{"id":"https://openalex.org/W298729516","doi":null,"title":"MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells.","display_name":"MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W298729516","mag":"298729516","pmid":"https://pubmed.ncbi.nlm.nih.gov/21796275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3142940"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2148818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3142940","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3142940","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Liang Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liang Zhu","raw_affiliation_strings":["Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017601084","display_name":"Wusheng Yan","orcid":"https://orcid.org/0000-0002-4722-1156","observed_orcids":["https://orcid.org/0000-0002-4722-1156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wusheng Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010423488","display_name":"Jaime Rodriguez\u2010Canales","orcid":"https://orcid.org/0000-0002-0885-2377","observed_orcids":["https://orcid.org/0000-0002-0885-2377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaime Rodriguez-Canales","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063527525","display_name":"Alex M. Rosenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex M Rosenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101603422","display_name":"Nan Hu","orcid":"https://orcid.org/0009-0009-0845-6532","observed_orcids":["https://orcid.org/0009-0009-0845-6532","https://orcid.org/0000-0002-0516-0738","https://orcid.org/0000-0001-8356-8571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063007431","display_name":"Alisa M. Goldstein","orcid":"https://orcid.org/0000-0002-7538-3582","observed_orcids":["https://orcid.org/0000-0002-7538-3582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alisa M Goldstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080559639","display_name":"Philip R. Taylor","orcid":"https://orcid.org/0000-0003-0163-1421","observed_orcids":["https://orcid.org/0000-0003-0163-1421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip R Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110109606","display_name":"Heidi S. Erickson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heidi S Erickson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111388717","display_name":"Michael R. Emmert\u2010Buck","orcid":"https://orcid.org/0009-0009-8623-9605","observed_orcids":["https://orcid.org/0009-0009-8623-9605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R Emmert-Buck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113446714","display_name":"Michael A. Tangrea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A Tangrea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8292,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90366634,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"1","issue":"5","first_page":"574","last_page":"584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.8510000109672546},{"id":"https://openalex.org/keywords/esophageal-squamous-epithelium","display_name":"esophageal squamous epithelium","score":0.8939999938011169},{"id":"https://openalex.org/keywords/basal-cells","display_name":"basal cells","score":0.5199999809265137},{"id":"https://openalex.org/keywords/differentiated-cells","display_name":"differentiated cells","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.6320000290870667},{"id":"https://openalex.org/keywords/mir-25","display_name":"miR-25","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mir-106b","display_name":"miR-106b","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":1.0},{"id":"https://openalex.org/keywords/mir-203","display_name":"miR-203","score":1.0},{"id":"https://openalex.org/keywords/mir-145","display_name":"miR-145","score":1.0},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7200000286102295},{"id":"https://openalex.org/keywords/laser-capture-microdissection","display_name":"laser capture microdissection","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8328552842140198},{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.807099461555481},{"id":"https://openalex.org/C11242284","wikidata":"https://www.wikidata.org/wiki/Q4293202","display_name":"Microdissection","level":3,"score":0.7009057998657227},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.54108065366745},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5303364992141724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.516351580619812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5094719529151917},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4976666271686554},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.48212552070617676},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46789443492889404},{"id":"https://openalex.org/C2994415158","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal squamous cell carcinoma","level":3,"score":0.4671831429004669},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3742067515850067},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.35978078842163086},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2565194070339203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2433488965034485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23652708530426025},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07878178358078003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0741930902004242},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2148818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3142940","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3142940","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3142940","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:21796275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21796275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"mag:298729516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21796275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2148818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3142940","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2821380108","display_name":"Molecular