{"id":"https://openalex.org/W2987308024","doi":"https://doi.org/10.7554/elife.49874.030","title":"Author response: Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria","display_name":"Author response: Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria","publication_year":2019,"publication_date":"2019-09-12","ids":{"openalex":"https://openalex.org/W2987308024","doi":"https://doi.org/10.7554/elife.49874.030","mag":"2987308024"},"language":"en","primary_location":{"id":"doi:10.7554/elife.49874.030","doi":"https://doi.org/10.7554/elife.49874.030","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.49874.030","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.49874.030","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091731055","display_name":"Ceereena Ubaida\u2010Mohien","orcid":"https://orcid.org/0000-0002-4301-4758","observed_orcids":["https://orcid.org/0000-0002-4301-4758"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ceereena Ubaida-Mohien","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061406584","display_name":"Alexey E. Lyashkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexey Lyashkov","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072301103","display_name":"Marta Gonz\u00e1lez\u2010Freire","orcid":"https://orcid.org/0000-0001-9741-2826","observed_orcids":["https://orcid.org/0000-0001-9741-2826"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Gonzalez-Freire","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007577603","display_name":"Ravi Tharakan","orcid":"https://orcid.org/0000-0001-5895-9271","observed_orcids":["https://orcid.org/0000-0001-5895-9271"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Tharakan","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048605983","display_name":"Michelle D Shardell","orcid":"https://orcid.org/0000-0002-5283-2082","observed_orcids":["https://orcid.org/0000-0002-5283-2082"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Shardell","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011459975","display_name":"Ruin Moaddel","orcid":"https://orcid.org/0000-0002-6812-0127","observed_orcids":["https://orcid.org/0000-0002-6812-0127"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruin Moaddel","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029506023","display_name":"Richard D. Semba","orcid":"https://orcid.org/0000-0002-8350-2908","observed_orcids":["https://orcid.org/0000-0002-8350-2908"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D Semba","raw_affiliation_strings":["Johns Hopkins Medical Institute","Johns Hopkins Medical Institute, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medical Institute","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Medical Institute, Baltimore, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058369658","display_name":"Chee W. Chia","orcid":"https://orcid.org/0000-0003-3218-0141","observed_orcids":["https://orcid.org/0000-0003-3218-0141"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chee W Chia","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044404083","display_name":"Myriam Gorospe","orcid":"https://orcid.org/0000-0001-5439-3434","observed_orcids":["https://orcid.org/0000-0001-5439-3434"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myriam Gorospe","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102732991","display_name":"Ranjan Sen","orcid":"https://orcid.org/0000-0002-1916-3905","observed_orcids":["https://orcid.org/0000-0002-1916-3905"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranjan Sen","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048196698","display_name":"Luigi Ferrucci","orcid":"https://orcid.org/0000-0002-6273-1613","observed_orcids":["https://orcid.org/0000-0002-6273-1613"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luigi Ferrucci","raw_affiliation_strings":["Intramural Research Program, National Institute on Aging, National Institutes of Health","Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States"],"raw_orcid":"https://orcid.org/0000-0002-6273-1613","affiliations":[{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/skeletal-muscle-aging","display_name":"skeletal muscle aging","score":0.9200000166893005},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.5870000123977661},{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.6890000104904175},{"id":"https://openalex.org/keywords/rna-processing","display_name":"RNA processing","score":0.7369999885559082},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7680000066757202},{"id":"https://openalex.org/keywords/spliceosome","display_name":"spliceosome","score":0.8550000190734863},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.49900001287460327},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"muscle weakness","score":0.4970000088214874},{"id":"https://openalex.org/keywords/human-aging","display_name":"human