{"id":"https://openalex.org/W2990449309","doi":"https://doi.org/10.1289/isee.2011.01669","title":"A COMPREHENSIVE ANALYSIS OF DNA METHYLATION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA INDICATES DIFFERENCES BETWEEN VIRAL AND CHEMICAL INDUCED CARCINOGENESIS","display_name":"A COMPREHENSIVE ANALYSIS OF DNA METHYLATION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA INDICATES DIFFERENCES BETWEEN VIRAL AND CHEMICAL INDUCED CARCINOGENESIS","publication_year":2011,"publication_date":"2011-09-13","ids":{"openalex":"https://openalex.org/W2990449309","doi":"https://doi.org/10.1289/isee.2011.01669","mag":"2990449309"},"language":"en","primary_location":{"id":"doi:10.1289/isee.2011.01669","doi":"https://doi.org/10.1289/isee.2011.01669","is_oa":false,"landing_page_url":"https://doi.org/10.1289/isee.2011.01669","pdf_url":null,"source":{"id":"https://openalex.org/S4210195765","display_name":"ISEE Conference Abstracts","issn_l":"1078-0475","issn":["1078-0475","2169-2181"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISEE Conference Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017815080","display_name":"Justin A. Colacino","orcid":"https://orcid.org/0000-0002-5882-4569","observed_orcids":["https://orcid.org/0000-0002-5882-4569"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin A. Colacino","raw_affiliation_strings":["University of Michigan School of Public Health, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan School of Public Health, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039655682","display_name":"Emily Light","orcid":"https://orcid.org/0009-0002-0272-9535","observed_orcids":["https://orcid.org/0009-0002-0272-9535"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Light","raw_affiliation_strings":["University of Michigan Medical School, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073554595","display_name":"Dana C. Dolinoy","orcid":"https://orcid.org/0000-0002-3304-2456","observed_orcids":["https://orcid.org/0000-0002-3304-2456"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana C. Dolinoy","raw_affiliation_strings":["University of Michigan School of Public Health, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan School of Public Health, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103025966","display_name":"Sonia A. Duffy","orcid":"https://orcid.org/0000-0002-8123-2692","observed_orcids":["https://orcid.org/0000-0002-8123-2692"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia Duffy","raw_affiliation_strings":["University of Michigan School of Nursing, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan School of Nursing, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028712728","display_name":"Maureen A. Sartor","orcid":"https://orcid.org/0000-0001-6155-5702","observed_orcids":["https://orcid.org/0000-0001-6155-5702"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen Sartor","raw_affiliation_strings":["University of Michigan Center for Computational Biology and Bioinformatics, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Center for Computational Biology and Bioinformatics, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090412207","display_name":"Douglas Brian Chepeha","orcid":"https://orcid.org/0000-0001-9062-3719","observed_orcids":["https://orcid.org/0000-0001-9062-3719"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Chepeha","raw_affiliation_strings":["University of Michigan Medical School, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jon McHugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon McHugh","raw_affiliation_strings":["University of Michigan Medical School, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101623032","display_name":"Divya Patel","orcid":"https://orcid.org/0000-0003-2659-3695","observed_orcids":["https://orcid.org/0000-0003-2659-3695","https://orcid.org/0000-0001-9627-2745"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Patel","raw_affiliation_strings":["Yale University School of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103688436","display_name":"Jeremy M. E. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Taylor","raw_affiliation_strings":["University of Michigan School of Public Health, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan School of Public Health, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083855375","display_name":"Gregory T. Wolf","orcid":"https://orcid.org/0000-0002-3219-9515","observed_orcids":["https://orcid.org/0000-0002-3219-9515"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Wolf","raw_affiliation_strings":["University of Michigan Medical School, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076508788","display_name":"Thomas E. Carey","orcid":"https://orcid.org/0000-0002-5202-7518","observed_orcids":["https://orcid.org/0000-0002-5202-7518"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Carey","raw_affiliation_strings":["University of Michigan Medical School, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087457107","display_name":"Laura S. Rozek","orcid":"https://orcid.org/0000-0001-6731-7000","observed_orcids":["https://orcid.org/0000-0001-6731-7000","https://orcid.org/0009-0008-1136-8667"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura S. Rozek","raw_affiliation_strings":["University of Michigan School of Public Health, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan School of Public Health, United States","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2011","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/viral-carcinogenesis","display_name":"viral oncogenesis","score":0.7350000143051147},{"id":"https://openalex.org/keywords/chemical-carcinogenesis","display_name":"chemical carcinogenesis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7129999995231628},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8209999799728394},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9850000143051147},{"id":"https://openalex.org/keywords/differentially-methylated-genes","display_name":"differentially