{"id":"https://openalex.org/W2989587494","doi":"https://doi.org/10.1093/neuonc/noy148.520","title":"IMMU-17. PEPTIDE VACCINE IMMUNOTHERAPY BIOMARKERS AND RESPONSE PATTERNS IN PEDIATRIC GLIOMAS","display_name":"IMMU-17. PEPTIDE VACCINE IMMUNOTHERAPY BIOMARKERS AND RESPONSE PATTERNS IN PEDIATRIC GLIOMAS","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W2989587494","doi":"https://doi.org/10.1093/neuonc/noy148.520","mag":"2989587494"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noy148.520","doi":"https://doi.org/10.1093/neuonc/noy148.520","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.520","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi124/26281983/noy148.520.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi124/26281983/noy148.520.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103236468","display_name":"Sabine Mueller","orcid":"https://orcid.org/0000-0002-8216-9357","observed_orcids":["https://orcid.org/0000-0002-8216-9357","https://orcid.org/0000-0002-3452-5150"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soeren Mueller","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056492340","display_name":"Sameer Agnihotri","orcid":"https://orcid.org/0000-0001-6584-3795","observed_orcids":["https://orcid.org/0000-0001-6584-3795"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameer Agnihotri","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002552541","display_name":"Karsen E. Shoger","orcid":"https://orcid.org/0000-0002-1894-7361","observed_orcids":["https://orcid.org/0000-0002-1894-7361"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karsen Shoger","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022345601","display_name":"Max I. Myers","orcid":"https://orcid.org/0009-0001-4981-8992","observed_orcids":["https://orcid.org/0009-0001-4981-8992"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max Myers","raw_affiliation_strings":["University of Pittsburgh Department of Neurological Surgery, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh Department of Neurological Surgery, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074166220","display_name":"Clarence Villanueva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clarence Villanueva","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091597843","display_name":"Aaron  A. Diaz","orcid":"https://orcid.org/0000-0001-9059-9501","observed_orcids":["https://orcid.org/0000-0001-9059-9501"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Diaz","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058793243","display_name":"Hideho Okada","orcid":"https://orcid.org/0000-0003-0076-9920","observed_orcids":["https://orcid.org/0000-0003-0076-9920"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hideho Okada","raw_affiliation_strings":["UCSF Department of Neurological Surgery, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF Department of Neurological Surgery, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080784534","display_name":"Ian F. Pollack","orcid":"https://orcid.org/0000-0003-1765-357X","observed_orcids":["https://orcid.org/0000-0003-1765-357X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Pollack","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022169733","display_name":"Gary Kohanbash","orcid":"https://orcid.org/0000-0002-3953-8022","observed_orcids":["https://orcid.org/0000-0002-3953-8022"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Kohanbash","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25744271,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"suppl_6","first_page":"vi124","last_page":"vi125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.05900000035762787,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-low-grade-glioma","display_name":"pediatric low-grade glioma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.6380000114440918},{"id":"https://openalex.org/keywords/peripheral-blood-gene-expression","display_name":"peripheral blood gene expression","score":0.671999990940094},{"id":"https://openalex.org/keywords/t-cell-activation-markers","display_name":"T cell activation markers","score":0.8370000123977661},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.718999981880188},{"id":"https://openalex.org/keywords/ido1","display_name":"IDO1","score":0.921999990940094},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monocyte-response","display_name":"monocyte response","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7860000133514404},{"id":"https://openalex.org/keywords/antigen-specific-t-cell-responses","display_name":"antigen-specific T cell