aging","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.89139723777771},{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.7936532497406006},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5622511506080627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5360344648361206},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3779710829257965},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3453756272792816},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.20925986766815186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20572063326835632},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1501249074935913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.49874.030","doi":"https://doi.org/10.7554/elife.49874.030","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.49874.030","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.49874.030","doi":"https://doi.org/10.7554/elife.49874.030","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.49874.030","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.6899999976158142,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2981995922","https://openalex.org/W3135569667","https://openalex.org/W2958687458","https://openalex.org/W3123588791","https://openalex.org/W7136096385","https://openalex.org/W4415600010","https://openalex.org/W2157061952","https://openalex.org/W2054520612","https://openalex.org/W2067522878","https://openalex.org/W2098876769"],"abstract_inverted_index":{"As":[0],"humans":[1,381],"age,":[2],"their":[3],"muscles":[4,22,130,164,328,378],"become":[5,131],"weaker,":[6],"making":[7],"it":[8,93,356],"increasingly":[9],"harder":[10],"for":[11,75],"them":[12],"to":[13,89,96,124,252,258,285,299,360,389],"move,":[14],"a":[15,98,106,270],"condition":[16],"known":[17,293],"as":[18,294,380],"sarcopenia.":[19],"Analyzing":[20],"old":[21],"in":[23,54,70,82,105,145,191,202,206,213,222,304,337,348],"other":[24,215],"animals":[25],"revealed":[26,161],"that":[27,46,66,116,162,174,182,309,334,345],"they":[28,32,40,77,136],"produce":[29,183],"energy":[30],"inefficiently,":[31],"destroy":[33],"more":[34,220,230,341],"proteins":[35,104,143,173,185,189,200,239,308],"than":[36],"younger":[37,327],"muscles,":[38],"and":[39,85,155,187,212,248,279,326,329,391],"have":[41,168],"high":[42],"levels":[43,139,306,350],"of":[44,62,101,115,128,140,158,165,171,209,288,307,366,377],"molecules":[45,65,216],"cause":[47],"inflammation.":[48],"These":[49],"characteristics":[50],"may":[51,384],"be":[52,267,276],"involved":[53,190],"causing":[55],"muscle":[56,147,367],"weakness.":[57],"Proteomics":[58],"is":[59,94,357],"the":[60,64,72,102,113,126,138,142,163,172,179,193,203,207,254,260,264,289,302,305,314,322,335,346,364,374],"study":[61],"proteins,":[63,211],"play":[67],"many":[68],"roles":[69],"keeping":[71],"body":[73],"working:":[74],"example,":[76],"accelerate":[78],"chemical":[79,196],"reactions,":[80],"participate":[81],"copying":[83,241],"DNA":[84,242],"help":[86,385],"cells":[87],"respond":[88],"stimuli.":[90],"Using":[91],"proteomics,":[92],"possible":[95,359],"examine":[97],"large":[99],"number":[100],"different":[103,286],"tissue,":[107],"which":[108,282],"can":[109,266,283],"provide":[110],"information":[111],"about":[112],"state":[114],"tissue.":[117],"Ubaida-Mohien":[118,225,318],"et":[119,226,319],"al.":[120,227,320],"used":[121],"this":[122,250,395],"approach":[123],"answer":[125],"question":[127],"why":[129],"weaker":[132],"with":[133,195,370],"age.":[134,159],"First,":[135],"analyzed":[137],"all":[141],"found":[144],"skeletal":[146],"collected":[148],"from":[149,324],"58":[150],"healthy":[151],"volunteers":[152],"between":[153],"20":[154],"87":[156],"years":[157],"This":[160,332],"older":[166,223,325,338,383],"people":[167,339],"fewer":[169,188],"copies":[170],"make":[175,238,259],"up":[176],"ribosomes":[177,255],"\u2013":[178,186],"cellular":[180],"machines":[181],"new":[184,387],"providing":[192],"cell":[194],"energy.":[197],"In":[198,297],"contrast,":[199],"implicated":[201],"immune":[204],"system,":[205],"maintenance":[208],"existing":[210],"processing":[214],"called":[217],"RNAs":[218,311,315,323],"were":[219],"abundant":[221],"muscles.":[224],"then":[228],"looked":[229],"closely":[231],"at":[232],"changes":[233,379],"involving":[234],"RNA":[235,246,265,336],"processing.":[236],"Cells":[237],"by":[240,269],"sequences":[243],"into":[244],"an":[245],"template":[247,251],"using":[249],"instruct":[253],"on":[256],"how":[257,373],"specific":[261],"protein.":[262],"Before":[263],"\u2018read\u2019":[268],"ribosome,":[271],"however,":[272],"some":[273],"parts":[274],"must":[275],"cut":[277],"out":[278],"others":[280],"added,":[281],"lead":[284],"versions":[287],"final":[290],"RNA,":[291],"also":[292],"alternative":[295,342],"transcripts.":[296],"order":[298],"check":[300],"whether":[301],"difference":[303],"process":[310],"was":[312,351],"affecting":[313],"being":[316],"produced,":[317],"extracted":[321],"compared":[330],"them.":[331],"showed":[333],"had":[340],"transcripts,":[343],"confirming":[344],"change":[347],"protein":[349,375],"having":[352],"downstream":[353],"effects.":[354],"Currently,":[355],"not":[358],"prevent":[361,390],"or":[362],"delay":[363],"loss":[365],"strength":[368],"associated":[369],"aging.":[371],"Understanding":[372],"make-up":[376],"grow":[382],"find":[386],"ways":[388],"perhaps":[392],"even":[393],"reverse":[394],"decline.":[396]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-11-22T00:00:00"}
