{"id":"https://openalex.org/W2989745522","doi":"https://doi.org/10.1101/855346","title":"Escort-like somatic cells mediate early mouse fetal ovarian development but surface-derived Lgr5+ cells support primordial follicles","display_name":"Escort-like somatic cells mediate early mouse fetal ovarian development but surface-derived Lgr5+ cells support primordial follicles","publication_year":2019,"publication_date":"2019-11-26","ids":{"openalex":"https://openalex.org/W2989745522","doi":"https://doi.org/10.1101/855346","mag":"2989745522"},"language":"en","primary_location":{"id":"doi:10.1101/855346","doi":"https://doi.org/10.1101/855346","is_oa":true,"landing_page_url":"https://doi.org/10.1101/855346","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/855346","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043560926","display_name":"Wanbao Niu","orcid":"https://orcid.org/0000-0002-3182-3259","observed_orcids":["https://orcid.org/0000-0002-3182-3259"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanbao Niu","raw_affiliation_strings":["Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016264819","display_name":"Allan C. Spradling","orcid":"https://orcid.org/0000-0002-5251-1801","observed_orcids":["https://orcid.org/0000-0002-5251-1801"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan C. Spradling","raw_affiliation_strings":["Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016264819"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I196817621","https://openalex.org/I4210117844"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-development","display_name":"ovarian development","score":0.8230000138282776},{"id":"https://openalex.org/keywords/lgr5-cells","display_name":"Lgr5+ cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ovarian-surface-epithelium","display_name":"ovarian surface epithelium","score":0.8100000023841858},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/primordial-follicles","display_name":"primordial follicles","score":0.9480000138282776},{"id":"https://openalex.org/keywords/wnt4","display_name":"Wnt4","score":0.7710000276565552},{"id":"https://openalex.org/keywords/germline-cysts","display_name":"germline cysts","score":0.6790000200271606},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.4699999988079071},{"id":"https://openalex.org/keywords/evolutionary-conservation","display_name":"evolutionary conservation","score":0.4429999887943268},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8023865222930908},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.7974869012832642},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.6925345659255981},{"id":"https://openalex.org/C2781430442","wikidata":"https://www.wikidata.org/wiki/Q15321841","display_name":"WNT4","level":4,"score":0.6105330586433411},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5853562355041504},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.526646614074707},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4408864974975586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33876872062683105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20817404985427856},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.20585083961486816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19922369718551636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06579941511154175},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/855346","doi":"https://doi.org/10.1101/855346","is_oa":true,"landing_page_url":"https://doi.org/10.1101/855346","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/12149910","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/poster/Escort-like_somatic_cells_mediate_early_mouse_fetal_ovarian_development_but_surface-derived_LGR5_cells_support_primordial_follicles/12149910","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Poster"},{"id":"doi:10.6084/m9.figshare.12149910.v1","doi":"https://doi.org/10.6084/m9.figshare.12149910.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.12149910.