methylated genes","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7603071928024292},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.706538200378418},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.689011812210083},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6805933713912964},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6496461033821106},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.626880407333374},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5396125316619873},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5242205858230591},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5222100615501404},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4785528779029846},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.4583011269569397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4227459728717804},{"id":"https://openalex.org/C2778355491","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Tobacco smoke","level":2,"score":0.42041438817977905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.396016389131546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3515141010284424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22117027640342712},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2029963731765747},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11596599221229553},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1289/isee.2011.01669","doi":"https://doi.org/10.1289/isee.2011.01669","is_oa":false,"landing_page_url":"https://doi.org/10.1289/isee.2011.01669","pdf_url":null,"source":{"id":"https://openalex.org/S4210195765","display_name":"ISEE Conference Abstracts","issn_l":"1078-0475","issn":["1078-0475","2169-2181"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISEE Conference Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987747319","https://openalex.org/W7098330096","https://openalex.org/W852888104","https://openalex.org/W6908782466","https://openalex.org/W2115640312","https://openalex.org/W2168850910","https://openalex.org/W2160085967","https://openalex.org/W7095356138","https://openalex.org/W3152644843","https://openalex.org/W2605034121"],"abstract_inverted_index":{"Background:":[0],"Head":[1,109],"and":[2,31,59,78,81,110,134,158,176,229,252,270,292],"neck":[3,82],"squamous":[4],"cell":[5],"carcinomas":[6],"(HNSCC)":[7],"are":[8,64],"the":[9,16,105,116,206,262],"eighth":[10],"most":[11],"commonly":[12],"diagnosed":[13],"cancers":[14,39,54,83],"in":[15,68,98,196,205,216],"U.S":[17],"population.":[18],"The":[19],"risk":[20,43],"of":[21,107,203,265,277],"developing":[22],"HNSCC":[23,101],"is":[24],"increased":[25],"with":[26,33,56,194],"exposure":[27,58],"to":[28,51,153,184,212,236],"tobacco,":[29],"alcohol":[30,60,227],"infection":[32],"human":[34],"papilloma":[35],"virus":[36],"(HPV).":[37],"HPV-induced":[38,177],"have":[40],"a":[41,238],"distinct":[42,147],"profile":[44],"as":[45,47],"well":[46],"improved":[48],"prognosis":[49],"compared":[50],"chemically":[52],"induced":[53],"associated":[55],"tobacco":[57],"use.":[61],"Epigenetic":[62],"changes":[63,74],"an":[65,246],"important":[66],"mechanism":[67],"carcinogenic":[69],"progression,":[70],"but":[71],"how":[72],"these":[73],"differ":[75,155,165],"between":[76,166,174],"viral-":[77],"chemical-induced":[79],"head":[80],"remains":[84],"unknown.":[85],"Methods:":[86],"We":[87],"quantified":[88],"CpG":[89,93,122],"methylation":[90,123,143,202,244],"at":[91,125,245],"1505":[92],"sites":[94,204],"across":[95],"807":[96],"genes":[97,188],"70":[99],"well-annotated":[100],"tumor":[102,148],"samples":[103],"from":[104,256],"University":[106],"Michigan":[108],"Neck":[111],"SPORE":[112],"patient":[113],"population":[114],"using":[115],"Illumina":[117],"Goldengate":[118],"Methylation":[119],"Cancer":[120],"Panel.":[121],"levels":[124],"each":[126],"locus":[127],"were":[128,151],"normalized":[129],"based":[130,141,189,281],"on":[131,142,190,282],"probe":[132],"length":[133],"guanine-cytosine":[135],"content.":[136],"Results:":[137],"Unsupervised":[138],"hierarchical":[139],"clustering":[140],"values":[144],"identified":[145],"3":[146],"clusters,":[149,167],"which":[150],"found":[152,211,235],"significantly":[154,214],"by":[156,199,289],"age":[157],"smoking":[159,230],"status.":[160],"HPV":[161,232],"status":[162,233],"did":[163],"not":[164],"indicating":[168],"some":[169],"common":[170],"shared":[171],"epigenetically-regulated":[172],"pathways":[173],"chemically-":[175],"tumors.":[178,218],"Weighted":[179],"linear":[180],"modeling":[181],"was":[182,210,234,287],"used":[183],"identify":[185],"differentially":[186],"methylated":[187],"epidemiological":[191],"characteristics.":[192],"Consistent":[193],"previous":[195],"vitro":[197],"findings":[198],"our":[200],"group,":[201],"CCNA1":[207],"promoter":[208],"region":[209],"be":[213,237],"higher":[215],"HPV+":[217],"After":[219],"adjusting":[220],"for":[221,242,275],"cancer":[222],"site,":[223],"stage,":[224],"age,":[225],"gender,":[226],"consumption,":[228],"status,":[231],"statistically":[239],"significant":[240],"predictor":[241],"DNA":[243],"additional":[247],"11":[248],"genes,":[249],"including":[250],"CASP8":[251],"SYBL1.":[253],"Conclusions:":[254],"Findings":[255],"this":[257],"study":[258,286],"provide":[259,272],"insight":[260],"into":[261],"epigenetic":[263],"regulation":[264],"viral":[266],"vs.":[267],"chemical":[268],"carcinogenesis":[269],"could":[271],"novel":[273],"targets":[274],"development":[276],"individualized":[278],"therapeutic":[279],"regimens":[280],"environmental":[283],"exposures.":[284],"This":[285],"funded":[288],"NIH/NCI":[290],"CA097248":[291],"NIH/NIEHS":[293],"T32":[294],"ES07062.":[295]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-12-05T00:00:00"}
