{"id":"https://openalex.org/W2990219485","doi":"https://doi.org/10.15252/embj.2019102406","title":"Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor","display_name":"Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor","publication_year":2019,"publication_date":"2019-11-29","ids":{"openalex":"https://openalex.org/W2990219485","doi":"https://doi.org/10.15252/embj.2019102406","mag":"2990219485","pmid":"https://pubmed.ncbi.nlm.nih.gov/31782549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6939200"},"language":"en","primary_location":{"id":"doi:10.15252/embj.2019102406","doi":"https://doi.org/10.15252/embj.2019102406","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embj.2019102406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2019102406","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2019102406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010537002","display_name":"Rebecca Elizabeth Vargas","orcid":"https://orcid.org/0000-0002-9850-7568","observed_orcids":["https://orcid.org/0000-0002-9850-7568"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca E Vargas","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134779826","display_name":"Vy Thuy Duong","orcid":"https://orcid.org/0000-0003-2781-2001","observed_orcids":["https://orcid.org/0000-0003-2781-2001"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vy Thuy Duong","raw_affiliation_strings":["Department of Chemistry, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321761","display_name":"Han Han","orcid":"https://orcid.org/0000-0003-2222-5270","observed_orcids":["https://orcid.org/0000-0003-2222-5270"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han Han","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112465542","display_name":"ALBERT TA","orcid":"https://orcid.org/0000-0003-0812-6030","observed_orcids":["https://orcid.org/0000-0003-0812-6030"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Paul Ta","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342250","display_name":"Yuxuan Chen","orcid":"https://orcid.org/0000-0003-0727-1834","observed_orcids":["https://orcid.org/0000-0003-0727-1834","https://orcid.org/0009-0002-0283-6488","https://orcid.org/0009-0003-1063-2052","https://orcid.org/0009-0005-4634-804X","https://orcid.org/0009-0009-5283-7789"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuxuan Chen","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082500178","display_name":"Shiji Zhao","orcid":"https://orcid.org/0000-0002-4514-0897","observed_orcids":["https://orcid.org/0000-0002-4514-0897"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiji Zhao","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101408134","display_name":"Bing Yang","orcid":"https://orcid.org/0000-0002-7701-1862","observed_orcids":["https://orcid.org/0000-0002-7701-1862"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Yang","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068774326","display_name":"Gayoung Seo","orcid":"https://orcid.org/0000-0002-6738-2686","observed_orcids":["https://orcid.org/0000-0002-6738-2686"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayoung Seo","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062472699","display_name":"Kimberly Chuc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Chuc","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019355399","display_name":"Sunwoo Oh","orcid":"https://orcid.org/0000-0001-9205-4660","observed_orcids":["https://orcid.org/0000-0001-9205-4660"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunwoo Oh","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057239696","display_name":"Amal El Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amal El Ali","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070550477","display_name":"Olga V. Razorenova","orcid":"https://orcid.org/0000-0002-9442-6170","observed_orcids":["https://orcid.org/0000-0002-9442-6170"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga V Razorenova","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365539","display_name":"Junjie Chen","orcid":"https://orcid.org/0000-0002-1493-2189","observed_orcids":["https://orcid.org/0000-0002-1493-2189"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junjie Chen","raw_affiliation_strings":["Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-1493-2189","affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032088629","display_name":"Ray Luo","orcid":"https://orcid.org/0000-0002-6346-8271","observed_orcids":["https://orcid.org/0000-0002-6346-8271"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ray Luo","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA","Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA","Department of Materials Science and Engineering, University of California, Irvine, Irvine, CA, USA","Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6346-8271","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342478","display_name":"Xu Li","orcid":"https://orcid.org/0000-0002-9401-6382","observed_orcids":["https://orcid.org/0000-0002-9401-6382"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xu Li","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China"],"raw_orcid":"https://orcid.org/0000-0002-9401-6382","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100759568","display_name":"Wenqi