{"id":"https://openalex.org/W2988694373","doi":"https://doi.org/10.2147/cmar.s225607","title":"Local Tumor Ischemia-Reperfusion Mediated By Ultrasound-Targeted Microbubble Destruction Enhances The Anti-Tumor Efficacy Of Doxorubicin Chemotherapy","display_name":"Local Tumor Ischemia-Reperfusion Mediated By Ultrasound-Targeted Microbubble Destruction Enhances The Anti-Tumor Efficacy Of Doxorubicin Chemotherapy","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2988694373","doi":"https://doi.org/10.2147/cmar.s225607","mag":"2988694373","pmid":"https://pubmed.ncbi.nlm.nih.gov/31807068","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6842279"},"language":"en","primary_location":{"id":"doi:10.2147/cmar.s225607","doi":"https://doi.org/10.2147/cmar.s225607","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s225607","pdf_url":"https://www.dovepress.com/getfile.php?fileID=53754","source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2988694373"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=53754","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002261945","display_name":"Manxiang Wu","orcid":"https://orcid.org/0000-0003-3378-4860","observed_orcids":["https://orcid.org/0000-0003-3378-4860"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manxiang Wu","raw_affiliation_strings":["Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102074148","display_name":"Zhuqing Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128628","display_name":"Peking University Shenzhen Hospital","ror":"https://ror.org/03kkjyb15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuqing Song","raw_affiliation_strings":["Department of Breast Surgery, Peking University Shenzhen Hospital, Shenzhen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Peking University Shenzhen Hospital, Shenzhen, People's Republic of China","institution_ids":["https://openalex.org/I4210128628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409617","display_name":"Shiyu Zhang","orcid":"https://orcid.org/0000-0002-4806-8982","observed_orcids":["https://orcid.org/0000-0002-4806-8982"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyu Zhang","raw_affiliation_strings":["Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023638756","display_name":"Qing Dan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Dan","raw_affiliation_strings":["Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015741559","display_name":"Caiyun Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151893264","display_name":"Jiamusi University","ror":"https://ror.org/01vasff55","country_code":"CN","type":"education","lineage":["https://openalex.org/I151893264"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caiyun Tang","raw_affiliation_strings":["Pharmaceutical Analysis Department, College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Analysis Department, College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China","institution_ids":["https://openalex.org/I151893264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045809285","display_name":"Chao Peng","orcid":"https://orcid.org/0000-0002-6814-2676","observed_orcids":["https://orcid.org/0000-0002-6814-2676","https://orcid.org/0009-0005-4129-4441","https://orcid.org/0000-0003-2843-0689"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Peng","raw_affiliation_strings":["Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100678815","display_name":"Liang Yu","orcid":"https://orcid.org/0000-0001-7044-7391","observed_orcids":["https://orcid.org/0000-0001-7044-7391"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Liang","raw_affiliation_strings":["Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425777","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0003-4623-8076","observed_orcids":["https://orcid.org/0000-0003-4623-8076"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Wang","raw_affiliation_strings":["Department of Neurosurgery, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, People's Republic of China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003299639","display_name":"Yingjia Li","orcid":"https://orcid.org/0000-0002-8885-2317","observed_orcids":["https://orcid.org/0000-0002-8885-2317"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingjia Li","raw_affiliation_strings":["Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003299639"],"corresponding_institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.2335,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.44384509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"Volume 