{"id":"https://openalex.org/W2986212304","doi":"https://doi.org/10.17077/etd.5ret-l5fa","title":"Understanding microglia in the immune response to mouse hepatitis virus infection","display_name":"Understanding microglia in the immune response to mouse hepatitis virus infection","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2986212304","doi":"https://doi.org/10.17077/etd.5ret-l5fa","mag":"2986212304"},"language":"en","primary_location":{"id":"doi:10.17077/etd.5ret-l5fa","doi":"https://doi.org/10.17077/etd.5ret-l5fa","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.5ret-l5fa","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730591960002771/13731041290002771","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081897682","display_name":"Dorthea L. Wheeler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dorthea L. Wheeler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005548506","display_name":"Ashutosh Kumar Mangalam","orcid":"https://orcid.org/0000-0002-9926-2531","observed_orcids":["https://orcid.org/0000-0002-9926-2531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashutosh Mangalam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9926-2531","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056006599","display_name":"John T. Harty","orcid":"https://orcid.org/0000-0001-7266-2802","observed_orcids":["https://orcid.org/0000-0001-7266-2802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Harty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7266-2802","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090796277","display_name":"Vladimir P. Badovinac","orcid":"https://orcid.org/0000-0003-3180-2439","observed_orcids":["https://orcid.org/0000-0003-3180-2439"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir Badovinac","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3180-2439","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051474892","display_name":"Stanley M. Perlman","orcid":"https://orcid.org/0000-0003-4213-2354","observed_orcids":["https://orcid.org/0000-0003-4213-2354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stanley Perlman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4213-2354","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013701270","display_name":"Jon C. D. Houtman","orcid":"https://orcid.org/0000-0002-5307-9854","observed_orcids":["https://orcid.org/0000-0002-5307-9854"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon Houtman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5307-9854","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081897682"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mouse-hepatitis-virus","display_name":"mouse hepatitis virus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neurotropic-coronavirus","display_name":"neurotropic coronavirus","score":0.8019999861717224},{"id":"https://openalex.org/keywords/viral-encephalitis","display_name":"viral encephalitis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/interneurons","display_name":"interneurons","score":0.6510000228881836},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microglia-depletion","display_name":"microglia depletion","score":0.8610000014305115},{"id":"https://openalex.org/keywords/csf1r-inhibitor","display_name":"CSF1R inhibitor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.6940000057220459},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/viral-replication-control","display_name":"viral replication control","score":0.5139999985694885},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.682235598564148},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6563504934310913},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6243308782577515},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4702184200286865},{"id":"https://openalex.org/C3019983190","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis a virus","level":3,"score":0.4577329456806183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4299890995025635},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41985422372817993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3787907361984253},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1605779230594635}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.17077/etd.5ret-l5fa","doi":"https://doi.org/10.17077/etd.5ret-l5fa","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.5ret-l5fa","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},{"id":"pmh:oai:alma.01IOWA_INST:11730591970002771","doi":null,"is_oa":true,"landing_page_url":"https://iro.uiowa.edu/esploro/outputs/doctoral/Understanding-microglia-in-the-immune-response/9983776830602771","pdf_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730591960002771/13731041290002771","source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},{"id":"pmh:oai:ir.uiowa.edu:etd-8414","doi":null,"is_oa":false,"landing_page_url":"https://ir.uiowa.edu/etd/6880","pdf_url":null,"source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"dissertation"}],"best_oa_location":{"id":"pmh:oai:alma.01IOWA_INST:11730591970002771","doi":null,"is_oa":true,"landing_page_url":"https://iro.uiowa.edu/esploro/outputs/doctoral/Understanding-microglia-in-the-immune-response/9983776830602771","pdf_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730591960002771/13731041290002771","source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2986212304.pdf","grobid_xml":"https://content.openalex.org/works/W2986212304.