{"id":"https://openalex.org/W2990439730","doi":null,"title":"Sleep and circadian dysregulation in depressive illness : pharmacological implications","display_name":"Sleep and circadian dysregulation in depressive illness : pharmacological implications","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2990439730","mag":"2990439730"},"language":"en","primary_location":{"id":"pmh:oai:americanae.aecid.es:3076450","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uca.edu.ar/handle/123456789/1658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropsychiatry. 2011, 8 (6)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.uca.edu.ar/handle/123456789/1658","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065268240","display_name":"Daniel Pedro Cardinali","orcid":"https://orcid.org/0000-0002-0813-9088","observed_orcids":["https://orcid.org/0000-0002-0813-9088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel P. Cardinali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071016733","display_name":"Seithikurippu Ratnas Pandi-Perumal","orcid":"https://orcid.org/0000-0002-8686-7259","observed_orcids":["https://orcid.org/0000-0002-8686-7259"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seithikurippu R. Pandi\u2010Perumal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8686-7259","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014900608","display_name":"Gregory M. Brown","orcid":"https://orcid.org/0000-0003-3222-9013","observed_orcids":["https://orcid.org/0000-0003-3222-9013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory M. Brown","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3222-9013","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.3219082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.6890000104904175},{"id":"https://openalex.org/keywords/sleep-wake-cycle","display_name":"sleep-wake cycle","score":0.5720000267028809},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7580000162124634},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9549999833106995},{"id":"https://openalex.org/keywords/seasonal-affective-disorder","display_name":"seasonal affective disorder","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/melatonin-secretion","display_name":"melatonin secretion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.6869999766349792},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.8320000171661377},{"id":"https://openalex.org/keywords/agomelatine","display_name":"agomelatine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/melatonin-receptor-agonists","display_name":"melatonin receptor agonists","score":0.7440000176429749},{"id":"https://openalex.org/keywords/5-ht2c-receptor-antagonism","display_name":"5-HT2C receptor antagonism","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6779605746269226},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5604450702667236},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.49239981174468994},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4595038592815399},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4533975124359131},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4418621063232422},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.4172712564468384},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25199270248413086},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.2125127911567688},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:3076450","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uca.edu.ar/handle/123456789/1658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropsychiatry. 2011, 8 (6)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/194457","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/194457","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ucacris:123456789/1658","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uca.edu.ar/handle/123456789/1658","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Neuropsychiatry. 2011, 8 (6)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:2990439730","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.uca.edu.ar/bitstream/123456789/1658/1/sleep-circadian-dysregulation-indepressive-illness.