{"id":"https://openalex.org/W2987005177","doi":"https://doi.org/10.1248/bpb.b19-00510","title":"Chemerin-9 Peptide Enhances Memory and Ameliorates A\u03b21\u201342-Induced Object Memory Impairment in Mice","display_name":"Chemerin-9 Peptide Enhances Memory and Ameliorates A\u03b21\u201342-Induced Object Memory Impairment in Mice","publication_year":2019,"publication_date":"2019-11-18","ids":{"openalex":"https://openalex.org/W2987005177","doi":"https://doi.org/10.1248/bpb.b19-00510","mag":"2987005177","pmid":"https://pubmed.ncbi.nlm.nih.gov/31748466"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.b19-00510","doi":"https://doi.org/10.1248/bpb.b19-00510","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b19-00510","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/43/2/43_b19-00510/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/bpb/43/2/43_b19-00510/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017377057","display_name":"Zelin Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZeLin Lei","raw_affiliation_strings":["Key Laboratory of Biotherapy and Regenerative Medicine, the First Hospital of Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Biotherapy and Regenerative Medicine, the First Hospital of Lanzhou University","institution_ids":["https://openalex.org/I4210163492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101914319","display_name":"Yaqin Lu","orcid":"https://orcid.org/0000-0003-3416-628X","observed_orcids":["https://orcid.org/0000-0003-3416-628X"]},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YaQin Lu","raw_affiliation_strings":["Department of Neurology, the First Hospital of Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Hospital of Lanzhou University","institution_ids":["https://openalex.org/I4210163492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102935885","display_name":"Xue Bai","orcid":"https://orcid.org/0000-0002-8268-931X","observed_orcids":["https://orcid.org/0000-0002-8268-931X"]},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Bai","raw_affiliation_strings":["Key Laboratory of Biotherapy and Regenerative Medicine, the First Hospital of Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Biotherapy and Regenerative Medicine, the First Hospital of Lanzhou University","institution_ids":["https://openalex.org/I4210163492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101084603","display_name":"Zhenxiu Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZhenXiu Jiang","raw_affiliation_strings":["Department of Neurology, the First Hospital of Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Hospital of Lanzhou University","institution_ids":["https://openalex.org/I4210163492"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100701203","display_name":"Qin Yu","orcid":"https://orcid.org/0000-0002-5703-8646","observed_orcids":["https://orcid.org/0000-0002-5703-8646","https://orcid.org/0009-0007-2656-468X"]},"institutions":[{"id":"https://openalex.org/I4210163492","display_name":"First Hospital of Lanzhou University","ror":"https://ror.org/05d2xpa49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Yu","raw_affiliation_strings":["Key Laboratory of Biotherapy and Regenerative Medicine, the First Hospital of Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Biotherapy and Regenerative Medicine, the First Hospital of Lanzhou University","institution_ids":["https://openalex.org/I4210163492"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210163492"],"apc_list":null,"apc_paid":null,"fwci":0.8953,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.68783525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"2","first_page":"272","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemerin","display_name":"chemerin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8730000257492065},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cmklr1","display_name":"CMKLR1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/memory-enhancement","display_name":"memory enhancement","score":0.5519999861717224},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.871999979019165},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9229999780654907},{"id":"https://openalex.org/keywords/microglial-chemotaxis","display_name":"microglial chemotaxis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/novel-object-recognition","display_name":"novel object recognition","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C199901988","wikidata":"https://www.wikidata.org/wiki/Q18031045","display_name":"Chemerin","level":5,"score":0.7757450342178345},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.6105741262435913},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5567697882652283},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5137987732887268},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48870041966438293},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.47891056537628174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4760030210018158},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4670112729072571},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.45628437399864197},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4191426634788513},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4169192910194397},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4079289138317108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3782491683959961},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.282731831073761},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26880383491516113},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021641","descriptor_name":"Recognition, Psychology","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1248/bpb.b19-00510","doi":"https://doi.org/10.1248/bpb.b19-00510","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b19-00510","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/43/2/43_b19-00510/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:31748466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31748466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/371547","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/371547","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/419184","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/419184","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/431264","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/431264","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/440329","doi":null,"is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/440329","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"}],"best_oa_location":{"id":"doi:10.1248/bpb.b19-00510","doi":"https://doi.org/10.1248/bpb.b19-00510","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b19-00510","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/43/2/43_b19-00510/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2987005177.pdf","grobid_xml":"https://content.openalex.org/works/W2987005177.