{"id":"https://openalex.org/W2986155203","doi":"https://doi.org/10.1093/neuonc/noz175.1152","title":"SCIDOT-16. T2-WEIGHTED IMAGING MAY BE INDICATIVE OF DRUG DISTRIBUTION IN GLIOBLASTOMA PATIENTS","display_name":"SCIDOT-16. T2-WEIGHTED IMAGING MAY BE INDICATIVE OF DRUG DISTRIBUTION IN GLIOBLASTOMA PATIENTS","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2986155203","doi":"https://doi.org/10.1093/neuonc/noz175.1152","mag":"2986155203"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noz175.1152","doi":"https://doi.org/10.1093/neuonc/noz175.1152","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.1152","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6846504","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087584073","display_name":"Pamela Jackson","orcid":"https://orcid.org/0000-0002-8424-4007","observed_orcids":["https://orcid.org/0000-0002-8424-4007"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela Jackson","raw_affiliation_strings":["Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107994274","display_name":"Minjee Kim","orcid":"https://orcid.org/0000-0002-0035-4437","observed_orcids":["https://orcid.org/0000-0002-0035-4437"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minjee Kim","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052721598","display_name":"Andrea J. Hawkins-Daarud","orcid":"https://orcid.org/0000-0002-6391-4155","observed_orcids":["https://orcid.org/0000-0002-6391-4155"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Hawkins-Daarud","raw_affiliation_strings":["Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027970167","display_name":"Kyle Singleton","orcid":"https://orcid.org/0000-0002-9969-8474","observed_orcids":["https://orcid.org/0000-0002-9969-8474"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Singleton","raw_affiliation_strings":["Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055522460","display_name":"Afroz Shareef Mohammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Afroz Mohammad","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112556126","display_name":"Terence C. Burns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terence Burns","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042333597","display_name":"Ian F. Parney","orcid":"https://orcid.org/0000-0002-9702-8047","observed_orcids":["https://orcid.org/0000-0002-9702-8047"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Parney","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058133357","display_name":"Leland Hu","orcid":"https://orcid.org/0000-0001-9282-7619","observed_orcids":["https://orcid.org/0000-0001-9282-7619"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leland Hu","raw_affiliation_strings":["Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059989712","display_name":"Timothy J. Kaufmann","orcid":"https://orcid.org/0000-0001-7483-1569","observed_orcids":["https://orcid.org/0000-0001-7483-1569"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Kaufmann","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037781231","display_name":"William F. Elmquist","orcid":"https://orcid.org/0000-0002-7478-3429","observed_orcids":["https://orcid.org/0000-0002-7478-3429"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Elmquist","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015247761","display_name":"Jann Nagina Sarkaria","orcid":"https://orcid.org/0000-0001-7489-4885","observed_orcids":["https://orcid.org/0000-0001-7489-4885"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jann Sarkaria","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014011778","display_name":"Kristin R. Swanson","orcid":"https://orcid.org/0000-0002-2464-6119","observed_orcids":["https://orcid.org/0000-0002-2464-6119"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Swanson","raw_affiliation_strings":["Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.1358,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50068278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"Supplement_6","first_page":"vi274","last_page":"vi275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/t2-weighted-imaging","display_name":"T2-weighted imaging","score":0.8560000061988831},{"id":"https://openalex.org/keywords/flair","display_name":"FLAIR","score":0.8389999866485596},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cefazolin","display_name":"cefazolin","score":0.7979999780654907},{"id":"https://openalex.org/keywords/levetiracetam","display_name":"levetiracetam","score":1.0},{"id":"https://openalex.org/keywords/brain-to-plasma-ratio","display_name":"brain-to-plasma ratio","score":0.9380000233650208},{"id":"https://openalex.org/keywords/image-guided-biopsy","display_name":"image-guided biopsy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7124108076095581},{"id":"https://openalex.org/C101070640","wikidata":"https://www.wikidata.org/wiki/Q3737215","display_name":"Fluid-attenuated inversion