{"id":"https://openalex.org/W2989940110","doi":null,"title":"Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis.","display_name":"Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis.","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2989940110","mag":"2989940110","pmid":"https://pubmed.ncbi.nlm.nih.gov/31214480","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6538399"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5544429","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6538399","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6538399","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007988649","display_name":"Laetitia Pouzol","orcid":"https://orcid.org/0000-0001-8727-1142","observed_orcids":["https://orcid.org/0000-0001-8727-1142"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I4405257665","display_name":"Idorsia Pharmaceuticals Ltd (Switzerland)","ror":"https://ror.org/05j00sy30","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210136915","https://openalex.org/I4405257665"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["AU","CH"],"is_corresponding":false,"raw_author_name":"Laetitia Pouzol","raw_affiliation_strings":["Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665"]},{"raw_affiliation_string":"Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085181623","display_name":"Luca Piali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I4405257665","display_name":"Idorsia Pharmaceuticals Ltd (Switzerland)","ror":"https://ror.org/05j00sy30","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210136915","https://openalex.org/I4405257665"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["AU","CH"],"is_corresponding":false,"raw_author_name":"Luca Piali","raw_affiliation_strings":["Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665"]},{"raw_affiliation_string":"Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103026431","display_name":"Claude C.A. Bernard","orcid":"https://orcid.org/0000-0003-2816-5328","observed_orcids":["https://orcid.org/0000-0003-2816-5328"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I4405257665","display_name":"Idorsia Pharmaceuticals Ltd (Switzerland)","ror":"https://ror.org/05j00sy30","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210136915","https://openalex.org/I4405257665"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["AU","CH"],"is_corresponding":false,"raw_author_name":"Claude Ca Bernard","raw_affiliation_strings":["Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665"]},{"raw_affiliation_string":"Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081955261","display_name":"Marianne M. A. Martinic","orcid":"https://orcid.org/0000-0003-4407-3423","observed_orcids":["https://orcid.org/0000-0003-4407-3423"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I4405257665","display_name":"Idorsia Pharmaceuticals Ltd (Switzerland)","ror":"https://ror.org/05j00sy30","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210136915","https://openalex.org/I4405257665"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["AU","CH"],"is_corresponding":false,"raw_author_name":"Marianne M Martinic","raw_affiliation_strings":["Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665"]},{"raw_affiliation_string":"Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081189299","display_name":"Beat Steiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I4405257665","display_name":"Idorsia Pharmaceuticals Ltd (Switzerland)","ror":"https://ror.org/05j00sy30","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210136915","https://openalex.org/I4405257665"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["AU","CH"],"is_corresponding":false,"raw_author_name":"Beat Steiner","raw_affiliation_strings":["Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665"]},{"raw_affiliation_string":"Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020829373","display_name":"Martine Clozel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I4405257665","display_name":"Idorsia Pharmaceuticals Ltd (Switzerland)","ror":"https://ror.org/05j00sy30","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210136915","https://openalex.org/I4405257665"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["AU","CH"],"is_corresponding":false,"raw_author_name":"Martine Clozel","raw_affiliation_strings":["Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Pouzol and Clozel were with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and are presently with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Piali was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research, and is presently with Hoffmann la Roche in Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I95056601"]},{"raw_affiliation_string":"Dr. Bernard is with Monash University, Faculty of Medicine, Nursing & Health Sciences in Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Dr. Martinic is with Idorsia Pharmaceuticals Ltd. in Allschwil, Switzerland","institution_ids":["https://openalex.org/I4405257665"]},{"raw_affiliation_string":"Dr. Steiner was with Actelion Pharmaceuticals Ltd. in Allschwil, Switzerland, at the time of this