Wang","orcid":"https://orcid.org/0000-0003-4053-5088","observed_orcids":["https://orcid.org/0000-0003-4053-5088"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wenqi Wang","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4053-5088","affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032088629","https://openalex.org/A5100342478","https://openalex.org/A5100365539","https://openalex.org/A5100759568"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I204250578","https://openalex.org/I3133055985"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":1.2638,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.73640035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"39","issue":"1","first_page":"e102406","last_page":"e102406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ww-domain","display_name":"WW domain","score":0.9350000023841858},{"id":"https://openalex.org/keywords/py-motif","display_name":"PY motif","score":0.7149999737739563},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.859000027179718},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.847000002861023},{"id":"https://openalex.org/keywords/binding-specificity","display_name":"binding specificity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/alpha-catenin","display_name":"alpha-catenin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.890999972820282},{"id":"https://openalex.org/keywords/organ-size-control","display_name":"organ size control","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C204491159","wikidata":"https://www.wikidata.org/wiki/Q24726881","display_name":"WW domain","level":3,"score":0.940222978591919},{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.872963547706604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6426681280136108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6077443361282349},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4702317416667938},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.46869587898254395},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.43537044525146484},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.42894458770751953},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.4214555621147156},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4130449593067169},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3183108866214752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26729124784469604},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.11794865131378174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074585","descriptor_name":"WW Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090683","descriptor_name":"Hippo Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.15252/embj.2019102406","doi":"https://doi.org/10.15252/embj.2019102406","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embj.2019102406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2019102406","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6689320","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6939200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:31782549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31782549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6939200","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6939200/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7cr2b8vx","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7cr2b8vx","pdf_url":"https://escholarship.org/content/qt7cr2b8vx/qt7cr2b8vx.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The EMBO Journal, vol 39, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15252/embj.2019102406","doi":"https://doi.org/10.15252/embj.2019102406","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embj.2019102406","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2019102406","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1315042094","display_name":null,"funder_award_id":"P30 CA062203","funder_id":"https://openalex.org/F4320337616","funder_display_name":"Chao Family Comprehensive Cancer Center"},{"id":"https://openalex.org/G1924634781","display_name":null,"funder_award_id":"W81XWH-09-1-0409","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G2786445062","display_name":null,"funder_award_id":"RSG-18-009-01-CCG","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4101219923","display_name":"AMBER force field consortium: a coherent biomolecular simulation platform","funder_award_id":"R01GM079383","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4604468691","display_name":"SYSTEMATIC INVESTIGATION OF KEY SURVIVAL AND GROWTH PATHWAYS IN BREAST CANCER","funder_award_id":"W81XWH0910409","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5038268228","display_name":"Multiscale Models of Wound Cell Plasticity for Regeneration","funder_award_id":"U01AR073159","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G575396618","display_name":"Novel regulations of the Hippo tumor suppressor pathway","funder_award_id":"RSG-18-009-01-CCG","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8326847054","display_name":"Mathematical, Computational and Systems