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3076450","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uca.edu.ar/handle/123456789/1658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropsychiatry. 2011, 8 (6)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":150,"referenced_works":["https://openalex.org/W21495289","https://openalex.org/W24957977","https://openalex.org/W55149496","https://openalex.org/W79115161","https://openalex.org/W88627979","https://openalex.org/W100052691","https://openalex.org/W107422749","https://openalex.org/W120655898","https://openalex.org/W145630688","https://openalex.org/W175729059","https://openalex.org/W203760682","https://openalex.org/W204785327","https://openalex.org/W1491141181","https://openalex.org/W1524125780","https://openalex.org/W1529328461","https://openalex.org/W1555810878","https://openalex.org/W1557411044","https://openalex.org/W1580029690","https://openalex.org/W1761390008","https://openalex.org/W1965532359","https://openalex.org/W1965988574","https://openalex.org/W1968110800","https://openalex.org/W1968910255","https://openalex.org/W1969732746","https://openalex.org/W1970151346","https://openalex.org/W1972688277","https://openalex.org/W1973469708","https://openalex.org/W1974254409","https://openalex.org/W1974832835","https://openalex.org/W1975894144","https://openalex.org/W1976832482","https://openalex.org/W1978301558","https://openalex.org/W1981026457","https://openalex.org/W1981440072","https://openalex.org/W1984461780","https://openalex.org/W1987762685","https://openalex.org/W1989813549","https://openalex.org/W1990454576","https://openalex.org/W1992860227","https://openalex.org/W1994631945","https://openalex.org/W1994797371","https://openalex.org/W1995403973","https://openalex.org/W1996172219","https://openalex.org/W1999452516","https://openalex.org/W2002293846","https://openalex.org/W2004762037","https://openalex.org/W2004949799","https://openalex.org/W2005066505","https://openalex.org/W2005597128","https://openalex.org/W2006273514","https://openalex.org/W2009316393","https://openalex.org/W2013891609","https://openalex.org/W2013946239","https://openalex.org/W2013987967","https://openalex.org/W2014069918","https://openalex.org/W2014398726","https://openalex.org/W2018707355","https://openalex.org/W2020391798","https://openalex.org/W2022032351","https://openalex.org/W2024038995","https://openalex.org/W2027559955","https://openalex.org/W2028906997","https://openalex.org/W2029026390","https://openalex.org/W2029586222","https://openalex.org/W2030522079","https://openalex.org/W2037264357","https://openalex.org/W2037874659","https://openalex.org/W2038307473","https://openalex.org/W2039169515","https://openalex.org/W2039923358","https://openalex.org/W2044341469","https://openalex.org/W2048106194","https://openalex.org/W2048998557","https://openalex.org/W2051525211","https://openalex.org/W2052205140","https://openalex.org/W2053307047","https://openalex.org/W2053430956","https://openalex.org/W2054391435","https://openalex.org/W2054823538","https://openalex.org/W2058361018","https://openalex.org/W2060355724","https://openalex.org/W2060596157","https://openalex.org/W2063928651","https://openalex.org/W2064452700","https://openalex.org/W2065062277","https://openalex.org/W2065962732","https://openalex.org/W2069528131","https://openalex.org/W2069915228","https://openalex.org/W2070095833","https://openalex.org/W2072667078","https://openalex.org/W2073145669","https://openalex.org/W2073570537","https://openalex.org/W2073749725","https://openalex.org/W2077672521","https://openalex.org/W2080755125","https://openalex.org/W2084240932","https://openalex.org/W2084800079","https://openalex.org/W2085323249","https://openalex.org/W2085628760","https://openalex.org/W2086546977","https://openalex.org/W2086754066","https://openalex.org/W2087067458","https://openalex.org/W2087282502","https://openalex.org/W2090455592","https://openalex.org/W2095622762","https://openalex.org/W2096579248","https://openalex.org/W2096630257","https://openalex.org/W2101704044","https://openalex.org/W2101963851","https://openalex.org/W2103431948","https://openalex.org/W2108914538","https://openalex.org/W2111049704","https://openalex.org/W2112544235","https://openalex.org/W2113790044","https://openalex.org/W2115576097","https://openalex.org/W2118917324","https://openalex.org/W2119347604","https://openalex.