{"id":"https://openalex.org/W2989166350","doi":"https://doi.org/10.1038/s41598-019-51859-6","title":"Platform for ergonomic intraoral photodynamic therapy using low-cost, modular 3D-printed components: Design, comfort and clinical evaluation","display_name":"Platform for ergonomic intraoral photodynamic therapy using low-cost, modular 3D-printed components: Design, comfort and clinical evaluation","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2989166350","doi":"https://doi.org/10.1038/s41598-019-51859-6","mag":"2989166350","pmid":"https://pubmed.ncbi.nlm.nih.gov/31676807"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-51859-6","doi":"https://doi.org/10.1038/s41598-019-51859-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-51859-6","pdf_url":"https://www.nature.com/articles/s41598-019-51859-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-51859-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058568678","display_name":"Srivalleesha Mallidi","orcid":"https://orcid.org/0000-0003-1547-1764","observed_orcids":["https://orcid.org/0000-0003-1547-1764"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srivalleesha Mallidi","raw_affiliation_strings":["Department of Biomedical Engineering, Tufts University Medford Massachusetts, Massachusetts, USA","Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tufts University Medford Massachusetts, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068985110","display_name":"Amjad  P. Khan","orcid":"https://orcid.org/0000-0002-2566-0393","observed_orcids":["https://orcid.org/0000-0002-2566-0393"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amjad P. Khan","raw_affiliation_strings":["Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387566","display_name":"Hui Liu","orcid":"https://orcid.org/0000-0002-3335-3756","observed_orcids":["https://orcid.org/0000-0002-3335-3756","https://orcid.org/0000-0002-6233-3973"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Liu","raw_affiliation_strings":["Department of Physics, University of Massachusetts at Boston, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Massachusetts at Boston, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010164812","display_name":"Liam Daly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liam Daly","raw_affiliation_strings":["Department of Engineering, University of Massachusetts at Boston, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Massachusetts at Boston, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003364034","display_name":"Grant Rudd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grant Rudd","raw_affiliation_strings":["Department of Engineering, University of Massachusetts at Boston, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Massachusetts at Boston, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033555555","display_name":"Paola Leon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Leon","raw_affiliation_strings":["Department of Engineering, University of Massachusetts at Boston, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Massachusetts at Boston, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101650672","display_name":"Shakir Khan","orcid":"https://orcid.org/0000-0002-2797-9592","observed_orcids":["https://orcid.org/0000-0002-2797-9592"]},"institutions":[{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shakir Khan","raw_affiliation_strings":["Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India","institution_ids":["https://openalex.org/I171210897"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bilal M. A. Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bilal M. A. Hussain","raw_affiliation_strings":["Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India","institution_ids":["https://openalex.org/I171210897"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Syed A. Hasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Syed A. Hasan","raw_affiliation_strings":["Department of Oto-Rhino-Laryngology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-Laryngology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India","institution_ids":["https://openalex.org/I171210897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029686833","display_name":"Shahid A. Siddique","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shahid A. Siddique","raw_affiliation_strings":["Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India","institution_ids":["https://openalex.org/I171210897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056282324","display_name":"Kafil Akhtar","orcid":"https://orcid.org/0000-0002-3482-1195","observed_orcids":["https://orcid.org/0000-0002-3482-1195"]},"institutions":[{"id":"https://openalex.org/I154971649","display_name":"Jawaharlal Nehru Medical College Hospital","ror":"https://ror.org/04q32pk93","country_code":"IN","type":"education","lineage":["https://openalex.org/I154971649"]},{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kafil Akhtar","raw_affiliation_strings":["Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India","institution_ids":["https://openalex.org/I154971649","https://openalex.org/I171210897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112355840","display_name":"Meredith