11","issue":null,"first_page":"9387","last_page":"9395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasound-targeted-microbubble-destruction","display_name":"ultrasound-targeted microbubble destruction","score":0.9819999933242798},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/chemotherapy-enhancement","display_name":"chemotherapy enhancement","score":0.7699999809265137},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9879999756813049},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.847000002861023},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7604981660842896},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7046251893043518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5934454798698425},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5527674555778503},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5077839493751526},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.468943327665329},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.45740795135498047},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4514528512954712},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.44832271337509155},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3696168065071106},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3361961245536804},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2781160771846771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21066653728485107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12537530064582825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09166991710662842},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/cmar.s225607","doi":"https://doi.org/10.2147/cmar.s225607","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s225607","pdf_url":"https://www.dovepress.com/getfile.php?fileID=53754","source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},{"id":"pmid:31807068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31807068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer management and research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6842279","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6842279/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Manag Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:dbbb6179174241119def2141e5c1d689","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dbbb6179174241119def2141e5c1d689","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Management and Research, Vol Volume 11, Pp 9387-9395 (2019)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/49536","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/local-tumor-ischemia-reperfusion-mediated-by-ultrasound-targeted-micro-peer-reviewed-article-CMAR","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/cmar.s225607","doi":"https://doi.org/10.2147/cmar.s225607","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s225607","pdf_url":"https://www.dovepress.com/getfile.php?fileID=53754","source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1954302049","display_name":null,"funder_award_id":"81871371","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5177287703","display_name":"\u80bf\u7624\u65b0\u751f\u8840\u7ba1\u9776\u5411\u5fae\u6ce1-\u53cc\u914d\u4f53\u4fee\u9970\u7684\u8f7d\u836f\u7eb3\u7c73\u7c92\u590d\u5408\u7269\u4f53\u7cfb\u6784\u5efa\u53ca\u5176\u6297\u80bf\u7624\u6027\u80fd\u8bc4\u4ef7","funder_award_id":"81371559","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7051682672","display_name":null,"funder_award_id":"201804010106","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7153271569","display_name":"\u8d85\u58f0\u6fc0\u53d1\u8f7d\u6c27\u76f8\u53d8\u7eb3\u7c73\u6ef4-\u643aiRGD\u80bd\u8f7d\u836f\u809d\u7d20\u7eb3\u7c73\u7c92\u590d\u5408\u7269\u514b\u670d\u80bf\u7624\u591a\u836f\u8010\u836f\u53ca\u5176\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"81671709","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G779460790","display_name":"\u8f7d\u963f\u9709\u7d20\u8f7d\u6c27\u76f8\u53d8\u6c1f\u78b3\u7eb3\u7c73\u6db2\u6ef4-\u5de8\u566c\u7ec6\u80de\u9776\u5411\u9012\u9001\u4f53\u7cfb\u6784\u5efa\u53ca\u5176\u63d0\u9ad8\u80bf\u7624\u4e4f\u6c27\u533a\u57df\u9776\u5411\u6cbb\u7597\u6548\u679c\u7684\u7814\u7a76","funder_award_id":"81701711","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8074529264","display_name":null,"funder_award_id":"KQJSCX20170331161449","funder_id":"https://openalex.org/F4320335790","funder_display_name":"Shenzhen Peacock Plan"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335790","display_name":"Shenzhen Peacock Plan","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2988694373.pdf","grobid_xml":"https://content.openalex.org/works/W2988694373.