{"id":"https://openalex.org/W2986985633","doi":"https://doi.org/10.1182/blood-2019-124602","title":"A Phase I Trial of Venetoclax in Combination with BEAM Conditioning Chemotherapy (V-BEAM) with Autologous Stem Cell Transplantation in Non-Hodgkin Lymphoma","display_name":"A Phase I Trial of Venetoclax in Combination with BEAM Conditioning Chemotherapy (V-BEAM) with Autologous Stem Cell Transplantation in Non-Hodgkin Lymphoma","publication_year":2019,"publication_date":"2019-11-13","ids":{"openalex":"https://openalex.org/W2986985633","doi":"https://doi.org/10.1182/blood-2019-124602","mag":"2986985633"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2019-124602","doi":"https://doi.org/10.1182/blood-2019-124602","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2019-124602","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009726852","display_name":"Allison Marie Winter","orcid":"https://orcid.org/0000-0002-8437-7539","observed_orcids":["https://orcid.org/0000-0002-8437-7539"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison M. Winter","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011076004","display_name":"Kirsten Marie Boughan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4210119077","display_name":"University Hospitals Seidman Cancer Center","ror":"https://ror.org/02kb97560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten M Boughan","raw_affiliation_strings":["Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I4210119077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001877903","display_name":"Jack Khouri","orcid":"https://orcid.org/0000-0002-2473-6528","observed_orcids":["https://orcid.org/0000-0002-2473-6528"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Khouri","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016048836","display_name":"Paolo Fabrizio Caimi","orcid":"https://orcid.org/0000-0003-1436-0464","observed_orcids":["https://orcid.org/0000-0003-1436-0464"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210119077","display_name":"University Hospitals Seidman Cancer Center","ror":"https://ror.org/02kb97560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo Caimi","raw_affiliation_strings":["University Hospitals Seidman Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Seidman Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005991606","display_name":"Faiz Anwer","orcid":"https://orcid.org/0000-0001-6914-7439","observed_orcids":["https://orcid.org/0000-0001-6914-7439"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faiz Anwer","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013926915","display_name":"Brenda Cooper","orcid":"https://orcid.org/0000-0001-9376-9377","observed_orcids":["https://orcid.org/0000-0001-9376-9377"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210119077","display_name":"University Hospitals Seidman Cancer Center","ror":"https://ror.org/02kb97560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenda Cooper","raw_affiliation_strings":["Seidman Cancer Center, University Hospitals, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seidman Cancer Center, University Hospitals, Cleveland, OH","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013162117","display_name":"Deepa Jagadeesh","orcid":"https://orcid.org/0000-0002-1772-0659","observed_orcids":["https://orcid.org/0000-0002-1772-0659"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Jagadeesh","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011431831","display_name":"Robert M. Dean","orcid":"https://orcid.org/0000-0003-2559-563X","observed_orcids":["https://orcid.org/0000-0003-2559-563X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Dean","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023728016","display_name":"Aaron Thomas Gerds","orcid":"https://orcid.org/0000-0002-3422-1309","observed_orcids":["https://orcid.org/0000-0002-3422-1309"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron T. Gerds","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011655907","display_name":"Ronald M. Sobecks","orcid":"https://orcid.org/0000-0003-1608-3261","observed_orcids":["https://orcid.org/0000-0003-1608-3261"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Sobecks","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013767912","display_name":"Brad L. Pohlman","orcid":"https://orcid.org/0000-0001-6006-3714","observed_orcids":["https://orcid.org/0000-0001-6006-3714"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Pohlman","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112129467","display_name":"Matt E Kalaycio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt Kalaycio","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050880000","display_name":"Betty