{"id":"https://openalex.org/W2990161111","doi":null,"title":"m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation.","display_name":"m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2990161111","mag":"2990161111","pmid":"https://pubmed.ncbi.nlm.nih.gov/31632576"},"language":"en","primary_location":{"id":"pmid:31632576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31632576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6789218","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100428245","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-4433-5393","observed_orcids":["https://orcid.org/0000-0002-4433-5393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Li","raw_affiliation_strings":["Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lijun Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lijun Zhu","raw_affiliation_strings":["Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yanhong Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanhong Shi","raw_affiliation_strings":["Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044925584","display_name":"Jingnan Liu","orcid":"https://orcid.org/0000-0002-4325-1796","observed_orcids":["https://orcid.org/0000-0002-4325-1796"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingnan Liu","raw_affiliation_strings":["Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Lin","raw_affiliation_strings":["Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100329981","display_name":"Xi Chen","orcid":"https://orcid.org/0000-0002-7995-6202","observed_orcids":["https://orcid.org/0000-0002-7995-6202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi Chen","raw_affiliation_strings":["Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, No. 900 Hospital of The Joint Logistic Support Force Fuzhou 350025, Fujian, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.9459,"has_fulltext":false,"cited_by_count":157,"citation_normalized_percentile":{"value":0.98213701,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"11","issue":"9","first_page":"6084","last_page":"6092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fto-gene","display_name":"FTO","score":0.9350000023841858},{"id":"https://openalex.org/keywords/n6-methyladenosine","display_name":"N6-methyladenosine","score":0.8799999952316284},{"id":"https://openalex.org/keywords/m6a-demethylation","display_name":"m6A demethylation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pkm2","display_name":"PKM2","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mrna-modification","display_name":"mRNA modification","score":0.6179999709129333},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8100000023841858},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4790000021457672},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8090087175369263},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.7266955375671387},{"id":"https://openalex.org/C202199734","wikidata":"https://www.wikidata.org/wiki/Q900386","display_name":"Demethylation","level":5,"score":0.658994197845459},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6449465155601501},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6283053755760193},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5748779773712158},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5215578079223633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47362038493156433},{"id":"https://openalex.org/C2779742787","wikidata":"https://www.wikidata.org/wiki/Q18026064","display_name":"Glypican 3","level":3,"score":0.4657764136791229},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4350031316280365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.322978138923645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3171626925468445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2923237681388855},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20599037408828735},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15514245629310608},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15327534079551697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13975933194160461},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10064762830734253},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:31632576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31632576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6789218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6789218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2990161111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31632576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6789218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6789218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2119621449","https://openalex.org/W2579378735","https://openalex.org/W2770747479","https://openalex.org/W2780860952","https://openalex.org/W2792126617","https://openalex.org/W2805703720","https://openalex.org/W2839771928","https://openalex.org/W2885965305","https://openalex.org/W2891713480","https://openalex.org/W2898521994","https://openalex.org/W2899253639","https://openalex.org/W2901468688","https://openalex.org/W2901655220","https://openalex.org/W2912654445","https://openalex.org/W2921763102","https://openalex.org/W2921990922","https://openalex.org/W2922969171","https://openalex.org/W2922983245","https://openalex.org/W2931058147","https://openalex.org/W2939194362","https://openalex.org/W2941225619","https://openalex.org/W2942683196","https://openalex.org/W2942822940","https://openalex.org/W2943695742","https://openalex.org/W2947674709","https://openalex.org/W2969232224","https://openalex.org/W2980397655"],"related_works":["https://openalex.org/W4289550263","https://openalex.org/W3204273758","https://openalex.org/W2887189912","https://openalex.org/W2062893434","https://openalex.org/W4213454396","https://openalex.org/W2954225372","https://openalex.org/W2799831822","https://openalex.org/W2473115738","https://openalex.org/W2531142332","https://openalex.org/W2568193334"],"abstract_inverted_index":{"N6-methyladenosine":[0],"(m6A)":[1],"acts":[2],"as":[3],"the":[4,19,24,32,38,42,54,66,76,85,92,99,106,112],"most":[5],"common":[6],"mRNA":[7,96],"modification":[8,40],"in":[9,23,37,41,53,79,111],"mammal":[10],"cells.":[11,58],"Fat":[12],"Mass":[13],"and":[14,57,78,83,97,115],"Obesity-associated":[15],"protein":[16],"(FTO)":[17],"is":[18],"firstly":[20],"identified":[21],"demethylase":[22],"m6A":[25,39,117],"modification.":[26,118],"This":[27],"research":[28],"tries":[29],"to":[30,50,65],"discover":[31],"potential":[33],"roles":[34],"of":[35,61,69,73,94,109],"FTO":[36,46,62,74,90,110],"hepatocellular":[43],"carcinoma":[44],"(HCC).":[45],"level":[47],"was":[48,63],"found":[49],"be":[51],"up-regulated":[52],"HCC":[55,70,113],"tissue":[56],"The":[59],"over-expression":[60],"correlated":[64],"poor":[67],"prognosis":[68],"individuals.":[71],"Knockdown":[72],"suppressed":[75],"proliferation":[77],"vivo":[80],"tumor":[81],"growth,":[82],"induced":[84],"G0/G1":[86],"phase":[87],"arrest.":[88],"Mechanically,":[89],"triggered":[91],"demethylation":[93],"PKM2":[95],"accelerated":[98],"translated":[100],"production.":[101],"Overall,":[102],"this":[103],"finding":[104],"suggests":[105],"critical":[107],"function":[108],"oncogenesis":[114],"its":[116]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":23}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}