{"id":"https://openalex.org/W2990109974","doi":null,"title":"Microfluidic Systems For Studying Cell Motility","display_name":"Microfluidic Systems For Studying Cell Motility","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W2990109974","mag":"2990109974"},"language":"en","primary_location":{"id":"pmh:oai:uta-ir.tdl.org:10106/5163","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10106/5163","pdf_url":null,"source":{"id":"https://openalex.org/S4306400392","display_name":"UTA ResearchCommons (University of Texas Arlington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189196454","host_organization_name":"The University of Texas at Arlington","host_organization_lineage":["https://openalex.org/I189196454"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"M.S."},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10106/5163","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037867807","display_name":"Srikanth Vasudevan","orcid":"https://orcid.org/0000-0001-6314-5328","observed_orcids":["https://orcid.org/0000-0001-6314-5328"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Srikanth Vasudevan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6314-5328","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5037867807"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.28299999237060547,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cell-matrix-interactions","display_name":"cell-matrix interactions","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.7549999952316284},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8209999799728394},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.8980000019073486},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.7229999899864197},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/collagen-type-1","display_name":"collagen type 1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.8489999771118164},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":0.7789999842643738},{"id":"https://openalex.org/keywords/microchannel-devices","display_name":"microchannel devices","score":0.6639999747276306},{"id":"https://openalex.org/keywords/single-cell-tracking","display_name":"single-cell tracking","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.5836231112480164},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5136606097221375},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3773842751979828},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3554612994194031},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35009801387786865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28612637519836426},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28378236293792725},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2677459120750427},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2071683406829834},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20021644234657288}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uta-ir.tdl.org:10106/5163","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10106/5163","pdf_url":null,"source":{"id":"https://openalex.org/S4306400392","display_name":"UTA ResearchCommons (University of Texas Arlington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189196454","host_organization_name":"The University of Texas at Arlington","host_organization_lineage":["https://openalex.org/I189196454"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"M.S."},{"id":"mag:2990109974","doi":null,"is_oa":false,"landing_page_url":"https://rc.library.uta.edu/uta-ir/handle/10106/5163","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uta-ir.tdl.org:10106/5163","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10106/5163","pdf_url":null,"source":{"id":"https://openalex.org/S4306400392","display_name":"UTA ResearchCommons (University of Texas Arlington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189196454","host_organization_name":"The University of Texas at Arlington","host_organization_lineage":["https://openalex.org/I189196454"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"M.S."},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W137121887","https://openalex.org/W622330410","https://openalex.org/W1498758340","https://openalex.org/W1505624690","https://openalex.org/W1515660230","https://openalex.org/W1588322702","https://openalex.org/W1613109732","https://openalex.org/W1759648464","https://openalex.org/W1850667805","https://openalex.org/W1868186915","https://openalex.org/W1880815184","https://openalex.org/W1913092726","https://openalex.org/W1964413664","https://openalex.org/W1971500740","https://openalex.org/W1977455576","https://openalex.org/W1979259404","https://openalex.org/W1979712769","https://openalex.org/W1979832807","https://openalex.org/W1985234764","https://openalex.org/W1986172289","https://openalex.org/W1986612792","https://openalex.org/W1991170716","https://openalex.org/W2002545202","https://openalex.org/W2008656304","https://openalex.org/W2012362519","https://openalex.org/W2012758254","https://openalex.org/W2018723867","https://openalex.org/W2019438752","https://openalex.org/W2024286012","https://openalex.org/W2027260033","https://openalex.org/W2027475151","https://openalex.org/W2030450624","https://openalex.org/W2033987226","https://openalex.org/W2036291324","https://openalex.org/W2036564583","https://openalex.org/W2037315654","https://openalex.org/W2037858935","https://openalex.org/W2038782830","https://openalex.org/W2045321300","https://openalex.org/W2049132016","https://openalex.org/W2053216099","https://openalex.org/W2054548538","https://openalex.org/W2057934195","https://openalex.org/W2058800364","https://openalex.org/W2061829345","https://openalex.org/W2068022987","https://openalex.org/W2076970569","https://openalex.org/W2078782272","https://openalex.org/W2081833509","https://openalex.org/W2086641174","https://openalex.org/W2092322285","https://openalex.org/W2100268880","https://openalex.org/W2100