{"id":"https://openalex.org/W2990420133","doi":"https://doi.org/10.4155/tde-2019-0060","title":"Formulation of Polymeric Nanoparticles of Antidepressant Drug for Intranasal Delivery","display_name":"Formulation of Polymeric Nanoparticles of Antidepressant Drug for Intranasal Delivery","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2990420133","doi":"https://doi.org/10.4155/tde-2019-0060","mag":"2990420133","pmid":"https://pubmed.ncbi.nlm.nih.gov/31744396"},"language":"en","primary_location":{"id":"doi:10.4155/tde-2019-0060","doi":"https://doi.org/10.4155/tde-2019-0060","is_oa":false,"landing_page_url":"https://doi.org/10.4155/tde-2019-0060","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054160869","display_name":"Parva Jani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110116418","display_name":"Maharaja Sayajirao University of Baroda","ror":"https://ror.org/01bx8ja67","country_code":"IN","type":"education","lineage":["https://openalex.org/I110116418"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Parva Jani","raw_affiliation_strings":["Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara 390001, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara 390001, Gujarat, India","institution_ids":["https://openalex.org/I110116418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074973795","display_name":"Jigar D. Vanza","orcid":"https://orcid.org/0000-0002-5670-4571","observed_orcids":["https://orcid.org/0000-0002-5670-4571"]},"institutions":[{"id":"https://openalex.org/I110116418","display_name":"Maharaja Sayajirao University of Baroda","ror":"https://ror.org/01bx8ja67","country_code":"IN","type":"education","lineage":["https://openalex.org/I110116418"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jigar Vanza","raw_affiliation_strings":["Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara 390001, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara 390001, Gujarat, India","institution_ids":["https://openalex.org/I110116418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069865945","display_name":"Nilima Pandya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110116418","display_name":"Maharaja Sayajirao University of Baroda","ror":"https://ror.org/01bx8ja67","country_code":"IN","type":"education","lineage":["https://openalex.org/I110116418"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nilima Pandya","raw_affiliation_strings":["Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara 390001, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Kalabhavan Campus, Vadodara 390001, Gujarat, India","institution_ids":["https://openalex.org/I110116418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041260160","display_name":"Hemal Tandel","orcid":"https://orcid.org/0009-0003-0922-6444","observed_orcids":["https://orcid.org/0009-0003-0922-6444"]},"institutions":[{"id":"https://openalex.org/I110116418","display_name":"Maharaja Sayajirao University of Baroda","ror":"https://ror.org/01bx8ja67","country_code":"IN","type":"education","lineage":["https://openalex.org/I110116418"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hemal Tandel","raw_affiliation_strings":["Faculty of Pharmacy\rThe Maharaja Sayajirao University of Baroda\rKalabhavan Campus\rVadodara 390001\rGujarat\rIndia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy\rThe Maharaja Sayajirao University of Baroda\rKalabhavan Campus\rVadodara 390001\rGujarat\rIndia","institution_ids":["https://openalex.org/I110116418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I110116418"],"apc_list":null,"apc_paid":null,"fwci":1.5326,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.76780552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"10","issue":"11","first_page":"683","last_page":"696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agomelatine","display_name":"agomelatine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.921999990940094},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.8270000219345093},{"id":"https://openalex.org/keywords/nose-to-brain-drug-delivery","display_name":"nose-to-brain delivery","score":0.9629999995231628},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pluronic-f127","display_name":"Pluronic F127","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nanoprecipitation","display_name":"nanoprecipitation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/factorial-design-optimization","display_name":"factorial design optimization","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7459999918937683},{"id":"https://openalex.org/keywords/nasal-mucosa-permeability","display_name":"nasal mucosa permeability","score":0.8410000205039978},{"id":"https://openalex.org/keywords/nasal-toxicity","display_name":"nasal toxicity","score":0.9229999780654907},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.9359999895095825},{"id":"https://openalex.org/keywords/immobility-time","display_name":"immobility time","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.645318329334259},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.5937682390213013},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.5674694776535034},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5563656687736511},{"id":"https://openalex.org/C2780472526","wikidata":"https://www.wikidata.org/wiki/Q409373","display_name":"Glycolic