{"id":"https://openalex.org/W2990104767","doi":"https://doi.org/10.1071/rdv32n2ab43","title":"43 Actions of colony-stimulating factor 3 on the maturing oocyte and developing embryo in cattle","display_name":"43 Actions of colony-stimulating factor 3 on the maturing oocyte and developing embryo in cattle","publication_year":2019,"publication_date":"2019-12-02","ids":{"openalex":"https://openalex.org/W2990104767","doi":"https://doi.org/10.1071/rdv32n2ab43","mag":"2990104767"},"language":"en","primary_location":{"id":"doi:10.1071/rdv32n2ab43","doi":"https://doi.org/10.1071/rdv32n2ab43","is_oa":false,"landing_page_url":"https://doi.org/10.1071/rdv32n2ab43","pdf_url":null,"source":{"id":"https://openalex.org/S199941106","display_name":"Reproduction Fertility and Development","issn_l":"1031-3613","issn":["1031-3613","1448-5990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320302","host_organization_name":"CSIRO Publishing","host_organization_lineage":["https://openalex.org/P4310320302"],"host_organization_lineage_names":["CSIRO Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction, Fertility and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053846972","display_name":"Elizabeth A. Jannaman","orcid":"https://orcid.org/0000-0003-2461-6793","observed_orcids":["https://orcid.org/0000-0003-2461-6793"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Jannaman","raw_affiliation_strings":["AUniversity of Florida, Gainesville, FL, USA","University of Florida, Gainesville FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AUniversity of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115603285","display_name":"Yao Xiao","orcid":"https://orcid.org/0000-0002-5153-6839","observed_orcids":["https://orcid.org/0000-0002-5153-6839"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Xiao","raw_affiliation_strings":["AUniversity of Florida, Gainesville, FL, USA","University of Florida, Gainesville FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AUniversity of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028606515","display_name":"Peter James Hansen","orcid":"https://orcid.org/0000-0003-3061-9333","observed_orcids":["https://orcid.org/0000-0003-3061-9333"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Hansen","raw_affiliation_strings":["AUniversity of Florida, Gainesville, FL, USA","University of Florida, Gainesville FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AUniversity of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, Gainesville FL, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":0.2314,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.6123086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"32","issue":"2","first_page":"147","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bovine-oocyte-maturation","display_name":"bovine oocyte maturation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.8220000267028809},{"id":"https://openalex.org/keywords/embryo-developmental-competence","display_name":"embryo developmental competence","score":0.7580000162124634},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.4490000009536743},{"id":"https://openalex.org/keywords/cyp11a1","display_name":"CYP11A1","score":0.7639999985694885},{"id":"https://openalex.org/keywords/notch2","display_name":"Notch2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sex-sorted-semen","display_name":"sex-sorted semen","score":0.5019999742507935},{"id":"https://openalex.org/keywords/cattle-embryo-development","display_name":"cattle embryo development","score":0.3840000033378601},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.3779999911785126},{"id":"https://openalex.org/keywords/embryo-culture-medium-supplementation","display_name":"embryo culture medium supplementation","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.8631640076637268},{"id":"https://openalex.org/C28748434","wikidata":"https://www.wikidata.org/wiki/Q170145","display_name":"Zygote","level":4,"score":0.8187013864517212},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.748801589012146},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.73960942029953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7376120686531067},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6227938532829285},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5711264610290527},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.44685062766075134},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38373851776123047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32913076877593994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09350430965423584},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1071/rdv32n2ab43","doi":"https://doi.org/10.1071/rdv32n2ab43","is_oa":false,"landing_page_url":"https://doi.org/10.1071/rdv32n2ab43","pdf_url":null,"source":{"id":"https://openalex.org/S199941106","display_name":"Reproduction