org/W2119709085","https://openalex.org/W2120729007","https://openalex.org/W2122446987","https://openalex.org/W2126469441","https://openalex.org/W2126862274","https://openalex.org/W2127233109","https://openalex.org/W2128257083","https://openalex.org/W2130018654","https://openalex.org/W2134977136","https://openalex.org/W2135777766","https://openalex.org/W2137633946","https://openalex.org/W2139003235","https://openalex.org/W2139154756","https://openalex.org/W2141706399","https://openalex.org/W2143210222","https://openalex.org/W2144411579","https://openalex.org/W2147689776","https://openalex.org/W2152501812","https://openalex.org/W2153403353","https://openalex.org/W2157611470","https://openalex.org/W2159011576","https://openalex.org/W2160174541","https://openalex.org/W2161165271","https://openalex.org/W2163920027","https://openalex.org/W2165834747","https://openalex.org/W2167610922","https://openalex.org/W2171656883","https://openalex.org/W2404574292","https://openalex.org/W2418274017","https://openalex.org/W2419547192","https://openalex.org/W2463004917","https://openalex.org/W3020903920","https://openalex.org/W4297872962"],"related_works":["https://openalex.org/W2048106194","https://openalex.org/W2027966268","https://openalex.org/W2155971415","https://openalex.org/W2119617632","https://openalex.org/W1966006827","https://openalex.org/W2088747929","https://openalex.org/W2039180486","https://openalex.org/W1994689166","https://openalex.org/W2552464249","https://openalex.org/W2920968777"],"abstract_inverted_index":{"Circadian":[0],"rhythm":[1,51],"abnormalities,":[2],"as":[3,103],"shown":[4],"by":[5],"sleep/wake":[6,141,213],"cycle":[7,214],"disturbances,":[8],"constitute":[9],"one":[10],"the":[11,22,48,88,104,140,145,150,200,228,234,237],"most":[12,146],"prevalent":[13],"signs":[14],"of":[15,52,84,149,158,194,202,219,230,236],"depressive":[16,36,97,220],"illness,":[17],"advances":[18],"or":[19,25,42],"delays":[20],"in":[21,27,32,47,57,64,96,127,186,198,233],"circadian":[23,89,93,231],"phase,":[24],"changes":[26],"rhythms\u00b4":[28],"amplitude,":[29],"being":[30],"documented":[31],"patients":[33,58,188,204],"with":[34,59,66,135,189],"major":[35],"disorder":[37,41],"(MDD),":[38],"seasonal":[39],"affective":[40],"bipolar":[43],"disorder.":[44],"The":[45,160],"disturbances":[46,76],"amplitude":[49],"and":[50,77,116,165,175,179,196],"melatonin":[53,163,173],"secretion":[54],"that":[55,71,86],"occur":[56],"depression":[60],"resemble":[61],"those":[62],"seen":[63],"subjects":[65],"chronobiological":[67,75],"disorders,":[68],"thus":[69],"suggesting":[70],"a":[72,136],"link":[73],"between":[74],"depressed":[78,203],"mood":[79,201],"exists.":[80],"Studies":[81],"testing":[82],"variants":[83],"genes":[85],"control":[87],"system":[90],"have":[91,122],"reported":[92],"gene":[94],"polymorphisms":[95],"illness.":[98],"Although":[99],"many":[100],"antidepressants":[101],"such":[102],"tricyclics,":[105],"monoamine":[106],"oxidase":[107],"inhibitors,":[108,111],"serotonin-norepinephrine":[109],"reuptake":[110,119],"several":[112],"serotonin":[113,118,167],"receptor":[114,177],"antagonists":[115],"selective":[117,166],"inhibitors":[120],"(SSRIs)":[121],"all":[123],"been":[124,184,206],"found":[125],"successful":[126],"treating":[128,187],"depression,":[129],"their":[130,156],"use":[131],"is":[132],"often":[133],"associated":[134],"disruptive":[137],"effect":[138],"on":[139],"cycle.":[142],"SSRIs,":[143],"currently":[144],"widely":[147],"prescribed":[148],"antidepressants,":[151],"are":[152],"well":[153],"known":[154],"for":[155],"exacerbation":[157],"insomnia.":[159],"recently":[161],"introduced":[162],"agonist":[164,178],"antagonist":[168,181],"antidepressant,":[169],"agomelatine,":[170],"which":[171],"has":[172,183,205],"MT1":[174],"MT2":[176],"5-HT2c":[180],"properties,":[182],"useful":[185],"MDD.":[190],"Its":[191],"rapid":[192],"onset":[193],"action":[195],"effectiveness":[197],"improving":[199],"attributed":[207],"to":[208,211,223,226],"its":[209],"ability":[210],"improve":[212],"quality.":[215],"Thus,":[216],"current":[217],"conceptualization":[218],"illness":[221],"needs":[222],"be":[224],"expanded":[225],"include":[227],"role":[229],"dysregulation":[232],"development":[235],"disease.":[238]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}
