{"id":"https://openalex.org/W2989736192","doi":"https://doi.org/10.1038/s41398-019-0657-5","title":"Childhood intelligence attenuates the association between biological ageing and health outcomes in later life","display_name":"Childhood intelligence attenuates the association between biological ageing and health outcomes in later life","publication_year":2019,"publication_date":"2019-11-28","ids":{"openalex":"https://openalex.org/W2989736192","doi":"https://doi.org/10.1038/s41398-019-0657-5","mag":"2989736192","pmid":"https://pubmed.ncbi.nlm.nih.gov/31780646","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6883059"},"language":"en","primary_location":{"id":"doi:10.1038/s41398-019-0657-5","doi":"https://doi.org/10.1038/s41398-019-0657-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-019-0657-5","pdf_url":"https://www.nature.com/articles/s41398-019-0657-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41398-019-0657-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020054146","display_name":"Anna J. Stevenson","orcid":"https://orcid.org/0000-0002-0435-3562","observed_orcids":["https://orcid.org/0000-0002-0435-3562"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna J. Stevenson","raw_affiliation_strings":["Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039534831","display_name":"Daniel L. McCartney","orcid":"https://orcid.org/0000-0003-3242-0360","observed_orcids":["https://orcid.org/0000-0003-3242-0360"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel L. McCartney","raw_affiliation_strings":["Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057514003","display_name":"Robert Francis Hillary","orcid":"https://orcid.org/0000-0002-2595-552X","observed_orcids":["https://orcid.org/0000-0002-2595-552X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert F. Hillary","raw_affiliation_strings":["Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065331652","display_name":"Paul H. Redmond","orcid":"https://orcid.org/0000-0001-8272-8596","observed_orcids":["https://orcid.org/0000-0001-8272-8596"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Redmond","raw_affiliation_strings":["Department for Psychology, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Psychology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107192894","display_name":"Adele M. Taylor","orcid":"https://orcid.org/0000-0003-4541-4568","observed_orcids":["https://orcid.org/0000-0003-4541-4568"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adele M. Taylor","raw_affiliation_strings":["Department for Psychology, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Psychology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401607","display_name":"Qian Zhang","orcid":"https://orcid.org/0000-0002-0769-1057","observed_orcids":["https://orcid.org/0000-0002-0769-1057"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Qian Zhang","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025726582","display_name":"Allan F. McRae","orcid":"https://orcid.org/0000-0001-5286-5485","observed_orcids":["https://orcid.org/0000-0001-5286-5485"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Allan F. McRae","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088747780","display_name":"Tara L. Spires\u2010Jones","orcid":"https://orcid.org/0000-0003-2530-0598","observed_orcids":["https://orcid.org/0000-0003-2530-0598"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tara L. Spires-Jones","raw_affiliation_strings":["Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK","UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007623614","display_name":"Andrew Mark McIntosh","orcid":"https://orcid.org/0000-0002-0198-4588","observed_orcids":["https://orcid.org/0000-0002-0198-4588"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew M. McIntosh","raw_affiliation_strings":["Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"raw_orcid":"https://orcid.org/0000-0002-0198-4588","affiliations":[{"raw_affiliation_string":"Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049892384","display_name":"Ian J. Deary","orcid":"https://orcid.org/0000-0002-1733-263X","observed_orcids":["https://orcid.org/0000-0002-1733-263X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian J. Deary","raw_affiliation_strings":["Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK","Department for Psychology, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Department for Psychology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066436360","display_name":"Riccardo Emilio Marioni","orcid":"https://orcid.org/0000-0003-4430-4260","observed_orcids":["https://orcid.org/0000-0003-4430-4260"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Riccardo E. Marioni","raw_affiliation_strings":["Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk","Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk","Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK","Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066436360"],"corresponding_institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"],"apc_list":{"value":4095,"currency":"USD","value_usd":4095},"apc_paid":{"value":4095,"currency":"USD","value_usd":4095},"fwci":0.9922,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.73798797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"323","last_page":"323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-age-acceleration","display_name":"epigenetic age acceleration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.765999972820282},{"id":"https://openalex.org/keywords/children-s-intelligence","display_name":"child intelligence","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cognitive-ability","display_name":"cognitive