{"id":"https://openalex.org/W2987376294","doi":"https://doi.org/10.1186/s40478-019-0828-x","title":"Microglial motility in Alzheimer\u2019s disease and after A\u03b242 immunotherapy: a human post-mortem study","display_name":"Microglial motility in Alzheimer\u2019s disease and after A\u03b242 immunotherapy: a human post-mortem study","publication_year":2019,"publication_date":"2019-11-08","ids":{"openalex":"https://openalex.org/W2987376294","doi":"https://doi.org/10.1186/s40478-019-0828-x","mag":"2987376294","pmid":"https://pubmed.ncbi.nlm.nih.gov/31703599","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6842157"},"language":"en","primary_location":{"id":"doi:10.1186/s40478-019-0828-x","doi":"https://doi.org/10.1186/s40478-019-0828-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40478-019-0828-x","pdf_url":"https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0828-x","source":{"id":"https://openalex.org/S2764650462","display_name":"Acta Neuropathologica Communications","issn_l":"2051-5960","issn":["2051-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0828-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013498870","display_name":"Diana Franco-Bocanegra","orcid":"https://orcid.org/0000-0001-6267-1975","observed_orcids":["https://orcid.org/0000-0001-6267-1975"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Diana K. Franco-Bocanegra","raw_affiliation_strings":["Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019380073","display_name":"Bethany E. George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bethany George","raw_affiliation_strings":["Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086195254","display_name":"Laurie C. Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laurie C. Lau","raw_affiliation_strings":["Clinical and Experimental Sciences, Faculty of Medicine, Sir Henry Wellcome Laboratories, University of Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Experimental Sciences, Faculty of Medicine, Sir Henry Wellcome Laboratories, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064532444","display_name":"Clive Holmes","orcid":"https://orcid.org/0000-0003-1999-6912","observed_orcids":["https://orcid.org/0000-0003-1999-6912"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I2802073232","display_name":"Southern Health NHS Foundation Trust","ror":"https://ror.org/03qesm017","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802073232"]},{"id":"https://openalex.org/I2802213945","display_name":"Moorgreen Hospital","ror":"https://ror.org/02jb7ng92","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802073232","https://openalex.org/I2802213945"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clive Holmes","raw_affiliation_strings":["Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK","Memory Assessment and Research Centre, Moorgreen Hospital, Southern Health Foundation Trust, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Memory Assessment and Research Centre, Moorgreen Hospital, Southern Health Foundation Trust, Southampton, UK","institution_ids":["https://openalex.org/I2802073232","https://openalex.org/I2802213945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082712367","display_name":"James A. R. Nicoll","orcid":"https://orcid.org/0000-0002-9444-7246","observed_orcids":["https://orcid.org/0000-0002-9444-7246"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James A. R. Nicoll","raw_affiliation_strings":["Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK","Department of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Department of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK","institution_ids":["https://openalex.org/I2802965805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008325892","display_name":"Delphine Boche","orcid":"https://orcid.org/0000-0002-5884-130X","observed_orcids":["https://orcid.org/0000-0002-5884-130X"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Delphine Boche","raw_affiliation_strings":["Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK. d.boche@soton.ac.uk","Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK"],"raw_orcid":"https://orcid.org/0000-0002-5884-130X","affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK. d.boche@soton.ac.uk","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Clinical Neurosciences, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 806, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008325892"],"corresponding_institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":3.821,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.94403565,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"174","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglial-motility","display_name":"microglial motility","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iba1","display_name":"Iba1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/p2y12-receptor","display_name":"P2Y12 receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cofilin-1","display_name":"cofilin-1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/coronin-1a","display_name":"CORO1A","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/phosphorylated-tau","display_name":"phosphorylated tau","score":0.9190000295639038},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.8029719591140747},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7763928771018982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5801074504852295},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37924546003341675},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3655562400817871},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3519614040851593},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33711788058280945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24552375078201294}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s40478-019-0828-x","doi":"https://doi.org/10.1186/s40478-019-0828-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40478-019-0828-x","pdf_url":"https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0828-x","source":{"id":"https://openalex.org/S2764650462","display_name":"Acta Neuropathologica Communications","issn_l":"2051-5960","issn":["2051-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6842157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6842157","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathol Commun","raw_type":"Text"},{"id":"pmid:31703599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31703599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neuropathologica communications","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:435262","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1186/s40478-019-0828-x>).","pdf_url":"https://eprints.soton.ac.uk/435262/1/ANEC_D_19_00388_R1_comments_to_reviewer_removed_.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:9acde3a5cec147d78d28690f9b1fa250","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9acde3a5cec147d78d28690f9b1fa250","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40478-019-0828-x","doi":"https://doi.org/10.1186/s40478-019-0828-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40478-019-0828-x","pdf_url":"https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0828-x","source":{"id":"https://openalex.org/S2764650462","display_name":"Acta Neuropathologica Communications","issn_l":"2051-5960","issn":["2051-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4466896990","display_name":null,"funder_award_id":"VCFoM/BocheD/TBC/170","funder_id":"https://openalex.org/F4320320277","funder_display_name":"University of Southampton"},{"id":"https://openalex.org/G5300737479","display_name":null,"funder_award_id":"SC037554","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"},{"id":"https://openalex.org/G6218106604","display_name":null,"funder_award_id":"ART/PG2006/4","funder_id":"https://openalex.org/F4320321081","funder_display_name":"Alzheimer\u2019s Research UK"}],"funders":[{"id":"https://openalex.org/F4320320021","display_name":"Parkinson's UK","ror":"https://ror.org/02417p338"},{"id":"https://openalex.org/F4320320277","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543"},{"id":"https://openalex.org/F4320321081","display_name":"Alzheimer\u2019s Research UK","ror":"https://ror.org/02ymzm013"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2987376294.pdf","grobid_xml":"https://content.openalex.org/works/W2987376294.