{"id":"https://openalex.org/W2986484442","doi":"https://doi.org/10.22029/eir.2018.1717","title":"The Role of Exercise and Hyperlipidaemia in Breast Cancer Progression","display_name":"The Role of Exercise and Hyperlipidaemia in Breast Cancer Progression","publication_year":2026,"publication_date":"2026-07-15","ids":{"openalex":"https://openalex.org/W2986484442","doi":"https://doi.org/10.22029/eir.2018.1717","mag":"2986484442","pmid":"https://pubmed.ncbi.nlm.nih.gov/29461968"},"language":"en","primary_location":{"id":"pmid:29461968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29461968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.22029/eir.2018.1717","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090465866","display_name":"Linda A. Buss","orcid":"https://orcid.org/0000-0001-5024-5282","observed_orcids":["https://orcid.org/0000-0001-5024-5282"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Buss, LA","raw_affiliation_strings":["Univ Otago, Dept Pathol, Mackenzie Canc Res Grp, Christchurch, New Zealand","Mackenzie Cancer Research Group; Department of Pathology; University of Otago; Christchurch New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Otago, Dept Pathol, Mackenzie Canc Res Grp, Christchurch, New Zealand","institution_ids":["https://openalex.org/I80281795"]},{"raw_affiliation_string":"Mackenzie Cancer Research Group; Department of Pathology; University of Otago; Christchurch New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038450225","display_name":"Gabi U. Dachs","orcid":"https://orcid.org/0000-0003-0017-5129","observed_orcids":["https://orcid.org/0000-0003-0017-5129"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Dachs, GU","raw_affiliation_strings":["Univ Otago, Dept Pathol, Mackenzie Canc Res Grp, Christchurch, New Zealand","Mackenzie Cancer Research Group; Department of Pathology; University of Otago; Christchurch New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Otago, Dept Pathol, Mackenzie Canc Res Grp, Christchurch, New Zealand","institution_ids":["https://openalex.org/I80281795"]},{"raw_affiliation_string":"Mackenzie Cancer Research Group; Department of Pathology; University of Otago; Christchurch New Zealand","institution_ids":["https://openalex.org/I80281795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I80281795"],"apc_list":null,"apc_paid":null,"fwci":2.7418,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.8396747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"24","issue":null,"first_page":"10","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.14429999887943268,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/breast-cancer-progression","display_name":"breast cancer progression","score":0.9430000185966492},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.734000027179718},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9359999895095825},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8180000185966492},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.953000009059906},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/circulating-factors","display_name":"circulating factors","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7354282736778259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7227733731269836},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5813541412353516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4887068271636963},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.48351457715034485},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4600735604763031},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4499906897544861},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.44230103492736816},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.41302207112312317},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3656657040119171},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19367897510528564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12312135100364685}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:29461968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29461968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Journal Article"},{"id":"doi:10.22029/eir.2018.1717","doi":"https://doi.org/10.22029/eir.2018.1717","is_oa":true,"landing_page_url":"https://doi.org/10.22029/eir.2018.1717","pdf_url":null,"source":{"id":"https://openalex.org/S7407052994","display_name":"Universit\u00e4tsbibliothek Gie\u00dfen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200763008","host_organization_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","host_organization_lineage":["https://openalex.org/I200763008"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"mag:2986484442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29461968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.22029/eir.2018.1717","doi":"https://doi.org/10.22029/eir.2018.1717","is_oa":true,"landing_page_url":"https://doi.org/10.22029/eir.2018.1717","pdf_url":null,"source":{"id":"https://openalex.org/S7407052994","display_name":"Universit\u00e4tsbibliothek Gie\u00dfen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200763008","host_organization_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","host_organization_lineage":["https://openalex.org/I200763008"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2564127551","https://openalex.org/W2774678207","https://openalex.org/W282460362","https://openalex.org/W2594631610","https://openalex.org/W3133750601","https://openalex.org/W2613408444","https://openalex.org/W7161636681","https://openalex.org/W2582186503","https://openalex.org/W1412334471","https://openalex.org/W4284671963"],"abstract_inverted_index":{"Exercise":[0],"reduces":[1],"the":[2,16,37,67,74,81,111,117,133],"risk":[3,61],"of":[4,19,40,76,84,91,110,114,119,125],"breast":[5,12,59],"cancer":[6,13,60],"development":[7],"and":[8,42,53,62,65,78,123],"improves":[9],"survival":[10],"in":[11,132],"patients.":[14],"However,":[15],"underlying":[17],"mechanisms":[18,69],"this":[20],"protective":[21],"effect":[22],"remain":[23],"to":[24,56,128],"be":[25],"fully":[26],"elucidated.":[27],"It":[28],"is":[29,86,100],"unclear":[30],"whether":[31],"exercise":[32,54,77,106],"can":[33],"attenuate":[34],"or":[35,57],"modify":[36],"pro-tumour":[38],"effects":[39,75,113],"obesity":[41],"related":[43],"conditions,":[44],"such":[45],"as":[46,96],"hyperlipidaemia.":[47],"This":[48],"review":[49],"summarises":[50],"how":[51],"hyperlipidaemia":[52,79,115],"contribute":[55],"reduce":[58],"progression,":[63],"respectively,":[64],"highlights":[66],"possible":[68],"behind":[70],"each.":[71],"In":[72],"particular,":[73],"on":[80],"immune":[82],"microenvironment":[83],"tumours":[85],"analysed.":[87],"The":[88],"potential":[89],"value":[90],"commonly":[92],"investigated":[93],"circulating":[94],"factors":[95],"exercise-modulated,":[97],"prognostic":[98],"biomarkers":[99],"also":[101],"discussed.":[102],"We":[103],"propose":[104],"that":[105],"may":[107],"alleviate":[108],"some":[109],"pro-tumorigenic":[112],"through":[116],"reduction":[118],"blood":[120],"lipid":[121],"levels":[122],"modulation":[124],"cytokine":[126],"release":[127],"induce":[129],"beneficial":[130],"changes":[131],"tumour":[134],"microenvironment.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}