{"id":"https://openalex.org/W2990440353","doi":"https://doi.org/10.3389/fphys.2019.01497","title":"In Pursuit of the Parietal Cell \u2013 An Evolution of Scientific Methodology and Techniques","display_name":"In Pursuit of the Parietal Cell \u2013 An Evolution of Scientific Methodology and Techniques","publication_year":2019,"publication_date":"2019-12-12","ids":{"openalex":"https://openalex.org/W2990440353","doi":"https://doi.org/10.3389/fphys.2019.01497","mag":"2990440353","pmid":"https://pubmed.ncbi.nlm.nih.gov/31920702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6920182"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2019.01497","doi":"https://doi.org/10.3389/fphys.2019.01497","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.01497","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.01497/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.01497/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014686052","display_name":"Vanessa M. Baratta","orcid":"https://orcid.org/0000-0001-7783-4749","observed_orcids":["https://orcid.org/0000-0001-7783-4749"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa Baratta","raw_affiliation_strings":["Department of Surgery, Yale University School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053768665","display_name":"Jason Own","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Own","raw_affiliation_strings":["Department of Surgery, Yale University School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108143113","display_name":"Chiara Di Renzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Di Renzo","raw_affiliation_strings":["Department of Surgery, Oncology and Gastroenterology, Hepatobiliary Surgery and Liver Transplantation, Padua University, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Oncology and Gastroenterology, Hepatobiliary Surgery and Liver Transplantation, Padua University, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021093293","display_name":"Jenna Ollodart","orcid":"https://orcid.org/0000-0003-4837-4194","observed_orcids":["https://orcid.org/0000-0003-4837-4194"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna Ollodart","raw_affiliation_strings":["Department of Surgery, Yale University School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065040724","display_name":"John Peter Geibel","orcid":"https://orcid.org/0000-0003-1147-7501","observed_orcids":["https://orcid.org/0000-0003-1147-7501"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John P. Geibel","raw_affiliation_strings":["Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, United States","Department of Surgery, Yale University School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Surgery, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":null,"display_name":"Maria Barahona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Barahona","raw_affiliation_strings":["Department of Surgery, Yale University School of Medicine, New Haven, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yale University School of Medicine, New Haven, CT, United States","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065040724"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.23661227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":null,"first_page":"1497","last_page":"1497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.23029999434947968,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parietal-cells","display_name":"parietal cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.7450000047683716},{"id":"https://openalex.org/keywords/confocal-microscopy","display_name":"confocal microscopy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gastric-organoids","display_name":"gastric organoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vacuolar-h-atpase","display_name":"vacuolar H+-ATPase","score":0.8460000157356262},{"id":"https://openalex.org/keywords/refractory-gastroesophageal-reflux-disease","display_name":"refractory gastroesophageal reflux disease","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gastric-epithelium","display_name":"gastric epithelium","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3917156457901001},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3645564317703247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31247448921203613}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphys.2019.01497","doi":"https://doi.org/10.3389/fphys.2019.01497","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.01497","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.01497/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6920182","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6920182","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:31920702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31920702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:21a4b2b65bc047bcbfd6f51d79a87b54","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/21a4b2b65bc047bcbfd6f51d79a87b54","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2019.01497","doi":"https://doi.org/10.3389/fphys.2019.01497","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.01497","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.01497/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000858260","display_name":"Training Program in Investigative Gastroenterology","funder_award_id":"T32DK007017","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990440353.pdf","grobid_xml":"https://content.openalex.org/works/W2990440353.