acid","level":4,"score":0.5449787378311157},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.5346167683601379},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5198588967323303},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5176344513893127},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5097190737724304},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4400676190853119},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4378824234008789},{"id":"https://openalex.org/C201253974","wikidata":"https://www.wikidata.org/wiki/Q1330121","display_name":"First pass effect","level":3,"score":0.4318862557411194},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.42573511600494385},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.3643070161342621},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3557954430580139},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3283464312553406},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28630971908569336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22280582785606384},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0857243537902832},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0678720772266388},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.059440433979034424},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067289","descriptor_name":"Behavior Observation Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4155/tde-2019-0060","doi":"https://doi.org/10.4155/tde-2019-0060","is_oa":false,"landing_page_url":"https://doi.org/10.4155/tde-2019-0060","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},{"id":"pmid:31744396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31744396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic delivery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W162711594","https://openalex.org/W199968895","https://openalex.org/W1605452004","https://openalex.org/W1971033910","https://openalex.org/W1982974605","https://openalex.org/W1988652094","https://openalex.org/W1991981331","https://openalex.org/W1999988002","https://openalex.org/W2009974403","https://openalex.org/W2010509095","https://openalex.org/W2015407801","https://openalex.org/W2020398834","https://openalex.org/W2034676523","https://openalex.org/W2035838068","https://openalex.org/W2040441523","https://openalex.org/W2044858446","https://openalex.org/W2046592858","https://openalex.org/W2047368765","https://openalex.org/W2047824475","https://openalex.org/W2051101763","https://openalex.org/W2054546290","https://openalex.org/W2057200138","https://openalex.org/W2063434630","https://openalex.org/W2066685510","https://openalex.org/W2076768230","https://openalex.org/W2087643277","https://openalex.org/W2102819518","https://openalex.org/W2119221152","https://openalex.org/W2139147593","https://openalex.org/W2157727875","https://openalex.org/W2162752807","https://openalex.org/W2307896665","https://openalex.org/W2334794785","https://openalex.org/W2412497043","https://openalex.org/W2415462217","https://openalex.org/W2440624146","https://openalex.org/W2559831753","https://openalex.org/W2568206242","https://openalex.org/W2577936949","https://openalex.org/W2599633442","https://openalex.org/W2751879169","https://openalex.org/W2779160048","https://openalex.org/W2790125956","https://openalex.org/W2868168748","https://openalex.org/W2897048101","https://openalex.org/W2901039212","https://openalex.org/W2953963565","https://openalex.org/W3085827563","https://openalex.org/W3214816818","https://openalex.org/W4210887160","https://openalex.org/W4250795354"],"related_works":["https://openalex.org/W2922040645","https://openalex.org/W2721615787","https://openalex.org/W2035838068","https://openalex.org/W2344128389","https://openalex.org/W2139147593","https://openalex.org/W4229058831","https://openalex.org/W4405406722","https://openalex.org/W4391226375","https://openalex.org/W4286258737","https://openalex.org/W1988652094"],"abstract_inverted_index":{"Aim:":[0],"The":[1,34,43,127],"manuscript":[2],"describes":[3],"the":[4,92,101,117,124],"performance":[5],"of":[6,22,123],"nanoparticles":[7,21,45,132],"loaded":[8],"with":[9,52,84,116],"antidepressant":[10,121,135],"drug":[11,14,86],"for":[12],"nose-to-brain":[13,138],"delivery.":[15],"Materials":[16],"&":[17],"methods:":[18],"Poly-lactic-co-glycolic":[19],"acid-loaded":[20],"agomelatine":[23],"were":[24,37,70],"prepared":[25,128],"by":[26,137],"nanoprecipitation":[27],"method":[28],"using":[29,39],"poloxamer":[30],"407":[31],"as":[32,76,140],"stabilizer.":[33],"process":[35],"parameters":[36],"optimized":[38,93],"factorial":[40],"design.":[41],"Results:":[42],"drug-loaded":[44],"having":[46],"low":[47],"particle":[48],"size":[49,54],"(<200":[50],"nm)":[51],"narrow":[53],"distribution":[55],"and":[56,69],"required":[57],"zeta":[58],"potential":[59],"(-22.7":[60],"mV)":[61],"to":[62,72],"avoid":[63],"aggregation":[64],"showed":[65,90,107,133],"sustained":[66],"release":[67],"profile":[68],"found":[71],"have":[73],"higher":[74],"permeability":[75],"observed":[77,141],"from":[78,97,142],"ex":[79],"vivo":[80],"studies":[81],"when":[82],"compared":[83],"plain":[85],"suspension.":[87],"Histopathology":[88],"test":[89],"that":[91],"formulation":[94,118],"was":[95],"free":[96],"nasal":[98,103],"toxicity":[99],"on":[100],"goat":[102],"mucosa.":[104],"Pharmacodynamic":[105],"study":[106],"significant":[108],"reduction":[109],"in":[110,113],"immobility":[111],"time":[112],"rats":[114],"treated":[115],"which":[119],"indicated":[120],"activity":[122,136],"formulation.":[125],"Conclusion:":[126],"agomelatin-loaded":[129],"poly-lactic-co-glycolic":[130],"acid":[131],"prominent":[134],"delivery":[139],"various":[143],"studies.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-05T00:00:00"}