{"id":"https://openalex.org/W2987242016","doi":null,"title":"Genetic Screening Approaches to Cancer Driver Characterization and Synthetic Lethal Target Discovery","display_name":"Genetic Screening Approaches to Cancer Driver Characterization and Synthetic Lethal Target Discovery","publication_year":2018,"publication_date":"2018-09-15","ids":{"openalex":"https://openalex.org/W2987242016","mag":"2987242016"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/41121232","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121232","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121232","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121232","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016018063","display_name":"Kristen E. Mengwasser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kristen E. Mengwasser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016018063"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.3481000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.3481000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.2583000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.09600000083446503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.9309999942779541},{"id":"https://openalex.org/keywords/brca2-deficiency","display_name":"BRCA2 deficiency","score":0.9850000143051147},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.8519999980926514},{"id":"https://openalex.org/keywords/apex2","display_name":"APEX2","score":0.8870000243186951},{"id":"https://openalex.org/keywords/fen1","display_name":"FEN1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.8970000147819519},{"id":"https://openalex.org/keywords/microhomology-mediated-end-joining","display_name":"microhomology-mediated end joining","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pd-l1-upregulation","display_name":"PD-L1 upregulation","score":0.925000011920929},{"id":"https://openalex.org/keywords/interferon-gamma-signaling","display_name":"interferon-gamma signaling","score":0.847000002861023},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.8379999995231628},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9049999713897705},{"id":"https://openalex.org/keywords/clk2","display_name":"CLK2","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9279999732971191},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cancer-driver-genes","display_name":"cancer driver genes","score":0.7459999918937683},{"id":"https://openalex.org/keywords/irf6","display_name":"IRF6","score":0.9819999933242798},{"id":"https://openalex.org/keywords/anoikis","display_name":"anoikis","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5065268278121948},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48600634932518005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39036986231803894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3272450864315033},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20721453428268433}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/41121232","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121232","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121232","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:2987242016","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/41121232","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/41121232","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121232","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41121232","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2987242016.pdf","grobid_xml":"https://content.openalex.org/works/W2987242016.grobid-xml"},"referenced_works_count":343,"referenced_works":["https://openalex.org/W1513515886","https://openalex.org/W1517051009","https://openalex.org/W1519739419","https://openalex.org/W1523413020","https://openalex.org/W1533555842","https://openalex.org/W1538419182","https://openalex.org/W1539241104","https://openalex.org/W1544851750","https://openalex.org/W1553276030","https://openalex.org/W1591054413","https://openalex