Pathology of Cancer","funder_award_id":"Z01SC010437","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W1556042150","https://openalex.org/W1606653994","https://openalex.org/W1894295571","https://openalex.org/W1964184380","https://openalex.org/W1966607967","https://openalex.org/W1970583256","https://openalex.org/W1972162902","https://openalex.org/W1976883966","https://openalex.org/W1977218806","https://openalex.org/W1984409810","https://openalex.org/W1985029768","https://openalex.org/W1986266236","https://openalex.org/W1986362763","https://openalex.org/W1986749171","https://openalex.org/W1996545149","https://openalex.org/W2000093333","https://openalex.org/W2004462371","https://openalex.org/W2008955962","https://openalex.org/W2011607173","https://openalex.org/W2014250634","https://openalex.org/W2016382173","https://openalex.org/W2017714432","https://openalex.org/W2020080445","https://openalex.org/W2020830322","https://openalex.org/W2026698180","https://openalex.org/W2027755252","https://openalex.org/W2028349099","https://openalex.org/W2029549744","https://openalex.org/W2031217896","https://openalex.org/W2034346151","https://openalex.org/W2035213975","https://openalex.org/W2035844407","https://openalex.org/W2042771775","https://openalex.org/W2043103956","https://openalex.org/W2043693107","https://openalex.org/W2045228008","https://openalex.org/W2045914559","https://openalex.org/W2049702532","https://openalex.org/W2050079849","https://openalex.org/W2053555736","https://openalex.org/W2072331122","https://openalex.org/W2072484559","https://openalex.org/W2072559448","https://openalex.org/W2075465108","https://openalex.org/W2077328830","https://openalex.org/W2078576279","https://openalex.org/W2083989142","https://openalex.org/W2084487847","https://openalex.org/W2085749269","https://openalex.org/W2088359708","https://openalex.org/W2092412751","https://openalex.org/W2099692224","https://openalex.org/W2104956231","https://openalex.org/W2106467446","https://openalex.org/W2107268184","https://openalex.org/W2107277218","https://openalex.org/W2109567968","https://openalex.org/W2109847775","https://openalex.org/W2113239055","https://openalex.org/W2115094397","https://openalex.org/W2126022174","https://openalex.org/W2127586500","https://openalex.org/W2130808338","https://openalex.org/W2131456432","https://openalex.org/W2131811102","https://openalex.org/W2135810600","https://openalex.org/W2135836598","https://openalex.org/W2139056019","https://openalex.org/W2141791387","https://openalex.org/W2143996639","https://openalex.org/W2145187069","https://openalex.org/W2149880040","https://openalex.org/W2150597604","https://openalex.org/W2151868278","https://openalex.org/W2152653683","https://openalex.org/W2159864284","https://openalex.org/W2160447597","https://openalex.org/W2162066487","https://openalex.org/W2162097274","https://openalex.org/W2162769953","https://openalex.org/W2163578933","https://openalex.org/W2167906380","https://openalex.org/W2699220065","https://openalex.org/W4230395858","https://openalex.org/W4233626828","https://openalex.org/W4237473415"],"related_works":["https://openalex.org/W2375396148","https://openalex.org/W3159852352","https://openalex.org/W2054065881","https://openalex.org/W2974702041","https://openalex.org/W2041778344","https://openalex.org/W2971408701","https://openalex.org/W4254585964","https://openalex.org/W2096629385","https://openalex.org/W2027400517","https://openalex.org/W3006124009"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"identified":[3],"several":[4],"dysregulated":[5],"microRNAs":[6,46,77,83,118],"in":[7,29,47,94,119,154],"esophageal":[8,30,49,54],"squamous":[9,31],"cell":[10,32,140,157],"carcinoma":[11],"(ESCC);":[12],"however,":[13],"to":[14,44,67],"date":[15],"there":[16],"are":[17],"no":[18],"ex":[19],"vivo":[20],"analyses":[21],"comparing":[22],"expression":[23,93,127],"levels":[24,153],"of":[25,98,116,150],"these":[26],"regulatory":[27,114],"molecules":[28],"tumors":[33],"versus":[34],"patient-matched":[35],"normal":[36,48,53],"epithelium.":[37],"We":[38],"describe":[39],"here":[40],"a":[41,129],"technical":[42],"strategy":[43],"evaluate":[45],"basal":[50],"cells":[51,56,60],"(NB),":[52],"differentiated":[55],"(ND),":[57],"and":[58,74,88,139,162],"tumor":[59],"(T).":[61],"Laser":[62],"capture":[63],"microdissection":[64],"was":[65,121],"used":[66],"procure":[68],"target":[69],"populations":[70,158],"from":[71,159],"five":[72,137],"cases":[73,138],"18":[75],"ESCC-associated":[76],"were":[78],"measured":[79],"by":[80,124],"RT-qPCR.":[81],"Five":[82],"(miR-25,":[84],"miR-106b,":[85],"miR-21,":[86],"miR-203,":[87],"miR-145)":[89],"demonstrated":[90],"consistent":[91],"differential":[92],"at":[95],"least":[96],"one":[97],"the":[99,117,135,144,148,166],"three":[100],"comparisons:":[101],"T":[102,105],"vs.":[103,106,110],"NB,":[104],"ND,":[107],"or":[108],"NB":[109],"ND.":[111],"The":[112],"potential":[113],"role":[115],"ESCC":[120],"further":[122],"evaluated":[123],"correlating":[125],"their":[126],"with":[128,170],"matched":[130],"mRNA":[131],"dataset,":[132],"which":[133],"included":[134],"same":[136],"populations.":[141],"In":[142],"conclusion,":[143],"present":[145],"work":[146],"demonstrates":[147],"feasibility":[149],"studying":[151],"microRNA":[152],"precisely":[155],"dissected":[156],"clinical":[160],"samples,":[161],"sheds":[163],"light":[164],"on":[165],"molecular":[167],"mechanisms":[168],"associated":[169],"ESCC.":[171]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