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W150307056","https://openalex.org/W937048895","https://openalex.org/W1490606256","https://openalex.org/W1972779889","https://openalex.org/W1976134975","https://openalex.org/W1993229857","https://openalex.org/W1998116984","https://openalex.org/W2004346004","https://openalex.org/W2012733189","https://openalex.org/W2018744127","https://openalex.org/W2022777216","https://openalex.org/W2041992938","https://openalex.org/W2043809682","https://openalex.org/W2061728585","https://openalex.org/W2065294001","https://openalex.org/W2068245543","https://openalex.org/W2070672521","https://openalex.org/W2072076646","https://openalex.org/W2072589877","https://openalex.org/W2075387097","https://openalex.org/W2085163888","https://openalex.org/W2096245406","https://openalex.org/W2110155791","https://openalex.org/W2114544688","https://openalex.org/W2129778797","https://openalex.org/W2141603634","https://openalex.org/W2152435635","https://openalex.org/W2153261612","https://openalex.org/W2317661976","https://openalex.org/W2575440227","https://openalex.org/W2588300671","https://openalex.org/W2605837602","https://openalex.org/W2606660042","https://openalex.org/W2621506039","https://openalex.org/W2712489347","https://openalex.org/W2758405107","https://openalex.org/W2766356594","https://openalex.org/W2945792041","https://openalex.org/W4288076435"],"related_works":["https://openalex.org/W2997803445","https://openalex.org/W4387519978","https://openalex.org/W2086269319","https://openalex.org/W3016540385","https://openalex.org/W1970608501","https://openalex.org/W3150631833","https://openalex.org/W4387765483","https://openalex.org/W4410320384","https://openalex.org/W2375371506","https://openalex.org/W1990532605"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ultrasound-targeted":[1],"microbubble":[2],"destruction":[3],"(UTMD)":[4],"has":[5],"been":[6],"shown":[7],"to":[8,14,24,52,65,112,121,255],"be":[9],"a":[10,21,184,236],"promising":[11],"noninvasive":[12],"technique":[13,241],"change":[15],"the":[16,44,54,71,76,85,102,110,113,139,151,194,207,219,227,257],"tumor":[17,35,48,68,77,114,140,221,243],"circulation,":[18],"thus":[19],"providing":[20],"potential":[22,254],"method":[23],"increase":[25],"reactive":[26],"oxygen":[27],"species":[28],"(ROS)":[29],"levels":[30,98,201],"in":[31,150,192,206],"tumors":[32,152],"by":[33],"inducing":[34],"tissue":[36],"ischemia-reperfusion":[37],"(IR).":[38],"In":[39,213,245],"this":[40],"study,":[41],"we":[42],"investigated":[43],"feasibility":[45],"of":[46,57,75,138,148,202,230,260],"local":[47,67,220],"IR":[49,163,181,195,208,222],"through":[50],"UTMD":[51,62,108,234,249],"enhance":[53,226],"anti-tumor":[55,103,215,228,258],"efficacy":[56,104,229,259],"doxorubicin":[58],"(DOX)":[59],"chemotherapy.":[60,232],"METHODS:":[61],"was":[63,78,81,105,130,153,187],"used":[64],"induce":[66],"IR.":[69,244],"After":[70],"major":[72,127],"blood":[73,128,136],"supply":[74,129],"restored,":[79],"DOX":[80,168,231],"intravenously":[82],"injected":[83],"into":[84],"tumor-bearing":[86],"mice.":[87],"The":[88,135,146,170],"superoxide":[89],"dismutase":[90],"(SOD)":[91],"and":[92,96,101,126,159,196,210,239],"catalase":[93],"(CAT)":[94],"activity":[95,147,172],"ROS":[97,203],"were":[99,204],"examined,":[100],"evaluated.":[106],"RESULTS:":[107],"blocked":[109],"circulation":[111],"for":[115,242],"30":[116,124],"mins.":[117],"Slow":[118],"reperfusion":[119],"began":[120],"occur":[122],"after":[123,132,162,180,189],"mins,":[125],"restored":[131],"1":[133,160,190],"hr.":[134],"perfusion":[137],"completely":[141],"recovered":[142],"at":[143,156,177],"2":[144,157,178],"hrs.":[145],"SOD":[149],"significantly":[154,225],"decreased":[155],"hrs":[158,179],"day":[161,191],"treatment":[164],"with":[165,247],"or":[166],"without":[167],"treatment.":[169],"CAT":[171],"showed":[173],"no":[174],"obvious":[175],"changes":[176],"treatment,":[182],"whereas":[183],"significant":[185],"decrease":[186],"found":[188],"both":[193],"DOX/IR":[197],"groups.":[198],"Moreover,":[199],"higher":[200],"produced":[205],"group":[209],"IR/DOX":[211],"group.":[212],"vivo":[214],"study":[216],"indicated":[217],"that":[218],"strategy":[223],"may":[224,250],"CONCLUSION:":[233],"provides":[235],"novel,":[237],"simple":[238],"non-invasive":[240],"combination":[246],"chemotherapy,":[248],"have":[251],"high":[252],"great":[253],"improve":[256],"chemotherapeutic":[261],"drugs.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2019-11-22T00:00:00"}