.org/W1592416724","https://openalex.org/W1635615463","https://openalex.org/W1642873092","https://openalex.org/W1805263181","https://openalex.org/W1809627231","https://openalex.org/W1838829111","https://openalex.org/W1894632965","https://openalex.org/W1940241680","https://openalex.org/W1963549191","https://openalex.org/W1964690949","https://openalex.org/W1967304777","https://openalex.org/W1967954493","https://openalex.org/W1969161035","https://openalex.org/W1969379752","https://openalex.org/W1969513645","https://openalex.org/W1969839636","https://openalex.org/W1970578083","https://openalex.org/W1972241251","https://openalex.org/W1973260880","https://openalex.org/W1973268287","https://openalex.org/W1973722969","https://openalex.org/W1973737947","https://openalex.org/W1977284533","https://openalex.org/W1977644920","https://openalex.org/W1977797997","https://openalex.org/W1982602899","https://openalex.org/W1984431444","https://openalex.org/W1984825396","https://openalex.org/W1987344383","https://openalex.org/W1987450903","https://openalex.org/W1987908519","https://openalex.org/W1989006164","https://openalex.org/W1989589242","https://openalex.org/W1989773675","https://openalex.org/W1991429659","https://openalex.org/W1991541709","https://openalex.org/W1994948218","https://openalex.org/W1995054229","https://openalex.org/W1995414938","https://openalex.org/W1996237158","https://openalex.org/W1996702301","https://openalex.org/W1999778948","https://openalex.org/W2000241906","https://openalex.org/W2000391750","https://openalex.org/W2002379520","https://openalex.org/W2002937040","https://openalex.org/W2004771750","https://openalex.org/W2005034776","https://openalex.org/W2005542290","https://openalex.org/W2008416190","https://openalex.org/W2009007206","https://openalex.org/W2009874228","https://openalex.org/W2009931781","https://openalex.org/W2010121426","https://openalex.org/W2010677667","https://openalex.org/W2011458181","https://openalex.org/W2013743651","https://openalex.org/W2015806646","https://openalex.org/W2015866509","https://openalex.org/W2017289276","https://openalex.org/W2020991778","https://openalex.org/W2021805732","https://openalex.org/W2022495797","https://openalex.org/W2025015384","https://openalex.org/W2025180999","https://openalex.org/W2025183726","https://openalex.org/W2027051533","https://openalex.org/W2028921845","https://openalex.org/W2031203833","https://openalex.org/W2031211461","https://openalex.org/W2032691574","https://openalex.org/W2034269086","https://openalex.org/W2034860356","https://openalex.org/W2036018577","https://openalex.org/W2037898576","https://openalex.org/W2039123767","https://openalex.org/W2041783360","https://openalex.org/W2042318018","https://openalex.org/W2042386784","https://openalex.org/W2042499074","https://openalex.org/W2042688595","https://openalex.org/W2043375872","https://openalex.org/W2043696829","https://openalex.org/W2044433401","https://openalex.org/W2045435533","https://openalex.org/W2045493291","https://openalex.org/W2046331787","https://openalex.org/W2046972425","https://openalex.org/W2047404721","https://openalex.org/W2047924613","https://openalex.org/W2049553585","https://openalex.org/W2050293032","https://openalex.org/W2050973237","https://openalex.org/W2051184323","https://openalex.org/W2052586474","https://openalex.org/W2052730188","https://openalex.org/W2052814975","https://openalex.org/W2056441083","https://openalex.org/W2057256947","https://openalex.org/W2058764316","https://openalex.org/W2059390353","https://openalex.org/W2060833726","https://openalex.org/W2061081736","https://openalex.org/W2061650108","https://openalex.org/W2062722187","https://openalex.org/W2064808006","https://openalex.org/W2064815984","https://openalex.org/W2066861312","https://openalex.org/W2067117419","https://openalex.org/W2067427915","https://openalex.org/W2068427957","https://openalex.org/W2069252806","https://openalex.org/W2070376367","https://openalex.org/W2070527044","https://openalex.org/W2072448714","https://openalex.org/W2075469565","https