{"id":"https://openalex.org/W2986335694","doi":"https://doi.org/10.1093/neuonc/noz175.594","title":"MNGI-12. PLEIOTROPIC MLLT10 VARIATION CONFERS RISK OF MENINGIOMA, BREAST, AND OVARIAN CANCERS","display_name":"MNGI-12. PLEIOTROPIC MLLT10 VARIATION CONFERS RISK OF MENINGIOMA, BREAST, AND OVARIAN CANCERS","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2986335694","doi":"https://doi.org/10.1093/neuonc/noz175.594","mag":"2986335694"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noz175.594","doi":"https://doi.org/10.1093/neuonc/noz175.594","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.594","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_6/vi142/30634201/noz175.594.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_6/vi142/30634201/noz175.594.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050523491","display_name":"Kyle M. Walsh","orcid":"https://orcid.org/0000-0002-5879-9981","observed_orcids":["https://orcid.org/0000-0002-5879-9981"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Walsh","raw_affiliation_strings":["Duke University School of Medicine, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074736636","display_name":"Chenan Zhang","orcid":"https://orcid.org/0000-0003-1773-4441","observed_orcids":["https://orcid.org/0000-0003-1773-4441"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenan Zhang","raw_affiliation_strings":["UCSF, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011282627","display_name":"Lisa Calvocoressi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Calvocoressi","raw_affiliation_strings":["Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038840836","display_name":"Helen M. Hansen","orcid":"https://orcid.org/0000-0001-5456-4985","observed_orcids":["https://orcid.org/0000-0001-5456-4985"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Hansen","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038248146","display_name":"Andrew Berchuck","orcid":"https://orcid.org/0000-0002-1940-1467","observed_orcids":["https://orcid.org/0000-0002-1940-1467"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Berchuck","raw_affiliation_strings":["Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063929778","display_name":"Joellen M. Schildkraut","orcid":"https://orcid.org/0000-0002-0990-9339","observed_orcids":["https://orcid.org/0000-0002-0990-9339"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joellen Schildkraut","raw_affiliation_strings":["University of Virginia, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012085802","display_name":"Melissa L. Bondy","orcid":"https://orcid.org/0000-0002-0278-414X","observed_orcids":["https://orcid.org/0000-0002-0278-414X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Bondy","raw_affiliation_strings":["Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043076766","display_name":"Joseph Leo Wiemels","orcid":"https://orcid.org/0000-0003-4838-9951","observed_orcids":["https://orcid.org/0000-0003-4838-9951"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Wiemels","raw_affiliation_strings":["University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101626650","display_name":"Elizabeth B. Claus","orcid":"https://orcid.org/0000-0001-9867-8124","observed_orcids":["https://orcid.org/0000-0001-9867-8124"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Claus","raw_affiliation_strings":["Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"Supplement_6","first_page":"vi142","last_page":"vi142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.11110000312328339,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.0828000009059906,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mllt10","display_name":"MLLT10","score":0.9430000185966492},{"id":"https://openalex.org/keywords/meningioma","display_name":"meningioma","score":0.859000027179718},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8220000267028809},{"id":"https://openalex.org/keywords/estrogen-receptor-status","display_name":"estrogen receptor status","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hormone-use","display_name":"hormone use","score":0.3930000066757202},{"id":"https://openalex.org/keywords/cancer-risk-loci","display_name":"cancer risk loci","score":0.45899999141693115},{"id":"https://openalex.org/keywords/sex-differences-in-cancer-risk","display_name":"sex differences in cancer risk","score":0.6320000290870667},{"id":"https://openalex.org/keywords/fine-mapping","display_name":"fine mapping","score":0.46799999475479126},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6984823346138},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6462298035621643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6297743320465088},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6177455186843872},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5882806181907654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5541262626647949},{"id":"https://openalex.org/C2779160599","wikidata":"https://www.wikidata.org/wiki/Q369157","display_name":"Meningioma","level":2,"score":0.5502840280532837},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.495630145072937},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4716445803642273},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.301503449678421},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2557642459869385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23958176374435425},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20501580834388733},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18156912922859192},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14899256825447083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noz175.594","doi":"https://doi.org/10.1093/neuonc/noz175.594","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.594","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_6/vi142/30634201/noz175.594.