{"id":"https://openalex.org/W2990164947","doi":"https://doi.org/10.1038/s41598-019-54308-6","title":"Early life nutrition influences susceptibility to chronic inflammatory colitis in later life","display_name":"Early life nutrition influences susceptibility to chronic inflammatory colitis in later life","publication_year":2019,"publication_date":"2019-12-02","ids":{"openalex":"https://openalex.org/W2990164947","doi":"https://doi.org/10.1038/s41598-019-54308-6","mag":"2990164947","pmid":"https://pubmed.ncbi.nlm.nih.gov/31792267","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6889478"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-54308-6","doi":"https://doi.org/10.1038/s41598-019-54308-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-54308-6","pdf_url":"https://www.nature.com/articles/s41598-019-54308-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-54308-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039664930","display_name":"Delphine Ley","orcid":"https://orcid.org/0000-0002-7280-7861","observed_orcids":["https://orcid.org/0000-0002-7280-7861"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Delphine Ley","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France. delphine.ley@inserm.fr","LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)"],"raw_orcid":"https://orcid.org/0000-0002-7280-7861","affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France. delphine.ley@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)","institution_ids":["https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066843507","display_name":"Jean\u2010Luc Desseyn","orcid":"https://orcid.org/0000-0001-6876-8049","observed_orcids":["https://orcid.org/0000-0001-6876-8049"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Luc Desseyn","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France","LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)"],"raw_orcid":"https://orcid.org/0000-0001-6876-8049","affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)","institution_ids":["https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038687992","display_name":"Val\u00e9rie Gouyer","orcid":"https://orcid.org/0000-0002-4223-7060","observed_orcids":["https://orcid.org/0000-0002-4223-7060"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Gouyer","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France","LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)","institution_ids":["https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018481064","display_name":"S\u00e9gol\u00e8ne Plet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9gol\u00e8ne Plet","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France","LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)","institution_ids":["https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066849637","display_name":"Sebastian Tims","orcid":"https://orcid.org/0000-0001-7519-1575","observed_orcids":["https://orcid.org/0000-0001-7519-1575"]},"institutions":[{"id":"https://openalex.org/I4210090873","display_name":"Danone (France)","ror":"https://ror.org/00aj77a24","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210090873"]},{"id":"https://openalex.org/I4210159242","display_name":"Nutricia Research (Netherlands)","ror":"https://ror.org/04yx5fa32","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210159242"]},{"id":"https://openalex.org/I4400600905","display_name":"Danone Nutricia Research (Netherlands)","ror":"https://ror.org/04hxnp039","country_code":"NL","type":"company","lineage":["https://openalex.org/I4400600905"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Sebastian Tims","raw_affiliation_strings":["Danone Nutricia Research, Utrecht, The Netherlands","Danone Research (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danone Nutricia Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210159242","https://openalex.org/I4400600905"]},{"raw_affiliation_string":"Danone Research (France)","institution_ids":["https://openalex.org/I4210090873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059953191","display_name":"Ingrid B. Renes","orcid":"https://orcid.org/0000-0002-2638-1679","observed_orcids":["https://orcid.org/0000-0002-2638-1679"]},"institutions":[{"id":"https://openalex.org/I4210090873","display_name":"Danone (France)","ror":"https://ror.org/00aj77a24","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210090873"]},{"id":"https://openalex.org/I4210159242","display_name":"Nutricia Research (Netherlands)","ror":"https://ror.org/04yx5fa32","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210159242"]},{"id":"https://openalex.org/I4400600905","display_name":"Danone Nutricia Research (Netherlands)","ror":"https://ror.org/04hxnp039","country_code":"NL","type":"company","lineage":["https://openalex.org/I4400600905"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Ingrid Renes","raw_affiliation_strings":["Danone Nutricia Research, Utrecht, The Netherlands","Danone Research (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danone Nutricia Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210159242","https://openalex.org/I4400600905"]},{"raw_affiliation_string":"Danone Research (France)","institution_ids":["https://openalex.org/I4210090873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085392818","display_name":"Mona Mischke","orcid":"https://orcid.org/0000-0001-6260-5740","observed_orcids":["https://orcid.org/0000-0001-6260-5740"]},"institutions":[{"id":"https://openalex.org/I4210090873","display_name":"Danone (France)","ror":"https://ror.org/00aj77a24","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210090873"]},{"id":"https://openalex.org/I4210159242","display_name":"Nutricia Research (Netherlands)","ror":"https://ror.org/04yx5fa32","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210159242"]},{"id":"https://openalex.org/I4400600905","display_name":"Danone