{"id":"https://openalex.org/W2989733252","doi":null,"title":"Cholestatic pruritus : an update.","display_name":"Cholestatic pruritus : an update.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2989733252","mag":"2989733252","pmid":"https://pubmed.ncbi.nlm.nih.gov/30888758"},"language":"en","primary_location":{"id":"pmid:30888758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30888758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta gastro-enterologica Belgica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022580132","display_name":"C De Vloo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C De Vloo","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080844718","display_name":"Frederik Nevens","orcid":"https://orcid.org/0000-0003-2905-5112","observed_orcids":["https://orcid.org/0000-0003-2905-5112"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"F Nevens","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3915,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.88955331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"82","issue":"1","first_page":"75","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholestatic-pruritus","display_name":"cholestatic pruritus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/intrahepatic-cholestasis-of-pregnancy","display_name":"intrahepatic cholestasis of pregnancy","score":0.984000027179718},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bile-salts","display_name":"bile salts","score":0.6819999814033508},{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":0.949999988079071},{"id":"https://openalex.org/keywords/opioid-induced-pruritus","display_name":"opioid-induced pruritus","score":0.5950000286102295},{"id":"https://openalex.org/keywords/pruritogens","display_name":"pruritogens","score":0.7450000047683716},{"id":"https://openalex.org/keywords/bile-acid-sequestrants","display_name":"bile acid sequestrants","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cholestyramine","display_name":"cholestyramine","score":0.9359999895095825},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mars","display_name":"Mars","score":0.7179999947547913},{"id":"https://openalex.org/keywords/nasobiliary-drainage","display_name":"nasobiliary drainage","score":0.7940000295639038},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2778697171","wikidata":"https://www.wikidata.org/wiki/Q418006","display_name":"Cholestyramine","level":3,"score":0.774023711681366},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.7011916041374207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7009243965148926},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5683212876319885},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.5555755496025085},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.445512592792511},{"id":"https://openalex.org/C2778620825","wikidata":"https://www.wikidata.org/wiki/Q1344633","display_name":"Enterohepatic circulation","level":3,"score":0.4175992012023926},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3986906111240387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39119333028793335},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3448482155799866},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.22947871685028076},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D002780","descriptor_name":"Cholestasis, Intrahepatic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002792","descriptor_name":"Cholestyramine Resin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011537","descriptor_name":"Pruritus","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011537","descriptor_name":"Pruritus","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:30888758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30888758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta gastro-enterologica Belgica","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/637078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30888758","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Gastro-Enterologica Belgica, vol. 82 (1), (75-82)","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2989733252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30888758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W121381377","https://openalex.org/W270754910","https://openalex.org/W1219313770","https://openalex.org/W1513808626","https://openalex.org/W1550677738","https://openalex.org/W1697750107","https://openalex.org/W1877623990","https://openalex.org/W1964018867","https://openalex.org/W2000729096","https://openalex.org/W2013241580","https://openalex.org/W2022923096","https://openalex.org/W2023931013","https://openalex.org/W2055077741","https://openalex.org/W2056483924","https://openalex.org/W2065612717","https://openalex.org/W2071987840","https://openalex.org/W2075054530","https://openalex.org/W2078404599","https://openalex.org/W2080561720","https://openalex.org/W2088682754","https://openalex.org/W2098877656","https://openalex.org/W2120577168","https://openalex.org/W2169053291","https://openalex.org/W2229648568","https://openalex.org/W2363278517","https://openalex.org/W2395316968","https://openalex.org/W2586480777","https://openalex.org/W2749610744","https://openalex.org/W2807617765"],"related_works":["https://openalex.org/W4308674815","https://openalex.org/W4307771971","https://openalex.org/W1488469491","https://openalex.org/W2411711754","https://openalex.org/W2023752243","https://openalex.org/W2034426999","https://openalex.org/W3017176778","https://openalex.org/W1968369999","https://openalex.org/W2775651257","https://openalex.org/W4392164679"],"abstract_inverted_index":{"Pruritus":[0],"is":[1,41],"a":[2,82,90],"common,":[3],"troublesome":[4],"symptom":[5],"in":[6,14,21,103,113,179],"patients":[7],"with":[8,94,123,170],"cholestatic":[9],"liver":[10],"diseases,":[11],"especially":[12],"frequent":[13],"intrahepatic":[15],"cholestasis":[16],"of":[17,36,63,71,77,96,109,136],"pregnancy":[18],"(ICP)":[19],"and":[20,57,112,115],"primary":[22],"biliary":[23],"cholangitis":[24],"(PBC).":[25],"Cholestatic":[26],"associated":[27],"pruritus":[28,79,134],"can":[29,157],"have":[30,48,88],"profound":[31],"effects":[32],"on":[33],"the":[34,75,107,120,137,180],"quality":[35],"life.":[37],"The":[38,85],"underlying":[39],"mechanism":[40],"still":[42],"poorly":[43],"understood.":[44],"Severe":[45],"potential":[46],"pruritogens":[47,97,110],"been":[49],"discussed,":[50],"such":[51,151],"as":[52,67,152],"bile":[53,99],"salts,":[54],"opioids,":[55],"steroid":[56],"lysophosphatidic":[58],"acid":[59,100],"(LPA),":[60],"but":[61],"none":[62],"these":[64],"are":[65,173],"considered":[66],"key":[68],"mediators.":[69],"Because":[70],"this":[72],"unraveling":[73],"pathophysiology":[74],"treatment":[76],"hepatogenic":[78],"often":[80],"represents":[81],"clinical":[83],"challenge.":[84],"EASL":[86],"guidelines":[87],"suggested":[89],"step-wise":[91],"approach,":[92],"starting":[93],"elimination":[95],"by":[98,118,140],"sequestrants":[101],"(cholestyramine),":[102],"second":[104],"line":[105,117],"managing":[106],"metabolism":[108],"(rifampicin)":[111],"third-line":[114],"fourth-":[116],"modifying":[119],"itch":[121],"perception":[122],"\u03bc-opioid":[124],"antagonist":[125],"or":[126,148],"selective":[127],"serotonin":[128],"reuptake":[129],"inhibitors":[130],"(SSRI).":[131],"In":[132],"treatment-refractory":[133],"interruption":[135],"enterohepatic":[138],"cycle":[139],"molecular":[141],"absorbent":[142],"recirculating":[143],"system":[144],"(MARS),":[145],"nasobiliairy":[146],"drainage":[147],"experimental":[149],"therapy":[150,156],"Ultraviolet":[153],"B":[154],"light":[155],"be":[158,163],"considered.":[159],"Liver":[160],"transplantation":[161],"may":[162],"reserved":[164],"for":[165],"intractable":[166],"pruritus.":[167],"Clinical":[168],"trials":[169],"novel":[171],"agents":[172],"ongoing,":[174],"potentially":[175],"providing":[176],"efficacious":[177],"options":[178],"future.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-05T00:00:00"}
