{"id":"https://openalex.org/W2986111131","doi":"https://doi.org/10.4103/trp.trp_37_19","title":"A case-based approach to aggressive variants of papillary thyroid carcinoma with literature review","display_name":"A case-based approach to aggressive variants of papillary thyroid carcinoma with literature review","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2986111131","doi":"https://doi.org/10.4103/trp.trp_37_19","mag":"2986111131"},"language":"en","primary_location":{"id":"doi:10.4103/trp.trp_37_19","doi":"https://doi.org/10.4103/trp.trp_37_19","is_oa":true,"landing_page_url":"https://doi.org/10.4103/trp.trp_37_19","pdf_url":null,"source":{"id":"https://openalex.org/S2764746808","display_name":"Thyroid Research and Practice","issn_l":"0973-0354","issn":["0973-0354","2250-1452"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid Research and Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/trp.trp_37_19","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110647802","display_name":"JosephAntoine Flordelis Chatto","orcid":"https://orcid.org/0000-0003-4862-3509","observed_orcids":["https://orcid.org/0000-0003-4862-3509"]},"institutions":[{"id":"https://openalex.org/I4405282336","display_name":"Gov. Celestino Gallares Memorial Medical Center","ror":"https://ror.org/05pmb4g53","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I4405282336"]}],"countries":["PH"],"is_corresponding":true,"raw_author_name":"JosephAntoine Flordelis Chatto","raw_affiliation_strings":["Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines","Dr. Joseph Antoine Flordelis Chatto, Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines. E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines","institution_ids":["https://openalex.org/I4405282336"]},{"raw_affiliation_string":"Dr. Joseph Antoine Flordelis Chatto, Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I4405282336"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050540342","display_name":"Annette L. Salillas","orcid":"https://orcid.org/0000-0002-6219-4934","observed_orcids":["https://orcid.org/0000-0002-6219-4934"]},"institutions":[{"id":"https://openalex.org/I4405281442","display_name":"Matias H. Aznar Memorial College of Medicine","ror":"https://ror.org/04bepaf88","country_code":"PH","type":"education","lineage":["https://openalex.org/I4405281442"]},{"id":"https://openalex.org/I4405282336","display_name":"Gov. Celestino Gallares Memorial Medical Center","ror":"https://ror.org/05pmb4g53","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I4405282336"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"AnnetteLaurente Salillas","raw_affiliation_strings":["Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines","Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol; Department of Pathology, MHAM College of Medicine, Cebu City, Philippines","Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol","Department of Pathology, MHAM College of Medicine, Cebu City, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines","institution_ids":["https://openalex.org/I4405282336"]},{"raw_affiliation_string":"Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol; Department of Pathology, MHAM College of Medicine, Cebu City, Philippines","institution_ids":["https://openalex.org/I4405281442","https://openalex.org/I4405282336"]},{"raw_affiliation_string":"Department of Pathology, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol","institution_ids":["https://openalex.org/I4405282336"]},{"raw_affiliation_string":"Department of Pathology, MHAM College of Medicine, Cebu City, Philippines","institution_ids":["https://openalex.org/I4405281442"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110647802"],"corresponding_institution_ids":["https://openalex.org/I4405282336"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"3","first_page":"128","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12631","display_name":"Head and Neck Anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tall-cell-variant","display_name":"tall cell variant","score":0.9929999709129333},{"id":"https://openalex.org/keywords/columnar-cell-variant","display_name":"columnar cell variant","score":0.9990000128746033},{"id":"https://openalex.org/keywords/solid-variant","display_name":"solid variant","score":0.9800000190734863},{"id":"https://openalex.org/keywords/fine-needle-aspiration-cytology","display_name":"fine needle aspiration cytology","score":0.9580000042915344},{"id":"https://openalex.org/keywords/preoperative-diagnosis","display_name":"preoperative diagnosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/extrathyroidal-extension","display_name":"extrathyroidal extension","score":0.8190000057220459},{"id":"https://openalex.org/keywords/angiolymphatic-invasion","display_name":"angiolymphatic invasion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8456128835678101},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5903380513191223},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5878592133522034},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5848816633224487},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5818291902542114},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5345949530601501},{"id":"https://openalex.org/C2776170712","wikidata":"https://www.wikidata.org/wiki/Q180071","display_name":"Fine-needle aspiration","level":3,"score":0.5045098066329956},{"id":"https://openalex.org/C2910118542","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Columnar