{"id":"https://openalex.org/W2989629664","doi":"https://doi.org/10.1097/mpg.0000000000002571","title":"Bye Bye Benzoate","display_name":"Bye Bye Benzoate","publication_year":2019,"publication_date":"2019-11-25","ids":{"openalex":"https://openalex.org/W2989629664","doi":"https://doi.org/10.1097/mpg.0000000000002571","mag":"2989629664","pmid":"https://pubmed.ncbi.nlm.nih.gov/31978006"},"language":"en","primary_location":{"id":"doi:10.1097/mpg.0000000000002571","doi":"https://doi.org/10.1097/mpg.0000000000002571","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpg.0000000000002571","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067193959","display_name":"Sarah A.F. Henkel","orcid":"https://orcid.org/0000-0002-7189-8829","observed_orcids":["https://orcid.org/0000-0002-7189-8829"]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A.F. Henkel","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA","Accepted 15 November, 2019","Received 6 November, 2019","The authors report no conflicts of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Accepted 15 November, 2019","institution_ids":[]},{"raw_affiliation_string":"Received 6 November, 2019","institution_ids":[]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069377290","display_name":"Patrick James McKiernan","orcid":"https://orcid.org/0000-0002-8466-8504","observed_orcids":["https://orcid.org/0000-0002-8466-8504"]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick J. McKiernan","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA","Accepted 15 November, 2019","Received 6 November, 2019","The authors report no conflicts of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Accepted 15 November, 2019","institution_ids":[]},{"raw_affiliation_string":"Received 6 November, 2019","institution_ids":[]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069377290"],"corresponding_institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"2","first_page":"158","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-benzoate","display_name":"sodium benzoate","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hyperammonemia","display_name":"hyperammonemia","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.7020000219345093},{"id":"https://openalex.org/keywords/pediatric-liver-disease","display_name":"pediatric liver disease","score":0.7940000295639038},{"id":"https://openalex.org/keywords/urea-cycle-disorders","display_name":"urea cycle disorders","score":0.859000027179718},{"id":"https://openalex.org/keywords/lactulose","display_name":"lactulose","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hippurate","display_name":"hippurate","score":0.5049999952316284},{"id":"https://openalex.org/keywords/ammonia-lowering-therapy","display_name":"ammonia-lowering therapy","score":0.47699999809265137},{"id":"https://openalex.org/keywords/glycine-conjugation","display_name":"glycine conjugation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/salt-loading","display_name":"salt loading","score":0.3529999852180481},{"id":"https://openalex.org/keywords/ammonia-monitoring","display_name":"ammonia monitoring","score":0.4309999942779541},{"id":"https://openalex.org/keywords/developmental-outcomes","display_name":"developmental outcomes","score":0.4399999976158142},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.4740000069141388},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.40400001406669617},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2781099255","wikidata":"https://www.wikidata.org/wiki/Q1640868","display_name":"Hyperammonemia","level":2,"score":0.929162859916687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.821773886680603},{"id":"https://openalex.org/C77061444","wikidata":"https://www.wikidata.org/wiki/Q595994","display_name":"Urea cycle","level":4,"score":0.7912904620170593},{"id":"https://openalex.org/C2780325230","wikidata":"https://www.wikidata.org/wiki/Q642548","display_name":"Hepatic encephalopathy","level":3,"score":0.6300896406173706},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.582198977470398},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5114775896072388},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.45472729206085205},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4348449110984802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4302777945995331},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4269244074821472},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.41611039638519287},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.38922592997550964},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.1265411674976349},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.1040942370891571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09551352262496948},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020160","descriptor_name":"Sodium