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W587957453","https://openalex.org/W953610276","https://openalex.org/W1522048223","https://openalex.org/W1552123779","https://openalex.org/W1778265476","https://openalex.org/W1890450187","https://openalex.org/W1921378646","https://openalex.org/W1923608016","https://openalex.org/W1965942744","https://openalex.org/W1967872727","https://openalex.org/W1980776054","https://openalex.org/W1989120547","https://openalex.org/W2007424284","https://openalex.org/W2016487675","https://openalex.org/W2020116343","https://openalex.org/W2021246324","https://openalex.org/W2021254337","https://openalex.org/W2023860553","https://openalex.org/W2024494606","https://openalex.org/W2025563134","https://openalex.org/W2028706091","https://openalex.org/W2032260378","https://openalex.org/W2033808845","https://openalex.org/W2036031491","https://openalex.org/W2037991275","https://openalex.org/W2045644501","https://openalex.org/W2046922635","https://openalex.org/W2047218978","https://openalex.org/W2057088223","https://openalex.org/W2062438517","https://openalex.org/W2065571575","https://openalex.org/W2070179823","https://openalex.org/W2087243986","https://openalex.org/W2089651740","https://openalex.org/W2092983959","https://openalex.org/W2096407545","https://openalex.org/W2107653986","https://openalex.org/W2110495164","https://openalex.org/W2119695679","https://openalex.org/W2131955682","https://openalex.org/W2132767601","https://openalex.org/W2136980622","https://openalex.org/W2139668747","https://openalex.org/W2154279865","https://openalex.org/W2155704304","https://openalex.org/W2166404409","https://openalex.org/W2169514045","https://openalex.org/W2744378930","https://openalex.org/W2747092724","https://openalex.org/W2791242328","https://openalex.org/W2913630595","https://openalex.org/W2944501272","https://openalex.org/W2967335028","https://openalex.org/W4238843899"],"related_works":["https://openalex.org/W7027375065","https://openalex.org/W4406156213","https://openalex.org/W2967946348","https://openalex.org/W2537442607","https://openalex.org/W2019825857","https://openalex.org/W4408936344","https://openalex.org/W3033715700","https://openalex.org/W1967383957","https://openalex.org/W2598570847","https://openalex.org/W3177016638"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"suggests":[2],"that":[3,73,93,148,208,216,245],"the":[4,30,46,59,67,81,112,116,143,153,172,189,254],"inhibition":[5],"of":[6,32,98,114,131,174,219,256],"neuroinflammation":[7],"is":[8,56,221],"a":[9,76,223,250],"potential":[10,82],"target":[11],"for":[12,17,26,48,196,253],"therapeutic":[13],"or":[14],"preventive":[15],"strategies":[16],"Alzheimer\u2019s":[18],"disease":[19,88],"(AD).":[20],"Chemerin":[21],"has":[22],"attracted":[23],"particular":[24],"attention":[25],"its":[27,217],"role":[28],"in":[29,58,155,171,188],"regulation":[31],"inflammation.":[33],"In":[34,229],"addition,":[35],"amyloid":[36],"\u03b21\u201342":[37],"(A\u03b21\u201342)":[38],"can":[39],"interact":[40],"with":[41,150],"chemokine-like":[42],"receptor":[43,47],"1":[44],"(CMKLR1),":[45],"chemerin,":[49],"and":[50,61,64,105,122,157,185,199,239],"induce":[51],"microglial":[52],"chemotaxis.":[53],"Meanwhile,":[54,164],"CMKLR1":[55],"expressed":[57],"brain,":[60],"both":[62,115],"chemerin":[63,74],"A\u03b21\u201342":[65,85],"share":[66],"same":[68,192],"receptor.":[69],"Thus,":[70],"we":[71,146,206],"hypothesized":[72],"(C9),":[75],"chemerin-derived":[77],"nonapeptide,":[78],"may":[79,232,247],"have":[80],"to":[83],"ameliorate":[84,240],"mediated":[86],"AD":[87],"progression.":[89],"The":[90,191],"results":[91,113,193],"showed":[92],"an":[94],"intracerebroventricular":[95],"(i.c.v.)":[96],"injection":[97],"C9":[99,132,137,151,165,209,231,246],"(8":[100],"\u00b5g/kg)":[101,139],"facilitated":[102],"memory":[103,107,156,220,234,237,242],"formation":[104],"improved":[106],"retention,":[108,238],"as":[109,178],"evidenced":[110],"by":[111,161,227],"novel":[117,251],"object":[118,123],"recognition":[119,125],"test":[120],"(NOR)":[121],"location":[124],"(OLR)":[126],"tasks.":[127],"These":[128],"memory-enhancing":[129],"effects":[130],"were":[133,194],"also":[134,166],"observed":[135,207],"after":[136],"(2":[138],"was":[140],"infused":[141],"into":[142],"hippocampus.":[144,190],"Moreover,":[145],"found":[147],"treatment":[149,255],"reversed":[152],"de\ufb01cits":[154],"learning":[158],"ability":[159],"induced":[160,226],"oligomeric":[162],"A\u03b21\u201342.":[163],"signi\ufb01cantly":[167],"inhibited":[168],"A\u03b21\u201342-induced":[169,241],"increases":[170],"levels":[173],"pro-in\ufb02ammatory":[175],"cytokines":[176],"such":[177],"interleukin-1\u03b2":[179],"(IL-1\u03b2),":[180],"tumor":[181],"necrosis":[182],"factor-\u03b1":[183],"(TNF-\u03b1)":[184],"interleukin-6":[186],"(IL-6)":[187],"obtained":[195],"Western":[197],"blotting":[198],"enzyme-linked":[200],"immunosorbent":[201],"assay":[202],"(ELISA)":[203],"experiments.":[204],"Finally,":[205],"did":[210],"not":[211,222],"affect":[212],"locomotor":[213],"activity,":[214],"suggesting":[215,244],"improvement":[218],"false":[224],"positive":[225],"hypolocomotion.":[228],"conclusion,":[230],"facilitate":[233],"formation,":[235],"prolong":[236],"impairment,":[243],"potentially":[248],"represent":[249],"strategy":[252],"AD.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}