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1549733918","https://openalex.org/W1581267597","https://openalex.org/W1742698850","https://openalex.org/W1776501149","https://openalex.org/W1801131809","https://openalex.org/W1823419340","https://openalex.org/W1870043354","https://openalex.org/W1964041350","https://openalex.org/W1965572078","https://openalex.org/W1966765900","https://openalex.org/W1991989649","https://openalex.org/W2018348569","https://openalex.org/W2031869158","https://openalex.org/W2040533389","https://openalex.org/W2043257604","https://openalex.org/W2044090829","https://openalex.org/W2045590748","https://openalex.org/W2052652421","https://openalex.org/W2053675728","https://openalex.org/W2053876965","https://openalex.org/W2060167539","https://openalex.org/W2063808031","https://openalex.org/W2066943555","https://openalex.org/W2072476769","https://openalex.org/W2081560349","https://openalex.org/W2082414904","https://openalex.org/W2092921112","https://openalex.org/W2094660330","https://openalex.org/W2095733296","https://openalex.org/W2097971052","https://openalex.org/W2106758408","https://openalex.org/W2111419867","https://openalex.org/W2111433735","https://openalex.org/W2112516157","https://openalex.org/W2115825207","https://openalex.org/W2116281786","https://openalex.org/W2117170669","https://openalex.org/W2121886693","https://openalex.org/W2122828560","https://openalex.org/W2131686384","https://openalex.org/W2143461767","https://openalex.org/W2144610554","https://openalex.org/W2148034536","https://openalex.org/W2152446053","https://openalex.org/W2152914442","https://openalex.org/W2167710782","https://openalex.org/W2288003409","https://openalex.org/W2414662940","https://openalex.org/W2531941507","https://openalex.org/W2790181372","https://openalex.org/W2793302204","https://openalex.org/W2799675696","https://openalex.org/W2891888347","https://openalex.org/W2891981854","https://openalex.org/W2917074522","https://openalex.org/W2945016564","https://openalex.org/W2951541013","https://openalex.org/W2955533479","https://openalex.org/W2970157750","https://openalex.org/W4288076435"],"related_works":["https://openalex.org/W2981086012","https://openalex.org/W7067714640","https://openalex.org/W3190756206","https://openalex.org/W6902005331","https://openalex.org/W596582092","https://openalex.org/W1581267597","https://openalex.org/W1987849263","https://openalex.org/W2086960363","https://openalex.org/W2144610554","https://openalex.org/W2021746261"],"abstract_inverted_index":{"Microglial":[0],"function":[1],"is":[2,49,213],"highly":[3],"dependent":[4],"on":[5],"cell":[6],"motility,":[7],"with":[8,47,134,150,159],"baseline":[9,227],"motility":[10,18,31,48,229],"required":[11],"for":[12,89],"homeostatic":[13,141,201],"surveillance":[14],"activity":[15],"and":[16,36,53,69,87,101,103,107,138,153,172,203,221],"directed":[17],"to":[19,182,208],"migrate":[20],"towards":[21],"a":[22,185],"source":[23],"of":[24,44,63,77,83,124],"injury.":[25],"Experimental":[26],"evidence":[27],"suggests":[28],"impaired":[29],"microglial":[30,93,228],"in":[32,51,131,145,161,165,177,184,215,236],"Alzheimer's":[33],"disease":[34],"(AD)":[35],"therefore":[37],"we":[38],"have":[39],"investigated":[40],"whether":[41],"the":[42,56,91,140,146,166,197,200,233],"expression":[43,123],"proteins":[45,94,128,174],"associated":[46],"altered":[50],"AD":[52,67,71,132,167],"affected":[54],"by":[55],"A\u03b2":[57,160,194],"immunotherapy":[58,180],"using":[59,116],"post-mortem":[60],"brain":[61,84],"tissue":[62],"32":[64],"controls,":[65,135],"44":[66],"cases,":[68],"16":[70],"cases":[72],"from":[73],"our":[74],"unique":[75],"group":[76,148],"patients":[78],"immunised":[79],"against":[80],"A\u03b242":[81,106],"(iAD).Sections":[82],"were":[85,143,175],"immunolabelled":[86],"quantified":[88],"(i)":[90],"motility-related":[92,127],"Iba1,":[95],"cofilin":[96],"1":[97],"(CFL1),":[98],"coronin-1a":[99],"(CORO1A)":[100],"P2RY12,":[102,139],"(ii)":[104],"pan-A\u03b2,":[105],"phosphorylated":[108],"tau":[109],"(ptau).":[110],"The":[111,122],"neuroinflammatory":[112],"environment":[113],"was":[114,129],"characterised":[115],"Meso":[117],"Scale":[118],"Discovery":[119],"multiplex":[120],"assays.":[121],"all":[125],"four":[126],"unmodified":[130],"compared":[133,149],"whereas":[136,179],"Iba1":[137,152,202,220],"markers,":[142],"increased":[144,176,219,226],"iAD":[147,169],"AD.":[151,216],"P2RY12":[154,204,222],"showed":[155],"significant":[156],"positive":[157],"correlations":[158],"controls":[162],"but":[163,210,230],"not":[164],"or":[168],"groups.":[170],"Pro-":[171],"anti-inflammatory":[173],"AD,":[178],"appears":[181,195],"result":[183],"slightly":[186],"less":[187],"pro-inflammatory":[188],"environment.Our":[189],"findings":[190],"suggest":[191],"that":[192],"as":[193],"during":[196],"ageing":[198],"process,":[199],"-positive":[205],"microglia":[206],"respond":[207],"A\u03b2,":[209],"this":[211],"response":[212],"absent":[214],"A\u03b2-immunisation":[217],"promoted":[218],"expression,":[223],"likely":[224],"reflecting":[225],"without":[231],"restoring":[232],"profile":[234],"observed":[235],"controls.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-11-22T00:00:00"}