://openalex.org/W2075956249","https://openalex.org/W2075968056","https://openalex.org/W2077098920","https://openalex.org/W2077436902","https://openalex.org/W2077813812","https://openalex.org/W2077858999","https://openalex.org/W2083122374","https://openalex.org/W2083431317","https://openalex.org/W2084369408","https://openalex.org/W2085247907","https://openalex.org/W2086132527","https://openalex.org/W2086535578","https://openalex.org/W2087967021","https://openalex.org/W2088580309","https://openalex.org/W2089031587","https://openalex.org/W2090336268","https://openalex.org/W2094366129","https://openalex.org/W2095618958","https://openalex.org/W2095692889","https://openalex.org/W2097995306","https://openalex.org/W2098414192","https://openalex.org/W2098737737","https://openalex.org/W2099062342","https://openalex.org/W2100122648","https://openalex.org/W2100525241","https://openalex.org/W2101581360","https://openalex.org/W2101749257","https://openalex.org/W2102140136","https://openalex.org/W2102298863","https://openalex.org/W2102358336","https://openalex.org/W2103653214","https://openalex.org/W2103894337","https://openalex.org/W2104224322","https://openalex.org/W2105707021","https://openalex.org/W2106080156","https://openalex.org/W2107043033","https://openalex.org/W2107150019","https://openalex.org/W2107429737","https://openalex.org/W2110835998","https://openalex.org/W2112121482","https://openalex.org/W2113199099","https://openalex.org/W2114029728","https://openalex.org/W2114031931","https://openalex.org/W2114104545","https://openalex.org/W2114843025","https://openalex.org/W2114907977","https://openalex.org/W2117307067","https://openalex.org/W2117692326","https://openalex.org/W2118028844","https://openalex.org/W2118211359","https://openalex.org/W2124371549","https://openalex.org/W2124985265","https://openalex.org/W2125616358","https://openalex.org/W2125732268","https://openalex.org/W2127101185","https://openalex.org/W2128035403","https://openalex.org/W2129063117","https://openalex.org/W2129136620","https://openalex.org/W2132546867","https://openalex.org/W2132734902","https://openalex.org/W2132889907","https://openalex.org/W2132920733","https://openalex.org/W2133075384","https://openalex.org/W2133465414","https://openalex.org/W2139964075","https://openalex.org/W2141349182","https://openalex.org/W2141579854","https://openalex.org/W2147052402","https://openalex.org/W2147693262","https://openalex.org/W2147952959","https://openalex.org/W2149441684","https://openalex.org/W2149843709","https://openalex.org/W2151092292","https://openalex.org/W2151476386","https://openalex.org/W2152897456","https://openalex.org/W2153056550","https://openalex.org/W2153966196","https://openalex.org/W2154745259","https://openalex.org/W2156063883","https://openalex.org/W2156182988","https://openalex.org/W2156353875","https://openalex.org/W2157852151","https://openalex.org/W2157899948","https://openalex.org/W2159170430","https://openalex.org/W2159312193","https://openalex.org/W2159574432","https://openalex.org/W2159623504","https://openalex.org/W2159993068","https://openalex.org/W2160276388","https://openalex.org/W2161696113","https://openalex.org/W2161793295","https://openalex.org/W2162290846","https://openalex.org/W2163980003","https://openalex.org/W2166084034","https://openalex.org/W2166662937","https://openalex.org/W2166672594","https://openalex.org/W2167532631","https://openalex.org/W2168233301","https://openalex.org/W2168396953","https://openalex.org/W2169816570","https://openalex.org/W2171115167","https://openalex.org/W2171190137","https://openalex.org/W2171805190","https://openalex.org/W2196159484","https://openalex.org/W2198093519","https://openalex.org/W2201689894","https://openalex.org/W2203229763","https://openalex.org/W2206969062","https://openalex.org/W2222086386","https://openalex.org/W2223708856","https://openalex.org/W2239872201","https://openalex.org/W2252568502","https://openalex.org/W2266605864","https://openalex.org/W2275311108","https://openalex.org/W2279561773","https://openalex.org/W2286927