{"id":"https://openalex.org/W2990400731","doi":"https://doi.org/10.1183/13993003.congress-2019.pa3011","title":"The value of immunological methods in the complex diagnostics of TB in chronic renal failure patients in the terminal stage","display_name":"The value of immunological methods in the complex diagnostics of TB in chronic renal failure patients in the terminal stage","publication_year":2019,"publication_date":"2019-09-28","ids":{"openalex":"https://openalex.org/W2990400731","doi":"https://doi.org/10.1183/13993003.congress-2019.pa3011","mag":"2990400731"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2019.pa3011","doi":"https://doi.org/10.1183/13993003.congress-2019.pa3011","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2019.pa3011","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021273859","display_name":"Olga Gordeeva","orcid":"https://orcid.org/0000-0002-7219-003X","observed_orcids":["https://orcid.org/0000-0002-7219-003X"]},"institutions":[{"id":"https://openalex.org/I4210141872","display_name":"Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences","ror":"https://ror.org/03z90hq89","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1318325419","https://openalex.org/I4210110862","https://openalex.org/I4210141872"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga Gordeeva","raw_affiliation_strings":["FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210141872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049441983","display_name":"Maxim V. Telepnev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141872","display_name":"Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences","ror":"https://ror.org/03z90hq89","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1318325419","https://openalex.org/I4210110862","https://openalex.org/I4210141872"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim Telepnev","raw_affiliation_strings":["FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210141872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067989372","display_name":"Irina Nikitina","orcid":"https://orcid.org/0000-0002-9232-5210","observed_orcids":["https://orcid.org/0000-0002-9232-5210"]},"institutions":[{"id":"https://openalex.org/I4210141872","display_name":"Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences","ror":"https://ror.org/03z90hq89","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1318325419","https://openalex.org/I4210110862","https://openalex.org/I4210141872"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina Nikitina","raw_affiliation_strings":["FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210141872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023874739","display_name":"Irina Yu. Shabalina","orcid":"https://orcid.org/0000-0002-5385-1808","observed_orcids":["https://orcid.org/0000-0002-5385-1808"]},"institutions":[{"id":"https://openalex.org/I4210141872","display_name":"Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences","ror":"https://ror.org/03z90hq89","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1318325419","https://openalex.org/I4210110862","https://openalex.org/I4210141872"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina Shabalina","raw_affiliation_strings":["FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210141872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071518085","display_name":"\u041b\u0430\u0440\u0438\u0441\u0430 \u041d\u0438\u043a\u043e\u043b\u0430\u0435\u0432\u043d\u0430 \u0427\u0435\u0440\u043d\u043e\u0443\u0441\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-6288-7549","observed_orcids":["https://orcid.org/0000-0001-6288-7549"]},"institutions":[{"id":"https://openalex.org/I4210141872","display_name":"Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences","ror":"https://ror.org/03z90hq89","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1318325419","https://openalex.org/I4210110862","https://openalex.org/I4210141872"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Larisa Chernousova","raw_affiliation_strings":["FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210141872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113909043","display_name":"Natalya Karpina","orcid":"https://orcid.org/0000-0001-9337-3903","observed_orcids":["https://orcid.org/0000-0001-9337-3903"]},"institutions":[{"id":"https://openalex.org/I4210141872","display_name":"Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences","ror":"https://ror.org/03z90hq89","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1318325419","https://openalex.org/I4210110862","https://openalex.org/I4210141872"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalya Karpina","raw_affiliation_strings":["FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210141872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049507039","display_name":"Irina V. Lyadova","orcid":"https://orcid.org/0000-0003-3147-5386","observed_orcids":["https://orcid.org/0000-0003-3147-5386"]},"institutions":[{"id":"https://openalex.org/I4210141872","display_name":"Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences","ror":"https://ror.org/03z90hq89","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1318325419","https://openalex.org/I4210110862","https://openalex.org/I4210141872"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina Lyadova","raw_affiliation_strings":["FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSBSI \u201cCentral TB Research Institute\u201d, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210141872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210141872"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA3011","last_page":"PA3011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12578","display_name":"Diagnosis and treatment of tuberculosis","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-diagnosis","display_name":"tuberculosis diagnosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8849999904632568},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.8560000061988831},{"id":"https://openalex.org/keywords/interferon-gamma-release-assay","display_name":"interferon-gamma release assay","score":0.9629999995231628},{"id":"https://openalex.org/keywords/quantiferon-tb-gold-plus","display_name":"QuantiFERON-TB Gold Plus","score":0.9330000281333923},{"id":"https://openalex.org/keywords/t-spot-tb","display_name":"T-SPOT.TB","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tuberculin-skin-test","display_name":"tuberculin skin test","score":0.847000002861023},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7707773447036743},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5957443118095398},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5241970419883728},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.5219511389732361},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5161758065223694},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5008590221405029},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4943418502807617},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.49409082531929016},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.4553859233856201},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4332071542739868},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4228111207485199},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3971823751926422},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19766470789909363},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2019.pa3011","doi":"https://doi.org/10.1183/13993003.congress-2019.pa3011","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2019.pa3011","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2017509372","https://openalex.org/W3090033100","https://openalex.org/W2029095622","https://openalex.org/W7119332835","https://openalex.org/W2779356680","https://openalex.org/W4406844919","https://openalex.org/W2567388158","https://openalex.org/W2390163873","https://openalex.org/W2906258937","https://openalex.org/W2363927732"],"abstract_inverted_index":{"Introduction:":[0],"There":[1],"is":[2],"lack":[3],"of":[4,9,15,42,86,93,141,152,164,186,197,204,216,224,230],"data":[5],"about":[6],"the":[7,13,24,40,60,84,91,117,231],"value":[8,41],"immunological":[10,43],"methods":[11,44],"in":[12,17,23,48,59,144,169,194,199],"diagnostics":[14,196],"TB":[16,46,170,176,198],"chronic":[18],"renal":[19],"failure":[20],"(CRF)":[21],"patients":[22,56,64,146,171,177,200],"terminal":[25,202],"stage,":[26],"who":[27],"are":[28],"immunocompromised":[29],"due":[30,137],"to":[31,138,148,175,236],"replacement":[32],"therapy":[33],"or":[34],"kidney":[35],"transplantation.":[36],"Aim:":[37],"To":[38],"evaluate":[39],"for":[45,66,71,183],"diagnosis":[47,118],"CRF":[49,55,145,173,241],"patients.":[50],"Material":[51],"and":[52,109,112],"Methods:":[53],"34":[54],"were":[57],"included":[58],"study":[61],"(18":[62],"(53%)":[63],"diagnosed":[65],"TB,":[67],"16":[68],"(47%)":[69],"\u2013":[70],"other":[72],"diseases).":[73],"Immunological":[74,189],"analysis":[75,160],"included:":[76],"tuberculosis":[77],"skin":[78,121],"tests;":[79],"QuantiFERON\u00ae-TB":[80],"Gold":[81],"Plus;":[82],"T-SPOT\u00ae;":[83],"determination":[85],"Mtb-specific":[87,165,225],"CD27-IFN-\u03b3+":[88],"cells":[89],"(\u201cMtb-CD27\u201d),":[90],"evaluation":[92],"CD4+,":[94],"CD8+,":[95],"CD19+,":[96],"CD16/CD56+":[97],"cells.":[98],"Results:":[99],"IGRAs":[100,217],"showed":[101],"low":[102,130,184],"sensitivity":[103,127,185,215],"(47%),":[104],"but":[105,129,206],"high":[106,126,150],"specificity":[107,131,229],"(93":[108],"94":[110],"%)":[111],"demonstrated":[113,161],"higher":[114],"concordance":[115],"with":[116,172,201,240],"(~70%)":[119],"than":[120],"tests":[122,190],"(64%).":[123],"Mtb-CD27":[124,232],"had":[125],"(82%),":[128],"(13%).":[132],"The":[133],"latter":[134],"was":[135],"likely":[136],"bystander":[139],"stimulation":[140],"CD4+":[142,156],"lymphocytes":[143,154,168],"leading":[147],"a":[149],"percentage":[151],"CD27-":[153],"within":[155],"population.":[157],"Flow":[158],"cytometry":[159],"lower":[162],"counts":[163,223],"IFN-\u03b3-producing":[166],"CD4":[167],"compared":[174],"without":[178],"CRF,":[179,205],"which":[180],"could":[181],"account":[182],"IGRAs.":[187],"Conclusions:":[188],"can":[191,218,233],"be":[192,210,219,234],"used":[193],"complex":[195],"stage":[203],"their":[207],"limitations":[208],"should":[209],"taken":[211],"into":[212],"account.":[213],"Low":[214,228],"explained":[220],"by":[221],"insufficient":[222],"IFN-\u03b3-producingCD4":[226],"lymphocytes.":[227],"attributed":[235],"pronounced":[237],"inflammation":[238],"associated":[239]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-12-05T00:00:00"}