Nutricia Research (Netherlands)","ror":"https://ror.org/04hxnp039","country_code":"NL","type":"company","lineage":["https://openalex.org/I4400600905"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Mona Mischke","raw_affiliation_strings":["Danone Nutricia Research, Utrecht, The Netherlands","Danone Research (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danone Nutricia Research, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210159242","https://openalex.org/I4400600905"]},{"raw_affiliation_string":"Danone Research (France)","institution_ids":["https://openalex.org/I4210090873"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034643275","display_name":"Fr\u00e9d\u00e8ric Gottrand","orcid":"https://orcid.org/0000-0002-5290-0436","observed_orcids":["https://orcid.org/0000-0002-5290-0436"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Gottrand","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France","LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, LIRIC UMR 995, F-59000, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"]},{"raw_affiliation_string":"LIRIC - Lille Inflammation Research International Center - U 995 (Facult\u00e9 de m\u00e9decine - \r\nP\u00f4le recherche-4\u00e8me \u00e9tage - \r\nPlace de Verdun - \r\nF-59045 Lille Cedex - - France)","institution_ids":["https://openalex.org/I4210128436"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5039664930"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1490,"currency":"EUR","value_usd":1606},"fwci":0.6548,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.61513301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"18111","last_page":"18111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-life-nutrition","display_name":"early life nutrition","score":0.9890000224113464},{"id":"https://openalex.org/keywords/postnatal-growth-restriction","display_name":"postnatal growth restriction","score":0.8759999871253967},{"id":"https://openalex.org/keywords/intestinal-maturation","display_name":"intestinal maturation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.8550000190734863},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.996999979019165},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.800000011920929},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lachnospiraceae","display_name":"Lachnospiraceae","score":0.8169999718666077},{"id":"https://openalex.org/keywords/odoribacter","display_name":"Odoribacter","score":0.781000018119812},{"id":"https://openalex.org/keywords/enterococcus","display_name":"Enterococcus","score":0.7649999856948853},{"id":"https://openalex.org/keywords/escherichia-shigella","display_name":"Escherichia-Shigella","score":0.8460000157356262},{"id":"https://openalex.org/keywords/staphylococcus","display_name":"Staphylococcus","score":0.8339999914169312},{"id":"https://openalex.org/keywords/weaning","display_name":"weaning","score":0.5630000233650208},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.46700000762939453},{"id":"https://openalex.org/keywords/first-1000-days-of-life","display_name":"first 1000 days","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2779704485","wikidata":"https://www.wikidata.org/wiki/Q3825240","display_name":"Lachnospiraceae","level":5,"score":0.7952358722686768},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.7541400194168091},{"id":"https://openalex.org/C2780655333","wikidata":"https://www.wikidata.org/wiki/Q333203","display_name":"Weaning","level":2,"score":0.6272310018539429},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.5827171206474304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5551309585571289},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.5281871557235718},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4487966299057007},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4276670217514038},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.4206683933734894},{"id":"https://openalex.org/C2776927270","wikidata":"https://www.wikidata.org/wiki/Q815962","display_name":"Colonization","level":2,"score":0.41947031021118164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40385890007019043},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.36823153495788574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2789548933506012},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.22847390174865723},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.18563315272331238},{"id":"https://openalex.org/C2777695942","wikidata":"https://www.wikidata.org/wiki/Q149075","display_name":"Firmicutes","level":4,"score":0.16304808855056763},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1149190366268158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11401990056037903},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007227","descriptor_name":"Infant Nutritional Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014886","descriptor_name":"Weaning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-019-54308-6","doi":"https://doi.org/10.1038/s41598-019-54308-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-54308-6","pdf_url":"https://www.nature.com/articles/s41598-019-54308-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:31792267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31792267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6889478","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6889478/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02459949v1","doi":null,"is_oa":true,"landing_page_url":"https://lilloa.hal.science/hal-02459949v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, 2019, 