responses","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.8032066822052002},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7339653968811035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6982589364051819},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.5933718085289001},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5843622088432312},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5452327132225037},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5235956907272339},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4894775152206421},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4506542682647705},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.44378143548965454},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4329395294189453},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.24571934342384338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1708633303642273},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.09195652604103088},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noy148.520","doi":"https://doi.org/10.1093/neuonc/noy148.520","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.520","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi124/26281983/noy148.520.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6217446","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6217446","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noy148.520","doi":"https://doi.org/10.1093/neuonc/noy148.520","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noy148.520","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/20/suppl_6/vi124/26281983/noy148.520.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2989587494.pdf","grobid_xml":"https://content.openalex.org/works/W2989587494.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2990939179","https://openalex.org/W2796417814","https://openalex.org/W2308211810","https://openalex.org/W2333324411","https://openalex.org/W2140738072","https://openalex.org/W4319957251","https://openalex.org/W7135044795","https://openalex.org/W4416847018","https://openalex.org/W4234403201","https://openalex.org/W2519568203"],"abstract_inverted_index":{"Low-grade":[0],"gliomas":[1],"(LGGs)":[2],"are":[3,180],"the":[4,182,201],"most":[5],"common":[6],"brain":[7],"tumor":[8],"affecting":[9],"children.":[10],"We":[11],"recently":[12],"reported":[13],"an":[14,129],"early":[15,130,147],"phase":[16,227],"clinical":[17,56,222],"trial":[18],"of":[19,39,55,80,150,171,203],"a":[20,87,115],"peptide-based":[21],"vaccine,":[22],"which":[23],"elicited":[24],"consistent":[25],"antigen-specific":[26],"T":[27,81,89,151],"cell":[28,82,90,152,169],"responses":[29,38,215],"in":[30,58,188,208],"pediatric":[31],"LGG":[32,209,229],"patients.":[33],"Additionally,":[34],"we":[35,61,162,179],"observed":[36,183],"radiologic":[37],"stable":[40],"disease":[41],"(SD),":[42],"partial":[43],"response":[44,48,57,91,109,119,133,184,235],"(PR),":[45],"and":[46,106,128,141,146,186],"near-complete/complete":[47],"(CR)":[49],"following":[50],"therapy.":[51],"To":[52],"identify":[53],"biomarkers":[54,187],"peripheral":[59,205],"blood,":[60],"performed":[62],"RNA":[63],"sequencing":[64],"on":[65],"PBMC":[66],"samples":[67],"collected":[68],"at":[69],"multiple":[70],"time":[71],"points.":[72],"Patients":[73,111],"who":[74],"showed":[75],"CR":[76,101],"demonstrated":[77,102,114],"elevated":[78,148],"levels":[79,149],"activation":[83,153,170],"markers,":[84],"accompanied":[85],"by":[86],"cytotoxic":[88],"shortly":[92],"after":[93],"treatment":[94,145],"initiation.":[95],"At":[96],"week":[97],"34,":[98],"patients":[99,191,210],"with":[100,112,137,157,167,174,193,212],"both":[103],"IFN":[104],"signaling":[105],"Poly-IC:LC":[107],"adjuvant":[108],"patterns.":[110,236],"PR":[113],"unique,":[116],"late":[117],"monocyte":[118],"signature.":[120],"Interestingly,":[121],"HLA-V":[122],"expression,":[123],"before":[124,144],"or":[125],"during":[126],"therapy,":[127],"monocytic":[131],"hematopoietic":[132],"were":[134,155],"strongly":[135],"associated":[136,156,166,211],"SD.":[138],"Low":[139],"IDO1":[140],"PD-L1":[142],"expression":[143],"markers":[154],"prolonged":[158],"progression-free":[159],"survival.":[160],"Furthermore,":[161],"identified":[163],"that":[164],"genes":[165],"dendritic":[168],"T-cells":[172],"correlated":[173],"IFN\u03b3":[175],"ELISPOT":[176],"counts.":[177],"Currently":[178],"validating":[181],"patterns":[185,207],"high-grade":[189],"glioma":[190],"treated":[192],"peptide":[194,218],"vaccine":[195,219,230],"immunotherapy.":[196,220],"Overall,":[197],"our":[198,217,225],"data":[199],"support":[200],"presence":[202],"unique":[204],"immune":[206],"different":[213],"radiographic":[214],"to":[216],"Future":[221],"trials,":[223],"including":[224],"ongoing":[226],"II":[228],"immunotherapy,":[231],"should":[232],"monitor":[233],"these":[234]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-05T00:00:00"}