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2746174222","https://openalex.org/W4389203327","https://openalex.org/W2141191777","https://openalex.org/W2154820490","https://openalex.org/W2786373847","https://openalex.org/W2113864136","https://openalex.org/W2040384417","https://openalex.org/W4403424342","https://openalex.org/W4380884677","https://openalex.org/W2067406816"],"abstract_inverted_index":{"Viral":[0],"infection":[1,43,48,92,208,285,338,356,411,435],"of":[2,14,19,47,65,80,117,120,128,177,205,214,220,279,291,308,429],"the":[3,10,17,22,39,45,61,143,163,178,203,218,242,276,289,300,305,313,329,352,384,414,419,430,443],"central":[4,244],"nervous":[5,245],"system":[6,246],"is":[7,286],"complicated":[8,287],"by":[9,147,266,288,304],"mostly":[11],"irreplaceable":[12],"nature":[13],"neurons,":[15,172,426],"as":[16,145],"loss":[18],"neurons":[20,34,85,190],"has":[21],"potential":[23],"to":[24,29,141,169,193,261,283,327,337,357,422,449],"result":[25],"in":[26,38,77,126,130,162,184,222,232,241,254,271,281,299,315,335,370,383,418,441],"permanent":[27],"damage":[28,363],"brain":[30,314],"function.":[31,211],"However,":[32],"whether":[33,84],"or":[35,86],"other":[36,87,171],"cells":[37,89,138,253,294,311,407],"CNS":[40,88,256],"sometimes":[41],"survive":[42,90,142,409,433],"and":[44,107,197,236,264,269,273,303,364,387,392,412,436,445],"effects":[46,204],"on":[49,209],"neuronal":[50],"function":[51,298],"are":[52,167,191,249],"largely":[53],"unknown.":[54],"To":[55,82],"address":[56],"this":[57,94,185,215],"question,":[58],"I":[59,97,319],"used":[60,320],"rJHM":[62],"strain":[63],"(rJ)":[64],"mouse":[66],"hepatitis":[67],"virus,":[68,96],"(MHV),":[69],"a":[70,99,113,174,199,321,340,439],"neurotropic":[71,341],"coronavirus,":[72],"which":[73,166],"causes":[74],"acute":[75,91],"encephalitis":[76],"susceptible":[78],"strains":[79],"mice.":[81],"determine":[83],"with":[93,123,295,339],"virulent":[95],"developed":[98],"recombinant":[100],"JHMV":[101],"that":[102,110,136,188,324,332,347,408],"expresses":[103],"Cre":[104],"recombinase":[105],"(rJ-Cre)":[106],"infected":[108],"mice":[109,122],"universally":[111],"expressed":[112],"silent":[114],"(floxed)":[115],"version":[116],"tdTomato.":[118],"Infection":[119],"these":[121,401],"rJ-Cre":[124],"resulted":[125,369],"expression":[127,150],"tdTomato":[129,149],"host":[131,395],"cells.":[132,180],"The":[133,181],"results":[134,182,345,376],"showed":[135],"some":[137,189],"were":[139,349],"able":[140],"infection,":[144,263],"demonstrated":[146],"continued":[148],"after":[151],"virus":[152,223],"antigen":[153],"could":[154],"no":[155],"longer":[156],"be":[157],"detected.":[158],"Most":[159],"notably,":[160],"interneurons":[161,428],"olfactory":[164,431],"bulb,":[165],"known":[168],"inhibit":[170],"represented":[173],"large":[175],"fraction":[176],"surviving":[179],"described":[183],"thesis":[186,216],"indicated":[187],"resistant":[192],"virus-mediated":[194],"cell":[195,373,390],"death":[196],"provide":[198,403],"framework":[200],"for":[201,230,381,393],"studying":[202],"prior":[206],"coronavirus":[207,342],"neuron":[210],"Another":[212],"aspect":[213],"concerns":[217],"role":[219,278,415,440],"microglia":[221,231,280,326,333,348,367,382,416,437],"infections.":[224],"Recent":[225],"findings":[226],"have":[227],"highlighted":[228],"roles":[229,331,380],"orchestrating":[233],"normal":[234],"development":[235],"refining":[237],"neural":[238],"network":[239],"connectivity":[240],"healthy":[243,301],"(CNS).":[247],"Microglia":[248],"not":[250],"only":[251],"vital":[252],"maintaining":[255],"homeostasis,":[257],"but":[258],"also":[259],"respond":[260],"injury,":[262],"disease,":[265],"undergoing":[267],"proliferation,":[268],"changes":[270],"transcription":[272],"morphology.":[274],"Understanding":[275],"specific":[277,330],"responding":[282],"viral":[284,398],"presence":[290],"non-microglial":[292],"myeloid":[293,310],"potentially":[296],"overlapping":[297],"brain,":[302],"rapid":[306],"infiltration":[307],"hematopoietic":[309],"into":[312,406,413],"diseased":[316],"states.":[317],"Here,":[318],"CSF1R":[322],"inhibitor":[323],"depletes":[325],"examine":[328],"play":[334,417,438],"response":[336,421,448],"(MHV).":[343],"My":[344],"show":[346],"required":[350],"during":[351],"first":[353],"days":[354],"post":[355],"limit":[358],"MHV":[359,410,434],"replication,":[360],"subsequent":[361,394],"tissue":[362],"lethality.":[365],"Additionally,":[366],"depletion":[368],"ineffective":[371],"T":[372,389],"responses.":[374],"These":[375],"reveal":[377],"nonredundant,":[378],"critical":[379],"early":[385],"innate":[386,444],"virus-specific":[388],"responses":[391],"protection":[396],"from":[397],"encephalitis.":[399],"Overall":[400],"studies":[402],"new":[404],"insight":[405],"immune":[420,447],"MHV.":[423],"Specifically,":[424],"many":[425],"especially":[427],"bulb":[432],"both":[442],"adaptive":[446],"viruses.":[450]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-11-22T00:00:00"}