750","https://openalex.org/W2289657957","https://openalex.org/W2289712604","https://openalex.org/W2293531514","https://openalex.org/W2294207258","https://openalex.org/W2295526061","https://openalex.org/W2318605753","https://openalex.org/W2326303021","https://openalex.org/W2328999771","https://openalex.org/W2329648702","https://openalex.org/W2329659234","https://openalex.org/W2342536142","https://openalex.org/W2346643793","https://openalex.org/W2352491315","https://openalex.org/W2375577403","https://openalex.org/W2401455386","https://openalex.org/W2407603036","https://openalex.org/W2409391306","https://openalex.org/W2411238967","https://openalex.org/W2414684615","https://openalex.org/W2465860350","https://openalex.org/W2475180696","https://openalex.org/W2476568892","https://openalex.org/W2508673657","https://openalex.org/W2510686645","https://openalex.org/W2522313999","https://openalex.org/W2528228811","https://openalex.org/W2529484692","https://openalex.org/W2529778903","https://openalex.org/W2529904548","https://openalex.org/W2552700328","https://openalex.org/W2559804019","https://openalex.org/W2560899520","https://openalex.org/W2567345879","https://openalex.org/W2570190993","https://openalex.org/W2573434446","https://openalex.org/W2580665679","https://openalex.org/W2584184455","https://openalex.org/W2588146309","https://openalex.org/W2588916311","https://openalex.org/W2590023130","https://openalex.org/W2592060299","https://openalex.org/W2592643813","https://openalex.org/W2595182131","https://openalex.org/W2596164112","https://openalex.org/W2597062310","https://openalex.org/W2606367731","https://openalex.org/W2609130176","https://openalex.org/W2609973112","https://openalex.org/W2610193187","https://openalex.org/W2612431515","https://openalex.org/W2614442853","https://openalex.org/W2621170119","https://openalex.org/W2621271973","https://openalex.org/W2621295461","https://openalex.org/W2621549033","https://openalex.org/W2622499649","https://openalex.org/W2625411679","https://openalex.org/W2625452721","https://openalex.org/W2648902637","https://openalex.org/W2731960689","https://openalex.org/W2735132087","https://openalex.org/W2735914287","https://openalex.org/W2738383040","https://openalex.org/W2739132742","https://openalex.org/W2745207660","https://openalex.org/W2745330422","https://openalex.org/W2745624257","https://openalex.org/W2745732448","https://openalex.org/W2747774814","https://openalex.org/W2747856781","https://openalex.org/W2752227448","https://openalex.org/W2761228804","https://openalex.org/W2761995452","https://openalex.org/W2765893876","https://openalex.org/W2767183168","https://openalex.org/W2769376007","https://openalex.org/W2771737095","https://openalex.org/W2771850922","https://openalex.org/W2772524563","https://openalex.org/W2772899582","https://openalex.org/W2774081554","https://openalex.org/W2785803176","https://openalex.org/W2789627388","https://openalex.org/W2790574591","https://openalex.org/W2791401633","https://openalex.org/W2792417314","https://openalex.org/W2793364080","https://openalex.org/W2794385660","https://openalex.org/W2794577178","https://openalex.org/W2795686629","https://openalex.org/W2795941120","https://openalex.org/W2795993993","https://openalex.org/W2796107375","https://openalex.org/W2796153225","https://openalex.org/W2796153844","https://openalex.org/W2796208126","https://openalex.org/W2796408191","https://openalex.org/W2990471413","https://openalex.org/W4230040411","https://openalex.org/W7074028399","https://openalex.org/W7095159806"],"related_works":["https://openalex.org/W2030825362","https://openalex.org/W4221076958","https://openalex.org/W2914604310","https://openalex.org/W2331884961","https://openalex.org/W2319215931","https://openalex.org/W7133092334","https://openalex.org/W4396587959","https://openalex.org/W4404940657","https://openalex.org/W7095803146","https://openalex.org/W3176500835"],"abstract_inverted_index":{"Advances":[0],"in":[1,23,60,123,140,181,231,341],"genetic":[2,21,36],"screening":[3,42],"technology":[4],"have