ability","score":0.6740000247955322},{"id":"https://openalex.org/keywords/educational-attainment","display_name":"educational attainment","score":0.9679999947547913},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6840000152587891},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8460000157356262},{"id":"https://openalex.org/keywords/phenome-wide-association-study","display_name":"phenome-wide association study","score":0.7450000047683716},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.6259999871253967},{"id":"https://openalex.org/keywords/early-life-factors","display_name":"early life factors","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.6157891154289246},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5308830738067627},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.513067364692688},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4992241859436035},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.45809394121170044},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4403870105743408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43986976146698},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3457448482513428},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.24147158861160278},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08159738779067993}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004522","descriptor_name":"Educational Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007360","descriptor_name":"Intelligence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41398-019-0657-5","doi":"https://doi.org/10.1038/s41398-019-0657-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-019-0657-5","pdf_url":"https://www.nature.com/articles/s41398-019-0657-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},{"id":"doi:10.1101/588293","doi":"https://doi.org/10.1101/588293","is_oa":true,"landing_page_url":"https://doi.org/10.1101/588293","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/03/25/588293.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:6883059","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6883059","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry","raw_type":"Text"},{"id":"pmid:31780646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31780646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/fb3e6639-afa7-4d26-84dc-04d02a691513","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/fb3e6639-afa7-4d26-84dc-04d02a691513","pdf_url":"https://www.research.ed.ac.uk/files/123416719/s41398_019_0657_5.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stevenson, A, McCartney, D L, Hillary, R, Redmond, P, Taylor, A, Zhang, Q, McRae, A, Spires-Jones, T, McIntosh, A, Deary, I & Marioni, R 2019, 'Childhood intelligence attenuates the association between biological ageing and health outcomes in later life', Translational Psychiatry, vol. 9, 323. https://doi.org/10.1038/s41398-019-0657-5","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:a4fcb76e8d4448d584377423d94fff17","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a4fcb76e8d4448d584377423d94fff17","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry, Vol 9, Iss 1, Pp 1-8 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41398-019-0657-5","doi":"https://doi.org/10.1038/s41398-019-0657-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-019-0657-5","pdf_url":"https://www.nature.com/articles/s41398-019-0657-5.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1184531726","display_name":null,"funder_award_id":"MR/K026992/1","funder_id":"https://openalex.org/F4320320332","funder_display_name":"University of Edinburgh"},{"id":"https://openalex.org/G1394528540","display_name":"Centre for Cognitive Ageing &amp; Cognitive Epidemiology","funder_award_id":"MR/K026992/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1830711314","display_name":"Translational Neuroscience - training the next generation of basic neuroscientists to embrace clinical research.","funder_award_id":"108890","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2352317866","display_name":null,"funder_award_id":"MR/K026992/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G259633682","display_name":null,"funder_award_id":"104036/Z/14/Z","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2730595978","display_name":null,"funder_award_id":"108890/Z/15/Z","funder_id":"https://openalex.org/F4320320332","funder_display_name":"University of Edinburgh"},{"id":"https://openalex.org/G3561803360","display_name":null,"funder_award_id":"LBC1936","funder_id":"https://openalex.org/F4320320332","funder_display_name":"University of Edinburgh"},{"id":"https://openalex.org/G3669141092","display_name":null,"funder_award_id":"MR/M01311/1","funder_id":"https://openalex.org/F4320320201","funder_display_name":"Age UK"},{"id":"https://openalex.org/G3933842093","display_name":null,"funder_award_id":"MR/K026992/1","funder_id":"https://openalex.org/F4320329087","funder_display_name":"Centre for Cognitive Ageing and Cognitive Epidemiology"},{"id":"https://openalex.org/G3996179666","display_name":null,"funder_award_id":"MR/M01311/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4310415265","display_name":"Stratifying Resilience and Depression Longitudinally (STRADL)","funder_award_id":"104036/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4641403149","display_name":null,"funder_award_id":"BB/F019394/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G483280169","display_name":null,"funder_award_id":"ARUK-PG2017B\u221210","funder_id":"https://openalex.org/F4320321081","funder_display_name":"Alzheimer\u2019s Research