Cell","level":3,"score":0.4857178330421448},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16369178891181946},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.14712455868721008}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4103/trp.trp_37_19","doi":"https://doi.org/10.4103/trp.trp_37_19","is_oa":true,"landing_page_url":"https://doi.org/10.4103/trp.trp_37_19","pdf_url":null,"source":{"id":"https://openalex.org/S2764746808","display_name":"Thyroid Research and Practice","issn_l":"0973-0354","issn":["0973-0354","2250-1452"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid Research and Practice","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4103/trp.trp_37_19","doi":"https://doi.org/10.4103/trp.trp_37_19","is_oa":true,"landing_page_url":"https://doi.org/10.4103/trp.trp_37_19","pdf_url":null,"source":{"id":"https://openalex.org/S2764746808","display_name":"Thyroid Research and Practice","issn_l":"0973-0354","issn":["0973-0354","2250-1452"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid Research and Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1482380759","https://openalex.org/W1516462232","https://openalex.org/W1544494062","https://openalex.org/W1603825335","https://openalex.org/W1965562774","https://openalex.org/W1986414877","https://openalex.org/W1989924283","https://openalex.org/W1992856626","https://openalex.org/W1994933955","https://openalex.org/W2002850506","https://openalex.org/W2025600950","https://openalex.org/W2030838366","https://openalex.org/W2034082125","https://openalex.org/W2036920146","https://openalex.org/W2039072853","https://openalex.org/W2047793119","https://openalex.org/W2051606024","https://openalex.org/W2053465394","https://openalex.org/W2061668397","https://openalex.org/W2064013253","https://openalex.org/W2064051712","https://openalex.org/W2071434600","https://openalex.org/W2084239631","https://openalex.org/W2086737867","https://openalex.org/W2088690991","https://openalex.org/W2092724101","https://openalex.org/W2114882431","https://openalex.org/W2120911638","https://openalex.org/W2120969789","https://openalex.org/W2130293019","https://openalex.org/W2132219646","https://openalex.org/W2197037292","https://openalex.org/W2233597197","https://openalex.org/W2296201863","https://openalex.org/W2310728560","https://openalex.org/W2316088768","https://openalex.org/W2396174948","https://openalex.org/W2396858997","https://openalex.org/W2551678005","https://openalex.org/W2563443851","https://openalex.org/W2570649983","https://openalex.org/W2572375726","https://openalex.org/W2588067095","https://openalex.org/W2588121704","https://openalex.org/W2598540246","https://openalex.org/W2606000821","https://openalex.org/W2771157336","https://openalex.org/W2793905974"],"related_works":["https://openalex.org/W1984880449","https://openalex.org/W2039801734","https://openalex.org/W4365143205","https://openalex.org/W4285300580","https://openalex.org/W6966669261","https://openalex.org/W2884567013","https://openalex.org/W2160413879","https://openalex.org/W4286203091","https://openalex.org/W4409753201","https://openalex.org/W2604666481"],"abstract_inverted_index":{"Papillary":[0],"thyroid":[1,8],"caarcinoma":[2],"(PTC)":[3],"is":[4,41,76,108,125,144,188],"the":[5,23,45],"most":[6],"common":[7],"and":[9,32,60,64,86,121,171,183,197],"endocrine":[10],"malignancy.":[11],"Although":[12],"considered":[13],"to":[14,42,175,192],"be":[15],"indolent,":[16],"aggressive":[17],"variants":[18,195],"have":[19,163],"been":[20],"identified,":[21],"including":[22],"Tall":[24],"Cell":[25,28],"(TCV),":[26],"Columnar":[27],"(CCV),":[29],"Hobnail":[30],"(HPTC)":[31],"Solid":[33],"Variants":[34],"(SVPTC).":[35],"The":[36,73,105,141],"objective":[37],"of":[38,48,56,102,166],"this":[39],"study":[40],"pre-operatively":[43,83],"recognize":[44,193],"cytologic":[46],"features":[47,165],"these":[49,194],"variants.":[50],"Four":[51],"cases":[52],"with":[53,66,81,98,112,118,129,138,149],"final":[54],"diagnoses":[55],"TCV,":[57,168],"CCV,":[58,169],"HPTC":[59,130,170],"SVPTC":[61,150,172],"were":[62],"reviewed":[63],"compared":[65],"Fine":[67],"Needle":[68],"Aspiration":[69],"Biopsy":[70],"(FNAB)":[71],"smears.":[72],"first":[74],"case":[75,143],"a":[77,109,126,135,145],"44-year-old":[78],"female":[79,111,128,147],"diagnosed":[80,148],"TCV":[82],"through":[84,89],"FNAB":[85,187],"was":[87],"confirmed":[88],"tissue":[90],"biopsy":[91],"showing":[92,114,151],"malignant":[93],"glands":[94],"in":[95],"papillary":[96],"formation":[97],"greater":[99],"than":[100],"50%":[101],"tall":[103],"cells.":[104],"second":[106],"patient":[107],"54-year-old":[110],"CCV":[113],"stratified":[115],"columnar":[116],"cells":[117],"cytoplasmic":[119],"supranuclear":[120],"subnuclear":[122],"vacuoles.":[123],"Third":[124],"57-year-old":[127],"exhibiting":[131],"eccentrically-located":[132],"nuclei":[133],"imparting":[134],"hobnail":[136],"appearance":[137],"cellular":[139],"dyscohesiveness.":[140],"fourth":[142],"59-year-old":[146],"predominantly":[152],"solid":[153],"sheets":[154],"surrounded":[155],"by":[156],"thin,":[157],"delicate":[158],"fibrous":[159],"stroma.":[160],"They":[161],"all":[162],"nuclear":[164],"PTC.":[167],"are":[173],"related":[174],"extrathyroidal":[176],"extension,":[177],"angiolymphatic":[178],"invasion,":[179],"positive":[180],"surgical":[181],"margin":[182],"lymph":[184],"node":[185],"metastasis.":[186],"an":[189],"important":[190],"tool":[191],"preoperatively":[196],"plan":[198],"for":[199],"amore":[200],"comprehensive":[201],"management.":[202]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}