9, pp.18111. &#x27E8;10.1038/s41598-019-54308-6&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:9a4df9970bd2419dbfaeb7ee695fa980","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9a4df9970bd2419dbfaeb7ee695fa980","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)","raw_type":"article"},{"id":"pmh:oai:lilloa.univ-lille.fr:20.500.12210/18080","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.12210/18080","pdf_url":null,"source":{"id":"https://openalex.org/S4306402203","display_name":"LillOA (Universit\u00e9 de Lille (University Of Lille))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210123514","host_organization_name":"Centre d'\u00c9tudes en Civilisations, Langues et Lettres \u00c9trang\u00e8res","host_organization_lineage":["https://openalex.org/I4210123514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lilloa.univ-lille.fr:20.500.12210/18080.2","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.12210/18080.2","pdf_url":null,"source":{"id":"https://openalex.org/S4306402203","display_name":"LillOA (Universit\u00e9 de Lille (University Of Lille))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210123514","host_organization_name":"Centre d'\u00c9tudes en Civilisations, Langues et Lettres \u00c9trang\u00e8res","host_organization_lineage":["https://openalex.org/I4210123514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-54308-6","doi":"https://doi.org/10.1038/s41598-019-54308-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-54308-6","pdf_url":"https://www.nature.com/articles/s41598-019-54308-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310065","display_name":"Danone","ror":"https://ror.org/00aj77a24"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320316048","display_name":"Danone Nutricia Research","ror":"https://ror.org/04hxnp039"},{"id":"https://openalex.org/F4320320932","display_name":"Nutricia Research Foundation","ror":"https://ror.org/00vt3ry76"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990164947.pdf","grobid_xml":"https://content.openalex.org/works/W2990164947.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1545975510","https://openalex.org/W1582666859","https://openalex.org/W1963557723","https://openalex.org/W1967511524","https://openalex.org/W1970538271","https://openalex.org/W1970777915","https://openalex.org/W1991098319","https://openalex.org/W1992152055","https://openalex.org/W1992245975","https://openalex.org/W2012606594","https://openalex.org/W2016573192","https://openalex.org/W2038133823","https://openalex.org/W2048234569","https://openalex.org/W2050445005","https://openalex.org/W2054186211","https://openalex.org/W2055122412","https://openalex.org/W2055959752","https://openalex.org/W2060185417","https://openalex.org/W2061565958","https://openalex.org/W2061809258","https://openalex.org/W2065973763","https://openalex.org/W2072970694","https://openalex.org/W2075832262","https://openalex.org/W2077745853","https://openalex.org/W2078071678","https://openalex.org/W2083464392","https://openalex.org/W2088863626","https://openalex.org/W2091922579","https://openalex.org/W2101120467","https://openalex.org/W2103561589","https://openalex.org/W2105381419","https://openalex.org/W2107369528","https://openalex.org/W2107503719","https://openalex.org/W2108635800","https://openalex.org/W2115701239","https://openalex.org/W2124351063","https://openalex.org/W2140932205","https://openalex.org/W2143847855","https://openalex.org/W2149773503","https://openalex.org/W2150904379","https://openalex.org/W2155066423","https://openalex.org/W2155770880","https://openalex.org/W2161893601","https://openalex.org/W2162133321","https://openalex.org/W2163229571","https://openalex.org/W2164386968","https://openalex.org/W2165065263","https://openalex.org/W2166171121","https://openalex.org/W2170024099","https://openalex.org/W2174361627","https://openalex.org/W2259494215","https://openalex.org/W2263148332","https://openalex.org/W2321127585","https://openalex.org/W2414441825","https://openalex.org/W2414595201","https://openalex.org/W2590939865","https://openalex.org/W2593402845","https://openalex.org/W2924644564"],"related_works":["https://openalex.org/W3210128705","https://openalex.org/W4394620180","https://openalex.org/W4226431529","https://openalex.org/W2014930160","https://openalex.org/W1811901528","https://openalex.org/W7148365456","https://openalex.org/W2180351889","https://openalex.org/W7130688636","https://openalex.org/W2220636552","https://openalex.org/W2593402845"],"abstract_inverted_index":{"The":[0,117],"first":[1],"thousand":[2],"days":[3],"of":[4,10,30,47,71,113,119],"life":[5,23,56,126],"are":[6],"a":[7,44,94,136],"critical":[8],"time":[9],"development":[11],"in":[12,21,64,75,80,124,142],"humans":[13],"during":[14],"which":[15],"the":[16,72,114,128],"risk":[17],"profile":[18],"for":[19],"diseases":[20,37],"later":[22,65],"can":[24],"be":[25],"modified.":[26],"Nevertheless,":[27],"long-term":[28],"consequences":[29],"early":[31,55,125],"environment":[32],"on":[33],"susceptibility":[34,138],"to":[35,139],"intestinal":[36,59,73,82,122],"have":[38],"not":[39],"yet":[40],"been":[41],"assessed.":[42],"Using":[43],"mouse":[45],"model":[46],"postnatal":[48],"growth":[49],"restriction":[50],"(PNGR),":[51],"we":[52],"showed":[53],"that":[54],"nutrition":[57],"influences":[58],"maturation":[60],"and":[61,84,103,106,110,127],"gut":[62,86],"health":[63],"life.":[66],"PNGR":[67,92,132],"induced":[68,130],"an":[69,120],"alteration":[70],"barrier":[74,123],"pups":[76,90],"at":[77],"weaning,":[78],"resulting":[79],"increased":[81],"permeability,":[83],"affected":[85],"bacterial":[87,96],"colonization.":[88],"Specifically,":[89],"with":[91,135],"harbored":[93],"decreased":[95],"diversity,":[97],"higher":[98,137],"Enterococcus":[99],"spp.,":[100,102,105],"Staphylococcus":[101],"Escherichia-Shigella":[104],"lower":[107],"Odoribacter":[108],"spp.":[109],"several":[111],"members":[112],"Lachnospiraceae":[115],"family.":[116],"lack":[118],"efficient":[121],"dysbiosis":[129],"by":[131],"were":[133],"associated":[134],"chronic":[140],"colitis":[141],"adulthood.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}