K. Hamilton","orcid":"https://orcid.org/0000-0003-1252-6539","observed_orcids":["https://orcid.org/0000-0003-1252-6539"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty K. Hamilton","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034264716","display_name":"Marcos J. G. De Lima","orcid":"https://orcid.org/0000-0002-8568-4522","observed_orcids":["https://orcid.org/0000-0002-8568-4522","https://orcid.org/0000-0001-5541-6220"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4210119077","display_name":"University Hospitals Seidman Cancer Center","ror":"https://ror.org/02kb97560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcos de Lima","raw_affiliation_strings":["Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I4210119077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019494133","display_name":"Navneet S. Majhail","orcid":"https://orcid.org/0000-0001-7082-891X","observed_orcids":["https://orcid.org/0000-0001-7082-891X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navneet S. Majhail","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006235077","display_name":"Brian Thomas Hill","orcid":"https://orcid.org/0000-0001-8781-3327","observed_orcids":["https://orcid.org/0000-0001-8781-3327"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian T. Hill","raw_affiliation_strings":["Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"Supplement_1","first_page":"5705","last_page":"5705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neutrophil-and-platelet-engraftment","display_name":"neutrophil and platelet engraftment","score":0.8230000138282776},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8330000042915344},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7749999761581421},{"id":"https://openalex.org/keywords/double-hit-lymphoma","display_name":"double-hit lymphoma","score":0.703000009059906},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.7833014726638794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6841309070587158},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.6184042096138},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.5718092918395996},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.5243784785270691},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5085126161575317},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.508262574672699},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.5055780410766602},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.5041483640670776},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5025813579559326},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.499464750289917},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.47910645604133606},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4786761403083801},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.44360464811325073},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.42154043912887573},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33407795429229736},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.24487513303756714},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.1458197832107544},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.11936220526695251}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2019-124602","doi":"https://doi.org/10.1182/blood-2019-124602","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2019-124602","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2988810298","https://openalex.org/W2951228396","https://openalex.org/W3127362900","https://openalex.org/W7141078574","https://openalex.org/W2592986981","https://openalex.org/W2979549320","https://openalex.org/W2582696216","https://openalex.org/W2891067208","https://openalex.org/W2273537491","https://openalex.org/W2907545704"],"abstract_inverted_index":{"Background:":[0],"High-dose":[1],"chemotherapy":[2,20,540],"(HDCT)":[3],"followed":[4,192,268],"by":[5,75,106,193,269],"autologous":[6,543],"stem":[7,283,544],"cell":[8,96,545],"transplantation":[9],"(ASCT)":[10],"is":[11,38,80,104,142,529,548],"a":[12,39,124,143,198],"standard":[13,199,264],"treatment":[14],"both":[15,127],"as":[16,22,312],"consolidation":[17],"after":[18],"induction":[19],"and":[21,36,67,94,114,129,139,184,188,251,285,301,317,326,334,341,362],"second-line":[23],"therapy":[24,183],"depending":[25],"on":[26,214,225,236,247,259,400,459,481,494],"the":[27,100,153,288,346,352,386,389,531],"histologic":[28],"subtype":[29],"of":[30,77,102,117,126,155,174,205,266,282,297,314,350,356,388,404,463,485,498,533],"NHL.":[31],"BEAM":[32,160,267,311,538],"(BCNU,":[33],"etoposide,":[34],"cytarabine,":[35],"melphalan)":[37],"commonly":[40],"used":[41],"conditioning":[42,162,539],"regimen":[43],"for":[44,187],"NHL":[45,60],"but":[46],"often":[47],"fails":[48],"