":[5],"expanded":[6],"the":[7,16,31,90,95,106,141,314],"toolkit":[8],"for":[9,44,54,154,280],"systematic":[10],"perturbation":[11],"of":[12,63,143,206,283],"gene":[13],"function.":[14],"While":[15],"CRISPR-Cas9":[17],"system":[18],"robustly":[19],"probes":[20],"loss-of-function":[22],"mammalian":[24],"cells,":[25,136,171],"a":[26,121,130,150,204,281],"barcoded":[27,151],"ORFeome":[28,152],"library":[29,153],"offers":[30],"opportunity":[32],"to":[33,81,99,177,186,225,237,275],"systematically":[34,276],"study":[35],"gain-of-function.":[37],"We":[38,116,188,285,304,318],"employed":[39],"these":[40],"two":[41,61],"tools":[43],"three":[45,200],"purposes.":[46],"First,":[47],"we":[48,88,148,214,258],"performed":[49],"shRNA":[50],"and":[51,74,94,128,203,228,261,266,302,311,326],"CRISPR-based":[52],"screens":[53],"synthetic":[55,101,113],"lethality":[56],"with":[57,103,162,250],"BRCA2":[58,64,68,104],"deficiency,":[59],"pairs":[62],"isogenic":[65],"cell":[66,195],"lines.":[67],"mutation":[69],"commonly":[70,292],"drives":[71],"hereditary":[72],"breast":[73],"ovarian":[75],"cancer,":[76],"but":[77],"also":[78],"creates":[79],"vulnerability":[80],"PARP":[82,144],"inhibitor":[83,132,145],"treatment.":[84],"Among":[85],"other":[86],"genes,":[87],"found":[89,189,286,327],"AP":[91],"endonuclease":[92,97],"APEX2":[93],"flap":[96],"FEN1":[98,119,131],"be":[100],"lethal":[102,114],"deficiency;":[105],"base":[107],"excision":[108],"repair":[109],"(BER)":[110],"pathway":[111],"was":[112],"overall.":[115],"demonstrated":[117],"that":[118,129,156,192,210,216,234,296,328],"plays":[120],"role":[122],"microhomology-mediated":[124],"end":[125],"joining":[126],"(MMEJ)":[127],"selectively":[133],"targets":[134],"BRCA-deficient":[135],"offering":[137],"therapeutic":[138],"potential":[139],"setting":[142],"resistance.":[146],"Second,":[147],"screened":[149,305],"genes":[155,270,290],"either":[157],"upregulate":[158],"PD-L1":[159,166,197],"or":[160,247,272],"interfere":[161],"IFN\u03b3":[163,182,220],"signaling.":[164],"Tumor-expressed":[165],"engages":[167],"PD-1":[168],"on":[169,243],"T":[170],"dampening":[172],"T-cell":[173],"based":[174,242],"immune":[175],"responses":[176],"tumors,":[178],"while":[179],"defects":[180],"signaling":[183],"underlie":[184],"resistance":[185],"immunotherapy.":[187,238],"12":[190],"GPCRs":[191],"significantly":[193],"increase":[194],"surface":[196],"display,":[198],"including":[199,299],"LPARs":[201],"(LPAR1/2/5),":[202],"family":[205],"RNA-binding":[207],"proteins":[208],"(CELF3/4/5)":[209],"upregulates":[211],"PD-L1.":[212],"Conversely,":[213],"showed":[215],"CLK2":[217,222,244,251],"overexpression":[218],"antagonizes":[219],"signaling;":[221],"is":[223,229],"known":[224,265],"phosphorylate":[226],"PTPN1":[227],"amplified":[230],"tumor":[232,268],"types":[233],"respond":[235],"poorly":[236],"Thus,":[239,334],"segregating":[240],"patients":[241],"amplification":[245],"status":[246],"augmenting":[248],"immunotherapy":[249],"inhibitors":[252],"may":[253],"improve":[254],"clinical":[255],"responses.":[256],"Finally,":[257],"utilized":[259],"CRISPR":[260],"ORF-based":[262],"libraries":[263],"targeting":[264],"predicted":[267],"suppressor":[269],"(TSGs)":[271],"oncogenes":[273],"(OGs)":[274],"screen":[277],"cancer":[278,324,343],"drivers":[279,295,320],"variety":[282],"phenotypes.":[284],"at":[287],"least":[288],"20":[289],"not":[291],"annotated":[293],"as":[294],"enhanced":[297],"proliferation,":[298],"PAWR,":[300],"AMBRA1,":[301],"USP28.":[303],"OGs":[306],"bearing":[307],"tumor-associated":[308],"point":[309],"mutations":[310],"functionally":[312],"validated":[313],"MYCN":[315],"P44L":[316],"mutation.":[317],"mapped":[319],"across":[321],"multiple":[322],"hallmark":[323],"phenotypes":[325],"IRF6":[329],"knockout":[330],"promotes":[331],"anoikis":[332],"bypass.":[333],"functional":[335],"studies":[336],"can":[337],"augment":[338],"computational":[339],"approaches":[340],"identifying":[342],"driver":[344],"genes.":[345]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}