Benzoate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022124","descriptor_name":"Hyperammonemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/mpg.0000000000002571","doi":"https://doi.org/10.1097/mpg.0000000000002571","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpg.0000000000002571","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},{"id":"pmid:31978006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31978006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric gastroenterology and nutrition","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1567546512","https://openalex.org/W1596942853","https://openalex.org/W2018199913","https://openalex.org/W2548228953","https://openalex.org/W2740952285","https://openalex.org/W2937766364","https://openalex.org/W2982039461","https://openalex.org/W4241695142"],"related_works":["https://openalex.org/W2982039461","https://openalex.org/W4253346075","https://openalex.org/W1567546512","https://openalex.org/W4407783654","https://openalex.org/W2130927994","https://openalex.org/W2049520571","https://openalex.org/W2522684444","https://openalex.org/W4312552381","https://openalex.org/W2004915501","https://openalex.org/W1977769392"],"abstract_inverted_index":{"See":[0],"\u201cEfficacy":[1],"and":[2,37,56,107,133,136,200,225,251,259,345,408,450,459,513,552,579,641,678,767,772],"Safety":[3],"of":[4,10,17,42,54,104,111,138,143,245,253,341,397,402,469,484,506,525,546,584,603,624,643,660],"Sodium":[5,279,298,445,499,705],"Benzoate":[6],"in":[7,12,59,74,80,86,147,168,180,289,306,326,338,365,367,380,410,428,439,451,466,494,556,569,590,655,685,713,774,792],"The":[8,109,243,574,587,632,662],"Management":[9],"Hyperammonemia":[11],"Decompensated":[13],"Chronic":[14],"Liver":[15],"Disease":[16],"the":[18,102,134,157,188,302,339,394,434,467,481,485,495,557,582,594,621,639,665,681],"Childhood\u2014A":[19],"Double-blind":[20],"Randomized":[21],"Controlled":[22],"Trial\u201d":[23],"by":[24,239,581,716],"Snehavardhan":[25,389],"et":[26,390],"al":[27,391],"on":[28,52,72,504,674],"page":[29],"165.":[30],"Hepatic":[31],"encephalopathy":[32],"(HE)":[33],"is":[34,65,113,119,129,140,159,207,212,217,266,313,330,577,693,721,739],"a":[35,69,120,348,398,455,517,656,731],"serious,":[36],"often":[38],"under":[39],"recognized,":[40],"complication":[41],"childhood":[43,75],"liver":[44,307,343,371,382,415,531,572,627,630],"disease":[45,344,372,383,628],"(1).":[46],"HE":[47,112,181,216,226,235,366,409,549,773],"has":[48,77,281,376,561,647,760],"an":[49,130,652,695,778],"obvious":[50],"impact":[51,71],"quality":[53],"life":[55],"educational":[57],"achievement":[58,396],"childhood.":[60],"Clinical":[61],"experience":[62],"suggests":[63,355,598],"it":[64,206,329,346,375,560],"likely":[66],"to":[67,160,170,187,237,268,286,309,405,422,430,511,519,614,651,672,679,763,780],"have":[68,535],"negative":[70,634],"survival":[73],"as":[76,222,361,363,722,724,777],"been":[78,283,378,761],"proven":[79],"adults":[81,368],"(2).":[82],"In":[83,155,318,386],"addition,":[84],"evidence":[85],"adult":[87,775],"practice":[88,776],"shows":[89],"we":[90,536,539],"cannot":[91],"be":[92,178,324,360,541,607,615,670,764,790],"blas\u00e9":[93],"about":[94],"its":[95],"complete":[96],"reversibility":[97],"after":[98,249,442,593],"transplantation":[99],"(3),":[100],"emphasizing":[101],"importance":[103,642],"prompt":[105],"recognition":[106],"treatment.":[108],"pathogenesis":[110],"not":[114,177,193,228,277,377,637,694],"completely":[115],"understood":[116],"but":[117,192,328,374,487,610,700,729],"there":[118],"strong":[121],"association":[122],"with":[123,149,291,301,369,412,418,433,454,477,516,550,718,730],"elevated":[124,223],"ammonia":[125,163,211,224,288,441,474,491,568,592],"levels":[126],"(1,2).":[127],"Ammonia":[128],"established":[131,232],"neurotoxin":[132],"degree":[135],"duration":[137],"hyperammonemia":[139,407,419,728,771],"strongly":[141,220],"predictive":[142],"poor":[144],"developmental":[145],"outcome":[146],"children":[148,290,411,527],"urea":[150,745,749],"cycle":[151,746],"disorders":[152],"(UCD)":[153],"(4).":[154,297],"UCD,":[156],"aim":[158],"keep":[161],"venous":[162],"less":[164],"than":[165,463],"80":[166],"\u03bcmol":[167],"order":[169],"maximize":[171],"neurologic":[172],"potential.":[173],"These":[174,687],"targets":[175],"may":[176,359],"applicable":[179],"where":[182,215],"other":[183,701],"noxious":[184],"factors":[185],"contribute":[186],"clinical":[189,264],"picture":[190],"including,":[191],"limited":[194],"to,":[195],"mercaptans,":[196],"short-chain":[197],"fatty":[198],"acids":[199],"inflammatory":[201],"cytokines.":[202],"Given":[203],"these":[204,272,526,611,787],"uncertainties,":[205],"probably":[208],"best":[209],"that":[210,356,473,543,563,599,690],"only":[213],"monitored":[214],"present,":[218],"or":[219,276,426],"suspected,":[221],"are":[227,274,612],"synonymous.":[229],"Notwithstanding":[230],"this,":[231],"therapy":[233],"for":[234,247,548,664,727],"appears":[236],"work":[238,677],"reducing":[240,770],"plasma":[241,440,591],"ammonia.":[242],"standard":[244,545],"care":[246,547],"HE,":[248,327,507],"identification":[250],"treatment":[252,468,782],"any":[254],"precipitating":[255],"factor(s),":[256],"includes":[257],"lactulose":[258,364,551],"nonabsorbed":[260],"antibiotics.":[261],"A":[262],"common":[263],"dilemma":[265],"what":[267,534],"do":[269],"next":[270,682],"when":[271],"measures":[273],"insufficient":[275],"tolerable.":[278,616],"benzoate":[280,299,334,358,404,425,446,489,500,565,605,692,726],"long":[282],"used":[284,465],"successfully":[285],"lower":[287,460,567],"UCD":[292],"through":[293],"promoting":[294,748],"nitrogen":[295,711],"loss":[296],"conjugates":[300],"amino":[303],"acid":[304],"glycine":[305],"mitochondria":[308],"form":[310],"Hippurate,":[311],"which":[312,646],"then":[314],"rapidly":[315,493],"renally":[316],"excreted.":[317],"theory,":[319],"this":[320,387,618,644,675,714],"alternate":[321,709],"pathway":[322,710],"could":[323],"effective":[325,362,555,723,768],"unclear":[331],"if":[332],"sodium":[333,351,357,403,424,488,564,604,691,725,733],"would":[335],"undergo":[336],"conjugation":[337,717],"presence":[340],"severe":[342],"represents":[347],"significant":[349],"extra":[350],"load.":[352],"Limited":[353],"data":[354],"chronic":[370,414],"(5)":[373],"evaluated":[379],"pediatric":[381,571,626,666,794],"until":[384],"now.":[385],"issue,":[388],"(6)":[392],"describe":[393],"remarkable":[395],"randomized":[399,421,683,795],"controlled":[400],"trial":[401,684],"treat":[406],"decompensated":[413,625],"disease.":[416,573],"Children":[417],"were":[420],"receive":[423],"placebo":[427],"addition":[429],"standard-of-care":[431,781],"therapy,":[432],"primary":[435],"endpoint":[436],"being":[437],"reduction":[438],"5":[443,482],"days.":[444],"was":[447,514],"given":[448],"orally":[449],"nonconventional":[452],"dosing,":[453],"larger":[456],"loading":[457,596],"dose":[458,462,597],"maintenance":[461,601],"normally":[464],"UCD.":[470],"They":[471],"found":[472],"fell":[475],"equally":[476],"both":[478],"regimens":[479],"over":[480],"days":[483],"study":[486,619],"lowered":[490],"more":[492,608],"first":[496],"48":[497],"hours.":[498],"had":[501],"no":[502],"effect":[503],"resolution":[505],"overall":[508,633],"survival,":[509],"time":[510],"discharge":[512],"associated":[515],"trend":[518],"increased":[520],"ascites.":[521],"Tragically,":[522],"nearly":[523],"30%":[524],"subsequently":[528],"died":[529],"awaiting":[530],"transplantation.":[532,631],"So":[533],"learned?":[537],"Firstly,":[538],"can":[540,566,789],"reassured":[542],"conventional":[544],"rifaximin":[553],"seems":[554],"short-term.":[558],"Secondly,":[559],"shown":[562,762],"end-stage":[570],"effect,":[575],"however,":[576],"temporary":[578],"compromised":[580],"risk":[583],"fluid":[585],"overload.":[586],"rapid":[588],"fall":[589],"large":[595],"higher":[600],"doses":[602],"might":[606],"effective,":[609],"unlikely":[613],"Thirdly,":[617],"confirms":[620],"appalling":[622],"outlook":[623],"without":[629],"result":[635],"should":[636],"diminish":[638],"significance":[640],"study,":[645],"brought":[648],"some":[649],"objectivity":[650],"important":[653],"issue":[654],"very":[657],"ill":[658],"group":[659],"children.":[661],"challenge":[663],"hepatology":[667],"community":[668],"will":[669],"how":[671],"build":[673],"team's":[676],"plan":[680],"HE.":[686],"results":[688],"suggest":[689],"attractive":[696],"candidate":[697],"going":[698],"forward,":[699],"potential":[702],"agents":[703,788],"exist.":[704],"phenylbutyrate":[706],"also":[707,752],"promotes":[708],"excretion,":[712],"case":[715],"glutamine.":[719],"It":[720,759],"smaller":[732],"load":[734],"(7).":[735],"Another":[736],"exciting":[737],"option":[738],"l-ornithine":[740],"l-aspartate":[741],"(LOLA).":[742],"LOLA":[743],"stimulates":[744],"activity,":[747],"excretion":[750],"while":[751],"increasing":[753],"muscle":[754],"glutamine":[755],"synthesis":[756],"from":[757],"Ammonia.":[758],"well":[765],"tolerated":[766],"at":[769],"add-on":[779],"(8).":[783],"Let":[784],"us":[785],"hope":[786],"tested":[791],"future":[793],"trials.":[796]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-05T00:00:00"}