Biology","funder_award_id":"T32EB009418","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8812774062","display_name":"MBRS IMSD Program at the University of California, Irvine","funder_award_id":"R25GM055246","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000877839","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA062203","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000879561","display_name":"Multi-scaled Modeling of Electrostatic and Polarization Effects in Biomolecules","funder_award_id":"R35GM130367","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000910805","display_name":"Regulation and function of the Hippo pathway in growth control","funder_award_id":"R01GM126048","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337616","display_name":"Chao Family Comprehensive Cancer Center","ror":"https://ror.org/04gyf1771"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990219485.pdf","grobid_xml":"https://content.openalex.org/works/W2990219485.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W1505451204","https://openalex.org/W1604166471","https://openalex.org/W1927347955","https://openalex.org/W1964999292","https://openalex.org/W1968464875","https://openalex.org/W1968984443","https://openalex.org/W1971251199","https://openalex.org/W1971294322","https://openalex.org/W1972076214","https://openalex.org/W1972172786","https://openalex.org/W1973858755","https://openalex.org/W1975282060","https://openalex.org/W1977950302","https://openalex.org/W1980022131","https://openalex.org/W1980374511","https://openalex.org/W1983691421","https://openalex.org/W1990324370","https://openalex.org/W1994737524","https://openalex.org/W1995160678","https://openalex.org/W1996620464","https://openalex.org/W2003044806","https://openalex.org/W2004822259","https://openalex.org/W2006778392","https://openalex.org/W2007916618","https://openalex.org/W2011109079","https://openalex.org/W2013325082","https://openalex.org/W2014898742","https://openalex.org/W2015338902","https://openalex.org/W2015688756","https://openalex.org/W2018967631","https://openalex.org/W2019621646","https://openalex.org/W2022423243","https://openalex.org/W2030728145","https://openalex.org/W2042863014","https://openalex.org/W2043685957","https://openalex.org/W2048472525","https://openalex.org/W2049480511","https://openalex.org/W2050552243","https://openalex.org/W2050712486","https://openalex.org/W2056331158","https://openalex.org/W2060955824","https://openalex.org/W2065033398","https://openalex.org/W2065283382","https://openalex.org/W2066126934","https://openalex.org/W2066812797","https://openalex.org/W2067107606","https://openalex.org/W2068398383","https://openalex.org/W2077725608","https://openalex.org/W2078377283","https://openalex.org/W2078594804","https://openalex.org/W2079828953","https://openalex.org/W2084326807","https://openalex.org/W2088526239","https://openalex.org/W2091427349","https://openalex.org/W2094747616","https://openalex.org/W2095269197","https://openalex.org/W2096057003","https://openalex.org/W2106700146","https://openalex.org/W2108260772","https://openalex.org/W2113338056","https://openalex.org/W2114520383","https://openalex.org/W2118233996","https://openalex.org/W2118971140","https://openalex.org/W2122545341","https://openalex.org/W2133740934","https://openalex.org/W2134413226","https://openalex.org/W2139160260","https://openalex.org/W2139746915","https://openalex.org/W2142952771","https://openalex.org/W2143727653","https://openalex.org/W2147988069","https://openalex.org/W2148034459","https://openalex.org/W2148056172","https://openalex.org/W2153983456","https://openalex.org/W2155443196","https://openalex.org/W2157918066","https://openalex.org/W2161491446","https://openalex.org/W2162125140","https://openalex.org/W2168802470","https://openalex.org/W2173678604","https://openalex.org/W2204405057","https://openalex.org/W2206432990","https://openalex.org/W2313116527","https://openalex.org/W2327188447","https://openalex.org/W2332712348","https://openalex.org/W2404280981","https://openalex.org/W2407746632","https://openalex.org/W2468947127","https://openalex.org/W2482454958","https://openalex.org/W2509259734","https://openalex.org/W2515356632","https://openalex.org/W2519390626","https://openalex.org/W2578611102","https://openalex.org/W2606317265","https://openalex.org/W2616561032","https://openalex.org/W2619317414","https://openalex.org/W2775778321","https://openalex.org/W2782192257","https://openalex.org/W2783351753","https://openalex.org/W2788256001","https://openalex.org/W2796389902","https://openalex.org/W2800679771","https://openalex.org/W2800900894","https://openalex.org/W2801830494","https://openalex.org/W2883755802","https://openalex.org/W2898723593","https://openalex.org/W2971426501","https://openalex.org/W3033538834","https://openalex.org/W3207860887","https://openalex.org/W4211232835"],"related_works":["https://openalex.org/W2133740934","https://openalex.org/W2136743544","https://openalex.org/W7100421561","https://openalex.org/W3118947681","https://openalex.org/W2018967631","https://openalex.org/W2066812797","https://openalex.org/W2782192257","https://openalex.org/W116755959","https://openalex.org/W7202130829","https://openalex.org/W3083489920"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}