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1481600286","https://openalex.org/W1566584097","https://openalex.org/W1642286861","https://openalex.org/W1953113928","https://openalex.org/W1965157206","https://openalex.org/W1980017016","https://openalex.org/W1984853224","https://openalex.org/W1986472994","https://openalex.org/W2002042370","https://openalex.org/W2009021235","https://openalex.org/W2025063983","https://openalex.org/W2027686026","https://openalex.org/W2038462194","https://openalex.org/W2073924320","https://openalex.org/W2075158205","https://openalex.org/W2078795516","https://openalex.org/W2079840956","https://openalex.org/W2097387056","https://openalex.org/W2101496994","https://openalex.org/W2109191216","https://openalex.org/W2111696994","https://openalex.org/W2118169841","https://openalex.org/W2128487427","https://openalex.org/W2134381179","https://openalex.org/W2136759184","https://openalex.org/W2137696524","https://openalex.org/W2140133845","https://openalex.org/W2150354198","https://openalex.org/W2151775975","https://openalex.org/W2161480905","https://openalex.org/W2164890520","https://openalex.org/W2170575319","https://openalex.org/W2180149478","https://openalex.org/W2269928261","https://openalex.org/W2283066808","https://openalex.org/W2316990118","https://openalex.org/W2323796174","https://openalex.org/W2403946317","https://openalex.org/W2410034427","https://openalex.org/W2419833996","https://openalex.org/W2472685179","https://openalex.org/W2493796218","https://openalex.org/W2550831966","https://openalex.org/W2568959080","https://openalex.org/W2588772815","https://openalex.org/W2780586384","https://openalex.org/W2793163198","https://openalex.org/W2988428922","https://openalex.org/W3210836693","https://openalex.org/W4290174416"],"related_works":["https://openalex.org/W52455531","https://openalex.org/W2140133845","https://openalex.org/W1987180462","https://openalex.org/W1992503584","https://openalex.org/W87961311","https://openalex.org/W2139935548","https://openalex.org/W2375962773","https://openalex.org/W40838712","https://openalex.org/W939313849","https://openalex.org/W2112621974"],"abstract_inverted_index":{"The":[0],"stomach":[1],"has":[2],"unique":[3,160],"embryologic":[4],"and":[5,42,73,86],"anatomic":[6],"properties,":[7],"making":[8],"the":[9,12,26,47,98,102,133,156,164],"study":[10,157],"of":[11,22,29,39,56,101,158],"parietal":[13,48,57,70,74],"cell":[14,31,58,71,75,161],"technically":[15],"challenging.":[16],"Numerous":[17],"individuals":[18],"have":[19],"devoted":[20],"decades":[21],"research":[23],"to":[24,46,131,150,155],"unraveling":[25],"pathophysiological":[27],"basis":[28],"this":[30,128,159],"type.":[32],"Here,":[33],"we":[34,51,78,105,113,148],"perform":[35],"a":[36,89,121,152],"scoping":[37],"review":[38,129],"novel":[40],"in-vitro":[41,54],"in-vivo":[43],"methodology":[44],"pertaining":[45],"cell.":[49,103,142],"First,":[50],"evaluate":[52],"early":[53],"methods":[55],"analysis.":[59],"This":[60],"section":[61],"focuses":[62],"on":[63],"three":[64],"major":[65,134],"techniques:":[66],"gastric":[67,87,117],"gland":[68],"isolation,":[69,72],"culture.":[76],"Second,":[77],"discuss":[79,107],"more":[80],"contemporary":[81],"efforts":[82],"involving":[83],"confocal":[84],"microscopy":[85],"organoids,":[88],"new":[90],"technique":[91],"that":[92],"holds":[93],"much":[94],"promise":[95],"in":[96,136,144,163],"unveiling":[97],"temporal-spatial":[99],"dynamics":[100],"Finally,":[104],"will":[106],"findings":[108],"from":[109],"our":[110],"laboratory":[111],"where":[112],"identified":[114],"an":[115,138],"active":[116],"vacuolar":[118],"H-ATPase":[119],"as":[120],"putative":[122],"mechanism":[123],"for":[124],"refractory":[125],"GERD.":[126],"Overall,":[127],"aims":[130],"highlight":[132],"milestones":[135],"understanding":[137],"elusive":[139],"yet":[140],"important":[141],"Though":[143],"no":[145],"way":[146],"comprehensive,":[147],"hope":[149],"provide":[151],"birds-eye":[153],"view":[154],"type":[162],"gastrointestinal":[165],"tract.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-12-05T00:00:00"}