{"id":"https://openalex.org/W2990475748","doi":"https://doi.org/10.1021/acs.analchem.9b03689","title":"Enhanced Characterization of Membrane Protein Complexes by Ultraviolet Photodissociation Mass Spectrometry","display_name":"Enhanced Characterization of Membrane Protein Complexes by Ultraviolet Photodissociation Mass Spectrometry","publication_year":2019,"publication_date":"2019-11-25","ids":{"openalex":"https://openalex.org/W2990475748","doi":"https://doi.org/10.1021/acs.analchem.9b03689","mag":"2990475748","pmid":"https://pubmed.ncbi.nlm.nih.gov/31765130","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6949371"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.9b03689","doi":"https://doi.org/10.1021/acs.analchem.9b03689","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.9b03689","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6949371","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003628966","display_name":"Sarah N. Sipe","orcid":"https://orcid.org/0000-0003-4554-7571","observed_orcids":["https://orcid.org/0000-0003-4554-7571"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah N. Sipe","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031992891","display_name":"John W. Patrick","orcid":"https://orcid.org/0000-0003-0964-9327","observed_orcids":["https://orcid.org/0000-0003-0964-9327"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Patrick","raw_affiliation_strings":["Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040763385","display_name":"Arthur D. Laganowsky","orcid":"https://orcid.org/0000-0001-5012-5547","observed_orcids":["https://orcid.org/0000-0001-5012-5547"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Laganowsky","raw_affiliation_strings":["Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States"],"raw_orcid":"https://orcid.org/0000-0001-5012-5547","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052628663","display_name":"Jennifer S. Brodbelt","orcid":"https://orcid.org/0000-0003-3207-0217","observed_orcids":["https://orcid.org/0000-0003-3207-0217"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer S. Brodbelt","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States"],"raw_orcid":"https://orcid.org/0000-0003-3207-0217","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052628663"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.4431,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.78410781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"92","issue":"1","first_page":"899","last_page":"907"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-protein-complexes","display_name":"membrane protein complexes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chemical-chaperones","display_name":"chemical chaperones","score":0.9150000214576721},{"id":"https://openalex.org/keywords/amtb","display_name":"AmtB","score":0.6990000009536743},{"id":"https://openalex.org/keywords/aquaporin-z","display_name":"aquaporin Z","score":0.8980000019073486},{"id":"https://openalex.org/keywords/protein-sequence-coverage","display_name":"protein sequence coverage","score":0.5049999952316284},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.953000009059906},{"id":"https://openalex.org/keywords/gas-phase-ion-fragmentation","display_name":"gas-phase ion fragmentation","score":0.5099999904632568},{"id":"https://openalex.org/keywords/phospholipid-binding","display_name":"phospholipid binding","score":0.7929999828338623},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9259638786315918},{"id":"https://openalex.org/C54582936","wikidata":"https://www.wikidata.org/wiki/Q16814","display_name":"Photodissociation","level":2,"score":0.8008073568344116},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5419148206710815},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5349892973899841},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4853159785270691},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.47431015968322754},{"id":"https://openalex.org/C121932024","wikidata":"https://www.wikidata.org/wiki/Q5159376","display_name":"Conductance","level":2,"score":0.45032986998558044},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.42562365531921387},{"id":"https://openalex.org/C2776798109","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet","level":2,"score":0.4155645966529846},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2288193702697754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21062707901000977},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.17771857976913452},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010782","descriptor_name":"Photolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020346","descriptor_name":"Aquaporins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.analchem.9b03689","doi":"https://doi.org/10.1021/acs.analchem.9b03689","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.9b03689","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:31765130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31765130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6694340","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6949371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6949371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6949371","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6694340","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6949371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1213385702","display_name":"Native