recovery","level":3,"score":0.6347226500511169},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.603060781955719},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5609625577926636},{"id":"https://openalex.org/C2776429142","wikidata":"https://www.wikidata.org/wiki/Q1620189","display_name":"Brain biopsy","level":3,"score":0.47683992981910706},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4286843538284302},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.37252214550971985},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3498120903968811}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noz175.1152","doi":"https://doi.org/10.1093/neuonc/noz175.1152","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.1152","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6846504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6846504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6846504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6846504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3217098165","https://openalex.org/W3217177872","https://openalex.org/W2900119248","https://openalex.org/W4414069046","https://openalex.org/W2767562493","https://openalex.org/W2134371696","https://openalex.org/W2410254333","https://openalex.org/W1985149083","https://openalex.org/W2083113845","https://openalex.org/W4407740133"],"abstract_inverted_index":{"Abstract":[0],"OBJECTIVES":[1],"Dogma":[2],"suggests":[3],"that":[4,220,250,260],"for":[5,146,202],"brain":[6,67],"tumors,":[7],"regions":[8],"of":[9,44,62,111,165,194,200,226,235,257,261,282],"enhancement":[10,28],"on":[11,298],"T1-weighted":[12],"gadolinium":[13,87,296],"contrast":[14,88],"enhanced":[15,89],"(T1Gd)":[16],"magnetic":[17],"resonance":[18],"imaging":[19,55],"(MRI)":[20],"correlate":[21],"with":[22],"intravenously":[23],"delivered":[24],"drug":[25,63,147,155,283],"distribution":[26,297],"as":[27,159],"indicates":[29],"a":[30,254,268],"compromised":[31],"blood-brain":[32],"barrier":[33],"(BBB).":[34],"However,":[35],"poor":[36],"response":[37],"to":[38,116,169,190,210,259,271,287],"intravenous":[39],"therapies":[40],"highlights":[41],"the":[42,45,107,163,211,245,246,275,295],"importance":[43],"diffuse":[46],"disease":[47],"beyond":[48],"enhancing":[49],"regions.":[50],"This":[51],"study":[52],"investigated":[53],"whether":[54],"features":[56],"can":[57],"provide":[58],"an":[59,121,132,178],"accurate":[60],"prediction":[61],"distribution.":[64],"METHODS":[65],"Eight":[66],"tumor":[68],"patients":[69,118],"(7":[70],"gliomas":[71],"and":[72,91,113,127,139,144,229,239,264,291],"1":[73],"metastatic":[74],"adenocarcinoma)":[75],"were":[76,99,142,197,206],"included":[77],"in":[78],"this":[79],"Phase":[80],"0":[81],"trial.":[82],"Presurgery":[83],"T1-weighted,":[84],"T1Gd,":[85],"T2-weighted":[86,92,288],"(T2Gd),":[90],"Fluid":[93],"Attenuated":[94],"Inversion":[95],"Recovery":[96],"(T2FLAIR)":[97],"MRIs":[98],"acquired.":[100],"All":[101],"images":[102],"underwent":[103],"bias":[104],"correction":[105],"using":[106,149],"N4":[108],"algorithm,":[109],"standardization":[110],"intensities,":[112],"registration.":[114],"Prior":[115],"incision,":[117],"received":[119],"both":[120,203],"antibiotic":[122],"cefazolin":[123,227,265],"(6%":[124],"BBB":[125,130],"penetrance)":[126],"levetiracetam":[128,236,251],"(80%":[129],"penetrance),":[131],"anti-seizure":[133],"drug.":[134],"Subsequently,":[135],"multiple":[136],"blood":[137],"samples":[138,243],"image-guided":[140],"biopsies":[141],"taken":[143],"analyzed":[145,208],"concentration":[148,167],"liquid":[150],"chromatography":[151],"mass":[152],"spectrometry.":[153],"Biopsy":[154],"levels":[156],"are":[157],"reported":[158],"Brain-Plasma":[160],"Ratio":[161],"(BPR),":[162],"ratio":[164],"biopsy":[166,184,212],"relative":[168],"plasma":[170],"concentration.":[171],"Mean":[172],"image":[173,195],"intensity":[174,222,231],"was":[175,188,223,232],"extracted":[176],"from":[177],"8x8":[179],"mm":[180],"window":[181],"surrounding":[182],"each":[183],"location.":[185],"Regression":[186,217],"analysis":[187,218,277],"performed":[189],"determine":[191],"which":[192],"combination":[193],"types":[196],"linearly":[198,224,233],"predictive":[199,225,234],"BPR":[201,228,237,252,266],"drugs.":[204],"Correlations":[205],"also":[207],"according":[209,244],"location":[213],"radiographic":[214,247],"appearance.":[215],"RESULTS":[216],"revealed":[219,249],"T2Gd":[221],"FLAIR":[230,262],"(p=0.009":[238],"0.041,":[240],"respectively).":[241],"Grouping":[242],"appearance":[248],"had":[253,267],"similar":[255,269],"pattern":[256,270],"values":[258],"intensities":[263],"T2,":[272],"further":[273],"supporting":[274],"regression":[276],"results.":[278],"CONCLUSIONS":[279],"Local":[280],"concentrations":[281],"may":[284],"be":[285],"related":[286],"signals":[289],"(T2Gd":[290],"T2FLAIR)":[292],"rather":[293],"than":[294],"T1Gd":[299],"images.":[300]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}