A. August","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith August","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080667688","display_name":"Maria J. Troulis","orcid":"https://orcid.org/0009-0002-4085-4257","observed_orcids":["https://orcid.org/0009-0002-4085-4257","https://orcid.org/0000-0001-8795-0276"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Troulis","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029564172","display_name":"Filip \u010cu\u010dkov","orcid":"https://orcid.org/0000-0002-7504-0547","observed_orcids":["https://orcid.org/0000-0002-7504-0547"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filip Cuckov","raw_affiliation_strings":["Department of Engineering, University of Massachusetts at Boston, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Massachusetts at Boston, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107115177","display_name":"Jonathan P. Celli","orcid":"https://orcid.org/0000-0003-3560-0770","observed_orcids":["https://orcid.org/0000-0003-3560-0770"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan P. Celli","raw_affiliation_strings":["Department of Physics, University of Massachusetts at Boston, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Massachusetts at Boston, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058184923","display_name":"Tayyaba G. Hasan","orcid":"https://orcid.org/0000-0003-0871-6057","observed_orcids":["https://orcid.org/0000-0003-0871-6057"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tayyaba Hasan","raw_affiliation_strings":["Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. thasan@partners.org","Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. thasan@partners.org","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058184923"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":1.3215,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81684061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"15830","last_page":"15830"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.796999990940094},{"id":"https://openalex.org/keywords/low-cost-medical-device","display_name":"low-cost medical device","score":0.7549999952316284},{"id":"https://openalex.org/keywords/dosimetry","display_name":"dosimetry","score":0.7210000157356262},{"id":"https://openalex.org/keywords/led-light-source","display_name":"LED light source","score":0.8610000014305115},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ergonomic-design","display_name":"ergonomic design","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C3019308078","wikidata":"https://www.wikidata.org/wiki/Q229367","display_name":"3d printed","level":2,"score":0.7092232704162598},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.6486519575119019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5854849219322205},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5335498452186584},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.47457411885261536},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.46842849254608154},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.380876362323761},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32974129915237427},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25358131527900696},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-019-51859-6","doi":"https://doi.org/10.1038/s41598-019-51859-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-51859-6","pdf_url":"https://www.nature.com/articles/s41598-019-51859-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:31676807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31676807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:6825190","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6825190","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a1b414220c72481596da839cfb414680","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a1b414220c72481596da839cfb414680","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-51859-6","doi":"https://doi.org/10.1038/s41598-019-51859-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-51859-6","pdf_url":"https://www.nature.com/articles/s41598-019-51859-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Industry, innovation and infrastructure","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/9"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3810827797","display_name":null,"funder_award_id":"UH3 CA189901","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5083613575","display_name":null,"funder_award_id":"UH3CA189901","funder_id":"https://openalex.org/F4320338333","funder_display_name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute"},{"id":"https://openalex.org/G5134780737","display_name":null,"funder_award_id":"UH2CA189901","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8585985060","display_name":null,"funder_award_id":"UH3CA189901","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G9000100045","display_name":null,"funder_award_id":"UH3CA189901","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000328835","display_name":null,"funder_award_id":"UH2CA189901","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338333","display_name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","ror":"https://ror.org/00vkwep27"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2989166350.pdf","grobid_xml":"https://content.openalex.org/works/W2989166350.