{"id":"https://openalex.org/W298827240","doi":"https://doi.org/10.21236/ada433948","title":"Biomarkers of Selenium Action in Prostate Cancer","display_name":"Biomarkers of Selenium Action in Prostate Cancer","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W298827240","doi":"https://doi.org/10.21236/ada433948","mag":"298827240"},"language":"en","primary_location":{"id":"doi:10.21236/ada433948","doi":"https://doi.org/10.21236/ada433948","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada433948","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022356999","display_name":"Hongjuan Zhao","orcid":"https://orcid.org/0000-0001-6083-0370","observed_orcids":["https://orcid.org/0000-0001-6083-0370"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hongjuan Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022356999"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.9769999980926514},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7670000195503235},{"id":"https://openalex.org/keywords/methylseleninic-acid","display_name":"methylseleninic acid","score":0.9350000023841858},{"id":"https://openalex.org/keywords/selenomethionine","display_name":"selenomethionine","score":1.0},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/secreted-proteins","display_name":"secreted proteins","score":0.8069999814033508},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.9570000171661377},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.7161218523979187},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6906615495681763},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5746684670448303},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5228731632232666},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.49927234649658203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41112980246543884},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38243919610977173},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36143696308135986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27779680490493774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2579561769962311},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20720937848091125},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21236/ada433948","doi":"https://doi.org/10.21236/ada433948","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada433948","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA433948","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA433948","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7099999785423279,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2003519295","https://openalex.org/W2102243932","https://openalex.org/W7005275090","https://openalex.org/W2144547661","https://openalex.org/W7098963289","https://openalex.org/W1854069855","https://openalex.org/W2164070896","https://openalex.org/W2276698631","https://openalex.org/W2037637519","https://openalex.org/W7100588066"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2],"designed":[3],"to":[4,26,84,91,140],"identify":[5,27],"new,":[6],"mechanistically":[7],"relevant":[8],"biomarkers":[9],"of":[10,31,34,44,71,77],"selenium":[11,35,72],"responsiveness":[12],"for":[13],"use":[14],"in":[15,103,116,133,138],"intervention":[16],"trials.":[17],"We":[18],"have":[19,97],"completed":[20],"our":[21],"first":[22],"aim":[23],"which":[24],"is":[25],"common":[28,179],"molecular":[29,180],"targets":[30],"different":[32,177],"forms":[33,70],"that":[36,60],"are":[37,61],"secretory":[38,51,86],"using":[39],"bioinformatics":[40],"approaches":[41],"and":[42,47,50,55,64,101,113,122,142,154,163,178],"datasets":[43],"selenium-modulated":[45],"transcripts":[46],"membrane":[48,62],"bound":[49],"proteins.":[52],"17":[53],"genes":[54,59,125,146],"123":[56],"named":[57],"unique":[58,124],"bound/secretory":[63],"upregulated":[65],"by":[66,87,109],"three":[67],"or":[68],"two":[69],"respectively":[73],"were":[74,82,147],"selected.":[75],"Out":[76],"these":[78],"140":[79],"genes,":[80],"15":[81],"shown":[83],"be":[85],"conventional":[88],"methods":[89],"according":[90],"published":[92],"literature.":[93],"In":[94],"addition,":[95],"we":[96],"determined":[98],"the":[99,159],"similarities":[100],"differences":[102],"global":[104],"gene":[105],"expression":[106,127],"charges":[107],"induced":[108],"methylseleninic":[110],"acid":[111],"(MSA)":[112],"selenomethionine":[114],"(SM)":[115],"prostate":[117],"cancer":[118],"cells":[119,174],"LNCaP.":[120],"2,336":[121],"2,165":[123],"showed":[126],"changes":[128],"at":[129,134],"least":[130,135],"1.5":[131],"fold":[132],"3":[136],"samples":[137],"response":[139],"SM":[141,155,162],"MSA":[143,153,164],"respectively.":[144],"366":[145],"statistically":[148],"significantly":[149],"differentially":[150],"expressed":[151],"between":[152],"treated":[156],"cells.":[157],"At":[158],"same":[160],"concentration,":[161],"modulated":[165],"press.":[166],"However,":[167],"they":[168],"exert":[169],"their":[170],"effects":[171],"on":[172],"LACaP":[173],"through":[175],"both":[176],"targets.":[181]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
