{"id":"https://openalex.org/W2989615262","doi":"https://doi.org/10.1038/s41598-019-53745-7","title":"Immunophenotypes associated with bipolar disorder and lithium treatment","display_name":"Immunophenotypes associated with bipolar disorder and lithium treatment","publication_year":2019,"publication_date":"2019-11-25","ids":{"openalex":"https://openalex.org/W2989615262","doi":"https://doi.org/10.1038/s41598-019-53745-7","mag":"2989615262","pmid":"https://pubmed.ncbi.nlm.nih.gov/31767892","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6877517"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-53745-7","doi":"https://doi.org/10.1038/s41598-019-53745-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-53745-7","pdf_url":"https://www.nature.com/articles/s41598-019-53745-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-53745-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090756023","display_name":"Tai-Na Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tai-Na Wu","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080257216","display_name":"Chau\u2010Shoun Lee","orcid":"https://orcid.org/0000-0002-1509-4340","observed_orcids":["https://orcid.org/0000-0002-1509-4340"]},"institutions":[{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]},{"id":"https://openalex.org/I35926432","display_name":"Mackay Medical University","ror":"https://ror.org/00t89kj24","country_code":"TW","type":"education","lineage":["https://openalex.org/I35926432"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chau-Shoun Lee","raw_affiliation_strings":["Department of Medicine, MacKay Medical College; Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan","Department of Medicine, MacKay Medical College","Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, MacKay Medical College; Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802753785","https://openalex.org/I35926432"]},{"raw_affiliation_string":"Department of Medicine, MacKay Medical College","institution_ids":["https://openalex.org/I35926432"]},{"raw_affiliation_string":"Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802753785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056410716","display_name":"Bojian Wu","orcid":"https://orcid.org/0009-0007-1945-8707","observed_orcids":["https://orcid.org/0009-0007-1945-8707"]},"institutions":[{"id":"https://openalex.org/I4210086508","display_name":"Yuli Hospital","ror":"https://ror.org/00396f155","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210086508"]},{"id":"https://openalex.org/I4210121532","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/024w0ge69","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210121532","https://openalex.org/I4405257903"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Bo-Jian Wu","raw_affiliation_strings":["Yuli hospital, Ministry of Health and Welfare, Hualien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuli hospital, Ministry of Health and Welfare, Hualien, Taiwan","institution_ids":["https://openalex.org/I4210086508","https://openalex.org/I4210121532"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103603153","display_name":"Hsiao\u2010Ju Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086508","display_name":"Yuli Hospital","ror":"https://ror.org/00396f155","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210086508"]},{"id":"https://openalex.org/I4210121532","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/024w0ge69","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210121532","https://openalex.org/I4405257903"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiao-Ju Sun","raw_affiliation_strings":["Yuli hospital, Ministry of Health and Welfare, Hualien, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuli hospital, Ministry of Health and Welfare, Hualien, Taiwan","institution_ids":["https://openalex.org/I4210086508","https://openalex.org/I4210121532"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065756864","display_name":"Chieh-Hsing Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121532","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/024w0ge69","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210121532","https://openalex.org/I4405257903"]},{"id":"https://openalex.org/I4210124833","display_name":"Bali Psychiatric Center","ror":"https://ror.org/031drvr68","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210124833"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chieh-Hsing Chang","raw_affiliation_strings":["Bali Psychiatric Center, Ministry of Health and Welfare, Tamsui, Taiwan","Tsao-Tun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bali Psychiatric Center, Ministry of Health and Welfare, Tamsui, Taiwan","institution_ids":["https://openalex.org/I4210121532","https://openalex.org/I4210124833"]},{"raw_affiliation_string":"Tsao-Tun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan","institution_ids":["https://openalex.org/I4210121532"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073108451","display_name":"Chunying Chen","orcid":"https://orcid.org/0000-0002-6027-0315","observed_orcids":["https://orcid.org/0000-0002-6027-0315","https://orcid.org/0009-0007-9092-394X"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]},{"id":"https://openalex.org/I4210121532","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/024w0ge69","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210121532","https://openalex.org/I4405257903"]},{"id":"https://openalex.org/I4210124833","display_name":"Bali Psychiatric Center","ror":"https://ror.org/031drvr68","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210124833"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chun-Ying Chen","raw_affiliation_strings":["Bali Psychiatric Center, Ministry of Health and Welfare, Tamsui, Taiwan","School of Medicine, Chang Gung University; Community Medicine Research Center & Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan. kenchen@cgmh.org.tw","Tsao-Tun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bali Psychiatric Center, Ministry of Health and Welfare, Tamsui, Taiwan","institution_ids":["https://openalex.org/I4210121532","https://openalex.org/I4210124833"]},{"raw_affiliation_string":"School