ion mobility mass spectrometry studies of potassium inward rectifier channels: insight into gating and lipid binding","funder_award_id":"DP2GM123486","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4226750041","display_name":null,"funder_award_id":"F1155","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G5758036926","display_name":"UVPD Mass Spectrometry of Protein Complexes","funder_award_id":"R01GM121714","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1968682237","https://openalex.org/W1969050666","https://openalex.org/W1983285663","https://openalex.org/W1991555473","https://openalex.org/W2000798961","https://openalex.org/W2002508442","https://openalex.org/W2017690293","https://openalex.org/W2027492037","https://openalex.org/W2027572771","https://openalex.org/W2035503835","https://openalex.org/W2044008548","https://openalex.org/W2066759010","https://openalex.org/W2072470496","https://openalex.org/W2080765410","https://openalex.org/W2082259017","https://openalex.org/W2092597985","https://openalex.org/W2096892258","https://openalex.org/W2115690303","https://openalex.org/W2143904491","https://openalex.org/W2147869016","https://openalex.org/W2157085670","https://openalex.org/W2266319871","https://openalex.org/W2289676395","https://openalex.org/W2302819319","https://openalex.org/W2497675190","https://openalex.org/W2506227427","https://openalex.org/W2560633863","https://openalex.org/W2570411824","https://openalex.org/W2590291345","https://openalex.org/W2597717267","https://openalex.org/W2604632935","https://openalex.org/W2761470697","https://openalex.org/W2765884665","https://openalex.org/W2767084674","https://openalex.org/W2767144842","https://openalex.org/W2771709052","https://openalex.org/W2772157628","https://openalex.org/W2784544605","https://openalex.org/W2788851210","https://openalex.org/W2789582625","https://openalex.org/W2796300952","https://openalex.org/W2796336042","https://openalex.org/W2883882450","https://openalex.org/W2894708945","https://openalex.org/W2899777156","https://openalex.org/W2901913378","https://openalex.org/W2908584245","https://openalex.org/W2911977783","https://openalex.org/W2916290647","https://openalex.org/W2921184407","https://openalex.org/W2938148415"],"related_works":["https://openalex.org/W1991555473","https://openalex.org/W2935779552","https://openalex.org/W6908395268","https://openalex.org/W2406628871","https://openalex.org/W6964633734","https://openalex.org/W6958970625","https://openalex.org/W2032372830","https://openalex.org/W2497675190","https://openalex.org/W7169186255","https://openalex.org/W2938148415"],"abstract_inverted_index":{"Development":[0],"of":[1,17,24,30,46,59,64,72,78,111],"chemical":[2],"chaperones":[3],"to":[4,91,93,115],"solubilize":[5],"membrane":[6],"protein":[7,31],"complexes":[8],"in":[9,83],"aqueous":[10],"solutions":[11],"has":[12,35],"allowed":[13],"for":[14,49,75,105],"gas-phase":[15],"analysis":[16],"their":[18],"native-like":[19],"assemblies,":[20],"including":[21],"rapid":[22],"evaluation":[23],"stability":[25],"and":[26,68],"interacting":[27],"partners.":[28],"Characterization":[29],"primary":[32],"sequence,":[33],"however,":[34],"thus":[36],"far":[37],"been":[38,89],"limited.":[39],"Ultraviolet":[40],"photodissociation":[41],"(UVPD)":[42],"generates":[43],"a":[44,60],"multitude":[45],"sequence":[47,73,85],"ions":[48],"the":[50],"E.":[51],"coli":[52],"ammonia":[53],"channel":[54,77],"(AmtB),":[55],"provides":[56],"improved":[57],"localization":[58],"possible":[61],"post-translational":[62],"modification":[63],"aquaporin":[65],"Z":[66],"(AqpZ),":[67],"surpasses":[69],"previous":[70],"reports":[71],"coverage":[74],"mechanosensitive":[76],"large":[79],"conductance":[80],"(MscL).":[81],"Variations":[82],"UVPD":[84],"ion":[86],"abundance":[87],"have":[88],"shown":[90],"correspond":[92],"structural":[94],"changes":[95],"induced":[96],"upon":[97],"some":[98],"perturbation.":[99],"Preliminary":[100],"results":[101],"are":[102],"reported":[103],"here":[104],"elucidating":[106],"increased":[107],"rigidity":[108],"or":[109],"flexibility":[110],"MscL":[112],"when":[113],"bound":[114],"various":[116],"phospholipids.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-05T00:00:00"}