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6847155","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6847155","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noz175.594","doi":"https://doi.org/10.1093/neuonc/noz175.594","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.594","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_6/vi142/30634201/noz175.594.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2986335694.pdf","grobid_xml":"https://content.openalex.org/works/W2986335694.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4223946952","https://openalex.org/W1998457222","https://openalex.org/W2588877587","https://openalex.org/W2141759541","https://openalex.org/W3216390648","https://openalex.org/W3207625909","https://openalex.org/W4300307686","https://openalex.org/W1872439541","https://openalex.org/W2141775256","https://openalex.org/W1545232462"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"Women":[2],"ages":[3],"35\u201344":[4],"have":[5,16,62],"three-fold":[6],"higher":[7,238],"risk":[8,38,66,179,191,200,208,217,233,273],"of":[9,47,86,110,180,274],"meningioma":[10,37,55,65,111,181,199,263,299],"compared":[11],"to":[12,91,158],"men.":[13],"Epidemiologic":[14],"studies":[15,60],"implicated":[17],"exogenous":[18],"hormone":[19],"use,":[20],"but":[21,222,251,284],"endogenous":[22],"hormonal":[23],"factors":[24],"are":[25],"inconsistently":[26],"associated.":[27],"Elevated":[28],"body":[29,239],"mass":[30],"index":[31],"(BMI)":[32],"is":[33],"consistently":[34],"associated":[35,53,175,204,236],"with":[36,54,154,176,205,237,262],"in":[39,89,106,182,192],"both":[40],"men":[41,193],"and":[42,44,77,123,140,188,213,244,282],"women,":[43],"personal":[45],"history":[46],"breast":[48,76,117,215,226,278,289],"cancer":[49,118,125,207,216,227],"has":[50],"also":[51,203],"been":[52],"risk.":[56,264],"Recent":[57],"genome-wide":[58,247],"association":[59,153,261],"(GWAS)":[61],"identified":[63,166],"a":[64,97,167,268,294],"locus":[67],"on":[68],"chromosome":[69],"10p12":[70,87],"near":[71,170],"previous":[72],"GWAS":[73],"hits":[74],"for":[75,152,255],"ovarian":[78,124,206,280],"cancers.":[79],"METHODS":[80],"To":[81],"elucidate":[82],"the":[83,171],"pleiotropic":[84],"role":[85],"variation":[88],"predisposition":[90],"diverse":[92],"tumors":[93],"-":[94,101],"possibly":[95],"via":[96],"common":[98],"mediating":[99],"factor":[100],"we":[102],"performed":[103],"imputation\u2010based":[104],"fine\u2010mapping":[105],"three":[107],"case-control":[108],"datasets":[109],"(927":[112],"cases,":[113,120,127],"790":[114],"controls),":[115,122],"female":[116,275],"(28108":[119],"22209":[121],"(25509":[126],"40941":[128],"controls).":[129],"Analyses":[130],"were":[131,150],"stratified":[132],"by":[133],"sex":[134],"(meningioma),":[135],"estrogen":[136],"receptor":[137],"status":[138],"(breast),":[139],"histotype":[141],"(ovarian),":[142],"then":[143],"combined":[144],"using":[145],"ASSET":[146,164],"meta-analysis.":[147],"Lead":[148],"variants":[149],"queried":[151],">700":[155],"additional":[156],"traits":[157],"identify":[159,267],"potential":[160],"effect-mediators.":[161],"RESULTS":[162],"Two-sided":[163],"meta-analysis":[165],"lead":[168],"variant":[169],"MLLT10":[172,269],"promoter":[173],"(P=1.4x10-13)":[174],"significantly":[177],"increased":[178,190],"women":[183],"(OR=1.42,":[184],"95%":[185,195,210,219,229],"CI:":[186,196,211,220,230],"1.20\u20131.69)":[187],"non-significantly":[189],"(OR=1.19,":[194],"0.91\u20131.57).":[197],"The":[198,232],"allele":[201,234],"was":[202,235],"(OR=1.09,":[209],"1.06\u20131.12)":[212],"ER+":[214,277],"(OR=1.05,":[218],"1.02\u20131.08),":[221],"protected":[223],"against":[224,287],"ER-":[225,288],"(OR=0.91,":[228],"0.86\u20130.96).":[231],"fat":[240],"percentage,":[241],"waist":[242],"circumference":[243],"BMI":[245,256],"at":[246],"levels":[248],"(P<":[249],"5.0x10-8),":[250],"mediation":[252],"analysis":[253],"adjusting":[254],"did":[257],"not":[258],"attenuate":[259],"its":[260],"CONCLUSION":[265],"We":[266],"eQTL":[270],"that":[271],"confers":[272],"meningioma,":[276],"cancer,":[279,281],"obesity,":[283],"which":[285],"protects":[286],"cancer.":[290],"Our":[291],"results":[292],"implicate":[293],"possible":[295],"estrogenic":[296],"mechanism":[297],"underlying":[298],"tumorigenesis.":[300]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-11-22T00:00:00"}