{"id":"https://openalex.org/W2986459243","doi":"https://doi.org/10.1093/neuonc/noz175.115","title":"ANGI-04. A NOVEL TROY-JAK1 SIGNALING COMPLEX IN GLIOBLASTOMA INVASION","display_name":"ANGI-04. A NOVEL TROY-JAK1 SIGNALING COMPLEX IN GLIOBLASTOMA INVASION","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2986459243","doi":"https://doi.org/10.1093/neuonc/noz175.115","mag":"2986459243"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noz175.115","doi":"https://doi.org/10.1093/neuonc/noz175.115","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.115","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_6/vi30/30633995/noz175.115.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_6/vi30/30633995/noz175.115.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083453012","display_name":"Zonghui Ding","orcid":"https://orcid.org/0000-0001-9291-6435","observed_orcids":["https://orcid.org/0000-0001-9291-6435"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zonghui Ding","raw_affiliation_strings":["Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056185667","display_name":"Jean M. Kloss","orcid":"https://orcid.org/0000-0003-1640-5777","observed_orcids":["https://orcid.org/0000-0003-1640-5777"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Kloss","raw_affiliation_strings":["Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059934426","display_name":"Serdar Tuncali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serdar Tuncali","raw_affiliation_strings":["Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016790638","display_name":"Nhan L. Tran","orcid":"https://orcid.org/0000-0003-0908-9964","observed_orcids":["https://orcid.org/0000-0003-0908-9964"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nhan Tran","raw_affiliation_strings":["Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103252276","display_name":"Joseph C. Loftus","orcid":"https://orcid.org/0000-0001-9350-7182","observed_orcids":["https://orcid.org/0000-0001-9350-7182"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Loftus","raw_affiliation_strings":["Mayo Clinic Arizona, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Arizona, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210125099"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16680322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"Supplement_6","first_page":"vi30","last_page":"vi31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.10339999943971634,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/jak1","display_name":"JAK1","score":0.972000002861023},{"id":"https://openalex.org/keywords/stat3-activation","display_name":"STAT3 activation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6639999747276306},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.7099999785423279},{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.8709999918937683},{"id":"https://openalex.org/keywords/temozolomide-resistance","display_name":"temozolomide resistance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.8479999899864197},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6620000004768372},{"id":"https://openalex.org/keywords/receptor-signaling-complex","display_name":"receptor signaling complex","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.7664105892181396},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6732443571090698},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5425255298614502},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5115836262702942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4986557960510254},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4942739009857178},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.47247833013534546},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4456857442855835},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4232061207294464},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.39553359150886536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.333726704120636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24855345487594604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18129941821098328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08981934189796448},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06283453106880188}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noz175.115","doi":"https://doi.org/10.1093/neuonc/noz175.115","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.115","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_6/vi30/30633995/noz175.115.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6847222","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6847222","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noz175.115","doi":"https://doi.org/10.1093/neuonc/noz175.115","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.115","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_6/vi30/30633995/noz175.115.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2986459243.pdf","grobid_xml":"https://content.openalex.org/works/W2986459243.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3038341375","https://openalex.org/W2767954627","https://openalex.org/W2565095000","https://openalex.org/W2166988454","https://openalex.org/W2900289081","https://openalex.org/W2739863116","https://openalex.org/W2890808484","https://openalex.org/W1991865300","https://openalex.org/W1976987531","https://openalex.org/W2170656321"],"abstract_inverted_index":{"Abstract":[0],"Glioblastoma":[1],"(GBM)":[2],"is":[3,55],"the":[4,11,34,48,73,126,149,171,237,252,260,285],"most":[5],"common":[6],"and":[7,29,43,93,96,101,116,168,276,297],"deadly":[8],"malignancy":[9],"of":[10,21,38,67,72,166,173,257,267],"central":[12],"nervous":[13],"system":[14],"in":[15,91,94,119],"adults":[16],"with":[17,77,84,159,162,178,185,196,211],"a":[18,120,155,203,214,218,234,248],"median":[19],"survival":[20,118],"about":[22],"15":[23],"months":[24],"after":[25],"diagnosis.":[26],"Its":[27],"aggressive":[28],"highly":[30],"infiltrative":[31],"nature":[32],"renders":[33],"current":[35],"standard":[36],"treatment":[37],"maximal":[39],"surgical":[40],"resection,":[41],"radiation,":[42],"chemotherapy":[44],"relatively":[45],"ineffective.":[46],"Identifying":[47],"molecular":[49],"events":[50],"that":[51,138,152,193,229,284],"regulate":[52],"GBM":[53,88,109,277],"migration/invasion":[54],"required":[56],"to":[57,63,99,114,222,242,293],"develop":[58],"more":[59],"effective":[60],"therapeutic":[61,133,291,299],"regimens":[62],"treat":[64],"GBM.":[65],"Expression":[66],"TROY,":[68],"an":[69,131,289],"orphan":[70],"receptor":[71],"TNFR":[74],"superfamily,":[75],"increases":[76,97,112,170],"increasing":[78],"glial":[79],"tumor":[80],"grade,":[81],"inversely":[82],"correlates":[83],"patient":[85],"survival,":[86],"stimulates":[87,164],"cell":[89,110,278],"invasion":[90,296],"vitro":[92],"vivo,":[95],"resistance":[98],"temozolomide":[100],"radiation":[102],"therapy.":[103],"Conversely,":[104],"silencing":[105],"TROY":[106,127,140,153,163,175,194,204,215,232,249],"expression":[107,141],"inhibits":[108],"invasion,":[111],"sensitivity":[113],"temozolomide,":[115],"prolongs":[117],"preclinical":[121],"intracranial":[122],"xenograft":[123],"model.":[124],"Thus,":[125],"signaling":[128,157],"pathway":[129],"represents":[130,288],"attractive":[132],"target.":[134],"We":[135,145],"previously":[136],"reported":[137],"increased":[139],"strongly":[142],"activates":[143],"NF-kB.":[144],"have":[146],"identified":[147],"for":[148],"first":[150],"time":[151],"forms":[154],"unique":[156],"complex":[158,287],"JAK1.":[160,224],"Interaction":[161],"phosphorylation":[165],"JAK1":[167,179,197,212,258,268],"significantly":[169,271],"activation":[172,275],"STAT3.":[174],"specifically":[176],"associates":[177,210],"as":[180,202],"it":[181],"does":[182],"not":[183,247],"associate":[184],"other":[186],"JAK":[187],"family":[188],"members.":[189],"Co-immunoprecipitation":[190],"analysis":[191],"demonstrated":[192],"interacts":[195],"through":[198],"its":[199,207],"cytoplasmic":[200,219,253],"domain":[201,209,220,239],"variant":[205,216,235,250],"without":[206,217],"extracellular":[208,238],"while":[213],"fails":[221],"bind":[223],"Luciferase":[225],"reporter":[226],"assay":[227],"confirmed":[228],"full":[230],"length":[231],"or":[233,265],"lacking":[236,251],"are":[240],"able":[241],"induce":[243],"STAT3":[244,274],"activation,":[245],"but":[246],"domain.":[254],"Pharmacological":[255],"inhibition":[256],"by":[259,269],"FDA":[261],"approved":[262],"inhibitor":[263],"ruxolitinib":[264],"knockdown":[266],"siRNAs":[270],"inhibited":[272],"TROY-induced":[273],"migration.":[279],"Together,":[280],"our":[281],"data":[282],"indicate":[283],"TROY-JAK1":[286],"unappreciated":[290],"target":[292],"inhibit":[294],"glioma":[295],"decrease":[298],"resistance.":[300]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}