to":[49,55,72,151,275,286,306,328,343,373,542],"produce":[50],"durable":[51],"remission,":[52],"likely":[53],"due":[54],"inherent":[56],"chemoresistance.":[57],"Many":[58],"B-cell":[59,65],"subtypes":[61],"including":[62],"diffuse":[63],"large":[64],"lymphoma":[66,69],"double-hit":[68],"are":[70,185,274,368],"resistant":[71],"chemotherapy-induced":[73],"apoptosis":[74],"overexpression":[76],"Bcl-2.":[78],"Venetoclax":[79,547],"an":[81,401,460,482,495],"orally":[82],"administered":[83],"selective":[84],"Bcl-2":[85],"inhibitor":[86],"with":[87,108,123,159,169,190,263,310,323,330,339,345,537],"significant":[88],"single":[89,144],"agent":[90],"activity":[91],"in":[92,157,371,376,527,535,552],"CLL":[93],"mantle":[95],"lymphoma.":[97],"In":[98],"addition,":[99],"efficacy":[101,122],"venetoclax":[103,156,206,534],"potentiated":[105],"combination":[107,158,536],"rituximab":[109],"[Seymour":[110],"2018,":[111],"Kater":[112],"2018]":[113],"multiple":[115],"lines":[116],"preclinical":[118],"data":[119],"show":[120],"synergistic":[121],"range":[125],"novel":[128],"conventional":[130],"antineoplastic":[131],"agents":[132],"[Johnson-Farley":[133],"2015,":[134],"Li":[135],"2015].":[136],"Study":[137],"Design":[138],"Methods:":[140],"This":[141],"arm,":[145],"open-label,":[146],"dose-escalation":[147],"phase":[148,290],"I":[149],"trial":[150,196,392,526],"evaluate":[152],"safety":[154],"(V-BEAM)":[161],"chemotherapy.":[163],"Key":[164],"inclusion":[165],"criteria":[166],"include":[167,295],"patients":[168,358,370],"pathologically":[170],"confirmed":[171],"NHL,":[172],"regardless":[173],"specific":[175],"histology,":[176],"who":[177],"have":[178,359],"received":[179],"one":[180],"prior":[181,541],"systemic":[182],"eligible":[186],"proceeding":[189],"HDCT":[191],"ASCT.":[194,270,315],"The":[195,271],"employs":[197],"3+3":[200],"cohort-based":[201],"dose":[202,215,226,237,248,260,377],"escalation":[203],"design":[204],"(800":[207],"mg":[208,219,230,241,253],"daily":[209,220,231,242,254],"days":[210,221,232,243,255],"-7":[211,222,233,244,256],"through":[212,223,234,245,257],"-6":[213],"level":[216,227,238,249,261,378],"1,":[217],"800":[218,229,240,252],"-5":[224],"2,":[228],"-4":[235],"3,":[239],"-3":[246],"4,":[250],"-2":[258],"5)":[262],"doses":[265],"primary":[272],"objectives":[273,294],"assess":[276],"safety,":[277],"describe":[278],"dose-limiting":[279],"toxicities,":[280],"engraftment":[281,319],"cells":[284],"identify":[287],"recommended":[289],"II":[291],"dose.":[292],"Secondary":[293],"evaluation":[296],"progression-free":[298],"survival":[299,303],"(PFS)":[300],"overall":[302],"(OS)":[304],"compared":[305,327,342],"historical":[307],"controls":[308,329,344],"treated":[309],"part":[313],"Neutrophil":[316],"platelet":[318],"will":[320,336,382],"be":[321,337,374,383],"estimated":[322,338],"cumulative":[324],"incidence":[325],"Gray":[331],"test.":[332,348],"OS":[333],"PFS":[335],"Kaplan-Meier":[340],"log-rank":[347],"As":[349],"8/1/2019,":[351],"first":[353],"dosing":[354],"cohort":[355],"3":[357,369],"been":[360],"enrolled":[361,375],"successfully":[363],"completed":[364],"study":[365],"treatment.":[366],"There":[367],"screening":[372],"2.":[379],"Additional":[380],"accrual":[381],"presented":[384],"at":[385],"time":[387],"meeting.":[390],"Clinical":[391],"information:":[393],"NCT03713580.":[394],"Disclosures":[395],"Anwer:":[396],"Seattle":[397,513],"Genetics:":[398,514],"Membership":[399,458,480,493],"entity's":[402,461,483,496],"Board":[403,462,484,497],"Directors":[405,464,486,499],"or":[406,465,487,500],"advisory":[407,466,488,501],"committees;":[408,489],"In-Cyte:":[409],"Speakers":[410],"Bureau.":[411],"Gerds:Celgene":[412],"Corporation:":[413],"Consultancy,":[414,424,429,456,471,475,478,491,506,509,515],"Research":[415,419,425,430,433,437,453,468,472,503,511,518,521],"Funding;":[416,420,426,431,434,454,469,473,504,512,519],"Sierra":[417],"Oncology:":[418],"Pfizer:":[421],"Consultancy;":[422,440,443,447],"Incyte:":[423,446],"CTI":[427],"Biopharma:":[428],"Roche:":[432],"Imago":[435],"Biosciences:":[436],"Funding.":[438,522],"Majhail:Nkarta:":[439],"Atara":[441],"Bio:":[442],"Mallinckrodt:":[444],"Honoraria;":[445,476,507,516],"Anthem,":[448],"Inc.:":[449],"Consultancy.":[450],"Hill:TG":[451],"therapeutics:":[452],"Abbvie:":[455],"Honoraria,":[457,479,492,510],"committees,":[467,502],"Genentech:":[470],"Kite:":[474],"Gilead:":[477],"Pharmacyclics:":[490],"AstraZeneca:":[505],"Celegene:":[508],"Takeda:":[517],"Amgen:":[520],"OffLabel":[523],"Disclosure:":[524],"Our":[525],"progress":[528],"investigating":[530],"use":[532],"transplantation.":[546],"not":[549],"currently":[550],"approved":[551],"this":[553],"setting.":[554]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-11-22T00:00:00"}
