2019.pa550","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016007309","display_name":"Narumol Luekitinun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Narumol Luekitinun","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine and Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine and Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087585014","display_name":"Surakameth Mahasirimongkol","orcid":"https://orcid.org/0000-0002-7555-1056","observed_orcids":["https://orcid.org/0000-0002-7555-1056"]},"institutions":[{"id":"https://openalex.org/I1315836254","display_name":"Ministry of Public Health","ror":"https://ror.org/03rn0z073","country_code":"TH","type":"government","lineage":["https://openalex.org/I1315836254"]},{"id":"https://openalex.org/I4210126681","display_name":"Department of Medical Sciences","ror":"https://ror.org/03d5a9t15","country_code":"TH","type":"government","lineage":["https://openalex.org/I1315836254","https://openalex.org/I4210126681"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Surakameth Mahasirimongkol","raw_affiliation_strings":["Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand","institution_ids":["https://openalex.org/I1315836254","https://openalex.org/I4210126681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038520454","display_name":"Nusara Satproedprai","orcid":"https://orcid.org/0000-0001-8754-231X","observed_orcids":["https://orcid.org/0000-0001-8754-231X"]},"institutions":[{"id":"https://openalex.org/I1315836254","display_name":"Ministry of Public Health","ror":"https://ror.org/03rn0z073","country_code":"TH","type":"government","lineage":["https://openalex.org/I1315836254"]},{"id":"https://openalex.org/I4210126681","display_name":"Department of Medical Sciences","ror":"https://ror.org/03d5a9t15","country_code":"TH","type":"government","lineage":["https://openalex.org/I1315836254","https://openalex.org/I4210126681"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Nusara Satproedprai","raw_affiliation_strings":["Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand","institution_ids":["https://openalex.org/I1315836254","https://openalex.org/I4210126681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077443616","display_name":"Reiko Miyahara","orcid":"https://orcid.org/0000-0003-1998-505X","observed_orcids":["https://orcid.org/0000-0003-1998-505X"]},"institutions":[{"id":"https://openalex.org/I1315836254","display_name":"Ministry of Public Health","ror":"https://ror.org/03rn0z073","country_code":"TH","type":"government","lineage":["https://openalex.org/I1315836254"]},{"id":"https://openalex.org/I4210126681","display_name":"Department of Medical Sciences","ror":"https://ror.org/03d5a9t15","country_code":"TH","type":"government","lineage":["https://openalex.org/I1315836254","https://openalex.org/I4210126681"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Reiko Miyahara","raw_affiliation_strings":["Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand","institution_ids":["https://openalex.org/I1315836254","https://openalex.org/I4210126681"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036132368","display_name":"Kamon Kawkitinarong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kamon Kawkitinarong","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine and Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine and Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA550","last_page":"PA550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculous-pleurisy","display_name":"pleural tuberculosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gbp5","display_name":"GBP5","score":0.703000009059906},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":1.0},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7229999899864197},{"id":"https://openalex.org/keywords/malignant-pleural-effusion","display_name":"malignant pleural effusion","score":0.8510000109672546},{"id":"https://openalex.org/keywords/blood-gene-expression","display_name":"blood gene