699016","https://openalex.org/W2100959692","https://openalex.org/W2103587633","https://openalex.org/W2110685305","https://openalex.org/W2115046420","https://openalex.org/W2120038224","https://openalex.org/W2124112422","https://openalex.org/W2124918094","https://openalex.org/W2130774667","https://openalex.org/W2133862952","https://openalex.org/W2134745814","https://openalex.org/W2138559670","https://openalex.org/W2138872698","https://openalex.org/W2139899744","https://openalex.org/W2142540639","https://openalex.org/W2146369085","https://openalex.org/W2151335185","https://openalex.org/W2152585695","https://openalex.org/W2157794710","https://openalex.org/W2158751879","https://openalex.org/W2158935809","https://openalex.org/W2159378961","https://openalex.org/W2161054601","https://openalex.org/W2163563942","https://openalex.org/W2164562068","https://openalex.org/W2165174685","https://openalex.org/W2165742702","https://openalex.org/W2165926160","https://openalex.org/W2169071534","https://openalex.org/W2171864329","https://openalex.org/W2411780179","https://openalex.org/W2481235601"],"related_works":["https://openalex.org/W2791298693","https://openalex.org/W4386828662","https://openalex.org/W7011366268","https://openalex.org/W7123695504","https://openalex.org/W2130774667","https://openalex.org/W2736158588","https://openalex.org/W1589248154","https://openalex.org/W1989923134","https://openalex.org/W2065965599","https://openalex.org/W2185831992"],"abstract_inverted_index":{"It":[0,203],"is":[1,91,135,315],"very":[2],"imperative":[3],"to":[4,113,118,125,174,281,295,344,354,439,449],"develop":[5],"new":[6,278,437],"in":[7,13,32,38,61,94,99,180,198,264,288,303,420,444,457],"vitro":[8,95],"platforms":[9],"that":[10,18,44,58,97,123,206],"can":[11],"help":[12],"studying":[14,100,348],"the":[15,27,42,48,119,130,169,178,199,207,225,239,254,283,299,327,331,401,407,421,426,441],"complex":[16,300],"interactions":[17,301],"occur":[19],"between":[20,425],"cell-Extracellular":[21],"Matrix":[22],"proteins":[23,155,185,291],"and":[24,52,74,144,171,188,192,220,231,246,252,259,270,292,375,409,430,453],"also":[25,262],"during":[26,50,400],"process":[28],"of":[29,41,83,140,227,311,320,361,388,403,413,423,451,459],"cell":[30,71,85,146,181,200,313,350,404],"migration":[31,73,256,260,314,351,405,424,446],"vivo.":[33],"Such":[34],"tools":[35],"would":[36,455],"facilitate":[37],"better":[39],"understanding":[40],"mechanisms":[43,442],"are":[45,55,59],"employed":[46],"by":[47,150,386],"cells":[49,191,195,233,250,287],"growth":[51,212,226,237],"migration.":[53,414],"There":[54,415],"two":[56,321],"devices":[57],"presented":[60,274],"this":[62,454],"study;":[63],"1)":[64],"Multi-biomolecule":[65,87],"coated":[66,88,382],"lane":[67,89,429],"device":[68,78,90,134,306,318,358,379],"for":[69,79,307,347,411],"unbiased":[70,108],"preferential":[72],"2)":[75],"Novel":[76],"Microchannel":[77,305],"real":[80,308],"time":[81,309,395],"monitoring":[82,310],"tumor":[84,312],"migration.The":[86],"a":[92,145,211,235,277,316,417,436],"basic":[93],"platform":[96,273,438],"helps":[98],"cell-biomolecules":[101],"interaction":[102,110,284],"using":[103,137],"Microfluidics.":[104],"This":[105,272,433],"provides":[106],"an":[107],"cell-ECM":[109],"with":[111,326,352,364,383,447],"up":[112],"20":[114,336],"biomolecules":[115,294],"as":[116,435],"compared":[117],"commercially":[120],"available":[121],"techniques":[122],"restrict":[124],"2":[126],"or":[127],"less":[128],"at":[129],"same":[131],"time.":[132],"The":[133,248,356,378],"fabricated":[136],"PDMS":[138,151],"consisting":[139,319],"multiple":[141],"protein":[142],"lanes":[143,170,240,265,363],"seeding":[147,201,387],"area":[148],"separated":[149],"barrier.":[152],"Different":[153,394],"ECM":[154],"(fibronectin,":[156],"laminin,":[157],"collagen":[158,216,242,267],"type":[159,217,243],"1,":[160,218,244],"vitronectin,":[161],"bovine":[162],"serum":[163],"albumin,":[164],"Aggrecan)":[165],"were":[166,172,186,196,398],"seeded":[167,197],"into":[168],"allowed":[173],"be":[175],"absorbed":[176],"on":[177,257,298],"substrate":[179,380],"culture":[182],"incubator.":[183],"Unbound":[184],"washed":[187],"mammalian":[189],"neuronal":[190],"humanvGlioblastoma":[193],"Multiforme":[194,392],"area.":[202],"was":[204,261,381,416],"seen":[205],"cortical":[208],"neurons":[209,230],"showed":[210,234,253],"towards":[213,238,290,330],"Laminin,":[214],"fibronectin,":[215],"vitronectin":[219],"BSA":[221],"but":[222],"Aggrecan":[223],"inhibited":[224],"axons.":[228],"DRG":[229],"Schwann":[232],"robust":[236],"containing":[241,266],"fibronectin":[245,269],"Laminin.":[247],"hGBM":[249],"migrated":[251],"maximum":[255],"Laminin":[258],"observed":[263],"type1,":[268],"BSA.":[271],"here":[275],"introduces":[276],"scientific":[279],"technique":[280],"study":[282],"if":[285],"different":[286,322,365],"interest":[289],"other":[293,357],"throw":[296],"light":[297],"occurring":[302],"vivo.Novel":[304],"microfluidic":[317],"microchannel":[323],"patterns;":[324],"one":[325],"channels":[328,408],"tapering":[329],"distal":[332],"end":[333],"reservoir":[334],"(from":[335],"\u03bcm,":[337,339,341,368,370,372],"15":[338,369,431],"10":[340,371],"8":[342,373],"\u03bcm":[343,374],"5":[345,376,427],"\u03bcm)":[346],"single":[349],"respect":[353,448],"space.":[355],"design":[359],"consists":[360],"adjacent":[362],"dimensions":[366],"(20":[367],"\u03bcm).":[377],"laminin":[384],"followed":[385],"primary":[389],"human":[390],"Glioblastoma":[391],"cells.":[393],"point":[396],"images":[397],"taken":[399],"course":[402],"through":[406],"quantified":[410],"rate":[412,422],"significant":[418],"difference":[419],"um":[428],"um.":[432],"serves":[434],"understand":[440],"involved":[443],"cancer":[445],"availability":[450],"space":[452],"contribute":[456],"betterment":[458],"current":[460],"treatment":[461],"procedures.":[462]},"counts_by_year":[],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2019-12-05T00:00:00"}