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1594222220","https://openalex.org/W1964219512","https://openalex.org/W1967985847","https://openalex.org/W1969153176","https://openalex.org/W1989964747","https://openalex.org/W1997274512","https://openalex.org/W1997518252","https://openalex.org/W2020164256","https://openalex.org/W2022707174","https://openalex.org/W2045123489","https://openalex.org/W2057582695","https://openalex.org/W2076781802","https://openalex.org/W2081878562","https://openalex.org/W2089683169","https://openalex.org/W2099722388","https://openalex.org/W2105621285","https://openalex.org/W2133485607","https://openalex.org/W2142885730","https://openalex.org/W2149632932","https://openalex.org/W2153869743","https://openalex.org/W2160744361","https://openalex.org/W2171052791","https://openalex.org/W2253405669","https://openalex.org/W2269751847","https://openalex.org/W2535284666","https://openalex.org/W2558372344","https://openalex.org/W2610519902","https://openalex.org/W2807907317","https://openalex.org/W2889401384","https://openalex.org/W2950397183"],"related_works":["https://openalex.org/W632698381","https://openalex.org/W3165685416","https://openalex.org/W2073514222","https://openalex.org/W2360420977","https://openalex.org/W2327946202","https://openalex.org/W564069220","https://openalex.org/W2916696344","https://openalex.org/W2256492013","https://openalex.org/W2364896477","https://openalex.org/W1593746356"],"abstract_inverted_index":{"Oral":[0],"cancer":[1,26,85],"prevalence":[2],"is":[3,86],"increasing":[4],"at":[5,267],"an":[6,129,167,180],"alarming":[7],"rate":[8],"worldwide,":[9],"especially":[10],"in":[11,28,54,104,123,154,182,191,205,216,224,231,272,294],"developing":[12],"countries":[13],"which":[14],"lack":[15,107],"the":[16,24,101,158,172,175,185,192,198,221],"medical":[17],"infrastructure":[18,162],"to":[19,44,56,151,188,220],"manage":[20],"it.":[21],"For":[22],"example,":[23],"oral":[25,84,102,236,288],"burden":[27],"India":[29],"has":[30,116],"been":[31],"identified":[32],"as":[33,251,280],"a":[34,87,106,243,252,281],"public":[35],"health":[36],"crisis.":[37],"The":[38],"high":[39,62],"expense":[40],"and":[41,50,72,144,208,211],"logistical":[42],"barriers":[43],"obtaining":[45],"treatment":[46],"with":[47,61,75,141,234,242,263],"surgery,":[48],"radiotherapy":[49],"chemotherapy":[51],"often":[52],"result":[53],"progression":[55],"unmanageable":[57],"late":[58],"stage":[59,287],"disease":[60,266],"morbidity.":[63],"Even":[64],"when":[65],"curative,":[66],"these":[67,273],"approaches":[68],"can":[69,148,291],"be":[70,149,292],"cosmetically":[71],"functionally":[73],"disfiguring":[74],"extensive":[76,161],"side":[77],"effects.":[78],"An":[79],"alternate":[80],"effective":[81],"therapy":[82,92,95],"for":[83,112,255,285],"light":[88,114,131,139,176,218,248,257],"based":[89],"spatially-targeted":[90],"cytotoxic":[91],"called":[93],"photodynamic":[94],"(PDT).":[96],"Despite":[97],"excellent":[98],"healing":[99],"of":[100,108,135,160,166,174,184,213],"mucosa":[103],"PDT,":[105],"robust":[109],"enabling":[110],"technology":[111],"intraoral":[113,130,256],"delivery":[115,132,258],"limited":[117],"its":[118],"broader":[119],"implementation.":[120],"Leveraging":[121],"advances":[122],"3D":[124,137],"printing,":[125],"we":[126,178,196],"have":[127],"developed":[128],"system":[133],"consisting":[134],"modular":[136],"printed":[138],"applicators":[140,215,240],"pre-calibrated":[142],"dosimetry":[143],"mouth":[145],"props":[146],"that":[147,238,290],"utilized":[150,179],"perform":[152],"PDT":[153,279],"conscious":[155],"subjects":[156,233],"without":[157],"need":[159],"or":[163],"manual":[164],"positioning":[165],"optical":[168,186],"fiber.":[169],"To":[170],"evaluate":[171],"stability":[173,199],"applicators,":[177],"endoscope":[181],"lieu":[183],"fiber":[187,245],"monitor":[189],"motion":[190],"fiducial":[193],"markers.":[194],"Here":[195],"showcase":[197],"(less":[200],"than":[201],"2":[202],"mm":[203],"deviation":[204],"both":[206],"horizontal":[207],"vertical":[209],"axis)":[210],"ergonomics":[212],"our":[214,239,276],"delivering":[217],"precisely":[219],"target":[222],"location":[223],"ten":[225],"healthy":[226],"volunteers.":[227],"We":[228],"also":[229],"demonstrate":[230],"five":[232],"T1N0M0":[235],"lesions":[237,289],"coupled":[241,246],"low-cost":[244],"LED-based":[247],"source":[249],"served":[250],"complete":[253,260],"platform":[254],"achieving":[259],"tumor":[261],"response":[262],"no":[264],"residual":[265],"initial":[268],"histopathology":[269],"follow":[270],"up":[271],"patients.":[274],"Overall,":[275],"approach":[277],"potentiates":[278],"viable":[282],"therapeutic":[283],"option":[284],"early":[286],"delivered":[293],"low":[295],"resource":[296],"settings.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