expression","score":0.9660000205039978},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9586405158042908},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.7314223051071167},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6047644019126892},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4496786594390869},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42321449518203735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41680893301963806},{"id":"https://openalex.org/C163430725","wikidata":"https://www.wikidata.org/wiki/Q424532","display_name":"Effusion","level":2,"score":0.41350606083869934},{"id":"https://openalex.org/C2776517811","wikidata":"https://www.wikidata.org/wiki/Q7204732","display_name":"Pleural disease","level":4,"score":0.4118940234184265},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4117053151130676},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.28861725330352783},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19142553210258484}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2019.pa550","doi":"https://doi.org/10.1183/13993003.congress-2019.pa550","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2019.pa550","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390884153","https://openalex.org/W2012431091","https://openalex.org/W2947069177","https://openalex.org/W2177589786","https://openalex.org/W4390753123","https://openalex.org/W7129614436","https://openalex.org/W2897985470","https://openalex.org/W7119409570","https://openalex.org/W3162807581","https://openalex.org/W7134139127"],"abstract_inverted_index":{"Background:":[0],"Pleural":[1,245],"tuberculosis":[2,43],"(TB":[3],"pleura)":[4],"is":[5,25,52],"the":[6,61,104,110,116,122,142,196],"most":[7],"common":[8],"treatable":[9],"cause":[10],"of":[11,17,73,92,98,125,144],"lymphocytic":[12,74,82],"exudative":[13,75,83],"pleural":[14,22,66,76,84,93,168,175,207,235],"effusion.":[15,77],"Differentiation":[16],"TB":[18,50,148,156,186,243,254],"pleura":[19,51,149,157,187,255],"from":[20],"malignant":[21],"effusion":[23,85],"(MPE)":[24],"often":[26],"problematic":[27],"in":[28,40,49,65,71,115,185,233,253],"clinical":[29],"practice.":[30],"The":[31,167,206],"blood":[32,69,99,197,202,238,248],"TB-specific":[33,62,127],"genes":[34,63,128],"expression":[35,64,123],"and":[36,68,95,138,140,150,158,174,192,201,214,227,231,237,247],"its":[37,215],"diagnostic":[38],"implication":[39],"active":[41],"pulmonary":[42],"has":[44],"been":[45],"observed,":[46],"but":[47],"data":[48],"lacking.":[53],"Objective:":[54],"This":[55],"study":[56],"was":[57,86],"aimed":[58],"to":[59,88,120,189],"investigate":[60],"fluid":[67,94,236,246],"samples":[70,239],"settings":[72],"Methods:":[78],"Each":[79],"patient":[80],"with":[81,195,242],"asked":[87],"provide":[89],"3":[90,96],"ml":[91,97],"samples,":[100],"separately":[101],"collected":[102],"into":[103],"RNA":[105,111],"collection":[106],"tube,":[107],"processed":[108],"through":[109],"isolation":[112],"kit,":[113],"used":[114,252],"quantitative":[117],"real-time":[118],"PCR":[119],"measure":[121],"levels":[124],"10":[126],"(FCGR1B1,":[129],"FCGR1B2,":[130],"FCGR1A,":[131],"MAFB,":[132],"GBP5,":[133],"APOL1,":[134],"KCNJ15,":[135],"STAT1,":[136],"KAZN":[137],"CD53)":[139],"compared":[141],"level":[143],"each":[145],"gene":[146],"between":[147],"MPE":[151,160,190],"groups.":[152],"Results:":[153],"Total":[154],"16":[155],"18":[159],"patients":[161],"were":[162,181,240],"prospective":[163],"enrolled":[164],"during":[165],"2018-2019.":[166],"GBP5":[169,198,208,249],"(8.0":[170],"vs.":[171,178],"0.8,":[172],"p<0.001)":[173,180],"STAT1":[176,203,232],"(11.1":[177],"3.1,":[179],"significantly":[182],"higher":[183],"expressed":[184],"comparing":[188],"group":[191],"also":[193],"correlated":[194],"(r=0.384,":[199],"p=0.025)":[200],"(r=0.436,":[204],"p=0.010).":[205],"had":[209,220],"highest":[210],"AUROC":[211],"97.9%":[212],"(93.5-100%)":[213],"cut":[216],"point":[217],"at":[218],"3.0":[219],"sensitivity":[221],"93.8%,":[222],"specificity":[223],"100%,":[224],"PPV":[225],"100%":[226],"NPV":[228],"94.7%.":[229],"Conclusion:GBP5":[230],"both":[234],"associated":[241],"pleura.":[244],"can":[250],"be":[251],"diagnosis.":[256]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}