of Medicine, Chang Gung University; Community Medicine Research Center & Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan. kenchen@cgmh.org.tw","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"Tsao-Tun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan","institution_ids":["https://openalex.org/I4210121532"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143785817","display_name":"Chih-Ken Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]},{"id":"https://openalex.org/I4210121532","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/024w0ge69","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210121532","https://openalex.org/I4405257903"]},{"id":"https://openalex.org/I4210124833","display_name":"Bali Psychiatric Center","ror":"https://ror.org/031drvr68","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210124833"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Ken Chen","raw_affiliation_strings":["Bali Psychiatric Center, Ministry of Health and Welfare, Tamsui, Taiwan","School of Medicine, Chang Gung University; Community Medicine Research Center & Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan. kenchen@cgmh.org.tw","Tsao-Tun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan","Community Medicine Research Center & Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan","School of Medicine, Chang Gung University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bali Psychiatric Center, Ministry of Health and Welfare, Tamsui, Taiwan","institution_ids":["https://openalex.org/I4210121532","https://openalex.org/I4210124833"]},{"raw_affiliation_string":"School of Medicine, Chang Gung University; Community Medicine Research Center & Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan. kenchen@cgmh.org.tw","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"Tsao-Tun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan","institution_ids":["https://openalex.org/I4210121532"]},{"raw_affiliation_string":"Community Medicine Research Center & Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"School of Medicine, Chang Gung University","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534556","display_name":"Lawrence Shih\u2010Hsin Wu","orcid":"https://orcid.org/0000-0001-6275-8368","observed_orcids":["https://orcid.org/0000-0001-6275-8368"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Lawrence Shih-Hsin Wu","raw_affiliation_strings":["Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. lshwu@hotmail.com","Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. lshwu@hotmail.com","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112897132","display_name":"Andrew T. A. Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Andrew Tai-Ann Cheng","raw_affiliation_strings":["Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan. bmandrew@gate.sinica.edu.tw","Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. bmandrew@gate.sinica.edu.tw","Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. bmandrew@gate.sinica.edu.tw","Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan. bmandrew@gate.sinica.edu.tw","institution_ids":["https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. bmandrew@gate.sinica.edu.tw","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. bmandrew@gate.sinica.edu.tw","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5073108451","https://openalex.org/A5090756023","https://openalex.org/A5111534556","https://openalex.org/A5112897132"],"corresponding_institution_ids":["https://openalex.org/I173093425","https://openalex.org/I184693016","https://openalex.org/I3020100970","https://openalex.org/I4210096666","https://openalex.org/I4210111603","https://openalex.org/I4210121532","https://openalex.org/I4210124833","https://openalex.org/I4210126829","https://openalex.org/I84653119"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":0.9117,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.74123826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"17453","last_page":"17453"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-i-disorder","display_name":"bipolar I disorder","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lithium-response","display_name":"lithium response","score":0.8140000104904175},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8610000014305115},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.859000027179718},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.7749999761581421},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cd14-monocytes","display_name":"CD14+ monocytes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":1.0},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/activated-b-cells","display_name":"activated B cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.699999988079071},{"id":"https://openalex.org/keywords/han-chinese","display_name":"Han Chinese","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.7292349338531494},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6664274334907532},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.58707594871521},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5582392811775208},{"id":"https://openalex.org/C176290653","wikidata":"https://www.wikidata.org/wiki/Q21114013","display_name":"CD33","level":4,"score":0.4971950352191925},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.45611757040023804},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.44293439388275146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43139564990997314},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.406878799200058},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3141140341758728},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2532604932785034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23387056589126587},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16220593452453613},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.10352766513824463},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011619","descriptor_name":"Psychotropic Drugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011619","descriptor_name":"Psychotropic Drugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016651","descriptor_name":"Lithium Carbonate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016651","descriptor_name":"Lithium Carbonate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-019-53745-7","doi":"https://doi.org/10.1038/s41598-019-53745-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-53745-7","pdf_url":"https://www.nature.com/articles/s41598-019-53745-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6877517","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6877517","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31767892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31767892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7a065a1a49ba4b06937cc55e6699370f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7a065a1a49ba4b06937cc55e6699370f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-53745-7","doi":"https://doi.org/10.1038/s41598-019-53745-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-53745-7","pdf_url":"https://www.nature.com/articles/s41598-019-53745-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1707058745","display_name":null,"funder_award_id":"52102310023C","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"},{"id":"https://openalex.org/G5249415692","display_name":null,"funder_award_id":"AS 23-23, 52102310023C","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"},{"id":"https://openalex.org/G6309477159","display_name":null,"funder_award_id":"MOST 103-2325-B-001-025; 103-2314-B-182-011-MY3; 104-2325-B-001-008; 105-2325-B-001-008","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G946896677","display_name":null,"funder_award_id":"AS-2323","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"}],"funders":[{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2989615262.pdf","grobid_xml":"https://content.openalex.org/works/W2989615262.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W176107634","https://openalex.org/W1258940878","https://openalex.org/W1561569944","https://openalex.org/W1586360287","https://openalex.org/W1631661663","https://openalex.org/W1904703302","https://openalex.org/W1905007654","https://openalex.org/W1932486448","https://openalex.org/W1967211556","https://openalex.org/W1993490510","https://openalex.org/W1996097278","https://openalex.org/W2000171400","https://openalex.org/W2000725338","https://openalex.org/W2007609934","https://openalex.org/W2012053514","https://openalex.org/W2016996256","https://openalex.org/W2031584576","https://openalex.org/W2033274961","https://openalex.org/W2048650431","https://openalex.org/W2068783798","https://openalex.org/W2073310925","https://openalex.org/W2074405990","https://openalex.org/W2079384709","https://openalex.org/W2083294419","https://openalex.org/W2085065484","https://openalex.org/W2098597355","https://openalex.org/W2111925968","https://openalex.org/W2119215815","https://openalex.org/W2125337268","https://openalex.org/W2131761283","https://openalex.org/W2132811637","https://openalex.org/W2133646735","https://openalex.org/W2137554286","https://openalex.org/W2137569966","https://openalex.org/W2144067912","https://openalex.org/W2147068403","https://openalex.org/W2150413247","https://openalex.org/W2154658221","https://openalex.org/W2154889421","https://openalex.org/W2166530259","https://openalex.org/W2465989363","https://openalex.org/W2520233561","https://openalex.org/W2528328462","https://openalex.org/W2957333693"],"related_works":["https://openalex.org/W4393862200","https://openalex.org/W4403449774","https://openalex.org/W7219844277","https://openalex.org/W4393098475","https://openalex.org/W2588582710","https://openalex.org/W4385915586","https://openalex.org/W4294062007","https://openalex.org/W2017446917","https://openalex.org/W4385216158","https://openalex.org/W7163998397"],"abstract_inverted_index":{"Abstract":[0],"Immune":[1],"dysfunction":[2,201],"is":[3,51],"implicated":[4],"in":[5,15,33,58,116,128,146,195,202],"the":[6,16,59,83,131,184],"etiology":[7],"of":[8,65,86,94,122,133,162,186],"bipolar":[9,38],"disorder.":[10],"The":[11],"single-nucleotide":[12],"polymorphism":[13],"rs17026688":[14,193],"gene":[17],"encoding":[18],"glutamate":[19],"decarboxylase\u2013like":[20],"protein":[21],"1":[22],"(GADL1)":[23],"has":[24],"been":[25],"found":[26],"to":[27,177,183],"be":[28,114],"associated":[29,198],"with":[30,37,45,126,181,199],"lithium":[31,127,141,178],"response":[32],"Han":[34],"Chinese":[35],"patients":[36,44,75,89],"I":[39],"disorder":[40],"(BDI).":[41],"However,":[42],"whether":[43],"GADL1":[46,196],"polymorphisms":[47,194],"have":[48],"different":[49],"immunophenotypes":[50],"unknown.":[52],"To":[53],"address":[54],"this":[55],"issue,":[56],"differences":[57],"immune":[60,200],"profiles":[61],"based":[62],"on":[63],"analysis":[64],"peripheral":[66],"blood":[67],"mononuclear":[68],"cells":[69,166],"(PBMCs)":[70],"were":[71],"compared":[72],"among":[73],"BDI":[74,88,117,123,153,203],"and":[76,104,136,149],"healthy":[77,107],"controls":[78],"who":[79],"lack":[80],"or":[81,119],"carry":[82],"T":[84,96,99,168,172],"allele":[85],"rs17026688.":[87],"had":[90,157],"significantly":[91,159],"higher":[92,160],"percentages":[93],"total":[95],"cells,":[97,100,103,138],"CD4+":[98],"activated":[101],"B":[102],"monocytes":[105,135,148],"than":[106,167],"controls,":[108],"suggesting":[109,139],"that":[110,140,192],"immunologic":[111],"imbalance":[112],"might":[113],"involved":[115],"development":[118],"progression.":[120],"Treatment":[121],"patients-derived":[124],"PBMCs":[125],"vitro":[129],"increased":[130],"percentage":[132,161,185],"CD14+":[134,147],"dendritic":[137,150],"plays":[142],"an":[143],"immunomodulatory":[144],"role":[145],"cells.":[151,188],"Among":[152],"patients,":[154],"non-T":[155],"carriers":[156,173],"a":[158],"CD11b+/CD33lo/HLA-DR\u2212":[163],"myeloid-derived":[164],"suppressor":[165],"carriers.":[169],"Moreover,":[170],"only":[171],"exhibited":[174],"differential":[175],"sensitivity":[176],"therapeutic":[179],"use":[180],"respect":[182],"myeloid":[187],"These":[189],"findings":[190],"suggest":[191],"are":[197],"patients.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-12-05T00:00:00"}
