{"id":"https://openalex.org/W2990497052","doi":"https://doi.org/10.1183/13993003.congress-2019.pa1283","title":"Growth hormone releasing hormone receptor (GHRH-R) antagonist MIA-602 modulates fibrosis and gene expression in lungs of bleomycin-treated mice","display_name":"Growth hormone releasing hormone receptor (GHRH-R) antagonist MIA-602 modulates fibrosis and gene expression in lungs of bleomycin-treated mice","publication_year":2019,"publication_date":"2019-09-28","ids":{"openalex":"https://openalex.org/W2990497052","doi":"https://doi.org/10.1183/13993003.congress-2019.pa1283","mag":"2990497052"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2019.pa1283","doi":"https://doi.org/10.1183/13993003.congress-2019.pa1283","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2019.pa1283","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Idiopathic interstitial pneumonias","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023938993","display_name":"Robert M. Jackson","orcid":"https://orcid.org/0000-0001-5892-1193","observed_orcids":["https://orcid.org/0000-0001-5892-1193"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Jackson","raw_affiliation_strings":["Miami VAHS and U Miami, Miami, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami VAHS and U Miami, Miami, United States of America","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067447048","display_name":"Chongxu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164554","display_name":"Miami VA Healthcare System","ror":"https://ror.org/05myvb614","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119004","https://openalex.org/I4210164554"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chongxu Zhang","raw_affiliation_strings":["Miami VAHS, Miami, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami VAHS, Miami, United States of America","institution_ids":["https://openalex.org/I4210164554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058216583","display_name":"Ga\u00ebtan J.-R. Delcroix","orcid":"https://orcid.org/0000-0002-1768-4969","observed_orcids":["https://orcid.org/0000-0002-1768-4969"]},"institutions":[{"id":"https://openalex.org/I4210164554","display_name":"Miami VA Healthcare System","ror":"https://ror.org/05myvb614","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119004","https://openalex.org/I4210164554"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaetan Delcroix","raw_affiliation_strings":["Miami VAHS, Miami, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami VAHS, Miami, United States of America","institution_ids":["https://openalex.org/I4210164554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109179069","display_name":"Tengjiao Cui","orcid":"https://orcid.org/0000-0003-1108-1785","observed_orcids":["https://orcid.org/0000-0003-1108-1785"]},"institutions":[{"id":"https://openalex.org/I4210164554","display_name":"Miami VA Healthcare System","ror":"https://ror.org/05myvb614","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119004","https://openalex.org/I4210164554"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tengjiao Cui","raw_affiliation_strings":["Miami VAHS, Miami, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami VAHS, Miami, United States of America","institution_ids":["https://openalex.org/I4210164554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102873564","display_name":"Xianyang Zhang","orcid":"https://orcid.org/0000-0002-2512-1816","observed_orcids":["https://orcid.org/0000-0002-2512-1816"]},"institutions":[{"id":"https://openalex.org/I4210164554","display_name":"Miami VA Healthcare System","ror":"https://ror.org/05myvb614","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119004","https://openalex.org/I4210164554"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianyang Zhang","raw_affiliation_strings":["Miami VAHS, Miami, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami VAHS, Miami, United States of America","institution_ids":["https://openalex.org/I4210164554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089535546","display_name":"Mehdi Seyed Mirsaeidi","orcid":"https://orcid.org/0000-0001-5298-8442","observed_orcids":["https://orcid.org/0000-0001-5298-8442"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehdi Mirsaeidi","raw_affiliation_strings":["Miami VAHS and U Miami, Miami, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami VAHS and U Miami, Miami, United States of America","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027132967","display_name":"Aaron Lazerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Lazerson","raw_affiliation_strings":["University of Miami, Miami, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami, Miami, United States of America","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068739269","display_name":"Andrew Victor Schally","orcid":"https://orcid.org/0000-0003-1273-6747","observed_orcids":["https://orcid.org/0000-0003-1273-6747"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Schally","raw_affiliation_strings":["Miami VAHS and U