research","institution_ids":["https://openalex.org/I95056601"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6608,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.81733616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"3-4","first_page":"22","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ponesimod","display_name":"ponesimod","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dimethyl-fumarate","display_name":"dimethyl fumarate","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/disease-activity-control","display_name":"disease activity control","score":0.7039999961853027},{"id":"https://openalex.org/keywords/oral-disease-modifying-therapies","display_name":"oral disease-modifying therapy","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8671317100524902},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.6643115282058716},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.6551567912101746},{"id":"https://openalex.org/C2779357208","wikidata":"https://www.wikidata.org/wiki/Q6947292","display_name":"Myelin oligodendrocyte glycoprotein","level":4,"score":0.6509683728218079},{"id":"https://openalex.org/C2776819417","wikidata":"https://www.wikidata.org/wiki/Q418123","display_name":"Dimethyl fumarate","level":3,"score":0.6258049011230469},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5749383568763733},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5378469824790955},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.46505603194236755},{"id":"https://openalex.org/C2776036978","wikidata":"https://www.wikidata.org/wiki/Q425137","display_name":"Fingolimod","level":3,"score":0.45494911074638367},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4210554361343384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3660871982574463},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2433299720287323}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5544429","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6538399","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31214480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31214480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovations in clinical neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6538399","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6538399/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Clin Neurosci","raw_type":"Text"},{"id":"mag:2989940110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31214480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5544429","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6538399","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1523338791","https://openalex.org/W1590241149","https://openalex.org/W1654241956","https://openalex.org/W1943407914","https://openalex.org/W1967838438","https://openalex.org/W1978094617","https://openalex.org/W1981879391","https://openalex.org/W1986991730","https://openalex.org/W1994397357","https://openalex.org/W1995089232","https://openalex.org/W1999493557","https://openalex.org/W2006985918","https://openalex.org/W2019582599","https://openalex.org/W2022905263","https://openalex.org/W2027129171","https://openalex.org/W2029828395","https://openalex.org/W2030830834","https://openalex.org/W2031818503","https://openalex.org/W2035208392","https://openalex.org/W2045806831","https://openalex.org/W2051165446","https://openalex.org/W2056366270","https://openalex.org/W2061806673","https://openalex.org/W2068690343","https://openalex.org/W2068857175","https://openalex.org/W2070669288","https://openalex.org/W2093009907","https://openalex.org/W2095707498","https://openalex.org/W2097593378","https://openalex.org/W2102478723","https://openalex.org/W2104948944","https://openalex.org/W2123061840","https://openalex.org/W2124841143","https://openalex.org/W2134242739","https://openalex.org/W2138965836","https://openalex.org/W2148766438","https://openalex.org/W2153518194","https://openalex.org/W2154089780","https://openalex.org/W2156726966","https://openalex.org/W2158202057","https://openalex.org/W2167117206","https://openalex.org/W2167876561","https://openalex.org/W2172138286","https://openalex.org/W2340805753","https://openalex.org/W2400748902","https://openalex.org/W2415292231","https://openalex.org/W2565488452","https://openalex.org/W2597919924","https://openalex.org/W2759598986","https://openalex.org/W2767157758","https://openalex.org/W2792534498","https://openalex.org/W2794813666"],"related_works":["https://openalex.org/W2893673753","https://openalex.org/W4412441076","https://openalex.org/W4311331041","https://openalex.org/W6979214508","https://openalex.org/W4296392127","https://openalex.org/W4307049900","https://openalex.org/W4415143261","https://openalex.org/W3149798718","https://openalex.org/W4200181850","https://openalex.org/W1980976372"],"abstract_inverted_index":{"The":[0],"results":[1,23],"support":[2],"the":[3,22],"potential":[4],"therapeutic":[5],"benefits":[6],"of":[7,36],"combining":[8,26],"ponesimod":[9,27],"with":[10,19,28,45],"DMF":[11],"to":[12,43],"improve":[13],"disease":[14],"activity":[15],"control":[16],"in":[17],"patients":[18,44],"MS.":[20,46],"Additionally,":[21],"suggest":[24],"that":[25,32],"other":[29],"oral":[30],"agents":[31],"have":[33],"different":[34],"mechanisms":[35],"action":[37],"might":[38],"also":[39],"be":[40],"therapeutically":[41],"beneficial":[42]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-05T00:00:00"}