UK"},{"id":"https://openalex.org/G5067462658","display_name":null,"funder_award_id":"MR/K026992/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6275292782","display_name":"Stratifying Resilience and Depression Longitudinally (STRADL)","funder_award_id":"104036","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G666546157","display_name":null,"funder_award_id":"LBC1936","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6868616705","display_name":null,"funder_award_id":"/Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7010169560","display_name":"A genome-wide association study of non-pathological cognitive ageing","funder_award_id":"BB/F019394/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G718988473","display_name":null,"funder_award_id":"LBC1936","funder_id":"https://openalex.org/F4320320201","funder_display_name":"Age UK"},{"id":"https://openalex.org/G7771854671","display_name":null,"funder_award_id":"MR/K026992/1","funder_id":"https://openalex.org/F4320320201","funder_display_name":"Age UK"},{"id":"https://openalex.org/G8733687393","display_name":null,"funder_award_id":"LBC1936","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G9000063527","display_name":null,"funder_award_id":"108890/Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320320201","display_name":"Age UK","ror":"https://ror.org/050x9d346"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320320332","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90"},{"id":"https://openalex.org/F4320320984","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422"},{"id":"https://openalex.org/F4320321081","display_name":"Alzheimer\u2019s Research UK","ror":"https://ror.org/02ymzm013"},{"id":"https://openalex.org/F4320329087","display_name":"Centre for Cognitive Ageing and Cognitive Epidemiology","ror":null},{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2989736192.pdf","grobid_xml":"https://content.openalex.org/works/W2989736192.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1487542991","https://openalex.org/W1616789613","https://openalex.org/W1948861157","https://openalex.org/W1951724000","https://openalex.org/W1968530262","https://openalex.org/W1972757244","https://openalex.org/W1974047233","https://openalex.org/W1982595763","https://openalex.org/W1985305462","https://openalex.org/W1992354224","https://openalex.org/W1998446689","https://openalex.org/W2073145939","https://openalex.org/W2075862945","https://openalex.org/W2081778785","https://openalex.org/W2082402714","https://openalex.org/W2087211736","https://openalex.org/W2101043501","https://openalex.org/W2102093038","https://openalex.org/W2110065044","https://openalex.org/W2114338526","https://openalex.org/W2121091193","https://openalex.org/W2131298552","https://openalex.org/W2135752132","https://openalex.org/W2136785799","https://openalex.org/W2140575485","https://openalex.org/W2159296038","https://openalex.org/W2159536887","https://openalex.org/W2160556937","https://openalex.org/W2296421590","https://openalex.org/W2346842098","https://openalex.org/W2616134374","https://openalex.org/W2620649070","https://openalex.org/W2622458277","https://openalex.org/W2774486220","https://openalex.org/W2782975316","https://openalex.org/W2799846305","https://openalex.org/W2888810204","https://openalex.org/W2949100461","https://openalex.org/W2950371985"],"related_works":["https://openalex.org/W4321440558","https://openalex.org/W2993770134","https://openalex.org/W2949100461","https://openalex.org/W2981273727","https://openalex.org/W3029018467","https://openalex.org/W7221717869","https://openalex.org/W2912654909","https://openalex.org/W3112297004","https://openalex.org/W4312104577","https://openalex.org/W7155095402"],"abstract_inverted_index":{"The":[0],"identification":[1],"of":[2,13,17,22,53,59,70,97,136,152],"biomarkers":[3],"that":[4],"discriminate":[5],"individual":[6],"ageing":[7,14,24],"trajectories":[8],"is":[9,43],"a":[10,49,57,67,95],"principal":[11],"target":[12],"research.":[15],"Some":[16],"the":[18,134,137,150],"most":[19],"promising":[20],"predictors":[21],"biological":[23],"have":[25],"been":[26],"developed":[27],"using":[28],"DNA":[29],"methylation.":[30],"One":[31],"recent":[32],"candidate,":[33],"which":[34],"tracks":[35],"age-related":[36],"phenotypes":[37],"in":[38,56],"addition":[39],"to":[40,62,92],"chronological":[41,83],"age,":[42,84],"'DNAm":[44],"PhenoAge'.":[45],"Here,":[46],"we":[47],"performed":[48],"phenome-wide":[50],"association":[51],"analysis":[52],"this":[54],"biomarker":[55],"cohort":[58],"older":[60,158],"adults":[61],"assess":[63],"its":[64],"relationship":[65],"with":[66,82,94,106,117,124],"comprehensive":[68],"set":[69],"both":[71],"historical,":[72],"and":[73,102,105,123,144],"contemporaneously-measured,":[74],"phenotypes.":[75],"Higher":[76],"than":[77],"expected":[78],"DNAm":[79,109,142],"PhenoAge":[80,143],"compared":[81],"known":[85],"as":[86],"epigenetic":[87],"age":[88,113,121,129],"acceleration,":[89],"was":[90,115],"found":[91],"associate":[93],"number":[96],"blood,":[98],"cognitive,":[99],"physical":[100],"fitness":[101],"lifestyle":[103],"variables,":[104],"mortality.":[107],"Notably,":[108],"PhenoAge,":[110],"assessed":[111],"at":[112,120],"70,":[114],"associated":[116],"cognitive":[118,131],"ability":[119,132],"11,":[122],"educational":[125],"attainment.":[126],"Adjusting":[127],"for":[128],"11":[130],"attenuated":[133],"majority":[135],"cross-sectional":[138],"later-life":[139],"associations":[140],"between":[141],"health":[145],"outcomes.":[146],"These":[147],"results":[148],"highlight":[149],"importance":[151],"early":[153],"life":[154],"factors":[155],"on":[156],"healthy":[157],"ageing.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-05T00:00:00"}