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Poster"}],"best_oa_location":{"id":"doi:10.1101/855346","doi":"https://doi.org/10.1101/855346","is_oa":true,"landing_page_url":"https://doi.org/10.1101/855346","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W208781828","https://openalex.org/W566805059","https://openalex.org/W1042955896","https://openalex.org/W1498970130","https://openalex.org/W1534163224","https://openalex.org/W1575506668","https://openalex.org/W1910221226","https://openalex.org/W1964763257","https://openalex.org/W1966921340","https://openalex.org/W1972454580","https://openalex.org/W1978317619","https://openalex.org/W1986699895","https://openalex.org/W1988344228","https://openalex.org/W1994216131","https://openalex.org/W1995377029","https://openalex.org/W2005925459","https://openalex.org/W2006059948","https://openalex.org/W2006389441","https://openalex.org/W2012402101","https://openalex.org/W2018421328","https://openalex.org/W2022341048","https://openalex.org/W2030095917","https://openalex.org/W2031287458","https://openalex.org/W2036395605","https://openalex.org/W2043975801","https://openalex.org/W2044203359","https://openalex.org/W2044283072","https://openalex.org/W2048294889","https://openalex.org/W2050395183","https://openalex.org/W2054496326","https://openalex.org/W2055911575","https://openalex.org/W2061776278","https://openalex.org/W2064695569","https://openalex.org/W2067135122","https://openalex.org/W2067338267","https://openalex.org/W2071040218","https://openalex.org/W2078563810","https://openalex.org/W2082011400","https://openalex.org/W2087053296","https://openalex.org/W2096413852","https://openalex.org/W2099448734","https://openalex.org/W2111265072","https://openalex.org/W2114692975","https://openalex.org/W2124943870","https://openalex.org/W2129504414","https://openalex.org/W2133403778","https://openalex.org/W2134710117","https://openalex.org/W2138818297","https://openalex.org/W2143526409","https://openalex.org/W2144089726","https://openalex.org/W2146635117","https://openalex.org/W2147229982","https://openalex.org/W2148070806","https://openalex.org/W2162298564","https://openalex.org/W2163819958","https://openalex.org/W2175596213","https://openalex.org/W2215595807","https://openalex.org/W2217269418","https://openalex.org/W2269758801","https://openalex.org/W2303706388","https://openalex.org/W2397588214","https://openalex.org/W2463001323","https://openalex.org/W2486234036","https://openalex.org/W2535629412","https://openalex.org/W2594728656","https://openalex.org/W2601560871","https://openalex.org/W2747877289","https://openalex.org/W2773012129","https://openalex.org/W2786262159","https://openalex.org/W2794480084","https://openalex.org/W2804412818","https://openalex.org/W2894831682","https://openalex.org/W2899314508","https://openalex.org/W2918088085","https://openalex.org/W2924322433","https://openalex.org/W2944047992","https://openalex.org/W2951506174","https://openalex.org/W2983824808","https://openalex.org/W2999682815","https://openalex.org/W4233481311"],"related_works":["https://openalex.org/W3047354140","https://openalex.org/W2031287458","https://openalex.org/W2148846811","https://openalex.org/W2980244547","https://openalex.org/W3118104863","https://openalex.org/W2147229982","https://openalex.org/W7214641071","https://openalex.org/W7204175476","https://openalex.org/W3156220749","https://openalex.org/W4399221645"],"abstract_inverted_index":{"Abstract":[0],"Ovarian":[1],"murine":[2],"somatic":[3,29,41,147],"cells":[4,33,42,46,52,69,81,95,102,121],"are":[5],"essential":[6],"to":[7,135],"form":[8],"first":[9,72,131],"wave":[10,15,73,128,132],"medullar":[11,62],"follicles":[12,133],"and":[13,30,36,53,88,106,138,156],"second":[14,127],"primordial":[16,104],"follicles.":[17,74],"Using":[18],"single":[19],"cell":[20,148],"RNA":[21],"sequencing":[22],"we":[23,43],"characterized":[24],"the":[25,61,67,84,97],"transcriptomes":[26],"of":[27,57,70,100,119],"both":[28,58],"germline":[31,151],"ovarian":[32,85],"during":[34],"fetal":[35],"early":[37,54],"neonatal":[38],"development.":[39],"Wnt4-expressing":[40],"term":[44],"\u201cescort-like":[45],"(ELCs)\u201d":[47],"interact":[48],"with":[49],"incoming":[50],"germ":[51],"developing":[55],"cysts":[56],"sexes.":[59],"In":[60,75],"region,":[63],"ELCs":[64],"differentiate":[65],"into":[66],"granulosa":[68,101],"fast-growing":[71],"contrast,":[76],"after":[77],"E12.5,":[78],"Lgr5+":[79,120],"pre-granulosa":[80],"ingress":[82],"from":[83,110],"surface":[86],"epithelium":[87],"replace":[89],"cortical":[90],"escort-like":[91],"cells.":[92],"These":[93],"surface-derived":[94],"become":[96],"main":[98],"population":[99],"supporting":[103,150],"follicles,":[105,129],"differ":[107],"in":[108,154],"transcription":[109],"ELC":[111],"derivatives.":[112],"Reflecting":[113],"their":[114],"different":[115],"cellular":[116],"origins,":[117],"ablation":[118],"at":[122],"E16.5":[123],"using":[124],"Lgr5-DTR-EGFP":[125],"eliminates":[126],"but":[130],"continue":[134],"develop":[136],"normally":[137],"support":[139],"fertility.":[140],"Our":[141],"findings":[142],"provide":[143],"striking":[144],"evidence":[145],"that":[146],"behavior":[149],"cyst":[152],"development":[153],"mice":[155],"Drosophila":[157],"has":[158],"been":[159],"evolutionarily":[160],"conserved.":[161]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}