Miami, Miami, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami VAHS and U Miami, Miami, United States of America","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1283","last_page":"PA1283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bleomycin-induced-pulmonary-fibrosis","display_name":"bleomycin-induced lung fibrosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.871999979019165},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6940000057220459},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.800000011920929},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.656000018119812},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8050000071525574},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.6579999923706055},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.7179999947547913},{"id":"https://openalex.org/keywords/hydroxyproline","display_name":"hydroxyproline","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.5},{"id":"https://openalex.org/keywords/histones","display_name":"histones","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.9168278574943542},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6254454851150513},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.605375349521637},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5678727030754089},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5388581156730652},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.5212555527687073},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.463024765253067},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.45259666442871094},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35248297452926636},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34533053636550903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31913506984710693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3168126940727234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2709234654903412},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2019.pa1283","doi":"https://doi.org/10.1183/13993003.congress-2019.pa1283","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2019.pa1283","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Idiopathic interstitial pneumonias","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2906252060","https://openalex.org/W2964807003","https://openalex.org/W3096414590","https://openalex.org/W3094027664","https://openalex.org/W3041770785","https://openalex.org/W4410270891","https://openalex.org/W2780902845","https://openalex.org/W2491026387","https://openalex.org/W2082599327","https://openalex.org/W4385851296"],"abstract_inverted_index":{"GHRH-R":[0,43,47],"antagonist":[1],"MIA-602":[2,68,84,95,202],"partially":[3],"blocks":[4],"inflammation":[5,145],"and":[6,30,42,53,55,83,87,103,134,142,146,158,181],"fibrosis":[7,54,71,221],"in":[8,25,37,58,178,218,222],"a":[9],"mouse":[10,78,90,167],"model":[11],"of":[12,46,110,125,144,201,220],"intraperitoneal":[13],"bleomycin-induced":[14,211],"lung":[15,20,60,91,168,212],"fibrosis.":[16,227],"After":[17],"28":[18],"days,":[19],"hydroxyproline":[21],"content":[22],"nearly":[23],"doubled":[24],"mice":[26,38,130],"treated":[27,39,80,93,131,170],"with":[28,40,81,94,122,132,171],"bleomycin":[29,41,82,133],"vehicle,":[31],"but":[32],"it":[33],"did":[34],"not":[35],"increase":[36],"antagonist.":[44],"Inhibition":[45],"thus":[48],"might":[49],"limit":[50],"cellular":[51,207],"proliferation":[52],"be":[56],"therapeutic":[57],"fibrosing":[59],"diseases.":[61],"We":[62,98],"assessed":[63],"possible":[64],"mechanisms":[65],"by":[66,72],"which":[67,214],"could":[69,215],"modulate":[70,205],"sequencing":[73],"RNA":[74],"libraries":[75],"(RNA-seq)":[76],"from":[77,88,129],"lungs":[79,128],"or":[85,96],"vehicle":[86],"normal":[89,166],"fibroblasts":[92,169],"vehicle.":[97],"completed":[99],"gene":[100],"set":[101],"enrichment":[102],"pathway":[104],"analyses":[105],"based":[106],"on":[107],"functional":[108],"annotation":[109],"differentially":[111,117],"expressed":[112,118],"genes":[113,119,136,152,174,189],"to":[114,138,154,204,210],"find":[115],"if":[116],"were":[120,149,162,175,190],"associated":[121],"observed":[123],"effects":[124],"MIA-602.":[126],"In":[127,165],"MIA-602,":[135,172],"related":[137,153],"chemotaxis,":[139],"IL-1,":[140],"chemokines":[141],"regulation":[143],"ERK":[147],"cascade":[148],"upregulated.":[150],"Multiple":[151],"the":[155,206],"immune":[156,208],"response":[157,209],"T":[159],"cell":[160,179],"functions":[161],"notably":[163],"downregulated.":[164],"upregulated":[173],"markedly":[176],"enriched":[177],"cycle":[180],"DNA":[182],"replication":[183],"genes,":[184],"primarily":[185],"histones.":[186],"Down":[187],"regulated":[188],"much":[191],"less":[192],"enriched.":[193],"These":[194],"data":[195],"imply":[196],"that":[197],"one":[198],"key":[199],"action":[200],"is":[203],"injury,":[213],"potentially":[216],"result":[217],"limitation":[219],"diseases":[223],"like":[224],"idiopathic":[225],"pulmonary":[226]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-12-05T00:00:00"}