Fertility and Development","issn_l":"1031-3613","issn":["1031-3613","1448-5990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320302","host_organization_name":"CSIRO Publishing","host_organization_lineage":["https://openalex.org/P4310320302"],"host_organization_lineage_names":["CSIRO Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction, Fertility and Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3016128965","https://openalex.org/W2030472887","https://openalex.org/W2065967978","https://openalex.org/W2166184653","https://openalex.org/W1972640373","https://openalex.org/W7139086673","https://openalex.org/W3011750488","https://openalex.org/W2145945728","https://openalex.org/W1978317635","https://openalex.org/W2187956021"],"abstract_inverted_index":{"Colony-stimulating":[0],"factor":[1],"3":[2],"(CSF3),":[3],"also":[4],"known":[5],"as":[6],"granulocyte":[7],"colony-stimulating":[8],"factor,":[9],"has":[10],"been":[11],"reported":[12],"to":[13,26,58,63,109,260,273,333],"improve":[14],"blastocyst":[15,65,111,275],"yield":[16],"when":[17,35],"administered":[18],"during":[19,51],"oocyte":[20,50,326],"maturation":[21,52],"in":[22,30,91,144,197],"the":[23,48,55,64,110,122,151,217,220,229,274,331,337,343],"pig":[24],"and":[25,87,130,175,251,306,310,313,328,345],"increase":[27],"pregnancy":[28],"outcomes":[29],"specific":[31],"IVF":[32],"patient":[33],"populations":[34],"infused":[36],"transvaginally.":[37],"Here,":[38],"we":[39],"tested":[40],"whether":[41],"recombinant":[42],"bovine":[43,49],"CSF3":[44,102,167,247,270],"can":[45,324],"act":[46,329],"on":[47,54,103,107,219,228,271,330],"or":[53,77,106,163,187,203,216,227,234],"developing":[56],"embryo":[57,332],"modify":[59],"competence":[60,327],"for":[61,94,141,168,190,279],"development":[62,108,272],"stage.":[66,276],"For":[67,177,244],"Experiment":[68,178,245],"1,":[69,75,201,249],"oocytes":[70],"were":[71,84,89,182,195],"matured":[72],"with":[73,184],"0,":[74,200],"10,":[76,202,250],"100":[78,115,204,252,291],"ng":[79,116,205,253,292],"mL\u22121":[80,117,206,293],"of":[81,101,124,139,166,207,213,222,231,262,269,282,294,298,322,336],"CSF3.":[82,208],"Oocytes":[83],"then":[85],"fertilised":[86,183],"embryos":[88,132,236],"cultured":[90,196],"serum-free":[92],"medium":[93,198],"7.5":[95,261],"days.":[96],"There":[97,209],"was":[98,146,156,210,241,255,266,285,340],"no":[99,211,267],"effect":[100,212,268],"cleavage":[104],"rate":[105],"stage":[112],"except":[113],"that":[114,225,319],"reduced":[118],"(P":[119,127,133,158,287],"=":[120,128,134],"0.0366)":[121,129],"percentage":[123,221,230],"putative":[125,223,232],"zygotes":[126,194,224,233],"cleaved":[131,226,235],"0.0254)":[135],"becoming":[136,237],"blastocysts.":[137,238],"Expression":[138],"transcripts":[140],"93":[142],"genes":[143,170,284],"blastocysts":[145],"evaluated":[147],"by":[148,161,290,342],"RT-PCR":[149],"using":[150],"Fluidigm":[152],"platform.":[153],"Transcript":[154,277],"abundance":[155,278],"affected":[157],"<":[159,288],"0.05)":[160,289],"one":[162],"more":[164],"concentrations":[165,321],"4":[169,259],"only":[171],"(CYP11A1,":[172],"NOTCH2,":[173],"RAC1,":[174],"YAP1).":[176],"2,":[179],"cumulus-oocyte":[180],"complexes":[181],"either":[185],"X-":[186],"Y-sorted":[188],"semen":[189],"18-22":[191],"h.":[192],"Putative":[193],"containing":[199],"CSF3,":[214,295],"sex,":[215],"interaction":[218],"Gene":[239],"expression":[240],"not":[242],"determined.":[243],"3,":[246],"(0,":[248],"mL\u22121)":[254],"added":[256],"from":[257],"Day":[258],"development.":[263],"Again,":[264],"there":[265],"a":[280],"total":[281],"10":[283],"increased":[286],"including":[296],"markers":[297],"epiblast":[299,309],"(NANOG,":[300],"SOX2),":[301],"hypoblast":[302,311],"(ALPL,":[303],"FN1,":[304],"KDM2B,":[305],"PDGFRA),":[307],"both":[308],"(HNF4A),":[312],"trophectoderm":[314],"(TJAP1).":[315],"Results":[316],"are":[317],"indicative":[318],"high":[320],"CSF2":[323],"reduce":[325],"affect":[334],"characteristics":[335],"blastocyst.":[338],"Support":[339],"provided":[341],"Elanco":[344],"Larson":[346],"Endowment":[347],"Fund.":[348]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-12-05T00:00:00"}